Diagnosis and treatment in the era of precision medicine – Precision medicine and tailor-made medicine

Personalized Medicine Universe Pub Date : 2017-07-01 Epub Date: 2017-06-23 DOI:10.1016/j.pmu.2017.03.002
Masayoshi Nagata, Shigeo Horie
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引用次数: 1

Abstract

Recently, precision medicine has gained attention in several fields of medical society. Today's medical consensus revolves around Evidence-Based Medicine (EBM) built on the results of many randomized controlled trials. Ever since the advent of EBM, guidelines based on EBM have provided a basis for clinical decision-making. Treatments based on these guidelines largely improved the prognosis of a certain ailment. However, these guidelines can only provide the best fit based on the statistics. Treatments based on the statistics leave behind many un- or less-responsive patients. Herein, we explain in detail the concept of “precision medicine” launched by the Obama administration in the U.S., its difference from personalized medicine, how it started to take shape, and the benefits it is expected to bring to our society.

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精准医疗时代的诊疗——精准医疗和量身定制医疗
近年来,精准医学已经引起了医学界多个领域的关注。今天的医学共识围绕着基于许多随机对照试验结果的循证医学(EBM)。自循证医学出现以来,基于循证医学的指南为临床决策提供了依据。基于这些指导方针的治疗在很大程度上改善了某种疾病的预后。然而,这些指导方针只能提供基于统计数据的最佳匹配。基于统计数据的治疗留下了许多无反应或反应较差的患者。本文将详细阐述美国奥巴马政府提出的“精准医疗”概念,它与个性化医疗的区别,它是如何形成的,以及它有望给我们社会带来的好处。
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