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Exploration of a Nitromethane-Carbonylation Strategy

有机合成与工艺文献分享 2025-12-09 08:00
文章摘要
本文背景涉及有机合成中硝基甲烷羰基化策略的探索，旨在避免传统Gould−Jacobs环化反应在高温下导致的阻转异构体外消旋化问题。研究目的是开发一种温和的合成路径，以制备复杂阻转异构体硝基喹啉，并评估其长期可行性。结论表明，通过两步法羰基化序列，可在典型工厂操作温度下实现单一阻转异构体的合成，无外消旋风险，且对电子贫乏底物展现出中等至良好的收率，为相关合成工艺提供了替代方案。
Exploration of a Nitromethane-Carbonylation Strategy
查看文献： Exploration of a Nitromethane-Carbonylation Strategy during Route Design of an Atropisomeric KRASG12C Inhibitor
查看期刊：Journal of Organic Chemistry
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