{"title":"Electrochemical Trifluoromethylation of Alkenes Using the Unpurified CF3I Reagent from Fluoroform","authors":"Jiaming Cheng,Jinkun Fan,Chunhui Yang,Tengfei Pu,Qi Yang,Junyi Pan,Xu Cheng","doi":"10.1021/acs.joc.6c01627","DOIUrl":null,"url":null,"abstract":"Fluoroform (HCF3) is an excess industrial gas with a significant greenhouse effect. The utilization of fluoroform as the trifluoromethyl precursor could turn the waste into a value-added product. In this work, we report a protocol for converting fluoroform to CF3I, which was used directly in the electrochemical trifluoromethylation of alkenes facilitated by the orthogonal reactivity in two steps. This protocol could give the trifluoromethylated products in comparable yield to those obtained with a commercial CF3I solution. In particular, the iodine residue in the prepared CF3I has a positive effect in some examples, with advantages over commercial CF3I reagents.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"37 1","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Organic Chemistry","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1021/acs.joc.6c01627","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Fluoroform (HCF3) is an excess industrial gas with a significant greenhouse effect. The utilization of fluoroform as the trifluoromethyl precursor could turn the waste into a value-added product. In this work, we report a protocol for converting fluoroform to CF3I, which was used directly in the electrochemical trifluoromethylation of alkenes facilitated by the orthogonal reactivity in two steps. This protocol could give the trifluoromethylated products in comparable yield to those obtained with a commercial CF3I solution. In particular, the iodine residue in the prepared CF3I has a positive effect in some examples, with advantages over commercial CF3I reagents.
期刊介绍：
Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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