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Catalytic Activity of TPP for Electrophilic Aromatic Bromination

有机合成与工艺文献分享 2025-07-10 09:55
文章摘要
本文研究了三苯基膦（PPh3）在芳香溴化反应中的催化活性。背景方面，作者在前期工作中偶然发现PPh3能催化芳香溴化反应。研究目的是探索PPh3催化活性的普遍性，并评估其在工业应用中的可行性。实验结果表明，该催化体系适用于多种苯衍生物和有机溶剂，且能在溶剂闪点以下实现NBS的添加。在工艺安全评估中，发现反应热的特性使得内部温度难以控制，但通过精确评估反应热并采用NBS顺序添加的方法，成功将温升控制在5°C以下，使该溴化工艺的工业化应用具备安全性。
Catalytic Activity of TPP for Electrophilic Aromatic Bromination
查看文献： Catalytic Activity of Triphenylphosphine for Electrophilic Aromatic Bromination Using N-Bromosuccinimide and Process Safety Evaluation
查看期刊：Organic Process Research & Development
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