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Preparation of Free-Standing Defect-Free ZIF-8/PVA Membranes via Confined Reaction at the Quasi-Interface. 通过准界面限制反应制备独立无缺陷的 ZIF-8/PVA 膜。
IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-19 DOI: 10.1021/acsami.4c08304
Qingqi Zeng, Yan Guo, Lin Zhao, Tieqiang Wang, Liying Zhang, Fuqiang Fan, Yu Fu

Developing a facile strategy to synthesize free-standing defect-free metal-organic framework (MOF) membranes with high separation selectivity and good mechanical stability is very appealing but challenging. Herein, by confining the reaction of metal and ligand at the quasi-interface, a representative membrane composed of a continuous ZIF-8 layer and poly(vinyl alcohol) (PVA) was fabricated. The continuous ZIF-8 layer endowed the membrane with high separation efficiency, while PVA acted as a filler to eliminate the defection, synergistically achieving high selective ion transport and good mechanical stability. The continuous defect-free ZIF-8/PVA membrane showed excellent separation performance of selective ion transport with high Li+ permeance of 17.83 mol·m-2·h-1 as well as decent Li+/Mg2+ and Li+/Ca2+ selectivities of 24.60 and 244.58, respectively. The separation performance of the ZIF-8/PVA membrane remained stable after 10% strain, indicating its good mechanical stability. This work will promote the development of MOF-based membranes in practical applications.

开发一种简便的策略来合成具有高分离选择性和良好机械稳定性的独立无缺陷金属有机框架(MOF)膜非常有吸引力,但也极具挑战性。本文通过将金属和配体的反应限制在准界面上,制备了一种由连续 ZIF-8 层和聚乙烯醇(PVA)组成的代表性膜。连续的 ZIF-8 层赋予了膜较高的分离效率,而 PVA 则作为填充物消除了缺陷,两者协同作用实现了高选择性离子传输和良好的机械稳定性。连续无缺陷的 ZIF-8/PVA 膜表现出优异的选择性离子传输分离性能,Li+ 渗透率高达 17.83 mol-m-2-h-1,Li+/Mg2+ 和 Li+/Ca2+ 选择性分别为 24.60 和 244.58。ZIF-8/PVA 膜的分离性能在 10%应变后保持稳定,表明其具有良好的机械稳定性。这项工作将促进基于 MOF 的膜在实际应用中的发展。
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引用次数: 0
Capillary Force-Induced Graphene Spontaneous Transfer and Encapsulation of Silver Nanowires for Highly-Stable Transparent Electrodes. 毛细管力诱导石墨烯自发转移和封装银纳米线,实现高稳定性透明电极。
IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-19 DOI: 10.1021/acsami.4c06315
Tingting Hao, Haoyu Ji, Dong Xu, Dongqi Liu, Zichen Ren, Wenchao Liu, Yike Zhang, Jiawu Sun, Jiupeng Zhao, Leipeng Zhang, Yao Li

Silver nanowires (NWs) (AgNWs) have emerged as the most promising conductive materials in flexible optoelectronic devices owing to their excellent photoelectric properties and mechanical flexibility. It is widely acknowledged that the practical application of AgNW networks faces challenges, such as high surface roughness, poor substrate adhesion, and limited stability. Encapsulating AgNW networks with graphene has been recognized as a viable strategy to tackle these issues. However, conventional methods like self-assembly reduction-oxidation or chemical vapor deposition often yield graphene protective layers with inherent defects. Here, we propose a novel one-step hot-pressing method containing ethanol solution that combines the spontaneous transfer and encapsulation process of rGO films onto the surface of the AgNWs network, enabling the preparation of flexible rGO/AgNWs/PET (reduced graphene oxide/silver NWs/polyethylene terephthalate) electrodes. The composite electrode exhibits outstanding photoelectric properties (T ≈ 88%, R ≈ 6 Ω sq-1) and possesses a smooth surface, primarily attributed to the capillary force generated by ethanol evaporation, ensuring the integrity of the rGO delamination process on the original substrate. The capillary force simultaneously promotes the tight encapsulation of rGO and AgNWs, as well as the welding of the AgNWs junction, thereby enhancing the mechanical stability (20,000 bending cycles and 100 cycles of taping tests), thermal stability (∼30 °C and ∼25% humidity for 150 days), and environmental adaptability (100 days of chemical attack) of the electrode. The electrode's practical feasibility has been validated by its exceptional flexibility and cycle stability (95 and 98% retention after 5000 bending cycles and 12,000 s long-term cycles) in flexible electrochromic devices.

银纳米线(AgNWs)因其卓越的光电特性和机械柔韧性,已成为柔性光电器件中最有前途的导电材料。人们普遍认为,AgNW 网络的实际应用面临着各种挑战,如表面粗糙度高、基底附着力差和稳定性有限等。用石墨烯封装 AgNW 网络已被认为是解决这些问题的可行策略。然而,自组装还原氧化法或化学气相沉积法等传统方法往往会产生具有固有缺陷的石墨烯保护层。在这里,我们提出了一种新颖的一步热压法(含乙醇溶液),它将 rGO 薄膜的自发转移和封装过程结合到 AgNWs 网络表面,从而制备出柔性 rGO/AgNWs/PET(还原氧化石墨烯/银 NWs/聚对苯二甲酸乙二醇酯)电极。这种复合电极具有出色的光电特性(T ≈ 88%,R ≈ 6 Ω sq-1),表面光滑,这主要归功于乙醇蒸发产生的毛细力,确保了 rGO 在原始基底上分层过程的完整性。毛细力同时促进了 rGO 和 AgNWs 的紧密封装以及 AgNWs 结点的焊接,从而提高了电极的机械稳定性(20,000 次弯曲循环和 100 次绑带试验)、热稳定性(∼30 °C、∼25% 湿度条件下 150 天)和环境适应性(100 天的化学侵蚀)。该电极在柔性电致变色装置中表现出的优异柔韧性和循环稳定性(经过 5000 次弯曲循环和 12000 秒长期循环后分别达到 95% 和 98% 的保持率)验证了其实用性。
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引用次数: 0
Tough and Elastic Cellulose Composite Hydrogels/Films for Flexible Wearable Sensors. 用于柔性可穿戴传感器的韧性和弹性纤维素复合水凝胶/薄膜。
IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-19 DOI: 10.1021/acsami.4c08592
Tiangang Yang, Shao-Hao Lu, Honglin Zhu, Antonios Patetsos, Emma McDonald, Matthew D Mellor, Yangchao Luo, James F Rusling, Xueju Wang, Jie He

Cellulose and its composites, despite being abundant and sustainable, are typically brittle with very low flexibility/stretchability. This study reports a solution processing method to prepare porous, amorphous, and elastic cellulose hydrogels and films. Native cellulose dissolved in a water-ZnCl2 mixture can form ionic gels through in situ polymerization of acrylic acid (AA) to poly(acrylic acid) (PAA). The addition of up to 30 vol % AA does not change the solubility of cellulose in the water-ZnCl2 mixture. After polymerization, the formation of interpenetrated networks, resulting from the chemical cross-linking of PAA and the ionic/coordination binding among cellulose/PAA and ZnCl2, gives rise to strong, transparent, and ionically conductive hydrogels. These hydrogels can be used for wearable sensors to detect mechanical deformation under stretching, compression, and bending. Upon removal of ZnCl2 and drying the gels, semitransparent amorphous cellulose composite films can be obtained with a Young's modulus of up to 4 GPa. The rehydration of these films leads to the formation of tough, highly elastic composites. With a water content of 3-10.5%, cellulose-containing films as strong as paper also show typical characteristics of elastomers with an elongation of up to 1300%. Such composite films provide an alternative solution to resolving the material sustainability of natural polymers without compromising their mechanical properties.

纤维素及其复合材料尽管资源丰富且可持续,但通常较脆,柔韧性/伸展性很低。本研究报告了一种制备多孔、无定形和弹性纤维素水凝胶和薄膜的溶液加工方法。溶解在水-ZnCl2 混合物中的原生纤维素可通过丙烯酸(AA)与聚丙烯酸(PAA)的原位聚合形成离子凝胶。添加多达 30 Vol % 的 AA 不会改变纤维素在水-氯化锌混合物中的溶解度。聚合后,由于 PAA 的化学交联以及纤维素/PAA 和 ZnCl2 之间的离子/配位结合,形成了互穿网络,从而产生了坚固、透明和离子导电的水凝胶。这些水凝胶可用于可穿戴传感器,以检测拉伸、压缩和弯曲时的机械变形。去除氯化锌并干燥凝胶后,可获得半透明的无定形纤维素复合薄膜,其杨氏模量高达 4 GPa。这些薄膜的再水化可形成坚韧的高弹性复合材料。在含水量为 3-10.5% 的情况下,强度与纸张相当的含纤维素薄膜还能显示出弹性体的典型特征,伸长率高达 1300%。这种复合薄膜为解决天然聚合物的材料可持续性问题提供了另一种解决方案,同时又不影响其机械性能。
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引用次数: 0
Potassium Ion-Assisted Self-Assembled MXene-K-CNT Composite as High-Quality Sulfur-Loaded Hosts for Lithium-Sulfur Batteries. 钾离子辅助自组装 MXene-K-CNT 复合材料作为锂硫电池的高质量含硫宿主。
IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-19 DOI: 10.1021/acsami.4c04919
Yaoying Li, Ruoxi Yang, Jiawei Xie, Jia Li, Haifu Huang, Xianqing Liang, Dan Huang, Zhiqiang Lan, Haizhen Liu, Guangxu Li, Shuaikai Xu, Jin Guo, Wenzheng Zhou

We successfully synthesized hybrid MXene-K-CNT composites composed of alkalized two-dimensional (2D) metal carbide and carbon nanotubes (CNTs), which were employed as host materials for lithium-sulfur (Li-S) battery cathodes. The unique three-dimensional (3D) intercalated structure through electrostatic interactions by K+ ions in conjunction with the scaffolding effect provided by CNTs effectively inhibited the self-stacking of MXene nanosheets, resulting in an enhanced specific surface area (SSA) and ion transport capability. Moreover, the addition of CNTs and in situ-grown TiO2 considerably improved the conductivity of the cathode material. K+ ion etching created a more hierarchical porous structure in MXene, which further enhanced the SSA. The 3D framework effectively confined S embedded between nanosheet layers and suppressed volume changes of the cathode composite during charging/discharging processes. This combination of CNTs and alkalized nanosheets functioned as a physical and chemical dual adsorption system for lithium polysulfides (LiPSs). When subjected to a high current at 1.0C, S@MXene-K-0.5CNT with S-loaded of 1.2 mg cm-2 had an initial capacity of 919.6 mAh g-1 and capacity decay rate of merely 0.052% per cycle after 1000 cycles. Moreover, S@MXene-K-0.5CNT maintained good cycling stability even at a high current of up to 5.0C. These impressive results highlight the potential of alkalized 2D MXene nanosheets intercalated with CNTs as highly promising cathode materials for Li-S batteries. The study findings also have prospects for the development of next-generation Li-S batteries with high energy density and prolonged lifespans.

我们成功合成了由碱化二维(2D)金属碳化物和碳纳米管(CNTs)组成的混合 MXene-K-CNT 复合材料,并将其用作锂-硫(Li-S)电池阴极的宿主材料。通过 K+ 离子的静电相互作用形成的独特三维(3D)插层结构与 CNT 的支架效应相结合,有效抑制了 MXene 纳米片的自堆积,从而提高了比表面积(SSA)和离子传输能力。此外,添加 CNTs 和原位生长的 TiO2 还大大提高了阴极材料的导电性。K+ 离子蚀刻在 MXene 中形成了更多层次的多孔结构,进一步提高了比表面积。三维框架有效地限制了嵌入纳米片层之间的 S,并抑制了阴极复合材料在充电/放电过程中的体积变化。这种碳纳米管和碱化纳米片的组合成为锂多硫化物(LiPSs)的物理和化学双重吸附系统。当在 1.0C 下承受大电流时,S@MXene-K-0.5CNT,S 负载为 1.2 mg cm-2 ,初始容量为 919.6 mAh g-1,1000 次循环后容量衰减率仅为 0.052%。此外,S@MXene-K-0.5CNT,即使在高达 5.0C 的大电流下也能保持良好的循环稳定性。这些令人印象深刻的结果凸显了烷化二维 MXene 纳米片与 CNT 的插层作为极具潜力的锂-S 电池阴极材料的潜力。研究结果还为开发具有高能量密度和长寿命的下一代锂-S 电池带来了前景。
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引用次数: 0
Electrical Responsive Coating with a Multilayered TiO2-SnO2-RuO2 Heterostructure on Ti for Controlling Antibacterial Ability and Improving Osseointegration. 钛上的多层 TiO2-SnO2-RuO2 异质结构电响应涂层用于控制抗菌能力和改善骨结合。
IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-19 DOI: 10.1021/acsami.4c07114
Rui Zhou, Yifei Liu, Ming Li, Jianyun Cao, Jiahui Cheng, Daqing Wei, Baoqiang Li, Yaming Wang, Dechang Jia, Bailing Jiang, Ruslan Z Valiev, Yu Zhou

The bacterial infection and poor osseointegration of Ti implants could significantly compromise their applications in bone repair and replacement. Based on the carrier separation ability of the heterojunction and the redox reaction of pseudocapacitive metal oxides, we report an electrically responsive TiO2-SnO2-RuO2 coating with a multilayered heterostructure on a Ti implant. Owing to the band gap structure of the TiO2-SnO2-RuO2 coating, electron carriers are easily enriched at the coating surface, enabling a response to the endogenous electrical stimulation of the bone. With the formation of SnO2-RuO2 pseudocapacitance on the modified surface, the postcharging mode can significantly change the surface chemical state of the coating due to the redox reaction, enhancing the antibacterial ability and osteogenesis-related gene expression of the human bone marrow mesenchymal stem cells. Owing to the attraction for Ca2+, only the negatively postcharged SnO2@RuO2 can promote apatite deposition. The in vivo experiment reveals that the S-SnO2@RuO2-NP could effectively kill the bacteria colonized on the surface and promote osseointegration with the synostosis bonding interface. Thus, negatively charging the electrically responsive coating of TiO2-SnO2-RuO2 is a good strategy to endow modified Ti implants with excellent antibacterial ability and osseointegration.

钛植入物的细菌感染和骨结合不良会严重影响其在骨修复和替代中的应用。基于异质结的载流子分离能力和伪电容金属氧化物的氧化还原反应,我们在钛种植体上报告了一种具有多层异质结构的电响应 TiO2-SnO2-RuO2 涂层。由于 TiO2-SnO2-RuO2 涂层的带隙结构,电子载流子很容易在涂层表面富集,从而对骨的内源性电刺激做出响应。由于在改性表面形成了 SnO2-RuO2 伪电容,后充电模式可通过氧化还原反应显著改变涂层的表面化学状态,增强人骨髓间充质干细胞的抗菌能力和成骨相关基因的表达。由于对 Ca2+ 的吸引力,只有带负后电荷的 SnO2@RuO2 才能促进磷灰石沉积。体内实验表明,S-SnO2@RuO2-NP 能有效杀死表面定植的细菌,并促进与突触结合界面的骨结合。因此,TiO2-SnO2-RuO2负电涂层是赋予改性钛种植体卓越抗菌能力和骨结合能力的良好策略。
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引用次数: 0
Waste Polyethylene-Derived Carbon Dots: Administration of Metal-Free Oxidizing Agents for Tunable Properties and Photocatalytic Hyperactivity. 废聚乙烯衍生碳点:使用无金属氧化剂实现可调特性和光催化活性。
IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-19 DOI: 10.1021/acsami.4c08635
Bramhaiah Kommula, Sagnik Chakraborty, Maqsuma Banoo, Raj Sekhar Roy, Supriya Sil, Abhishek Swarnkar, Bhawna Rawat, Kamalakannan Kailasam, Ujjal K Gautam

The possibility of converting waste plastics into carbon dots (CDs) with 100% efficiencies using KMnO4 has emerged as a significant discovery in mitigating plastic pollution and upcycling. However, the lack of tunability of their properties, viz. aerial O2 harvesting, light-induced autophagy, and photoactivity using air as a free oxidant, has remained a bottleneck. Besides, the toxicity of KMnO4 makes the process less sustainable. Attempting to bridge these gaps, herein, we demonstrate the preparation of CDs using polyethylene with enormous controllability of their properties by utilizing less-toxic and metal-residue-free oxidizers, e.g., H2O2, HNO3, HClO4, and NaClO. We obtain structurally diverse CDs with controllable luminescent quantum yields (∼0.5-8%), excitonic lifetimes (1.3-2.3 ns), and binding energies (147-290 meV). These CDs exhibit a hugely extended range of molecular O2 harvesting (∼405-650 μM) with different amounts of strongly and weakly surface-bound O2 molecules within an estimated ratio of ∼0.77-2.51. Autophagy varied from 14 days to a nearly "no-autophagy" show. We efficiently utilized their oxygen harvesting and photocatalytic abilities to synthesize imine compounds from the corresponding amines in the open air (rate constant of ∼0.055 min-1), surpassing the literature efficiencies achieved using an O2 flow and noble metals. Notably, due to oxygen harvesting by CDs, no additional rate enhancement was observed after O2 purging, establishing the role of CDs in making free air an excellent oxidizing agent.

利用 KMnO4 将废塑料转化为碳点(CD)的效率可达 100%,这已成为减轻塑料污染和升级再循环方面的一项重大发现。然而,其特性(即空中获取氧气、光诱导自噬和使用空气作为自由氧化剂的光活性)缺乏可调性,这仍然是一个瓶颈。此外,KMnO4 的毒性也使这一过程难以为继。为了弥补这些不足,我们在本文中展示了利用聚乙烯制备光盘的方法,通过使用毒性较低且不含金属残留物的氧化剂(如 H2O2、HNO3、HClO4 和 NaClO),光盘的性质具有极大的可控性。我们获得了结构多样的 CD,其发光量子产率(∼0.5-8%)、激子寿命(1.3-2.3 ns)和结合能(147-290 meV)均可控。这些光盘显示出极大的分子氧气捕获范围(∼405-650 μM),强表面结合和弱表面结合的氧气分子数量不同,估计比例为∼0.77-2.51。自噬时间从 14 天到几乎 "无自噬 "不等。我们有效地利用了它们的氧气收集和光催化能力,在露天环境中从相应的胺中合成了亚胺化合物(速率常数为 ∼ 0.055 min-1),超过了文献中使用氧气流和贵金属所达到的效率。值得注意的是,由于 CDs 的集氧作用,在 O2 吹扫后没有观察到额外的速率提高,这证明了 CDs 在使自由空气成为极佳氧化剂方面所起的作用。
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引用次数: 0
Enhanced Capability of Hydrogen Evolution Photocathode by Laminated Interface Engineering of Co/MoS2 QDs/pyramid-black Si. 通过钴/MoS2 QDs/金字塔形黑硅的层叠界面工程增强氢演化光电阴极的能力
IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-19 DOI: 10.1021/acsami.4c07391
Weidong Cai, Zhixing Gan, Feng Nan, Shun Wang, Fuxiang Ji, Yiqiang Zhan

We present a novel and stable laminated structure to enhance the performance and stability of silicon (Si) photocathode devices for photoelectrochemical (PEC) water splitting. First, by utilizing Cu nanoparticle catalysts to work on a n+p-black Si substrate via the metal-assisted chemical etching, we can achieve the black silicon with a porous pyramid structure. The low depth holes on the surface of the pyramid caused by Cu etching not only help enhance the light capture capability with quite low surface reflectivity (<5%) but also efficiently protect the p-n junction from damage. To improve the charge migration efficiency and mitigate parasitic light absorption from cocatalysts at the same time, we drop casted quantum dots (QDs) MoS2 with the size of nanometer scale as the first layer of catalyst. Hence, we then can safely electrodeposit cocatalyst Co nanoparticles to further enhance interface transfer efficiency. The synergistic effects of cocatalysts and optimized light absorption from the morphology and QDs contributed to the overall enhancement of PEC performance, offering a promising pathway for an efficient, low cost, and stable (over 100 h) hydrogen production photocathode.

我们提出了一种新颖而稳定的层状结构,以提高硅(Si)光电阴极器件在光电化学(PEC)分水过程中的性能和稳定性。首先,通过金属辅助化学蚀刻,利用铜纳米颗粒催化剂在 n+p 黑硅衬底上工作,我们可以获得具有多孔金字塔结构的黑硅。铜蚀刻在金字塔表面造成的低深度孔洞不仅有助于增强光捕获能力,而且表面反射率相当低(2,作为第一层催化剂的尺寸为纳米级)。因此,我们可以安全地电沉积纳米 Co 催化剂,进一步提高界面转移效率。钴催化剂的协同效应以及形态和 QDs 的优化光吸收有助于全面提高 PEC 性能,为高效、低成本和稳定(超过 100 小时)的制氢光电阴极提供了一条可行的途径。
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引用次数: 0
In Situ Formation of an Artificial Lithium Oxalate-Rich Solid Electrolyte Interphase on 3D Ni Host for Highly Stable Lithium Metal Batteries. 在三维镍载体上原位形成富含草酸锂的人工固态电解质相,实现高稳定性锂金属电池。
IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-19 DOI: 10.1021/acsami.4c08044
Jaeyun Ha, Jinhee Lee, Garam Lee, Yong-Tae Kim, Jinsub Choi

Li metal, with a high theoretical capacity, is considered the most promising anode for next-generation high-energy-density batteries. However, the commercialization of the Li metal anode is limited owing to its high reactivity, significant volume expansion, continuous solid electrolyte interphase (SEI) layer degradation caused by undesirable Li deposition, and uncontrollable dendrite growth. This study demonstrates the in situ construction of a Li2C2O4-enriched SEI layer from NiC2O4 nanowires on three-dimensional Ni foam. The lithiophilic Li2C2O4-enriched SEI layer provides a uniform distribution of the electrical field and sufficient nucleation and deposition sites for Li without dendrite formation. Consequently, the stable Li2C2O4-enriched SEI layer successfully inhibits the formation of lithium dendrites, resulting in reversible Li stripping/plating behavior, maintained over an extended period of 5000 h with a deposition capacity of 1 mAh cm-2 at 1 mA cm-2. Additionally, a high cycling stability is observed in the full cell test with ∼70% capacity retention after 1300 cycles at 3 C. This approach offers a large-scale and facile synthesis process via the in situ precipitation growth of NiC2O4 followed by lithiation to form Li2C2O4. Furthermore, the significant stability of the Li2C2O4-enriched SEI layer aids the design of in situ-constructed SEI layers for highly stable Li metal batteries.

金属锂具有很高的理论容量,被认为是下一代高能量密度电池最有前途的阳极。然而,由于锂金属阳极的高反应性、显著的体积膨胀、不良锂沉积导致的固体电解质相间层(SEI)持续降解以及无法控制的枝晶生长,其商业化受到了限制。本研究展示了在三维镍泡沫上利用 NiC2O4 纳米线原位构建富含 Li2C2O4 的 SEI 层。亲锂的 Li2C2O4 富集 SEI 层提供了均匀分布的电场和足够的锂成核和沉积点,不会形成枝晶。因此,稳定的富含 Li2C2O4 的 SEI 层成功地抑制了锂枝晶的形成,从而产生了可逆的锂剥离/电镀行为,并在 1 mA cm-2 的条件下保持了 1 mAh cm-2 的沉积容量,持续时间长达 5000 h。此外,在全电池测试中还观察到了较高的循环稳定性,在 3 C 下循环 1300 次后,容量保持率为 70%。这种方法通过 NiC2O4 的原位沉淀生长,然后通过锂化形成 Li2C2O4,提供了一种大规模、简便的合成工艺。此外,富含 Li2C2O4 的 SEI 层具有显著的稳定性,有助于为高稳定性锂金属电池设计原位构建的 SEI 层。
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引用次数: 0
DNA Origami Enhanced Cytokine Immunotherapy for Alleviating Renal Ischemia-Reperfusion Injury. DNA Origami 增强细胞因子免疫疗法缓解肾缺血再灌注损伤。
IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-19 DOI: 10.1021/acsami.4c06110
Yu Fan, Chengshi Wang, Wenshu Dai, Yaojia Zhou, Gonggong Lu, Wei Li, Ling Li, Tao Lin

Renal ischemia-reperfusion injury (IRI) is a major contributing factor to the development of acute kidney injury (AKI) and has resulted in considerable morbidity and mortality. Persistent inflammatory responses and excessive reactive oxygen species (ROS) in the kidney following IRI can severely delay tissue repair, making it challenging to effectively promote IRI regeneration. Herein, we report an approach to enhance immunotherapy using interleukin-10 (IL-10) to promote IRI regeneration by loading IL-10 onto rectangular DNA origami nanostructures (rDON). rDON can significantly enhance the renal accumulation and retention time of IL-10, enabling it to effectively polarize type 1 macrophages into type 2 macrophages, thereby significantly reducing proinflammatory factors and increasing anti-inflammatory factors. In addition, DNA origami helps mitigate the harmful effects of ROS during renal IRI. The administration of IL-10-loaded DNA origami effectively improves kidney function, resulting in a notable reduction in blood urea nitrogen, serum uric acid, and serum creatinine levels. Our study demonstrates that the integration of anti-inflammatory cytokines within DNA origami holds promise as a strategic approach for cytokine immunotherapy in patients with AKI and other renal disorders.

肾缺血再灌注损伤(IRI)是导致急性肾损伤(AKI)的一个主要因素,并已造成相当高的发病率和死亡率。IRI后肾脏内持续的炎症反应和过量的活性氧(ROS)会严重延迟组织修复,因此有效促进IRI再生具有挑战性。在此,我们报告了一种利用白细胞介素-10(IL-10)促进IRI再生的增强免疫疗法方法,该方法是将IL-10载入矩形DNA折纸纳米结构(rDON)。rDON能显著增强IL-10在肾脏的蓄积和保留时间,使其能有效地将1型巨噬细胞极化为2型巨噬细胞,从而显著减少促炎因子,增加抗炎因子。此外,DNA origami 还有助于减轻肾脏 IRI 期间 ROS 的有害影响。服用含有 IL-10 的 DNA origami 能有效改善肾功能,从而明显降低血尿素氮、血清尿酸和血清肌酐水平。我们的研究表明,将抗炎细胞因子整合到 DNA 折纸中有望成为一种细胞因子免疫疗法的战略方法,用于治疗 AKI 和其他肾脏疾病患者。
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引用次数: 0
NIR-II Light-Actuated Nanomotors for Enhanced Photoimmunotherapy Toward Hepatocellular Carcinoma. 用于增强肝细胞癌光免疫疗法的近红外-II 光动纳米马达
IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-19 DOI: 10.1021/acsami.4c06994
Yichi Chen, Wenxin Xu, Huimin Tian, Junbin Gao, Yicheng Ye, Hanfeng Qin, Hong Wang, Yanzhen Song, Chuxiao Shao, Fei Peng, Yingfeng Tu

Light-propelled nanomotors, which can convert external light into mechanical motion, have shown considerable potential in the construction of a new generation of drug delivery systems. However, the therapeutic efficacy of light-driven nanomotors is always unsatisfactory due to the limited penetration depth of near-infrared-I (NIR-I) light and the inherent biocompatibility of the motor itself. Herein, an asymmetric nanomotor (Pd@ZIF-8/R848@M JNMs) with efficient motion capability is successfully constructed for enhanced photoimmunotherapy toward hepatocellular carcinoma. Under near-infrared-II (NIR-II) irradiation, Pd@ZIF-8/R848@M JNMs convert light energy into heat energy, exhibiting self-thermophoretic locomotion to penetrate deeper into tumor tissues to achieve photothermal therapy. At the same time, functionalized with an immune-activated agent Resiquimod (R848), our nanomotors could convert a "cold tumor" into a "hot tumor", transforming the immunosuppressive microenvironment into an immune-activated state, thus achieving immunotherapy. Dual photoimmunotherapy of the as-developed NIR-II light-driven Pd@ZIF-8/R848@M JNMs demonstrates considerable tumor inhibition effects, offering a promising therapeutic approach in the field of anticancer therapy.

光驱动纳米电机可以将外部光线转化为机械运动,在构建新一代药物输送系统方面已显示出相当大的潜力。然而,由于近红外光(NIR-I)的穿透深度有限以及马达本身固有的生物相容性,光驱动纳米马达的治疗效果总是不尽如人意。本文成功构建了一种具有高效运动能力的非对称纳米马达(Pd@ZIF-8/R848@M JNMs),用于增强对肝细胞癌的光免疫疗法。在近红外II(NIR-II)照射下,Pd@ZIF-8/R848@M JNMs能将光能转化为热能,表现出自热运动特性,从而深入肿瘤组织实现光热治疗。同时,我们的纳米马达在功能化了免疫激活剂 Resiquimod(R848)后,可将 "冷肿瘤 "转化为 "热肿瘤",将免疫抑制微环境转变为免疫激活状态,从而实现免疫治疗。所开发的近红外-II光驱动的Pd@ZIF-8/R848@M JNMs的双重光免疫疗法具有显著的肿瘤抑制效果,为抗癌治疗领域提供了一种前景广阔的治疗方法。
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