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Process for the Synthesis of Lofexidine Hydrochloride

有机合成与工艺文献分享 2025-09-18 07:31
文章摘要
背景：洛非西定盐酸盐是一种抗高血压药物，现用于治疗阿片依赖的身心症状，现有合成方法步骤多且产率低。研究目的：开发一种简化的洛非西定盐酸盐合成工艺，解决传统方法中产率低、使用腐蚀性试剂（如四氯化钛）以及副产物多的问题。结论：研究发现异丙醇钛可作为更安全有效的环化试剂替代四氯化钛，并通过一锅法成功优化了咪唑啉环的形成过程，减少了副产物（如二聚杂质17）的生成，提高了合成效率和实用性。
Process for the Synthesis of Lofexidine Hydrochloride
查看文献： An Easy, Convenient, and Safe Process for the Synthesis of Lofexidine Hydrochloride
查看期刊：Organic Process Research & Development
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