首页 > 化学

Removing TPPO from Reactions Using MgCl2 and Wet Milling

有机合成与工艺文献分享 2024-10-25 08:07
文章摘要
本文介绍了一种使用MgCl2和湿磨技术从反应中去除TPPO的方法。通过固体MgCl2与溶液中的TPPO反应，形成不溶性固体复合物，通过简单过滤即可从反应混合物中去除。研究发展表明，通过研磨再生颗粒表面是暴露更多MgCl2的关键，从而增加MgCl2与TPPO的络合速率。因此，引入了湿磨技术以提供研磨颗粒所需的剪切力，并为协议的放大提供更稳健的策略。实验证明，引入湿磨和MgCl2不会在研究反应中产生额外杂质。最终，该湿磨协议在14公斤规模的Mitsunobu偶联反应中成功应用，将粗混合物中的TPPO从37.18%降低到0.15%（HPLC），并在分离产品中降低到0.6%。
Removing TPPO from Reactions Using MgCl2 and Wet Milling
查看文献： Scalable Protocol for Removing Triphenylphosphine Oxide from Reactions Using MgCl2 and Wet Milling
查看期刊：Organic Process Research & Development
阅读全文
本站注明稿件来源为其他媒体的文/图等稿件均为转载稿，本站转载出于非商业性的教育和科研之目的，并不意味着赞同其观点或证实其内容的真实性。如转载稿涉及版权等问题，请作者速来电或来函联系。
推荐文献
Accounts of Chemical Research Accounts of Chemical Research
Corrigendum to "Do All Isolated Traumatic Subarachnoid Hemorrhages Need to Be Transferred to a Level 1 Trauma Center?"
DOI: 10.1177/00031348221119172 Pub Date : 2026-05-01 Date: 2022/8/19 0:00:00
IF 17.7 1区 化学 Q1
Accounts of Chemical Research
ACS Applied Polymer Materials ACS Applied Polymer Materials
Tuning Fiber Membrane Multiscale Configuration via Lens Current to Enhance Single-Electrode Triboelectric Nanogenerator Performance
DOI: 10.1021/acsapm.5c04895 Pub Date : 2026-03-27 Date: 2026/3/12 0:00:00
IF 4.7 2区 化学 Q2
ACS Applied Polymer Materials
Organic Process Research & Development Organic Process Research & Development
A Curious Case of Drug Substance Bulk Properties Affecting the Tablet Dissolution Profile for a Fixed Dose Combination Drug Product
DOI: 10.1021/acs.oprd.6c00016 Pub Date : 2026-04-03
IF 3.4 3区 化学 Q2
Organic Process Research & Development
最新文章
A High Yield Continuous-Flow Nitration Process
A High Yield Continuous-Flow Nitration Process
Org. Process Res. Dev. 2025, 29, 3150−3158. DOI: 10.1021/acs.oprd.5c00273◆This study presents an eff
2025-12-31
New Robust Synthetic Strategy toward FAPI-46
New Robust Synthetic Strategy toward FAPI-46
Org. Process Res. Dev. 2025, 29, 3138−3149. DOI: 10.1021/acs.oprd.5c00267◆The radiolabeled FAPI-46 h
2025-12-29
Optimizing the CHF6523 Isocoumarin Core Scaffold
Optimizing the CHF6523 Isocoumarin Core Scaffold
Org. Process Res. Dev. 2025, 29, 1809−1821. DOI: 10.1021/acs.oprd.5c00133◆A programmed approach for
2025-12-29
Evolution of the Synthesis Route for CC-99677 (2)
Evolution of the Synthesis Route for CC-99677 (2)
Org. Process Res. Dev. 2025, 29, 3159−3172. DOI: 10.1021/acs.oprd.5c00278◆A new route to intermediat
2025-12-26
有机合成与工艺文献分享
A High Yield Continuous-Flow Nitration Process
A High Yield Continuous-Flow Nitration Process 2025-12-31
New Robust Synthetic Strategy toward FAPI-46
New Robust Synthetic Strategy toward FAPI-46 2025-12-29
Optimizing the CHF6523 Isocoumarin Core Scaffold
Optimizing the CHF6523 Isocoumarin Core Scaffold 2025-12-29
Evolution of the Synthesis Route for CC-99677 (2)
Evolution of the Synthesis Route for CC-99677 (2) 2025-12-26
Evolution of the Synthesis Route for CC-99677 (1)
Evolution of the Synthesis Route for CC-99677 (1) 2025-12-24
热门类别
综合性期刊 物理 法学 地球科学 历史学
相关文章
Free Radical Biology and Medicine | 孙宏羽/施李杨团队揭示载脂蛋白J介导的肝肾互作轴驱动慢性肾病进展 祝贺！《Food Innovation and Advances》 入选新锐分区2区(原中科院期刊分区表) Journal of Sensor and Actuator Networks：参会旅行奖申请进行中 | MDPI Award 期刊面面聊 | Journal of Molecular and Cellular Cardiology Plus：IF2.2，CiteScore1.5，国际心脏研究学会 官方期刊 贵州大学何腾霞团队Synthetic and Systems Biotechnology：微生物中NirBD的功能分析及其对土壤氮储存与N2O排放的影响
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们：info@booksci.cn
Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1