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Ivanov Reaction in Flow

有机合成与工艺文献分享 2025-09-02 07:40
文章摘要
本文研究了在流动反应器中进行Ivanov反应以合成γ-酮酸16。背景涉及传统批次反应中因放热导致副产物生成和转化不完全的问题。研究目的是通过流动化学实现阴离子物种的时空分离，提高反应选择性和产品质量。结论表明，采用流动反应器成功解决了批次工艺中的问题，确定了羧酸盐13与双阴离子14的化学计量比为关键参数，并发现iPrMgCl作为碱和锂的亚化学计量添加对反应性能有积极影响。
Ivanov Reaction in Flow
查看文献： Application of Transition-Metal Catalysis, Biocatalysis, and Flow Chemistry as State-of-the-Art Technologies in the Synthesis of LCZ696
查看期刊：Journal of Organic Chemistry
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