首页 > 化学

Development of Adagrasib’s Commercial Manufacturing Route (1)

有机合成与工艺文献分享 2025-10-16 08:12
文章摘要
本文背景为Adagrasib是一种针对KRAS基因G12C点突变导致的非小细胞肺癌的新近获批疗法。研究目的旨在通过改变键形成顺序，开发出稳健且可扩展的Adagrasib商业化生产路线。结论表明，新路线将API产率提升至32%，并将步骤缩减至六个GMP步骤，同时通过研究吡啶14与手性哌嗪15的反应性，成功控制副产物低于1%，并实现无需保护基团即可获得区域选择性取代，显著提高了合成效率。
Development of Adagrasib’s Commercial Manufacturing Route (1)
查看文献： Development of Adagrasib’s Commercial Manufacturing Route
查看期刊：Organic Process Research & Development
阅读全文
本站注明稿件来源为其他媒体的文/图等稿件均为转载稿，本站转载出于非商业性的教育和科研之目的，并不意味着赞同其观点或证实其内容的真实性。如转载稿涉及版权等问题，请作者速来电或来函联系。
推荐文献
ACS Applied Polymer Materials ACS Applied Polymer Materials
Issue Publication Information
DOI: 10.1021/apv008i002_2033340 Pub Date : 2026-01-23
IF 4.7 2区 化学 Q2
ACS Applied Polymer Materials
Organic Process Research & Development Organic Process Research & Development
A New Rule(r) for Nitrobenzene-Based Synthesis of meso-Tetraarylporphyrins under Continuous-Flow: Design of Experiments-Guided Optimization
DOI: 10.1021/acs.oprd.5c00348 Pub Date : 2026-02-02
IF 3.4 3区 化学 Q2
Organic Process Research & Development
Accounts of Chemical Research Accounts of Chemical Research
Correction to “Expanding Horizons in Quantum Chemical Studies: The Versatile Power of MRSF-TDDFT”
DOI: 10.1021/acs.accounts.6c00063 Pub Date : 2026-02-04
IF 18.3 1区 化学 Q1
Accounts of Chemical Research
最新文章
A High Yield Continuous-Flow Nitration Process
A High Yield Continuous-Flow Nitration Process
Org. Process Res. Dev. 2025, 29, 3150−3158. DOI: 10.1021/acs.oprd.5c00273◆This study presents an eff
2025-12-31
New Robust Synthetic Strategy toward FAPI-46
New Robust Synthetic Strategy toward FAPI-46
Org. Process Res. Dev. 2025, 29, 3138−3149. DOI: 10.1021/acs.oprd.5c00267◆The radiolabeled FAPI-46 h
2025-12-29
Optimizing the CHF6523 Isocoumarin Core Scaffold
Optimizing the CHF6523 Isocoumarin Core Scaffold
Org. Process Res. Dev. 2025, 29, 1809−1821. DOI: 10.1021/acs.oprd.5c00133◆A programmed approach for
2025-12-29
Evolution of the Synthesis Route for CC-99677 (2)
Evolution of the Synthesis Route for CC-99677 (2)
Org. Process Res. Dev. 2025, 29, 3159−3172. DOI: 10.1021/acs.oprd.5c00278◆A new route to intermediat
2025-12-26
有机合成与工艺文献分享
A High Yield Continuous-Flow Nitration Process
A High Yield Continuous-Flow Nitration Process 2025-12-31
New Robust Synthetic Strategy toward FAPI-46
New Robust Synthetic Strategy toward FAPI-46 2025-12-29
Optimizing the CHF6523 Isocoumarin Core Scaffold
Optimizing the CHF6523 Isocoumarin Core Scaffold 2025-12-29
Evolution of the Synthesis Route for CC-99677 (2)
Evolution of the Synthesis Route for CC-99677 (2) 2025-12-26
Evolution of the Synthesis Route for CC-99677 (1)
Evolution of the Synthesis Route for CC-99677 (1) 2025-12-24
热门类别
综合性期刊 物理 法学 地球科学 历史学
相关文章
哈尔滨工业大学：均温板-石墨烯薄膜，热界面材料 | Transactions of Materials Research 德国Karlsruhe Institute of Technology招收电化学储能及联合培养CSC博士等 中国科学技术大学精准智能实验室招博士生1名-学校申请截止日2月28日 AI破解基因组天书，可分析1兆碱基，谷歌DeepMind模型AlphaGenome登《Nature》封面 德国Karlsruhe Institute of Technology招收电化学储能及联合培养CSC博士等
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们：info@booksci.cn
Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1