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Radium levels in Brazil nuts: A review of the literature. 巴西坚果中的镭含量:文献综述。
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-03-01 Epub Date: 2024-11-03 DOI: 10.1111/nbu.12717
Christian Koeder, Markus Keller

Brazil nuts are well known for their extraordinarily high selenium content. For this reason, they are frequently recommended as a kind of natural selenium 'supplement', particularly for certain population groups such as vegetarians and vegans in regions with low soil selenium levels. Typically, an intake of one or two Brazil nuts per day is recommended. Brazil nuts, however, also stand out from other nuts in terms of their high (albeit highly variable) radium content. The radium isotopes Ra-226 and Ra-228 emit alpha- and beta-radiation, with this type of radiation being particularly harmful when ingested. Consequently, it is important to consider radium levels in Brazil nuts before formulating recommendations for a long-term, daily intake of these nuts. To date, however, no comprehensive overview of radium levels in Brazil nuts has been published. Therefore, a literature review without time or language restrictions was conducted, including unpublished original data from Germany. The literature review (including the German data) indicated mean Ra-226 and Ra-228 levels of 49 (range: 17-205) mBq/g and 67 (range: 12-235) mBq/g, respectively. Assuming a consistent daily intake of one or two Brazil nuts, this would result in an effective dose of ~88-220 μSv/year. This level of exposure appears to be neither clearly harmful nor clearly harmless. As increased radioactivity exposure (at least at higher doses) is associated with increased cancer risk, randomised controlled trials assessing the effect of Brazil nuts on cancer risk biomarkers are needed.

巴西坚果以其极高的硒含量而闻名。因此,巴西坚果经常被推荐作为一种天然的硒 "补充剂",尤其适用于某些人群,如土壤硒含量较低地区的素食主义者和纯素食者。通常,建议每天摄入一到两个巴西坚果。不过,巴西坚果在镭含量(尽管变化很大)方面也有别于其他坚果。镭的同位素镭-226 和镭-228 会发出阿尔法和贝塔辐射,摄入这类辐射尤其有害。因此,在制定巴西坚果的长期、每日摄入量建议之前,必须考虑巴西坚果中的镭含量。然而,迄今为止,还没有关于巴西坚果中镭含量的全面概述。因此,我们不受时间和语言的限制进行了一次文献综述,其中包括德国未发表的原始数据。文献综述(包括德国的数据)显示,镭-226 和镭-228 的平均含量分别为 49(范围:17-205)毫贝克/克和 67(范围:12-235)毫贝克/克。假设每天持续摄入一到两个巴西坚果,其有效剂量为每年约 88-220 μSv。这一辐照水平似乎既不明显有害,也不明显无害。由于放射性暴露的增加(至少在较高剂量时)与癌症风险的增加有关,因此需要进行随机对照试验,评估巴西坚果对癌症风险生物标志物的影响。
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引用次数: 0
Dietary fats and cardiometabolic health-from public health to personalised nutrition: 'One for all' and 'all for one'. 膳食脂肪与心脏代谢健康——从公共卫生到个性化营养:“我为人人”和“人人为我”。
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-03-01 Epub Date: 2025-01-20 DOI: 10.1111/nbu.12722
Julie Anne Lovegrove

This paper provides a summary of the 2023 British Nutrition Foundation Annual Lecture by Professor Julie Lovegrove. Professor Lovegrove is the head of the Hugh Sinclair Unit of Human Nutrition at the University of Reading. Professor Lovegrove, who was nominated for the BNF Prize for her outstanding contribution to nutritional sciences has published over 300 scientific papers and made a major contribution to establishing the relevance of dietary fat quality in the development and prevention of cardiometabolic disease.

本文提供了由朱莉·洛夫格罗夫教授主持的2023年英国营养基金会年度讲座的摘要。洛夫格罗夫教授是雷丁大学休·辛克莱人类营养部门的负责人。Lovegrove教授因其对营养科学的杰出贡献而被提名为BNF奖,发表了300多篇科学论文,并为建立膳食脂肪质量与心脏代谢疾病的发展和预防的相关性做出了重大贡献。
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引用次数: 0
Deep learning and digital pathology powers prediction of HCC development in steatotic liver disease. 深度学习和数字病理学助力脂肪性肝病中 HCC 的发展预测。
IF 12.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 Epub Date: 2024-05-20 DOI: 10.1097/HEP.0000000000000904
Takuma Nakatsuka, Ryosuke Tateishi, Masaya Sato, Natsuka Hashizume, Ami Kamada, Hiroki Nakano, Yoshinori Kabeya, Sho Yonezawa, Rie Irie, Hanako Tsujikawa, Yoshio Sumida, Masashi Yoneda, Norio Akuta, Takumi Kawaguchi, Hirokazu Takahashi, Yuichiro Eguchi, Yuya Seko, Yoshito Itoh, Eisuke Murakami, Kazuaki Chayama, Makiko Taniai, Katsutoshi Tokushige, Takeshi Okanoue, Michiie Sakamoto, Mitsuhiro Fujishiro, Kazuhiko Koike

Background and aims: Identifying patients with steatotic liver disease who are at a high risk of developing HCC remains challenging. We present a deep learning (DL) model to predict HCC development using hematoxylin and eosin-stained whole-slide images of biopsy-proven steatotic liver disease.

Approach and results: We included 639 patients who did not develop HCC for ≥7 years after biopsy (non-HCC class) and 46 patients who developed HCC <7 years after biopsy (HCC class). Paired cases of the HCC and non-HCC classes matched by biopsy date and institution were used for training, and the remaining nonpaired cases were used for validation. The DL model was trained using deep convolutional neural networks with 28,000 image tiles cropped from whole-slide images of the paired cases, with an accuracy of 81.0% and an AUC of 0.80 for predicting HCC development. Validation using the nonpaired cases also demonstrated a good accuracy of 82.3% and an AUC of 0.84. These results were comparable to the predictive ability of logistic regression model using fibrosis stage. Notably, the DL model also detected the cases of HCC development in patients with mild fibrosis. The saliency maps generated by the DL model highlighted various pathological features associated with HCC development, including nuclear atypia, hepatocytes with a high nuclear-cytoplasmic ratio, immune cell infiltration, fibrosis, and a lack of large fat droplets.

Conclusions: The ability of the DL model to capture subtle pathological features beyond fibrosis suggests its potential for identifying early signs of hepatocarcinogenesis in patients with steatotic liver disease.

背景和目的:确定哪些脂肪性肝病患者具有罹患 HCC 的高风险仍然是一项挑战。我们提出了一种深度学习(DL)模型,利用苏木精和伊红染色的活检证实的脂肪性肝病全切片图像预测 HCC 的发展:我们纳入了 639 例活检后≥7 年未发展为 HCC 的患者(非 HCC 类)和 46 例发展为 HCC 的患者:DL 模型能够捕捉纤维化以外的细微病理特征,这表明它具有识别脂肪性肝病患者早期肝癌发生迹象的潜力。
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引用次数: 0
Exploring the role of macrophages in the pathogenesis of alcohol-associated liver disease. 探索巨噬细胞在酒精相关性肝病发病机制中的作用。
IF 12.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 Epub Date: 2024-06-18 DOI: 10.1097/HEP.0000000000000976
Prakash Ramachandran, Frank Tacke
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引用次数: 0
S-pecial delivery: Implications of HBV surface antigen subviral particles carrying microRNA payloads. S-pecial Delivery:携带 microRNA 有效载荷的 HBV 表面抗原亚病毒颗粒的意义。
IF 12.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 Epub Date: 2024-07-17 DOI: 10.1097/HEP.0000000000001029
Adam J Gehring
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引用次数: 0
Nutritional intelligence in the food system: Combining food, health, data and AI expertise. 食品系统中的营养智能:结合食品、健康、数据和人工智能专业知识。
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-03-01 Epub Date: 2025-01-12 DOI: 10.1111/nbu.12729
Danielle I McCarthy

Transformative change is needed across the food system to improve health and environmental outcomes. As food, nutrition, environmental and health data are generated beyond human scale, there is an opportunity for technological tools to support multifactorial, integrated, scalable approaches to address the complexities of dietary behaviour change. Responsible technology could act as a mechanistic conduit between research, policy, industry and society, enabling timely, informed decision making and action by all stakeholders across the food system. Domain expertise in food, nutrition and health should always be integrated into both the development and continuous deployment of AI-powered nutritional intelligence (NI) to ensure it is responsible, accurate, safe, useable and effective. Dietary behaviours are complex and improving diet-related health outcomes requires socio-cultural-demographic considerations within the design and deployment of NI tools. This article describes existing examples of NI within the food system and future opportunities. Human-in-the-loop approaches with food, health and nutrition experts involved at all stages including data acquisition, processing, output validation and ongoing quality assurance are essential to ensure evidence-based practice. The same ethical considerations should apply in this domain as in any other (e.g. privacy, inclusivity, robustness, transparency and accountability) and responsible practice must encompass rigorous standards and alignment with regulatory frameworks. Critical today and in the future is accessibility to appropriate high-quality food compositional data sets, which include up-to-date information on commercially available products that reflect the constantly evolving food landscape to realise the potential of responsible AI to help address the existing food system challenges.

整个食品系统都需要转型变革,以改善健康和环境成果。随着食品、营养、环境和健康数据的生成超出人类规模,技术工具有机会支持多因素、综合、可扩展的方法,以解决饮食行为变化的复杂性。负责任的技术可以成为研究、政策、行业和社会之间的机制性渠道,使整个食品系统的所有利益相关者都能及时做出知情决策并采取行动。食品、营养和健康领域的专业知识应始终融入人工智能驱动的营养智能(NI)的开发和持续部署中,以确保其负责任、准确、安全、可用和有效。膳食行为是复杂的,要改善与膳食相关的健康结果,就必须在设计和部署营养智能工具时考虑社会文化和人口因素。本文介绍了食品系统中现有的营养信息实例以及未来的机遇。由食品、健康和营养专家参与所有阶段(包括数据采集、处理、输出验证和持续质量保证)的 "人-环 "方法对于确保循证实践至关重要。与其他领域一样,这一领域也应考虑道德因素(如隐私、包容性、稳健性、透明度和问责制),负责任的做法必须包括严格的标准并与监管框架保持一致。目前和未来的关键是获得适当的高质量食品成分数据集,其中包括反映不断变化的食品状况的商业产品的最新信息,以实现负责任人工智能的潜力,帮助解决现有食品系统面临的挑战。
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引用次数: 0
High school athletes' practical knowledge on where to find and order third-party tested nutritional supplements increases after education when compared to a control group. 与对照组相比,高中运动员在接受教育后,对在哪里寻找和订购第三方检测的营养补充剂的实用知识有所增加。
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-03-01 Epub Date: 2024-11-25 DOI: 10.1111/nbu.12724
Emily Dow, Kinta D Schott, Lindsay Morton, Hannah Lybbert, Kahyun Nam, Colin Shumate, Pamela Kulinna, Floris C Wardenaar

To promote safe supplement use, athletes are advised to choose third-party tested (TPT) supplements to minimise doping risk. This study evaluated changes in knowledge on supplements in US high school athletes from a 2-week online supplement education programme. One group of sophomores (ED, n = 48) completed a Canvas course on safe supplement use, based on the Theory of Planned Behaviour, while the other group of freshmen (NOED, n = 38) did not. Participants completed questionnaires pre- and post-intervention to assess practical knowledge of finding and ordering TPT supplements, familiarity with World Anti-Doping Agency (WADA) banned substances and decision-making in supplement purchasing. Chi-Square and McNemar tests were applied with significance set at p ≤ 0.05. Pre-intervention no differences were found between groups (ages 14-17 years, 39.5% female) for any knowledge questions (p = 0.18). Post-intervention, ED participants were more likely to know where to find (58.3% vs. 39.5%, p = 0.041), and order (62.5% vs. 28.9%, p = 0.001) TPT supplements, and more athletes in ED (72.9%) than NOED (40.0%) reported deciding to purchase supplements themselves (p = 0.015). Parents were less influential in ED (75.0% vs. 92.1%, p = 0.019). Importantly, positive changes over time were larger for ED versus NOED in knowing where to find (28% vs. 13%, p = 0.04) and order (28% vs. 7%, p < 0.001) TPT supplements and WADA familiarity (19% vs. 5%, p = 0.01). Within-group changes showed ED improved on all practical knowledge questions (p = <0.001-0.008), whereas NOED only increased in knowing where to find TPT supplements (p = 0.003). These findings suggest an online educational programme may enhance practical knowledge of safe supplement use among high school athletes.

为了促进补充剂的安全使用,建议运动员选择经过第三方检测(TPT)的补充剂,以最大限度地降低使用兴奋剂的风险。本研究评估了为期两周的在线营养补充剂教育课程对美国高中运动员营养补充剂知识的影响。一组高二学生(ED,n = 48)根据计划行为理论完成了关于安全使用补充剂的 Canvas 课程,而另一组高一学生(NOED,n = 38)则没有完成该课程。参与者在干预前后填写了调查问卷,以评估寻找和订购 TPT 营养补充剂的实用知识、对世界反兴奋剂机构(WADA)禁用物质的熟悉程度以及购买营养补充剂的决策。采用 Chi-Square 和 McNemar 检验,显著性设定为 p ≤ 0.05。干预前,各组参与者(14-17 岁,39.5% 为女性)在任何知识问题上均无差异(p = 0.18)。干预后,ED 参与者更有可能知道在哪里可以找到(58.3% 对 39.5%,p = 0.041)和订购(62.5% 对 28.9%,p = 0.001)TPT 营养补充剂,并且有更多的 ED 运动员(72.9%)比 NOED 运动员(40.0%)自己决定购买营养补充剂(p = 0.015)。家长对 ED 运动员的影响较小(75.0% 对 92.1%,p = 0.019)。重要的是,随着时间的推移,ED 相对于 NOED 在知道去哪里找(28% 对 13%,p = 0.04)和订购(28% 对 7%,p = 0.04)方面的积极变化更大。
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引用次数: 0
Higher cost of gluten-free products compared to gluten-containing equivalents is mainly attributed to staple foods. 与含麸质的同类产品相比,无麸质产品的成本较高,这主要归因于主食。
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-03-01 Epub Date: 2024-10-26 DOI: 10.1111/nbu.12716
Eirini Bathrellou, Vasiliki Bountziouka, Despoina Lamprou, Evanthia Fragedaki, Eleftheria Papachristou, Frank Vriesekoop, Meropi D Kontogianni

The high cost of gluten-free products (GFPs) is being discussed as a potential barrier to adherence to a gluten-free diet, rendering monitoring of their pricing an ongoing demand in a market subject to continuous fluctuations. The current study aimed to assess the current pricing status of GFPs in the Greek retail market, with a focus on differences between staple and non-staple foods. The retail price and packaging weight of all available GFPs and their gluten-containing (GCPs) counterparts of a GFP-shopping basket (formulated based on the results of a preceding online survey) were recorded by visiting one store of the five most popular reported supermarket chains. The food categories were grouped into staple (e.g. breads, pasta and flours) and non-staple (e.g. chips, sweets and sauces) foods. Adjusting for supermarket chain and product type, a quantile mixed regression model was applied to assess the extent to which median product price (per 100 g) differed between GFPs and GCPs. The unique products recorded were 1058 (of which 408 GFPs), with a total of 2165 retail price recordings. While the overall median price/100 g of GFPs was not found to be significantly different from that of GCPs, the median price of staple GFPs was estimated to be higher than staple GCPs (+€1.03 [95% CI: €0.93; €1.13] per 100 g), whilst that of non-staple GFPs was slightly lower (-€0.20 [95% CI: -€0.37; -€0.02] per 100 g). In conclusion, the persisting higher cost of staple GFPs suggests the need for ongoing financial support for people with coeliac disease.

无麸质产品(GFP)的高昂成本被认为是影响人们坚持无麸质饮食的潜在障碍,因此在市场不断波动的情况下,对其定价的监控成为一项持续性需求。本研究旨在评估希腊零售市场上无麸质食品的定价现状,重点关注主食和非主食之间的差异。研究人员走访了五家最受欢迎的连锁超市中的一家商店,记录了一篮子 GFP(根据之前的在线调查结果制定)中所有现有 GFP 及其含麸质(GCP)对应食品的零售价格和包装重量。食品类别分为主食(如面包、面食和面粉)和副食(如薯片、糖果和调味品)。在对连锁超市和产品种类进行调整后,采用量化混合回归模型来评估普通食品店和普通食品店的产品价格中位数(每 100 克)的差异程度。记录的独特产品有 1058 种(其中 408 种为普通食品添加剂),零售价格记录总数为 2165 个。虽然发现 GFP 的总体中位价格/100 克与 GCP 的中位价格/100 克没有显著差异,但估计主食 GFP 的中位价格高于主食 GCP(+1.03 欧元 [95% CI:0.93 欧元;1.13 欧元]/100 克),而非主食 GFP 的中位价格略低(-0.20 欧元 [95% CI:-0.37 欧元;-0.02 欧元]/100 克)。总之,主食 GFP 的成本一直较高,这表明有必要为乳糜泻患者提供持续的经济支持。
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引用次数: 0
Neutrophil extracellular traps promote MASH fibrosis by metabolic reprogramming of HSC. 中性粒细胞胞外捕获物通过对肝星状细胞的代谢重编程促进 MASH 纤维化。
IF 12.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 Epub Date: 2024-01-24 DOI: 10.1097/HEP.0000000000000762
Yujia Xia, Yu Wang, Qi Xiong, Jiayi He, Han Wang, Mozaffarul Islam, Xinyu Zhou, Alex Kim, Hongji Zhang, Hai Huang, Allan Tsung

Background and aims: Metabolic dysfunction-associated steatohepatitis (MASH) fibrosis is a reversible stage of liver disease accompanied by inflammatory cell infiltration. Neutrophils extrude a meshwork of chromatin fibers to establish neutrophil extracellular traps (NETs), which play important roles in inflammatory response regulation. Our previous work demonstrated that NETs promote HCC in MASH. However, it is still unknown if NETs play a role in the molecular mechanisms of liver fibrosis.

Approach and results: Following 12 weeks of Western diet/carbon tetrachloride, MASH fibrosis was identified in C57BL/6 mice with increased NET formation. However, NET depletion using DNase I treatment or mice knocked out for peptidyl arginine deaminase type IV significantly attenuated the development of MASH fibrosis. NETs were demonstrated to induce HSCs activation, proliferation, and migration through augmented mitochondrial and aerobic glycolysis to provide additional bioenergetic and biosynthetic supplies. Metabolomic analysis revealed markedly an altered metabolic profile upon NET stimulation of HSCs that were dependent on arachidonic acid metabolism. Mechanistically, NET stimulation of toll-like receptor 3 induced cyclooxygenase-2 activation and prostaglandin E2 production with subsequent HSC activation and liver fibrosis. Inhibiting cyclooxygenase-2 with celecoxib reduced fibrosis in our MASH model.

Conclusions: Our findings implicate NETs playing a critical role in the development of MASH hepatic fibrosis by inducing metabolic reprogramming of HSCs through the toll-like receptor 3/cyclooxygenase-2/cyclooxygenase-2 pathway. Therefore, NET inhibition may represent an attractive treatment target for MASH liver fibrosis.

背景和目的:代谢功能障碍相关性脂肪性肝炎(MASH)-纤维化是肝病的一个可逆阶段,伴有炎症细胞浸润。中性粒细胞挤出染色质纤维网,建立中性粒细胞胞外陷阱(NET),在炎症反应调节中发挥重要作用。我们之前的研究表明,NETs 可促进 MASH 中肝细胞癌的发生。然而,NETs是否在肝纤维化的分子机制中发挥作用仍是未知数:方法和结果:西式饮食(WD)/四氯化碳(CCl4)12 周后,在 C57BL/6 小鼠中发现了 MASH-纤维化,NET 形成增加。然而,使用 DNase I 处理或敲除肽基精氨酸脱氨酶 IV 型(PAD4-/-)的小鼠进行 NET 清除,可显著减轻 MASH 纤维化的发展。实验证明,NETs能通过增强线粒体和有氧糖酵解提供额外的生物能和生物合成供应,诱导肝星状细胞(HSCs)活化、增殖和迁移。代谢组学分析表明,NET 刺激造血干细胞后,造血干细胞的代谢特征发生了明显改变,这种改变依赖于花生四烯酸代谢。从机理上讲,NET刺激toll样受体3(TLR3)会诱导环氧化酶2(COX-2)活化和前列腺素E2(PGE2)的产生,进而导致造血干细胞活化和肝纤维化。在我们的MASH模型中,用塞来昔布抑制COX-2可减少肝纤维化:我们的研究结果表明,NET通过TLR3/COX-2/PGE2途径诱导造血干细胞的代谢重编程,在MASH-肝纤维化的发展过程中发挥了关键作用。因此,抑制NET可能是治疗MASH肝纤维化的一个有吸引力的靶点。
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引用次数: 0
Effectiveness and safety of glecaprevir/pibrentasvir for 8 weeks in the treatment of patients with acute hepatitis C: A single-arm retrospective study. 格列卡韦/匹布特韦治疗急性丙型肝炎患者 8 周的有效性和安全性:单臂回顾性研究。
IF 12.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 Epub Date: 2024-05-20 DOI: 10.1097/HEP.0000000000000923
Stanislas Pol, Alexander J Thompson, Michelle Collins, Elisa Venier, Laurent Cotte, Montserrat Laguno Centeno, Jorge Mera, Thomas Reiberger, Margaret Burroughs, Dimitri G Semizarov, Alexandru M Iacob, Anne Welhaven, Linda M Fredrick, Joseph S Doyle

Background and aims: No direct-acting antiviral is currently approved for acute HCV infection, delaying treatment. We investigated the effectiveness and safety of 8-week glecaprevir/pibrentasvir (G/P) in patients with acute HCV infection.

Approach and results: This noninterventional, single-arm, retrospective chart review was designed to enroll adults/adolescents with acute HCV infection. Analyses were conducted on a full analysis set (FAS; all enrolled) and modified FAS (FAS excluding nonvirologic failures). The primary end point (modified FAS) was sustained virologic response at posttreatment week 12 (SVR12) with superiority to 92.6% threshold determined by historic chronic HCV G/P SVR12 rates. Secondary end points (FAS) included SVR12, on-treatment virologic failure, posttreatment relapse, and reinfection. Adverse events and safety laboratory values were assessed.Overall, 202 adults were enrolled; in the modified FAS, 150/151 (99.3%; 95% CI: 96.3-99.9) achieved SVR12, demonstrating superiority to efficacy threshold. In the FAS, the SVR12 rate was 74.3% and the on-treatment virologic failure rate was 0%. Relapse and reinfection rates after the final treatment visit (FAS) were 0.5% and 3%, respectively; 39 patients had missing SVR12 data. No on-treatment alanine aminotransferase elevations > 3 × upper limit of normal with total bilirubin > 2 × upper limit of normal were reported. All 53 patients with alanine aminotransferase Grade ≥ 2 at baseline improved to Grade 0/1 on treatment. No adverse eventss of hepatic decompensation/failure or leading to G/P discontinuation occurred. Two patients had serious adverse events unrelated to G/P.

Conclusions: Eight-week G/P therapy was effective and well-tolerated in patients with acute HCV infection. Data support further investigation of G/P in acute HCV to shorten care cascades, reduce transmission, and support HCV elimination.

背景和目的:目前尚无直接作用的抗病毒药物被批准用于急性HCV感染,从而延误了治疗。我们研究了在急性 HCV 感染患者中使用 8 周 glecaprevir/pibrentasvir (G/P) 的有效性和安全性:这项非干预性、单臂、回顾性病历审查旨在招募急性 HCV 感染的成人/青少年患者。对完整分析集(FAS;所有入选者)和修改后的 FAS(FAS 不包括非生命体征失败者)进行了分析。主要终点(修改后的 FAS)为治疗后第 12 周的持续病毒学应答(SVR12),优于根据历史慢性 HCV G/P SVR12 率确定的 92.6% 临界值。次要终点(FAS)包括 SVR12、治疗病毒学失败、治疗后复发和再感染。总共有 202 名成人接受了治疗;在修改后的 FAS 中,150/151(99.3%;95% CI:96.3-99.9)人达到了 SVR12,显示出疗效优于疗效阈值。在 FAS 中,SVR12 率为 74.3%,治疗中病毒学失败率为 0%。最后治疗访视(FAS)后的复发率和再感染率分别为 0.5% 和 3%;39 名患者 SVR12 数据缺失。未报告治疗期间丙氨酸氨基转移酶升高 > 3 倍正常值上限,总胆红素 > 2 倍正常值上限。基线时丙氨酸氨基转移酶≥2级的53名患者在治疗后均降至0/1级。没有发生肝功能失代偿/衰竭或导致停药的不良事件。两名患者出现了与G/P无关的严重不良事件:为期八周的 G/P 疗法对急性 HCV 感染患者有效且耐受性良好。数据支持进一步研究 G/P 在急性 HCV 感染中的应用,以缩短护理流程、减少传播并支持消除 HCV。
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