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Optimizing the CHF6523 Isocoumarin Core Scaffold

有机合成与工艺文献分享 2025-12-29 08:43
文章摘要
本文背景聚焦于有机合成领域，旨在优化CHF6523异香豆素核心骨架的合成工艺。研究目的是开发一种更高效、选择性更好的方法，通过分子内环化反应构建关键中间体，并解决放大生产中出现的主要副产物问题。结论表明，通过使用CuX2盐作为环化促进剂，并调整溶剂体系（如用2-Me-THF/IPA混合物替代二氯乙烷），成功提高了六元环形成的选择性，减少了有害试剂的使用，实现了更安全、环保的合成路径，为大规模生产奠定了基础。
Optimizing the CHF6523 Isocoumarin Core Scaffold
查看文献： Optimizing the CHF6523 Isocoumarin Core Scaffold: From the Preclinical Stage to Large-Scale Production
查看期刊：Organic Process Research & Development
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