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Upscaling Photoredox Cross-Coupling Reactions in Batch

有机合成与工艺文献分享 2025-05-06 08:49
文章摘要
本文探讨了光氧化还原介导的sp2-sp3交叉偶联反应在批量放大过程中面临的挑战及解决方案。背景方面，该反应由MacMillan、Doyle和Molander等团队开发，是一种将多种烷基引入多官能团化合物的有效工具。研究目的聚焦于解决批量放大时光穿透不足导致的反应时间延长和副产物增加问题。通过采用浸入式反应器（IW）装置，研究人员在10-400 mmol规模上成功进行了四种不同的光氧化还原催化碳-碳交叉偶联反应。结论指出，这种反应装置适用于均相和非均相反应混合物，为生命科学工业和学术界的化学家提供了在制备规模上应用这些高价值交叉偶联反应的可行方案。
Upscaling Photoredox Cross-Coupling Reactions in Batch
查看文献： Upscaling Photoredox Cross-Coupling Reactions in Batch Using Immersion-Well Reactors
查看期刊：Organic Process Research & Development
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