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EXPECTATION-MAXIMIZATION FOR STRUCTURE DETERMINATION DIRECTLY FROM CRYO-EM MICROGRAPHS. 期望最大化的结构测定直接从低温电镜显微照片。
IF 1.6 4区 数学 Q2 MATHEMATICS, APPLIED Pub Date : 2027-02-01 Epub Date: 2026-04-13 DOI: 10.3934/ipi.2026033
Shay Kreymer, Amit Singer, Tamir Bendory

A single-particle cryo-electron microscopy (cryo-EM) measurement, called a micrograph, consists of multiple two-dimensional tomographic projections of a three-dimensional (3-D) molecular structure at unknown locations, taken under unknown viewing directions. All existing cryo-EM algorithmic pipelines first locate and extract the projection images, and then reconstruct the structure from the extracted images. However, if the molecular structure is small, the signal-to-noise ratio (SNR) of the data is very low, making it challenging to accurately detect projection images within the micrograph. Consequently, all standard techniques fail in low-SNR regimes. To recover molecular structures from measurements of low SNR, and in particular small molecular structures, we devise an approximate expectation-maximization algorithm to estimate the 3-D structure directly from the micrograph, bypassing the need to locate the projection images. We corroborate our computational scheme with numerical experiments and present successful structure recoveries from simulated noisy measurements.

单粒子低温电子显微镜(cryo-EM)测量,称为显微图,由未知位置的三维(3-D)分子结构的多个二维层析投影组成,在未知的观察方向下拍摄。现有的cryo-EM算法管道都是先对投影图像进行定位和提取,然后根据提取的图像进行结构重构。然而,如果分子结构较小,则数据的信噪比(SNR)非常低,这使得在显微照片中准确检测投影图像具有挑战性。因此,所有标准技术在低信噪比条件下都失败了。为了从低信噪比的测量中恢复分子结构,特别是小分子结构,我们设计了一种近似期望最大化算法,直接从显微照片中估计三维结构,而不需要定位投影图像。我们用数值实验证实了我们的计算方案,并从模拟噪声测量中成功地恢复了结构。
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引用次数: 0
Threshold dynamics of a reaction-diffusion-advection schistosomiasis model with seasonality 具有季节性的反应-扩散-平流型血吸虫病模型的阈值动力学
IF 1.8 3区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2026-12-01 Epub Date: 2026-02-04 DOI: 10.1016/j.nonrwa.2026.104617
Yijie Zha , Xun Cao
This paper proposes a reaction-diffusion-advection schistosomiasis model with seasonality based on the life cycle of schistosomiasis (humans, eggs, snails, and cercariae). Using the next generation operator theory, we define the basic reproduction number R0 that characterizes the transmission potential of schistosomiasis, and further reveal the threshold dynamics of the system through the monotone dynamical system theory. Specifically, if R0≤1, the disease-free periodic solution is globally asymptotically stable, meaning that schistosomiasis will die out; if R0>1, the system admits a unique positive periodic solution that is globally asymptotically stable, indicating that the disease will break out. Numerically, we use data from Ourinhos, Brazil, to analyze the impact of diffusion rates, spatial heterogeneity, advection rates, and seasonality on the transmission of schistosomiasis.
基于血吸虫病的生命周期(人、卵、螺、尾蚴),提出了具有季节性的反应-扩散-平流血吸虫病模型。利用下一代算符理论,定义了表征血吸虫病传播潜力的基本繁殖数R0,并通过单调动力系统理论进一步揭示了系统的阈值动力学。具体地说,当R0≤1时,无病周期解全局渐近稳定,意味着血吸虫病将消失;若R0>;1,系统存在唯一的正周期解,且该解全局渐近稳定,表明疾病将爆发。数值上,我们使用来自巴西Ourinhos的数据来分析扩散率、空间异质性、平流率和季节性对血吸虫病传播的影响。
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引用次数: 0
Well-posedness results and global attractors for a generalized coupled dynamical system 一类广义耦合动力系统的适定性结果和全局吸引子
IF 1.8 3区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2026-12-01 Epub Date: 2026-02-04 DOI: 10.1016/j.nonrwa.2026.104615
Xiuwen Li , Zhenhai Liu , Jing Zhao
Our present paper investigates theoretical results concerning the well-posedness and global attractor of a novel class of generalized coupling dynamical systems (GCDSs). The system comprises an abstract nonlinear differential inclusion with a history-dependent (h.d.) operator and a generalized variational-hemivariational inequality (GVHVI) with two h.d. operators, formulated within Banach spaces. Our study unfolds in four key aspects. First, we introduce and establish the well-posedness results of the GVHVI by employing the surjectivity theorem for multivalued mappings and techniques from nonlinear functional analysis. Second, we consider and discuss the existence of solutions to the GCDSs by using fixed-point theory under some suitable assumptions. Third, we explore and derive the existence of global attractors for the multivalued semiflow (m-semiflow) described by the GCDSs under some sufficient conditions. Finally, we present an application to a coupled problem, demonstrating the applicability of our theoretical findings.
本文研究了一类新的广义耦合动力系统的适定性和全局吸引子的理论结果。该系统由一个具有历史相关算子的抽象非线性微分包含和一个具有两个历史相关算子的广义变分-半变分不等式(GVHVI)组成,在Banach空间中表述。我们的研究从四个关键方面展开。首先,利用多值映射的满射定理和非线性泛函分析技术,引入并建立了GVHVI的适定性结果。其次,在适当的假设条件下,利用不动点理论,考虑并讨论了gcds解的存在性。第三,在一些充分条件下,我们探索并推导了由gcds描述的多值半流(m-半流)的全局吸引子的存在性。最后,我们给出了一个耦合问题的应用,证明了我们的理论发现的适用性。
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引用次数: 0
Nontransitive Dice with Equal Means and Variances 具有等均值和方差的不可传递骰子
IF 0.8 4区 数学 Q3 MATHEMATICS Pub Date : 2026-10-20 DOI: 10.1134/S1064562426700134
A. N. Yakusheva

This study aims to investigate the nontransitivity of the stochastic precedence relation. The dice were taken as an example of discrete random variables with a finite set of values. The means and variances of the dice were assumed those of the classical dice. The whole variety of nontransitive sets containing three or four dice were found in case of one or two tosses and various ways to determine the advantage. The sets that reveal the strongest property of nontransitivity were obtained according to the specific function. The hypothesis has been tested about the emergence of nontransitivity after two tosses of dice in originally transitive sets.

研究了随机优先关系的非传递性。将骰子作为具有有限值集的离散随机变量的例子。该骰子的均值和方差假定与经典骰子相同。在一次或两次投掷的情况下,发现了包含三个或四个骰子的各种不可传递集合和各种确定优势的方法。根据具体的函数,得到了表现出最强非传递性的集合。对原传递集投掷两次骰子后出现不可传递性的假设进行了检验。
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引用次数: 0
Dynamic Game-theoretical Models of Innovation Management in Universities Taking into Account Opportunistic behavior 考虑机会主义行为的高校创新管理动态博弈论模型
IF 0.8 4区 数学 Q3 MATHEMATICS Pub Date : 2026-10-20 DOI: 10.1134/S1064562426700146
V. Yu. Kalachev, G. A. Ougolnitsky, A. B. Usov

The article studies the issues of innovation implementation in universities. A three-level hierarchically organized model is proposed to describe the process of innovation implementation in universities. The model includes agents (followers, in whose role teachers act), supervisors (subjects of middle-level management, universities) and a principal (leader, the state). The principal (the state) is the first to announce its behavior strategy. Supervisors choose their management strategies when the principal’s choice is already known, but the agents’ choice is not yet known. Agents (teachers) make their choice when the management strategies of the other subjects are already known. Supervisors, like agents, make their choice independently of each other. The principal subsidizes the innovative development of higher education institutions by allocating funds for the development of new electronic courses. The new electronic courses being developed are considered as innovative products that contribute to the innovative development of higher education institutions. Supervisors receive subsidies from the principal for the development and implementation of innovative products. They determine the required volume of new courses issued by agents. Agents develop new electronic training courses for subsequent sale and implementation in the educational process. Supervisors keep part of the subsidies received from the principal for themselves, and transfer part to agents. Agents receive subsidies, the amount of which depends on the demand for the courses they develop, and manage the quality of the courses they develop, improving their qualifications. The possibility of corruption in the system is provided for and methods for combating it are defined. Lower and middle management entities may be subject to corruption. Agents may offer bribes to supervisors, in exchange for which they inflate the portion of subsidies transferred to agents. An analysis is conducted of how the presence of corruption affects the innovative development of universities. Thus, a dynamic three-level model is constructed, in which the dynamics are described by a difference equation reflecting the change in the general innovative level of the education system depending on the agents’ controls. Algorithms for constructing a solution for different combinations of Stackelberg games with and without feedback on control between the state and universities and between universities and teachers are indicated. In a non-antagonistic game of universities among themselves, as in a game of teachers, a Nash equilibrium is built. The results of numerical experiments are presented, their analysis is given. A number of meaningful conclusions and recommendations are made.

本文对高校创新实施问题进行了研究。提出了一个描述高校创新实施过程的三级层次组织模型。该模型包括代理人(追随者,教师扮演他们的角色),监督者(中层管理主体,大学)和校长(领导者,国家)。校长(国家)首先宣布其行为策略。监事选择管理策略时,委托人的选择是已知的,代理人的选择是未知的。代理人(教师)在其他主体的管理策略已知的情况下做出选择。管理者和代理人一样,彼此独立地做出选择。校长通过拨款开发新的电子课程来资助高等教育机构的创新发展。正在开发的新型电子课程被认为是促进高等教育机构创新发展的创新产品。监事从校长那里获得开发和实施创新产品的补贴。他们决定由代理机构颁发的新课程所需的数量。代理商开发新的电子培训课程,以供后续销售和在教育过程中实施。监事从委托人那里得到的补贴,一部分归自己所有,一部分转给代理人。代理商获得补贴,补贴的数额取决于他们开发的课程的需求,并管理他们开发的课程的质量,提高他们的资格。提出了系统中腐败的可能性,并确定了打击腐败的方法。中低管理实体可能受到腐败的影响。代理人可能会向主管行贿,作为交换,他们会夸大转移给代理人的补贴比例。分析了腐败的存在如何影响大学的创新发展。因此,构建了一个动态的三层模型,其中的动态用一个差分方程来描述,该差分方程反映了教育系统的总体创新水平随主体控制的变化。给出了在国家和大学之间以及大学和教师之间的控制上有反馈和没有反馈的Stackelberg博弈不同组合的解的构造算法。在大学之间的非对抗性博弈中,就像在教师之间的博弈中一样,建立了纳什均衡。给出了数值实验结果,并对结果进行了分析。提出了一些有意义的结论和建议。
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引用次数: 0
Validation Technology for Autonomous Navigation Methods of Unmanned Aerial Vehicles Based on SLAM Algorithms 基于SLAM算法的无人机自主导航方法验证技术
IF 0.8 4区 数学 Q3 MATHEMATICS Pub Date : 2026-10-20 DOI: 10.1134/S1064562426700122
P. A. Ukhov, K. A. Stenin

The article proposes a technology for validating autonomous navigation methods for unmanned aerial vehicles based on simultaneous mapping and localization (SLAM) algorithms. The proposed technology is based on experimental studies using real flight data and includes the design of validation scenarios, synchronization and spatial alignment of trajectories, as well as the calculation of a set of quantitative metrics characterizing global and local accuracy, drift accumulation, and the stability of the navigation solution. As a demonstration example, the technology was evaluated using the VINS-Fusion visual-inertial algorithm using recordings of real UAV flights. The obtained results show that the proposed approach allows comparing different SLAM solutions under the same conditions and identifying flight modes that are most sensitive to error accumulation.

本文提出了一种基于同步测绘和定位(SLAM)算法的无人机自主导航方法验证技术。所提出的技术基于使用真实飞行数据的实验研究,包括验证场景的设计、轨迹的同步和空间对准,以及描述全局和局部精度、漂移积累和导航解决方案稳定性的一组定量指标的计算。作为演示示例,利用真实无人机飞行记录,使用vin - fusion视觉惯性算法对该技术进行了评估。结果表明,该方法可以比较相同条件下的不同SLAM方案,并识别出对误差积累最敏感的飞行模式。
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引用次数: 0
Topologically Consistent Fuzzy Clustering in a Neurodynamic Model of the Traveling Salesman Problem 旅行商问题神经动力学模型的拓扑一致模糊聚类
IF 0.8 4区 数学 Q3 MATHEMATICS Pub Date : 2026-10-20 DOI: 10.1134/S1064562426700110
V. A. Sudakov

A new neurodynamic model for joint optimization of the traveling salesman problem route and fuzzy cluster partitioning of a set of vertices is proposed. The model’s energy function includes three components: a Hopfield-Tank term encoding route feasibility constraints; a fuzzy means term ensuring geometric compactness of clusters; and a topological matching term penalizing for discontinuities in cluster membership between adjacent vertices along the route. An iterative minimization scheme is developed. The following convergence properties are proven: monotonic energy decrease and convergence of the energy sequence to a limit value. Computational experiments on a test example showed that the proposed model finds solutions that coincide with the global optimum, while the resulting clusters differ significantly from the results of the classical fuzzy c-means algorithm, reflecting the topology of the optimal route. The results of the study can be used for problems of delivery territory zoning, production operation planning, and condensation of large factor models.

提出了一种新的神经动力学模型,用于旅行商问题的路径优化和顶点集的模糊聚类划分。模型的能量函数包括三个部分:Hopfield-Tank项编码路线可行性约束;保证聚类几何紧性的模糊均值项以及一个拓扑匹配项,用于惩罚路径上相邻顶点之间的聚类隶属度不连续性。提出了一种迭代最小化方案。证明了该方法的收敛性:单调能量递减和能量序列收敛于一个极限值。在一个测试实例上的计算实验表明,该模型找到的解与全局最优解一致,而得到的聚类结果与经典模糊c均值算法的结果有显著差异,反映了最优路径的拓扑结构。研究结果可用于配送区域划分、生产作业规划、大因子模型的凝聚等问题。
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引用次数: 0
The Problem of Redistributing Quotas for Training between Structural Divisions of a Higher Educational Institution 高等院校结构部门间培训名额再分配问题
IF 0.8 4区 数学 Q3 MATHEMATICS Pub Date : 2026-10-20 DOI: 10.1134/S1064562426700158
V. Yu. Kalachev, G. A. Ougolnitsky, A. B. Usov

The problem of redistributing quotas for training among structural divisions of a higher education institution is considered. The problem of redistributing quotas has a wide range of applications, in particular, in preventing environmental pollution. The article assumes that a higher education institution has several structural divisions. The management of the higher education institution allocates some quotas for training to structural divisions (SD). The head of each SD can give part of the quota of his SD to another division, receiving some compensation in return. In this case, if the quota is not given, it must be fully used in the joint venture to which it was allocated. The head of each joint venture strives to maximize his gain, expressed by his objective function. For simplicity, it can be considered that the goal of the head of each joint venture is to maximize the amount of funds accumulated in the centralized fund of this joint venture. In this case, the head of the joint venture can manage the share of the quota allocated to him, which he wants to give or receive from another joint venture. It is shown in which cases all structural divisions manage to receive optimal quotas for them as a result of redistribution. Three cases are considered: when the total value of the quota that the divisions want to give is greater than, less than or equal to the total value of the quota that other structural divisions want to acquire. Algorithms for redistributing quotas in each of these cases are proposed. The study is conducted analytically for a particular type of input functions, which are taken as power functions. Numerical examples are given and an analysis of the results obtained is given. A number of meaningful conclusions are made.

在高等教育机构的结构部门之间重新分配培训配额的问题进行了考虑。重新分配配额的问题有广泛的应用,特别是在防止环境污染方面。本文假设高等教育机构有几个结构部门。高等教育机构的管理层分配一些培训配额给结构部门(SD)。每个部门的负责人可以将自己部门的部分配额分配给其他部门,并获得一定的补偿。在这种情况下,如果没有分配配额,则必须在分配配额的合资企业中充分使用配额。每个合资企业的负责人都努力使自己的收益最大化,这可以用他的目标函数来表达。为简单起见,可以认为每个合资企业的负责人的目标是使该合资企业集中基金中积累的资金最大化。在这种情况下,合资企业的负责人可以管理分配给他的配额份额,他希望从另一家合资企业获得或获得配额份额。在哪些情况下,由于重新分配,所有结构部门都设法获得最佳配额。考虑三种情况:当部门想要给予的配额总价值大于、小于或等于其他结构部门想要获得的配额总价值时。提出了在每种情况下的配额再分配算法。本文对某一类输入函数进行了解析性研究,并将其作为幂函数。给出了数值算例,并对所得结果进行了分析。得出了一些有意义的结论。
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引用次数: 0
Sectional Kolmogorov N-widths for parameter-dependent function spaces: a general framework with application to parametrized Friedrichs’ systems 参数相关函数空间的分段Kolmogorov n -宽度:一个应用于参数化friedrich系统的一般框架
IF 2.6 3区 数学 Q2 MATHEMATICS, APPLIED Pub Date : 2026-10-19 DOI: 10.1007/s10444-026-10375-8
Christian Engwer, Mario Ohlberger, Lukas Renelt

We investigate parametrized variational problems where for each parameter the solution may originate from a different parameter-dependent function space. Our main motivation is the theory of Friedrichs’ systems, a large abstract class of linear PDE problems whose solutions are sought in operator- (and thus parameter-)dependent graph spaces. Other applications include function spaces on parametrized domains or discretizations involving data-dependent stabilizers. Concerning the set of all parameter-dependent solutions, we argue that in these cases, the interpretation as a “solution manifold” widely adopted in the model order reduction community is no longer applicable. Instead, we propose a novel framework based on the theory of fiber bundles and explain how established concepts such as approximability generalize by introducing a sectional Kolmogorov N-width. Further, we prove exponential approximation rates of this N-width if a norm equivalence criterion is fulfilled. Applying this result to problems with Friedrichs’ structure then gives a sufficient criterion that can be easily verified.

我们研究了参数化变分问题,其中每个参数的解可能来自不同的参数相关函数空间。我们的主要动机是弗里德里希系统的理论,这是一个大的抽象类线性PDE问题,其解是在算子(因此是参数)相关的图空间中寻求的。其他应用包括参数化域上的函数空间或涉及数据相关稳定器的离散化。对于所有参数相关解的集合,我们认为在这些情况下,模型降阶界广泛采用的“解流形”解释不再适用。相反,我们提出了一个基于纤维束理论的新框架,并通过引入截面Kolmogorov n -宽度来解释诸如近似性之类的既定概念如何推广。进一步,在满足范数等价准则的情况下,证明了该n -宽度的指数逼近率。将这一结果应用于Friedrichs结构的问题,给出了一个容易验证的充分判据。
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引用次数: 0
Planar Coulomb Gas on a Jordan Arc at Any Temperature 任意温度下约当弧上的平面库仑气体
IF 3 1区 数学 Q1 MATHEMATICS Pub Date : 2026-10-19 DOI: 10.1002/cpa.70065
K. Courteaut, K. Johansson, F. Viklund
We study a planar Coulomb gas confined to a sufficiently smooth Jordan arc in the complex plane, at inverse temperature . Let be the normalized partition function, where is the capacity of , the entropy of the logarithmic equilibrium measure on , and . We compute the free energy as the number of particles tends to infinity, including the constant term: Here is an explicit Selberg integral, is half the Loewner energy of a certain Jordan curve associated to plus a term corresponding to the endpoints of the arc, and is the Fekete energy, related to the zero temperature limit of the model. We also prove an asymptotic formula for the Laplace transform of linear statistics for sufficiently regular test functions. As a consequence, the centered empirical measure converges to a Gaussian field with explicit asymptotic mean, and asymptotic variance given by the Dirichlet energy of the bounded harmonic extension of the test function outside of the arc. A key tool in our analysis is the arc‐Grunsky operator associated to , reminiscent of but different from the classical Grunsky operator. We derive several basic properties of the arc‐Grunsky operator, including an estimate analogous to the strengthened Grunsky inequality and the relation to the Dirichlet integral. In our proofs arises from the Fredholm determinant and a substantial part of the paper is devoted to relating this to the Loewner energy.
在逆温度下,我们研究了一个平面的库仑气体,它被限制在复平面上一个足够光滑的约当弧内。设为归一化配分函数,其中为的容量,为上的对数平衡测度的熵,为。当粒子的数量趋于无穷大时,我们计算自由能,包括常数项:这是一个显式的Selberg积分,是与某个Jordan曲线相关的Loewner能量的一半,加上对应于弧端点的一项,是Fekete能量,与模型的零温度极限有关。我们还证明了充分正则检验函数的线性统计量的拉普拉斯变换的渐近公式。因此,以中心为中心的经验测度收敛于具有显式渐近均值的高斯场,渐近方差由测试函数在弧外的有界调和扩展的狄利克雷能量给出。我们分析中的一个关键工具是弧-格伦斯基算子,它与经典的格伦斯基算子相似,但又不同。我们得到了arc‐Grunsky算子的几个基本性质,包括类似于强化Grunsky不等式的估计和与Dirichlet积分的关系。在我们的证明中,弗莱德霍姆行列式是由弗莱德霍姆行列式产生的,并且本文的大部分内容都致力于将弗莱德霍姆行列式与洛厄纳能联系起来。
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引用次数: 0
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