Monitoraggio degli effetti dell’inquinamento atmosferico in bambini (MAPEC) residenti vicino cementifici: disegno dello studio del progetto MAPEC Gubbio

Q4 Social Sciences Sistema Pub Date : 2024-01-01 DOI:10.48291/sisa.68.2.2

Mattia Acito, Tommaso Rondini, Edoardo Franceschini, Milena Villarini, Cristina Fatigoni

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Abstract

Key Words: pollution, micronuclei, particulate matter SUMMARY Objectives: the main goal of the proposed molecular epidemiology approach is to assess the association between airborne pollutants (e.g., particulate matter, nitrogen oxides, polycyclic aromatic hydrocarbons, etc.) and early biological (genotoxic) effects in children. Methods: early biological effect biomarkers (i.e., micronuclei and nuclear buds) will be assessed in exfo- liated buccal mucosa cells of 6–8-year scholars living in Gubbio (exposed) and in Città di Castello (controls). Free available data on airborne pollution will be gathered from the ARPA Umbria website, and indoor exposure to genotoxic xenobiotics will be assessed by administering an ad-hoc questionnaire. Both buccal mucosa cell sampling and airborne data collection will be repeated in 2 different seasons (Spring/Summer and Fall/Winter), characterized by different concentrations of pollutants. Conclusions: the whole dataset will be analyzed to detect the association between exposure to air pollutants and the frequency of early biological effect biomarkers. Autore per corrispondenza: edoardo.franceschini@unipg.it

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监测住在水泥厂附近的儿童(MAPEC)空气污染的影响:MAPEC gu比奥项目研究的设计

关键词：污染、微核、颗粒物目的：本文提出的分子流行病学方法的主要目的是评估空气污染物（如颗粒物、氮氧化物、多环芳烃等）与儿童早期生物学（遗传毒性）效应之间的关系。早期生物效应生物标志物（即微核和核芽）将在居住在古比奥的6 - 8岁的学生的口腔粘膜细胞中进行评估（暴露组）和citt di Castello（对照组）。将从ARPA翁布里亚网站上收集有关空气污染的免费数据，并通过管理一份特设问卷来评估室内暴露于遗传毒性异种抗生素的情况。口腔粘膜细胞取样和空气数据采集将在两个不同的季节（春/夏和秋/冬）重复进行，其特征是污染物浓度不同。 ；结论：将分析整个数据集，以检测暴露于空气污染物与早期生物效应生物标志物频率之间的关系。 ；

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