Hotspot areas of tetanus-unprotected births and its associated factors in Ethiopia: Spatial analysis of EDHS data.

IF 4.1 4区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Human Vaccines & Immunotherapeutics Pub Date : 2024-12-31 Epub Date: 2024-01-04 DOI:10.1080/21645515.2023.2298062
Anteneh Mengist Dessie, Melkamu Aderajew Zemene, Asaye Alamneh Gebeyehu, Natnael Atnafu Gebeyehu, Getachew Asmare Adella, Gizachew Ambaw Kassie, Misganaw Asmamaw Mengstie, Mohammed Abdu Seid, Endeshaw Chekol Abebe, Molalegn Mesele Gesese, Yenealem Solomon Kebede, Natnael Moges, Berihun Bantie, Sefineh Fenta Feleke, Tadesse Asmamaw Dejenie, Ermias Sisay Chanie, Wubet Alebachew Bayih, Natnael Amare Tesfa, Eden Workneh Aychew, Begizew Yimenu Mekuriaw, Denekew Tenaw Anley
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Abstract

Neonatal tetanus persists as a public health problem in many developing countries including Ethiopia. Maternal tetanus toxoid vaccination is a cornerstone to prevent neonatal tetanus. However, its prevalence is low in Ethiopia, and little has been devoted to its spatial epidemiology and associated factors. Hence, this study aimed to explore the spatial pattern and factors affecting tetanus-unprotected births in Ethiopia. A further analysis of the 2016 Ethiopia Demographic and Health Survey data was conducted, and a weighted sample of 7590 women was used for analysis. Spatial analysis was done using ArcGIS and SaTScan software. A binary logistic regression model was fitted to identify factors and variables with a p-value <.05 were considered as statistically significant. About 54.13% (95% CI: 53.01, 55.25) of births were not protected against neonatal tetanus, and spatial clustering of tetanus unprotected births was observed (Moran's I = 0.144, p-value = .028). The primary and secondary SaTScan clusters were detected in Northeastern Tigray, Eastern Amhara, and almost the entire Afar (RR = 1.34 & LLR = 66.5, p < .01), and in the Somali region, and the western border of Gambela (RR = 1.44 & LLR = 31.3, p < .01), respectively. Tetanus unprotected births were higher among women without formal education (AOR = 1.63; 95% CI: 1.29, 2.04), came from poor households (AOR = 1.27; 95% CI: 1.12, 1.45), who had no ANC contact (AOR = 6.97; 95% CI: 6.21, 7.88), and who were not exposed to the media (AOR = 1.26; 95% CI: 1.09, 1.47). Hence, tetanus-unprotected birth hotspots require priority interventions, and it is good if the targeted interventions consider the identified factors.

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埃塞俄比亚破伤风未受保护新生儿的热点地区及其相关因素:EDHS 数据的空间分析。
在包括埃塞俄比亚在内的许多发展中国家,新生儿破伤风一直是一个公共卫生问题。产妇接种破伤风类毒素疫苗是预防新生儿破伤风的基石。然而,新生儿破伤风在埃塞俄比亚的发病率很低,对其空间流行病学和相关因素的研究也很少。因此,本研究旨在探讨埃塞俄比亚破伤风未受保护新生儿的空间模式和影响因素。本研究对 2016 年埃塞俄比亚人口与健康调查数据进行了进一步分析,并使用 7590 名妇女的加权样本进行分析。使用 ArcGIS 和 SaTScan 软件进行了空间分析。拟合了一个二元逻辑回归模型,以确定 p 值为 0.028 的因素和变量。)在提格雷东北部、阿姆哈拉东部和几乎整个阿法尔地区发现了主要和次要的 SaTScan 群集(RR = 1.34 和 LLR = 66.5,p p = 0.028)。
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来源期刊
Human Vaccines & Immunotherapeutics
Human Vaccines & Immunotherapeutics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-IMMUNOLOGY
CiteScore
7.90
自引率
8.30%
发文量
489
审稿时长
3-6 weeks
期刊介绍: (formerly Human Vaccines; issn 1554-8619) Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics. Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.
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