Benjamin Philmus , Nicole E. Avalon , Yousong Ding , Drew T. Doering , Alessandra S. Eustáquio , William H. Gerwick , Hendrik Luesch , Jimmy Orjala , Shaz Sutherland , Arnaud Taton , Daniel Udwary
{"title":"Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery","authors":"Benjamin Philmus , Nicole E. Avalon , Yousong Ding , Drew T. Doering , Alessandra S. Eustáquio , William H. Gerwick , Hendrik Luesch , Jimmy Orjala , Shaz Sutherland , Arnaud Taton , Daniel Udwary","doi":"10.1039/d5np00016e","DOIUrl":null,"url":null,"abstract":"<div><div>Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we discuss the challenges faced by all natural product researchers, especially those that focus on cyanobacteria, and then describe progress that has been made in these areas. We also propose some solutions, paths forward, and thoughts for consideration on these challenges.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"43 2","pages":"Pages 286-300"},"PeriodicalIF":12.5000,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Reports","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S0265056825000820","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/15 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we discuss the challenges faced by all natural product researchers, especially those that focus on cyanobacteria, and then describe progress that has been made in these areas. We also propose some solutions, paths forward, and thoughts for consideration on these challenges.
期刊介绍：
Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis.
With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results.
NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
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