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Exploring the GMO narrative through labeling: strategies, products, and politics. 通过标签探索转基因叙述:战略、产品和政治。
IF 3.9 2区 农林科学 Q1 Agricultural and Biological Sciences Pub Date : 2024-12-31 Epub Date: 2024-02-25 DOI: 10.1080/21645698.2024.2318027
Camille D Ryan, Elizabeth Henggeler, Samantha Gilbert, Andrew J Schaul, John T Swarthout

Labels are influential signals in the marketplace intended to inform and to eliminate buyer confusion. Despite this, food labels continue to be the subject of debate. None more so than non-GMO (genetically modified organisms) labels. This manuscript provides a timeline of the evolution of GMO labels beginning with the early history of the anti-GMO movement to the current National Bioengineered Food Disclosure Standard in the United States. Using media and market intelligence data collected through Buzzsumo™ and Mintel™, public discourse of GMOs is analyzed in relation to sociopolitical events and the number of new food products with anti-GMO labels, respectively. Policy document and publication data is collected with Overton™ to illustrate the policy landscape for the GMO topic and how it has changed over time. Analysis of the collective data illustrates that while social media and policy engagement around the topic of GMOs has diminished over time, the number of new products with a GMO-free designation continues to grow. While discourse peaked at one point, and has since declined, our results suggest that the legacy of an anti-GMO narrative remains firmly embedded in the social psyche, evidenced by the continuing rise of products with GMO-free designation. Campaigns for GMO food labels to satisfy consumers' right to know were successful and the perceived need for this information now appears to be self-sustaining.

标签是市场上有影响力的信号,旨在提供信息并消除购买者的困惑。尽管如此,食品标签仍然是争论的焦点。非转基因(转基因生物)标签更是如此。本手稿提供了转基因生物标签演变的时间轴,从早期的反转基因运动历史开始,到美国现行的《国家生物工程食品披露标准》。通过 Buzzsumo™ 和 Mintel™ 收集的媒体和市场情报数据,分别结合社会政治事件和带有反转基因生物标签的新食品数量,分析了公众对转基因生物的讨论。我们还利用 Overton™ 收集了政策文件和出版物数据,以说明转基因生物主题的政策状况及其随着时间的推移而发生的变化。对集体数据的分析表明,虽然随着时间的推移,围绕转基因生物话题的社交媒体和政策参与有所减少,但带有无转基因生物标识的新产品数量却在持续增长。虽然讨论一度达到顶峰,但后来有所下降,我们的研究结果表明,反转基因论调在社会心理中仍然根深蒂固,这一点可以从不含转基因产品的持续增加中得到证明。为满足消费者的知情权而开展的转基因食品标签运动取得了成功,现在看来,对这一信息的认知需求正在自我维持。
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引用次数: 0
ShF5H1 overexpression increases syringyl lignin and improves saccharification in sugarcane leaves. ShF5H1 过表达可增加甘蔗叶片中的丁香基木质素并提高糖化率。
IF 3.9 2区 农林科学 Q1 Agricultural and Biological Sciences Pub Date : 2024-12-31 Epub Date: 2024-03-20 DOI: 10.1080/21645698.2024.2325181
Juan Pablo Portilla Llerena, Eduardo Kiyota, Fernanda Raquel Camilo Dos Santos, Julio C Garcia, Rodrigo Faleiro de Lima, Juliana Lischka Sampaio Mayer, Michael Dos Santos Brito, Paulo Mazzafera, Silvana Creste, Paula Macedo Nobile

The agricultural sugarcane residues, bagasse and straws, can be used for second-generation ethanol (2GE) production by the cellulose conversion into glucose (saccharification). However, the lignin content negatively impacts the saccharification process. This polymer is mainly composed of guaiacyl (G), hydroxyphenyl (H), and syringyl (S) units, the latter formed in the ferulate 5-hydroxylase (F5H) branch of the lignin biosynthesis pathway. We have generated transgenic lines overexpressing ShF5H1 under the control of the C4H (cinnamate 4-hydroxylase) rice promoter, which led to a significant increase of up to 160% in the S/G ratio and 63% in the saccharification efficiency in leaves. Nevertheless, the content of lignin was unchanged in this organ. In culms, neither the S/G ratio nor sucrose accumulation was altered, suggesting that ShF5H1 overexpression would not affect first-generation ethanol production. Interestingly, the bagasse showed a significantly higher fiber content. Our results indicate that the tissue-specific manipulation of the biosynthetic branch leading to S unit formation is industrially advantageous and has established a foundation for further studies aiming at refining lignin modifications. Thus, the ShF5H1 overexpression in sugarcane emerges as an efficient strategy to improve 2GE production from straw.

农业甘蔗残渣、甘蔗渣和秸秆可通过将纤维素转化为葡萄糖(糖化)用于生产第二代乙醇(2GE)。然而,木质素含量会对糖化过程产生负面影响。这种聚合物主要由愈创木基(G)、羟基苯基(H)和丁香基(S)单元组成,后者在木质素生物合成途径的阿魏酸 5-羟化酶(F5H)分支中形成。我们在 C4H(肉桂酸 4-羟化酶)水稻启动子的控制下产生了过表达 ShF5H1 的转基因品系,这使得叶片中的 S/G 比率显著提高了 160%,糖化效率提高了 63%。然而,该器官中的木质素含量没有变化。在茎秆中,S/G 比率和蔗糖积累都没有改变,这表明 ShF5H1 的过表达不会影响第一代乙醇的生产。有趣的是,甘蔗渣中的纤维含量明显更高。我们的研究结果表明,对导致 S 单位形成的生物合成分支进行组织特异性操作具有工业优势,并为旨在完善木质素改性的进一步研究奠定了基础。因此,在甘蔗中过表达 ShF5H1 是提高秸秆 2GE 产量的有效策略。
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引用次数: 0
Agricultural chemical use and the rural-urban divide in Canada. 加拿大农业化学品的使用和城乡差别。
IF 3.9 2区 农林科学 Q1 Agricultural and Biological Sciences Pub Date : 2024-12-31 Epub Date: 2024-02-20 DOI: 10.1080/21645698.2024.2318876
Stuart J Smyth, Sylvain Charlebois

Innovation is of fundamental importance for improving food production, as well as sustainability food production. Since 1960, food production has benefited from innovations in plant breeding technologies, fertilizer, chemicals and equipment. These innovations have dramatically increased food production, while the amount of land used has minimally increased. However, future food production increases are jeopardized from widening knowledge gaps between rural food producers and large urban food consuming populations. Over time, that gap has fueled disinformation. The development of disinformation business models contributes to urban consumers receiving inaccurate information about the importance of inputs essential to food production, resulting in political pressures being applied that are targeted at reductions in the use of many food production inputs. The use of chemicals are a frequent target of disinformation campaigns. This article examines how the lack of government clarity about the safe use of chemicals contributes to a lack of public information.

创新对于提高粮食产量和粮食生产的可持续性至关重要。自 1960 年以来,粮食生产得益于植物育种技术、化肥、化学品和设备方面的创新。这些创新极大地提高了粮食产量,而土地使用量的增加却微乎其微。然而,由于农村粮食生产者与庞大的城市粮食消费人口之间的知识差距不断扩大,未来的粮食增产受到威胁。随着时间的推移,这种差距助长了虚假信息。虚假信息商业模式的发展导致城市消费者对粮食生产所必需的投入品的重要性获得不准确的信息,从而施加政治压力,要求减少许多粮食生产投入品的使用。化学品的使用经常成为虚假宣传的目标。本文探讨了政府对化学品的安全使用缺乏明确规定是如何造成公众信息匮乏的。
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引用次数: 0
In-silico analysis and transformation of OsMYB48 transcription factor driven by CaMV35S promoter in model plant - Nicotiana tabacum L. conferring abiotic stress tolerance. 对CaMV35S启动子驱动的OsMYB48转录因子在模式植物--Nicotiana tabacum L.中赋予抗非生物性胁迫能力的内部分析和转化。
IF 3.9 2区 农林科学 Q1 Agricultural and Biological Sciences Pub Date : 2024-12-31 Epub Date: 2024-03-29 DOI: 10.1080/21645698.2024.2334476
Yumna Ahmad, Saqlain Haider, Javed Iqbal, Sana Naseer, Kotb A Attia, Arif Ahmed Mohammed, Sajid Fiaz, Tariq Mahmood

Global crop yield has been affected by a number of abiotic stresses. Heat, salinity, and drought stress are at the top of the list as serious environmental growth-limiting factors. To enhance crop productivity, molecular approaches have been used to determine the key regulators affecting stress-related phenomena. MYB transcription factors (TF) have been reported as one of the promising defensive proteins against the unfavorable conditions that plants must face. Different roles of MYB TFs have been suggested such as regulation of cellular growth and differentiation, hormonal signaling, mediating abiotic stress responses, etc. To gain significant insights, a comprehensive in-silico analysis of OsMYB TF was carried out in comparison with 21 dicot MYB TFs and 10 monocot MYB TFs. Their chromosomal location, gene structure, protein domain, and motifs were analyzed. The phylogenetic relationship was also studied, which resulted in the classification of proteins into four basic groups: groups A, B, C, and D. The protein motif analysis identified several conserved sequences responsible for cellular activities. The gene structure analysis suggested that proteins that were present in the same class, showed similar intron-exon structures. Promoter analysis revealed major cis-acting elements that were found to be responsible for hormonal signaling and initiating a response to abiotic stress and light-induced mechanisms. The transformation of OsMYB TF into tobacco was carried out using the Agrobacterium-mediated transformation method, to further analyze the expression level of a gene in different plant parts, under stress conditions. To summarize, the current studies shed light on the evolution and role of OsMYB TF in plants. Future investigations should focus on elucidating the functional roles of MYB transcription factors in abiotic stress tolerance through targeted genetic modification and CRISPR/Cas9-mediated genome editing. The application of omics approaches and systems biology will be indispensable in delineating the regulatory networks orchestrated by MYB TFs, facilitating the development of crop genotypes with enhanced resilience to environmental stressors. Rigorous field validation of these genetically engineered or edited crops is imperative to ascertain their utility in promoting sustainable agricultural practices.

全球作物产量受到多种非生物胁迫的影响。高温、盐度和干旱胁迫是最严重的环境生长限制因素。为了提高作物产量,人们采用分子方法来确定影响胁迫相关现象的关键调节因子。据报道,MYB 转录因子(TF)是一种很有前途的防御蛋白,能抵御植物必须面对的不利条件。人们认为 MYB 转录因子具有不同的作用,如调节细胞生长和分化、激素信号转导、介导非生物胁迫反应等。为了获得重要的洞察力,我们对 OsMYB TF 与 21 种双子叶植物 MYB TF 和 10 种单子叶植物 MYB TF 进行了全面的体内分析。分析了它们的染色体位置、基因结构、蛋白结构域和基序。此外,还研究了它们之间的系统发育关系,并将蛋白质分为 A、B、C 和 D 四个基本组。基因结构分析表明,同一类蛋白质具有相似的内含子-外显子结构。启动子分析发现了主要的顺式作用元件,这些元件负责激素信号转导,并启动对非生物胁迫和光诱导机制的响应。利用农杆菌介导的转化方法将 OsMYB TF 转化到烟草中,以进一步分析在胁迫条件下该基因在植物不同部位的表达水平。总之,目前的研究揭示了 OsMYB TF 在植物中的进化和作用。未来的研究应侧重于通过靶向遗传修饰和 CRISPR/Cas9 介导的基因组编辑,阐明 MYB 转录因子在非生物胁迫耐受性中的功能作用。在阐明 MYB 转录因子所协调的调控网络方面,应用全局学方法和系统生物学将是不可或缺的,这将有助于开发对环境胁迫具有更强抗逆性的作物基因型。必须对这些基因工程或编辑过的作物进行严格的实地验证,以确定它们在促进可持续农业实践中的效用。
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引用次数: 0
Lipid Nanovesicle Platforms for Hepatocellular Carcinoma Precision Medicine Therapeutics: Progress and Perspectives. 用于肝细胞癌精准医学治疗的脂质纳米囊平台:进展与展望》。
IF 2.3 4区 生物学 Q2 Medicine Pub Date : 2024-12-31 Epub Date: 2024-02-15 DOI: 10.1080/15476278.2024.2313696
Brandon M Lehrich, Evan R Delgado

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality globally. HCC is highly heterogenous with diverse etiologies leading to different driver mutations potentiating unique tumor immune microenvironments. Current therapeutic options, including immune checkpoint inhibitors and combinations, have achieved limited objective response rates for the majority of patients. Thus, a precision medicine approach is needed to tailor specific treatment options for molecular subsets of HCC patients. Lipid nanovesicle platforms, either liposome- (synthetic) or extracellular vesicle (natural)-derived present are improved drug delivery vehicles which may be modified to contain specific cargos for targeting specific tumor sites, with a natural affinity for liver with limited toxicity. This mini-review provides updates on the applications of novel lipid nanovesicle-based therapeutics for HCC precision medicine and the challenges associated with translating this therapeutic subclass from preclinical models to the clinic.

肝细胞癌(HCC)是全球癌症相关死亡的主要原因之一。HCC 具有高度异质性,不同的病因导致不同的驱动基因突变,从而增强了独特的肿瘤免疫微环境。目前的治疗方案,包括免疫检查点抑制剂和联合疗法,对大多数患者的客观反应率有限。因此,需要一种精准医疗方法,为 HCC 患者的分子亚群量身定制特定的治疗方案。脂质纳米囊平台,无论是脂质体(合成的)还是细胞外囊(天然的),都是经过改良的给药载体,可被修饰成含有针对特定肿瘤部位的特定载体,对肝脏具有天然的亲和力,且毒性有限。这篇微型综述介绍了基于新型脂质纳米囊泡的疗法在 HCC 精准医疗中的最新应用,以及将这一治疗亚类从临床前模型转化到临床所面临的挑战。
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引用次数: 0
Cloning and functional analysis of ZmMADS42 gene in maize. 玉米 ZmMADS42 基因的克隆和功能分析。
IF 3.9 2区 农林科学 Q1 Agricultural and Biological Sciences Pub Date : 2024-12-31 Epub Date: 2024-03-11 DOI: 10.1080/21645698.2024.2328384
Yang Zhao, Jianyu Lu, Bo Hu, Peng Jiao, Bai Gao, Zhenzhong Jiang, Siyan Liu, Shuyan Guan, Yiyong Ma

Maize (Zea mays L.) is the most important cereal crop in the world. Flowering period and photoperiod play important roles in the reproductive development of maize. This study, investigated ZmMADS42, a gene that is highly expressed in the shoot apical meristem. Agrobacterium infection was used to successfully obtain overexpressed ZmMADS42 plants. Fluorescence quantitative PCR revealed that the expression of the ZmMADS42 gene in the shoot apical meristem of transgenic plants was 2.8 times higher than that of the wild-type(WT). In addition, the expression of the ZmMADS42 gene in the endosperm was 2.4 times higher than that in the wild-type. The seed width of the T2 generation increased by 5.35%, whereas the seed length decreased by 7.78% compared with that of the wild-type. Dissection of the shoot tips of transgenic and wild-type plants from the 7-leaf stage to the 9-leaf stage revealed that the transgenic plants entered the differentiation stage earlier and exhibited more tassel meristems during their vegetative growth period. The mature transgenic plants were approximately 20 cm shorter in height and had a lower panicle position than the wild-type plants. Comparing the flowering period, the tasseling, powdering, and silking stages of the transgenic plants occurred 10 days earlier than those of the wild-type plants. The results showed that the ZmMADS42 gene played a significant role in regulating the flowering period and plant height of maize.

玉米(Zea mays L.)是世界上最重要的谷类作物。花期和光周期对玉米的生殖发育起着重要作用。本研究对 ZmMADS42 进行了研究,这是一个在芽顶端分生组织中高表达的基因。利用农杆菌感染成功获得了过表达 ZmMADS42 的植株。荧光定量 PCR 结果显示,转基因植株芽尖分生组织中 ZmMADS42 基因的表达量是野生型(WT)的 2.8 倍。此外,ZmMADS42 基因在胚乳中的表达量是野生型的 2.4 倍。与野生型相比,T2 代的种子宽度增加了 5.35%,而种子长度则减少了 7.78%。对转基因植株和野生型植株从 7 叶期到 9 叶期的芽尖进行解剖发现,转基因植株较早进入分化期,在无性生长期表现出更多的抽穗分生组织。成熟的转基因植株高度比野生型植株矮约 20 厘米,圆锥花序位置也比野生型植株低。比较花期,转基因植株的抽穗期、粉期和抽丝期比野生型植株早 10 天。结果表明,ZmMADS42 基因在调控玉米的花期和株高方面发挥了重要作用。
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引用次数: 0
Exosomes derived from TNF-α-treated bone marrow mesenchymal stem cells ameliorate myocardial infarction injury in mice. 从经 TNF-α 处理的骨髓间充质干细胞中提取的外泌体可改善小鼠心肌梗死损伤。
IF 2.3 4区 生物学 Q2 Medicine Pub Date : 2024-12-31 Epub Date: 2024-05-20 DOI: 10.1080/15476278.2024.2356341
Shuo Wang, Rubin Wu, Qincong Chen, Tao Liu, Liu Li

Exosomes derived from bone marrow mesenchymal stem cells (BMSCs) exhibit considerable therapeutic potential for myocardial regeneration. In our investigation, we delved into their impact on various aspects of myocardial infarction (MI), including cardiac function, tissue damage, inflammation, and macrophage polarization in a murine model. We meticulously isolated the exosomes from TNF-α-treated BMSCs and evaluated their therapeutic efficacy in a mouse MI model induced by coronary artery ligation surgery. Our comprehensive analysis, incorporating ultrasound, serum assessment, Western blot, and qRT-PCR, revealed that exosomes from TNF-α-treated BMSCs demonstrated significant therapeutic potential in reducing MI-induced injury. Treatment with these exosomes resulted in improved cardiac function, reduced infarct area, and increased left ventricular wall thickness in MI mice. On a mechanistic level, exosome treatment fostered M2 macrophage polarization while concurrently suppressing M1 polarization. Hence, exosomes derived from TNF-α-treated BMSCs emerge as a promising therapeutic strategy for alleviating MI injury in a mouse model.

从骨髓间充质干细胞(BMSCs)中提取的外泌体对心肌再生具有相当大的治疗潜力。在我们的研究中,我们深入探讨了外泌体对心肌梗死(MI)各方面的影响,包括在小鼠模型中对心脏功能、组织损伤、炎症和巨噬细胞极化的影响。我们从TNF-α处理过的BMSCs中精心分离出了外泌体,并在冠状动脉结扎手术诱发的小鼠心肌梗死模型中评估了它们的疗效。我们结合超声波、血清评估、Western 印迹和 qRT-PCR 进行的综合分析表明,TNF-α 处理过的 BMSCs 外泌体在减轻心肌梗死引起的损伤方面具有显著的治疗潜力。使用这些外泌体治疗后,心肌梗死小鼠的心功能得到改善,梗死面积缩小,左心室壁厚度增加。在机理层面上,外泌体治疗促进了M2巨噬细胞的极化,同时抑制了M1的极化。因此,从TNF-α处理过的BMSCs中提取的外泌体有望成为缓解小鼠模型中心肌梗死损伤的治疗策略。
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引用次数: 0
The evolution of media reportage on GMOs in Ghana following approval of first GM crop. 加纳批准第一种转基因作物后,媒体对转基因生物报道的演变。
IF 3.9 2区 农林科学 Q1 Agricultural and Biological Sciences Pub Date : 2024-12-31 Epub Date: 2024-06-10 DOI: 10.1080/21645698.2024.2365481
Joseph Opoku Gakpo, Dennis Baffour-Awuah

Ghana's parliament in 2011 passed the Biosafety Act to allow for the application of genetically modified organism (GMO) technology in the country's agriculture. In a vibrant democracy, there have been extensive media discussions on whether GM crops will benefit or harm citizens. In June 2022, the state GMO regulator, the National Biosafety Authority (NBA), approved the country's first GM crop (Bt cowpea) for environmental release, declaring the crop does not present an altered environmental risk or a food/feed safety concern. This study identified 3 of the country's most vibrant digital news outlets and did a content analysis of all GMO stories reported 18 months pre- and post-approval to assess whether the approval changed the focus of GMO issues the media reports on. 91 articles were identified. The results show media reports on the likely impact of GMOs on the country's food security shot up after the approval. However, media reports on the possible health, sociocultural, and environmental impact of GMOs declined. We observe the media and the public appear interested in deliberations on how the technology could address or worsen food insecurity and urge agricultural biotechnology actors in Ghana to focus on that in their sensitization activities.

加纳议会于 2011 年通过了《生物安全法》,允许在本国农业中应用转基因生物(GMO)技术。在一个充满活力的民主国家,媒体对转基因作物是造福还是损害公民进行了广泛的讨论。2022 年 6 月,国家转基因生物监管机构--国家生物安全局(NBA)批准了该国第一种转基因作物(Bt 豇豆)的环境释放,宣布该作物不会带来环境风险改变或食品/饲料安全问题。本研究确定了该国最活跃的 3 家数字新闻机构,并对批准前后 18 个月内报道的所有转基因生物故事进行了内容分析,以评估批准是否改变了媒体报道转基因生物问题的重点。共确定了 91 篇文章。结果显示,转基因生物获批后,媒体关于转基因生物可能对国家粮食安全造成影响的报道大幅增加。然而,媒体对转基因生物可能造成的健康、社会文化和环境影响的报道却有所减少。我们注意到,媒体和公众似乎对有关该技术如何解决或恶化粮食不安全问题的讨论很感兴趣,并敦促加纳的农业生物技术参与者在其宣传活动中关注这一点。
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引用次数: 0
An environmental risk assessment of IPD079Ea: a protein derived from Ophioglossum pendulum with activity against Diabrotica spp.In maize. IPD079Ea 的环境风险评估:一种从 Ophioglossum pendulum 提取的蛋白质,对玉米中的 Diabrotica spp.
IF 3.9 2区 农林科学 Q1 Agricultural and Biological Sciences Pub Date : 2024-12-31 Epub Date: 2024-01-18 DOI: 10.1080/21645698.2023.2299503
Bridget F O'Neill, Chad Boeckman, Kristine LeRoy, Chris Linderblood, Taylor Olson, Rachel Woods, Mary Challender

Farmers in North America face significant pressure from insects in their maize fields, particularly from corn rootworm (Diabrotica spp.). Research into proteins capable of insecticidal activity has found several produced by ferns. One protein, IPD079Ea, was derived from Ophioglossum pendulum and has shown activity against corn rootworm. An environmental risk assessment was conducted for maize event DP-915635-4, which provides control of corn rootworms via expression of the IPD079Ea protein. This assessment focused on IPD079Ea and characterized potential exposure and hazard to non-target organisms (NTOs). For exposure, estimated environmental concentrations (EECs) were calculated. For hazard, laboratory dietary toxicity studies were conducted with IPD079Ea and surrogate non-target organisms. Environmental risk was characterized by comparing hazard and exposure to calculate the margin of exposure (MOE). Based on the MOE values for DP-915635-4 maize, the IPD079Ea protein is not expected to result in unreasonable adverse effects on beneficial NTO populations at environmentally relevant concentrations.

北美农民的玉米田面临着巨大的虫害压力,尤其是玉米根虫(Diabrotica spp.)。对具有杀虫活性的蛋白质的研究发现,蕨类植物能产生几种蛋白质。其中一种名为 IPD079Ea 的蛋白质来源于 Ophioglossum pendulum,对玉米根虫具有杀虫活性。对玉米事件 DP-915635-4 进行了环境风险评估,该事件通过表达 IPD079Ea 蛋白质来控制玉米根虫。该评估的重点是 IPD079Ea,并描述了对非目标生物 (NTO) 的潜在暴露和危害。在暴露方面,计算了估计环境浓度 (EEC)。在危害方面,对 IPD079Ea 和替代非目标生物进行了实验室膳食毒性研究。通过比较危害和暴露,计算暴露阈值(MOE),从而确定环境风险的特征。根据 DP-915635-4 玉米的暴露限值,在环境相关浓度下,IPD079Ea 蛋白质预计不会对有益的非目标生物群造成不合理的不利影响。
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引用次数: 0
Best practices for acceptability of GM crops field trials conclusions: lessons for Africa. 转基因作物田间试验结论可接受性的最佳做法:非洲的经验教训。
IF 4.5 2区 农林科学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2024-12-31 Epub Date: 2024-07-09 DOI: 10.1080/21645698.2024.2376415
Paul Chege, Julia Njagi, John Komen, Godfrey Ngure, John Muriuki, Margaret Karembu

The ability to transfer information about the performance, safety, and environmental impacts of a genetically modified (GM) crop from confined field trials (CFTs) conducted in one location to another is increasingly gaining importance in biosafety regulatory assessment and decision-making. The CFT process can be expensive, time-consuming, and logistically challenging. Data transportability can help overcome these challenges by allowing the use of data obtained from CFTs conducted in one country to inform regulatory decision-making in another country. Applicability of transported CFT data would be particularly beneficial to the public sector product developers and small enterprises that develop innovative GM events but cannot afford to replicate redundant CFTs, as well as regulatory authorities seeking to improve the deployment of limited resources. This review investigates case studies where transported CFT data have successfully been applied in biosafety assessment and decision-making, with an outlook of how African countries could benefit from a similar approach.

将有关转基因作物的性能、安全性和环境影响的信息从一个地方的封闭田间试验(CFT)转移到另一个地方的能力,在生物安全监管评估和决策中的重要性日益增加。隔离田间试验过程可能成本高昂、耗时长,而且在后勤方面具有挑战性。数据可传输性有助于克服这些挑战,允许使用从一个国家进行的 CFT 中获得的数据为另一个国家的监管决策提供信息。对于公共部门的产品开发商和小型企业(这些企业开发创新的转基因产品,但无力重复多余的 CFT)以及寻求改善有限资源配置的监管机构来说,运输 CFT 数据的适用性尤其有益。本综述调查了在生物安全评估和决策中成功应用运输的 CFT 数据的案例研究,并展望了非洲国家如何从类似方法中获益。
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引用次数: 0
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