{"title":"Ultrastructural characterization of extracellular vesicles produced by <i>Encephalitozoon cuniculi</i>-infected B-1 cells.","authors":"Alicia Herrera Gutiérrez, Rayane Cristina Bego, Diva Denelle Spadacci-Morena, Patrícia Batista Xander, Anuska Marcelino Alvares-Saraiva, Elizabeth Cristina Pérez, Uziel Castillo Velázquez, Maria Anete Lallo","doi":"10.1080/01913123.2025.2580509","DOIUrl":null,"url":null,"abstract":"<p><p>Herein, we analyzed the ultrastructure of the EVs released by <i>E. cuniculi</i>-infected B-1 cells or uninfected. Clusters of exosomes, also called intraluminal vesicles (ILVs), were surrounded by a membrane that was continuous with the plasma membrane of B-1 cells, characterizing the EVs known as multivesicular cargo (MVC). Migrasomes corresponded to clusters of exosomes located in the projection of the cell membrane. Ectosomes originated via the budding of the plasma membrane. To conclude, we showed that <i>E. cuniculi</i>-infected B-1 cells or B-1 CDP secrete large amounts of EVS especially after challenge with <i>E. cuniculi</i>.</p>","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"28-36"},"PeriodicalIF":1.2000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ultrastructural Pathology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/01913123.2025.2580509","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/10/28 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MICROSCOPY","Score":null,"Total":0}
引用次数: 0
Abstract
Herein, we analyzed the ultrastructure of the EVs released by E. cuniculi-infected B-1 cells or uninfected. Clusters of exosomes, also called intraluminal vesicles (ILVs), were surrounded by a membrane that was continuous with the plasma membrane of B-1 cells, characterizing the EVs known as multivesicular cargo (MVC). Migrasomes corresponded to clusters of exosomes located in the projection of the cell membrane. Ectosomes originated via the budding of the plasma membrane. To conclude, we showed that E. cuniculi-infected B-1 cells or B-1 CDP secrete large amounts of EVS especially after challenge with E. cuniculi.
期刊介绍：
Ultrastructural Pathology is the official journal of the Society for Ultrastructural Pathology. Published bimonthly, we are the only journal to be devoted entirely to diagnostic ultrastructural pathology.
Ultrastructural Pathology is the ideal journal to publish high-quality research on the following topics:
Advances in the uses of electron microscopic and immunohistochemical techniques
Correlations of ultrastructural data with light microscopy, histochemistry, immunohistochemistry, biochemistry, cell and tissue culturing, and electron probe analysis
Important new, investigative, clinical, and diagnostic EM methods.
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