Chemical Reviews最新文献

The demand for highly functional chemical gas sensors has surged due to the increasing awareness of human health to monitor metabolic disorders or noncommunicable diseases, safety measures against harmful greenhouse and/or explosive gases, and determination of food freshness. Over the years of dedicated research, several types of chemiresistive gas sensors have been realized with appreciable sensitivities toward various gases. However, critical issues such as poor selectivity and sluggish response/recovery speeds continue to impede their widespread commercialization. Specifically, the mechanisms behind the selective response of some chemiresistive materials toward specific gas analytes remain unclear. In this review, we discuss state-of-the-art strategies employed to attain gas-selective chemiresistive materials, with particular emphasis on materials design, surface modification or functionalization with catalysts, defect engineering, material structure control, and integration with physical/chemical gas filtration media. The nature of material surface-gas interactions and the supporting mechanisms are elucidated, opening opportunities for optimizing the materials design, fine-tuning the gas sensing performance, and guiding the selection of the most appropriate materials for the accurate detection of specific gases. This review concludes with recommendations for future research directions and potential opportunities for further selectivity improvements.

The demand for highly functional chemical gas sensors has surged due to the increasing awareness of human health to monitor metabolic disorders or noncommunicable diseases, safety measures against harmful greenhouse and/or explosive gases, and determination of food freshness. Over the years of dedicated research, several types of chemiresistive gas sensors have been realized with appreciable sensitivities toward various gases. However, critical issues such as poor selectivity and sluggish response/recovery speeds continue to impede their widespread commercialization. Specifically, the mechanisms behind the selective response of some chemiresistive materials toward specific gas analytes remain unclear. In this review, we discuss state-of-the-art strategies employed to attain gas-selective chemiresistive materials, with particular emphasis on materials design, surface modification or functionalization with catalysts, defect engineering, material structure control, and integration with physical/chemical gas filtration media. The nature of material surface–gas interactions and the supporting mechanisms are elucidated, opening opportunities for optimizing the materials design, fine-tuning the gas sensing performance, and guiding the selection of the most appropriate materials for the accurate detection of specific gases. This review concludes with recommendations for future research directions and potential opportunities for further selectivity improvements.

The cell surface proteome, or surfaceome, is the hub for cells to interact and communicate with the outside world. Many disease-associated changes are hard-wired within the surfaceome, yet approved drugs target less than 50 cell surface proteins. In the past decade, the proteomics community has made significant strides in developing new technologies tailored for studying the surfaceome in all its complexity. In this review, we first dive into the unique characteristics and functions of the surfaceome, emphasizing the necessity for specialized labeling, enrichment, and proteomic approaches. An overview of surfaceomics methods is provided, detailing techniques to measure changes in protein expression and how this leads to novel target discovery. Next, we highlight advances in proximity labeling proteomics (PLP), showcasing how various enzymatic and photoaffinity proximity labeling techniques can map protein–protein interactions and membrane protein complexes on the cell surface. We then review the role of extracellular post-translational modifications, focusing on cell surface glycosylation, proteolytic remodeling, and the secretome. Finally, we discuss methods for identifying tumor-specific peptide MHC complexes and how they have shaped therapeutic development. This emerging field of neo-protein epitopes is constantly evolving, where targets are identified at the proteome level and encompass defined disease-associated PTMs, complexes, and dysregulated cellular and tissue locations. Given the functional importance of the surfaceome for biology and therapy, we view surfaceomics as a critical piece of this quest for neo-epitope target discovery.

The development of nucleic acid and protein drugs for oral delivery has lagged behind their production for conventional nonoral routes. Over the past decade, the evolution of DNA- and RNA-based technologies combined with the innovation of state-of-the-art delivery vehicles for nucleic acids has brought rapid advancements to the biopharmaceutical field. Nucleic acid therapies have the potential to achieve long-lasting effects, or even cures, by inhibiting or editing genes, which is not possible with conventional small-molecule drugs. However, challenges and limitations must be addressed before these therapies can provide cures for chronic conditions and rare diseases, rather than only offering temporary relief. Nucleic acids and proteins face premature degradation in the acidic, enzyme-rich stomach environment and are rapidly cleared by the liver. To overcome these challenges, various delivery vehicles have been developed to transport therapeutic compounds to the intestines, where the active compounds are released and gut microbiota and mucosal immune system also play an important role. This review provides a comprehensive overview of the promises and pitfalls associated with the oral route of administration of biologics, current delivery systems, applications of orally delivered therapeutics, and the challenges and considerations for translation of nucleic acid and protein therapeutics into clinical practice.