Potential molecular mechanism of Cangshu guiding phlegm pill in the treatment of T2DM based on metabolic abnormality diagnosis: detection of key biomarkers.

IF 3.2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Archives of Physiology and Biochemistry Pub Date : 2026-04-16 DOI:10.1080/13813455.2026.2657413

Jia Zeng, Dongfang Yin, Fang Yan, Shougen Li

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Abstract

Background and purpose: This study, based on the network pharmacology approach, aims to systematically explore the potential molecular mechanism of Cangshu Diantong Pill in treating type 2 diabetes (T2DM), and particularly emphasises the theoretical correlation between its mechanism of action and the modern metabolic abnormality diagnostic indicators.

Methods: The study first screened the active components in Cangshu Diantong Pill that have pharmacokinetic characteristics through databases such as TCMIP, it integrated disease databases to obtain T2DM-related targets and constructed a drug-disease intersection target network. Core targets included AKT2, TNF, ADIPOQ, IGF1, etc., all of which are key biomarkers in current metabolic abnormality diagnostics.

Results: Pathway enrichment showed that Cangshu Diantong Pill mainly exerts its effects by regulating signalling pathways.

Conclusion: The study suggests that Cangshu Diantong Pill's intervention on T2DM may manifest as a synergistic regulation of multiple metabolic abnormality links, and its theoretical action pathway is highly consistent with the modern metabolic diagnostic system.

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基于代谢异常诊断的苍舒导痰丸治疗T2DM的潜在分子机制：关键生物标志物的检测

背景与目的：本研究基于网络药理学方法，旨在系统探索苍术点痛丸治疗2型糖尿病（T2DM）的潜在分子机制，特别强调其作用机制与现代代谢异常诊断指标之间的理论相关性。方法：本研究首先通过TCMIP等数据库筛选参舒电痛丸中具有药动学特征的有效成分，整合疾病数据库获取t2dm相关靶点，构建药病交叉靶点网络。核心靶点包括AKT2、TNF、ADIPOQ、IGF1等，都是当前代谢异常诊断的关键生物标志物。结果：通路富集表明苍舒电痛丸主要通过调节信号通路发挥作用。结论：本研究提示苍舒电通丸干预T2DM可能表现为协同调节多种代谢异常环节，其理论作用途径与现代代谢诊断体系高度一致。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.