A Review of Electrochemical Biosensors for Diagnosis of Periodontal Disease: Focus on Electrochemical Sensing Strategies

IF 2.6 3区化学 Q2 CHEMISTRY, ANALYTICAL Electroanalysis Pub Date : 2026-10-26 DOI:10.1002/elan.70243

Zhen Zhang, Dongxu Wang, Longbiao Dong, Honglin Liu, Changjun Guan

{"title":"A Review of Electrochemical Biosensors for Diagnosis of Periodontal Disease: Focus on Electrochemical Sensing Strategies","authors":"Zhen Zhang, Dongxu Wang, Longbiao Dong, Honglin Liu, Changjun Guan","doi":"10.1002/elan.70243","DOIUrl":null,"url":null,"abstract":"Diagnosis of periodontal disease by biosensors has recently received abundant attention. In this review, recently reported biosensors developed for the diagnosis of periodontal disease are systematically collected, categorized, and reviewed. Currently, the main specific biomarkers for the detection of periodontal disease are Porphyromonas gingivalis (P. gingivalis) and its polymerase chain reaction (PCR) products. In addition, some nonspecific markers such as hydrogen sulfide (H2S), hydrogen peroxide (H2O2), sodium ions (Na+), lactoferrin, MMP-8, IL-1β, and odontogenic ameloblast-associated protein (ODAM) have been used for early detection of periodontal disease. In general, the choice of materials in these biosensors depends on interactions between materials and aptamers or application environments. In this paper, the diagnostic mechanism of the sensor and the interaction between the biorecognition element and signal transducer are analyzed. This review provides a systematic classification and comparative analysis of the detection techniques, biorecognition elements, target pathogens, and limits of detection (LOD) of these biosensors and discusses their applicability for early diagnosis of periodontal disease.","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 11","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electroanalysis","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/elan.70243","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Diagnosis of periodontal disease by biosensors has recently received abundant attention. In this review, recently reported biosensors developed for the diagnosis of periodontal disease are systematically collected, categorized, and reviewed. Currently, the main specific biomarkers for the detection of periodontal disease are Porphyromonas gingivalis (P. gingivalis) and its polymerase chain reaction (PCR) products. In addition, some nonspecific markers such as hydrogen sulfide (H₂S), hydrogen peroxide (H₂O₂), sodium ions (Na⁺), lactoferrin, MMP-8, IL-1β, and odontogenic ameloblast-associated protein (ODAM) have been used for early detection of periodontal disease. In general, the choice of materials in these biosensors depends on interactions between materials and aptamers or application environments. In this paper, the diagnostic mechanism of the sensor and the interaction between the biorecognition element and signal transducer are analyzed. This review provides a systematic classification and comparative analysis of the detection techniques, biorecognition elements, target pathogens, and limits of detection (LOD) of these biosensors and discusses their applicability for early diagnosis of periodontal disease.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

电化学生物传感器在牙周病诊断中的研究进展：以电化学传感策略为重点

生物传感器诊断牙周病近年来受到广泛关注。在这篇综述中，系统地收集、分类和回顾了最近报道的用于牙周病诊断的生物传感器。目前，检测牙周病的主要特异性生物标志物是牙龈卟啉单胞菌（P. gingivalis）及其聚合酶链反应产物。此外，一些非特异性标志物如硫化氢（H2S）、过氧化氢（H2O2）、钠离子（Na+）、乳铁蛋白、MMP-8、IL-1β和牙源性成釉细胞相关蛋白（ODAM）已被用于牙周病的早期检测。一般来说，这些生物传感器中材料的选择取决于材料与适体或应用环境之间的相互作用。本文分析了传感器的诊断机理以及生物识别元件与信号传感器之间的相互作用。本文对这些生物传感器的检测技术、生物识别要素、靶菌、检出限（LOD）进行了系统的分类和比较分析，并讨论了它们在牙周病早期诊断中的适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Electroanalysis 化学-电化学

CiteScore

6.00

自引率

3.30%

发文量

222

审稿时长

2.4 months

期刊介绍： Electroanalysis is an international, peer-reviewed journal covering all branches of electroanalytical chemistry, including both fundamental and application papers as well as reviews dealing with new electrochemical sensors and biosensors, nanobioelectronics devices, analytical voltammetry, potentiometry, new electrochemical detection schemes based on novel nanomaterials, fuel cells and biofuel cells, and important practical applications. Serving as a vital communication link between the research labs and the field, Electroanalysis helps you to quickly adapt the latest innovations into practical clinical, environmental, food analysis, industrial and energy-related applications. Electroanalysis provides the most comprehensive coverage of the field and is the number one source for information on electroanalytical chemistry, electrochemical sensors and biosensors and fuel/biofuel cells.