ADR, an optimized combination of ASIV, DLA, and R1, ameliorates blood-brain barrier disruption following rtPA thrombolysis at 4.5?h after stroke onset in mice via multitarget regulation.

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DOI:10.1016/j.jare.2026.07.058
作者：Yi Zhang, Fan-Kai Chen, Shan-Shan Yue, Chun-Shui Pan, Quan Li, Li Yan, Xin-Mei Huo, Kai Sun, Xiao-Qing Lu, Hong-Biao Liang, Shu-Qi Yao, Bo-Tong L
文献类型：期刊论文
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Elsevier

Abstract：Introduction: Administration of recombinant tissue plasminogen activator (rtPA) beyond 4.5  h after ischemic stroke exacerbates blood-brain barrier (BBB) disruption, leading to vasogenic cer

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