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A High Yield Continuous-Flow Nitration Process

有机合成与工艺文献分享 2025-12-31 08:31

文章摘要

本文背景涉及有机合成中硝化反应的重要性，传统方法在收率和安全性方面存在局限。研究目的是开发一种针对2-(丙硫基)嘧啶-4,6-二醇的高效、高收率连续流硝化工艺。通过将反应体系从AcOH/HNO3改为H2SO4/HNO3以解决底物溶解性问题，并优化连续流反应器参数（如酸浓度和温度控制），将反应收率提升至约97.5%。后处理工艺的改进使分离收率达到92.4%，较先前报道提高了12.4%以上。结论表明，通过连续流技术精确控制反应条件，特别是硫酸与硝酸浓度的适当组合及温度管理，有效抑制了嘧啶环开环等副反应，实现了该硝化过程的高收率和可放大性。

A High Yield Continuous-Flow Nitration Process

查看文献： A High Yield Continuous-Flow Nitration Process for the Synthesis of 5-Nitro-2-(propylthio)pyrimidine-4,6-diol
查看期刊：Organic Process Research & Development

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