Pub Date : 2025-03-25DOI: 10.1021/acs.est.5c0261310.1021/acs.est.5c02613
Gregory V. Lowry*, Zhiyong Jason Ren, Julie Beth Zimmerman and Margaret Mills,
{"title":"Welcoming ES&T’s 2025 Early Career Editorial Board","authors":"Gregory V. Lowry*, Zhiyong Jason Ren, Julie Beth Zimmerman and Margaret Mills, ","doi":"10.1021/acs.est.5c0261310.1021/acs.est.5c02613","DOIUrl":"https://doi.org/10.1021/acs.est.5c02613https://doi.org/10.1021/acs.est.5c02613","url":null,"abstract":"","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"59 11","pages":"5415–5416 5415–5416"},"PeriodicalIF":10.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143678751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Songbo Wei, Huan-Yu Tao, Zheng Duan, Yinsheng Wang
Epitranscriptomics is a rapidly evolving field, and it examines how chemical modifications on RNA regulate gene expression. Increasing lines of evidence support that exposure to various environmental agents can change substantially chemical modifications on RNA, thereby perturbing gene expression and contributing to disease development in humans. However, the molecular mechanisms through which environmental exposure impairs RNA modification-associated proteins (“reader”, “writer”, and “eraser” or RWE proteins) and alters the landscape of RNA modifications remain poorly understood. Here, we provide our perspectives on the current knowledge about how environmental exposure alters the epitranscriptome, where we focus on dynamic changes in RNA modifications and their regulatory proteins elicited by exposure to environmental agents. We discuss how these epitranscriptomic alterations may contribute to the development of human diseases, especially neurodegeneration and cancer. We also discuss the potential and technical challenges of harnessing RNA modifications as biomarkers for monitoring environmental exposure. Finally, we emphasize the need to integrate multiomics approaches to decipher the complex interplay between environmental exposure and the epitranscriptome and offer a forward-looking viewpoint on future research priorities that may inform public health interventions and environmental regulations.
{"title":"Environmental Exposure, Epitranscriptomic Perturbations, and Human Diseases","authors":"Songbo Wei, Huan-Yu Tao, Zheng Duan, Yinsheng Wang","doi":"10.1021/acs.est.5c00907","DOIUrl":"https://doi.org/10.1021/acs.est.5c00907","url":null,"abstract":"Epitranscriptomics is a rapidly evolving field, and it examines how chemical modifications on RNA regulate gene expression. Increasing lines of evidence support that exposure to various environmental agents can change substantially chemical modifications on RNA, thereby perturbing gene expression and contributing to disease development in humans. However, the molecular mechanisms through which environmental exposure impairs RNA modification-associated proteins (“reader”, “writer”, and “eraser” or RWE proteins) and alters the landscape of RNA modifications remain poorly understood. Here, we provide our perspectives on the current knowledge about how environmental exposure alters the epitranscriptome, where we focus on dynamic changes in RNA modifications and their regulatory proteins elicited by exposure to environmental agents. We discuss how these epitranscriptomic alterations may contribute to the development of human diseases, especially neurodegeneration and cancer. We also discuss the potential and technical challenges of harnessing RNA modifications as biomarkers for monitoring environmental exposure. Finally, we emphasize the need to integrate multiomics approaches to decipher the complex interplay between environmental exposure and the epitranscriptome and offer a forward-looking viewpoint on future research priorities that may inform public health interventions and environmental regulations.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"2 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143678072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ju Luo, Zhengshuo Zhan, Weiquan Li, Xin Zhang, Yang Lei
Electrochemical pH-swing systems have demonstrated significant potential across diverse applications, including chemical production, carbon capture, and water treatment. However, conventional systems predominantly depend on costly ion exchange membranes, which are often plagued by fouling and scaling challenges. Here, we introduce an ingenious electrochemically assisted calcium silicate (EACS) system capable of achieving a rapid pH swing from 8.5 to 10 within 1 h through the in situ utilization of H+ and OH– ions, eliminating the need for membranes. The EACS system incorporates a novel 3D-printed porous basket holder designed to house calcium silicate particles and a rod-shaped Ru–Ir anode. Under closed-circuit conditions, the packed calcium silicate reacts with H+ generated at the anode, releasing Ca2+ into bulk solution, while OH– produced at the cathode accumulates, resulting in an elevated bulk pH. This mechanism enables the EACS system to achieve exceptional phosphorus recovery efficiency (88.4%–96.6%) from various waste streams, with energy consumption as low as 24.4 kWh kg P–1. Long-term continuous flow experiments demonstrate that periodic replacement of depleted silicate minerals sustains system efficiency and stability. Furthermore, comparative analysis reveals that while carbonate and silicate minerals are functionally viable, silicate minerals exhibit superior performance in removal kinetics, product purity, and reduced carbon emissions. Notably, the effluent from the EACS system, enriched with Ca2+ and characterized by a high pH, exhibits potential for direct air carbon capture. The proposed EACS system offers a transformative approach to environmental remediation and industrial applications, leveraging the fundamental principle of pH-swing to open new avenues for sustainable solutions.
{"title":"Electrochemically Assisted Calcium Silicate Utilization for Phosphate Recovery","authors":"Ju Luo, Zhengshuo Zhan, Weiquan Li, Xin Zhang, Yang Lei","doi":"10.1021/acs.est.5c00378","DOIUrl":"https://doi.org/10.1021/acs.est.5c00378","url":null,"abstract":"Electrochemical pH-swing systems have demonstrated significant potential across diverse applications, including chemical production, carbon capture, and water treatment. However, conventional systems predominantly depend on costly ion exchange membranes, which are often plagued by fouling and scaling challenges. Here, we introduce an ingenious electrochemically assisted calcium silicate (EACS) system capable of achieving a rapid pH swing from 8.5 to 10 within 1 h through the in situ utilization of H<sup>+</sup> and OH<sup>–</sup> ions, eliminating the need for membranes. The EACS system incorporates a novel 3D-printed porous basket holder designed to house calcium silicate particles and a rod-shaped Ru–Ir anode. Under closed-circuit conditions, the packed calcium silicate reacts with H<sup>+</sup> generated at the anode, releasing Ca<sup>2+</sup> into bulk solution, while OH<sup>–</sup> produced at the cathode accumulates, resulting in an elevated bulk pH. This mechanism enables the EACS system to achieve exceptional phosphorus recovery efficiency (88.4%–96.6%) from various waste streams, with energy consumption as low as 24.4 kWh kg P<sup>–1</sup>. Long-term continuous flow experiments demonstrate that periodic replacement of depleted silicate minerals sustains system efficiency and stability. Furthermore, comparative analysis reveals that while carbonate and silicate minerals are functionally viable, silicate minerals exhibit superior performance in removal kinetics, product purity, and reduced carbon emissions. Notably, the effluent from the EACS system, enriched with Ca<sup>2+</sup> and characterized by a high pH, exhibits potential for direct air carbon capture. The proposed EACS system offers a transformative approach to environmental remediation and industrial applications, leveraging the fundamental principle of pH-swing to open new avenues for sustainable solutions.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"24 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143678068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Infectious inflammation caused by pathogens or environmental pollutants remains a major global health issue. Therefore the development of novel strategies to efficaciously control infectious inflammation is urgently required. Nuclear factor-κB (NF-κB) as the central activator of pro-inflammatory genes plays a pivotal role in infectious inflammation. Here, nanoscale chirality was designed to modulate the inflammatory response through enantiomer-dependent blockade of the NF-κB signaling pathway. Chiral gold nanoparticles (AuNPs) with good cytocompatibility were prepared through a one-pot seedless method under wild conditions, showing efficacious alleviation of lipopolysaccharide (LPS)-induced inflammation in vitro and in vivo only by AuNPs with levorotatory chirality (L-AuNPs) rather than the dextrorotatory enantiomer (D-AuNPs). Mechanism investigation elucidated that lysosomal acidification of macrophages was inhibited through a high cellular uptake of L-AuNPs due to their weak interaction energy with cell membranes. Accordingly, the NF-κB rather than mitogen-activated protein kinase pathway was blocked by L-AuNPs through the selective inhibition of p65 phosphorylation, wherein the nuclear translocation of p65 was simultaneously depressed, so the secretion of pro-inflammatory mediators was reduced significantly. This study suggests that imparting chirality to nanoparticles can provide a novel protocol to efficaciously modulate health risks arising from infectious inflammation by improving the uptake of nanoparticles with anti-inflammatory activity.
{"title":"Enantiomer-Dependent Uptake of Chiral Nanoparticles in Macrophages Modulates the Inflammatory Response through the NF-κB Pathway","authors":"Jinghua Hao, Yijin Tian, Jie Tang, Nali Zhu, Zhigang Li, Lingxiangyu Li, Yawei Wang, Guibin Jiang","doi":"10.1021/acs.est.4c12577","DOIUrl":"https://doi.org/10.1021/acs.est.4c12577","url":null,"abstract":"Infectious inflammation caused by pathogens or environmental pollutants remains a major global health issue. Therefore the development of novel strategies to efficaciously control infectious inflammation is urgently required. Nuclear factor-κB (NF-κB) as the central activator of pro-inflammatory genes plays a pivotal role in infectious inflammation. Here, nanoscale chirality was designed to modulate the inflammatory response through enantiomer-dependent blockade of the NF-κB signaling pathway. Chiral gold nanoparticles (AuNPs) with good cytocompatibility were prepared through a one-pot seedless method under wild conditions, showing efficacious alleviation of lipopolysaccharide (LPS)-induced inflammation in vitro and in vivo only by AuNPs with levorotatory chirality (L-AuNPs) rather than the dextrorotatory enantiomer (D-AuNPs). Mechanism investigation elucidated that lysosomal acidification of macrophages was inhibited through a high cellular uptake of L-AuNPs due to their weak interaction energy with cell membranes. Accordingly, the NF-κB rather than mitogen-activated protein kinase pathway was blocked by L-AuNPs through the selective inhibition of p65 phosphorylation, wherein the nuclear translocation of p65 was simultaneously depressed, so the secretion of pro-inflammatory mediators was reduced significantly. This study suggests that imparting chirality to nanoparticles can provide a novel protocol to efficaciously modulate health risks arising from infectious inflammation by improving the uptake of nanoparticles with anti-inflammatory activity.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"20 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143678069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jinglong Li, Jake W. O’Brien, Ben J. Tscharke, Rory Verhagen, Chang He, Katja M. Shimko, Xueting Shao, Naixiang Zhai, Tobias Hulleman, Jochen F. Mueller, Kevin V. Thomas
Despite Australia’s high antimicrobial use, their residues in wastewater and their impacts on receiving waters remain largely unknown. This study assessed the occurrence, removal, and risk for antimicrobial resistance (AMR) of 102 antimicrobial substances and selected transformation products (TPs) in wastewater effluent from 47 wastewater treatment plants (WWTPs) across Australia. Thirty-two antimicrobials and 13 TPs were detected, with 14 analytes occurring at >80% frequencies. Ampicillin, penicillin V, penicilloic V acid, fluconazole, and tazobactam M1 were observed with high median concentrations of >0.2 μg/L. Collectively, the WWTPs released 5.4 kg/day or 0.54 g/day/1000 inhabitants of antimicrobials/TPs into natural waters, with β-lactams, quinolones, nitroimidazoles/azoles, and sulfonamides comprising high volumes, which was correlated with the population’s socioeconomic statuses. Thirty-seven analytes were removed at rates >80% post-treatment, whereas quinolones, nitroimidazoles/azoles, lincosamides, and macrolide TPs were observed with poor removal efficiencies, which were affected by treatment processes and regional climate. Comparing measured concentrations with the predicted no-effect concentrations for AMR selection (PNECAMR), 7 antimicrobials exerted selection risk for resistant bacteria. Concerningly, ciprofloxacin posed medium/high risk in most of the assessed WWTPs. The accumulative effects of antimicrobial classes and certain TPs might further aggravate adverse impacts on AMR development. Our study provides insights into the presence and AMR implications of antimicrobials in treated wastewater, aiming to safeguard public health and ecosystems.
{"title":"Occurrence, Removal, and Risk Assessment of Antimicrobials and Their Transformation Products in Effluent from Australian Wastewater Treatment Plants","authors":"Jinglong Li, Jake W. O’Brien, Ben J. Tscharke, Rory Verhagen, Chang He, Katja M. Shimko, Xueting Shao, Naixiang Zhai, Tobias Hulleman, Jochen F. Mueller, Kevin V. Thomas","doi":"10.1021/acs.est.5c00425","DOIUrl":"https://doi.org/10.1021/acs.est.5c00425","url":null,"abstract":"Despite Australia’s high antimicrobial use, their residues in wastewater and their impacts on receiving waters remain largely unknown. This study assessed the occurrence, removal, and risk for antimicrobial resistance (AMR) of 102 antimicrobial substances and selected transformation products (TPs) in wastewater effluent from 47 wastewater treatment plants (WWTPs) across Australia. Thirty-two antimicrobials and 13 TPs were detected, with 14 analytes occurring at >80% frequencies. Ampicillin, penicillin V, penicilloic V acid, fluconazole, and tazobactam M1 were observed with high median concentrations of >0.2 μg/L. Collectively, the WWTPs released 5.4 kg/day or 0.54 g/day/1000 inhabitants of antimicrobials/TPs into natural waters, with β-lactams, quinolones, nitroimidazoles/azoles, and sulfonamides comprising high volumes, which was correlated with the population’s socioeconomic statuses. Thirty-seven analytes were removed at rates >80% post-treatment, whereas quinolones, nitroimidazoles/azoles, lincosamides, and macrolide TPs were observed with poor removal efficiencies, which were affected by treatment processes and regional climate. Comparing measured concentrations with the predicted no-effect concentrations for AMR selection (PNEC<sub>AMR</sub>), 7 antimicrobials exerted selection risk for resistant bacteria. Concerningly, ciprofloxacin posed medium/high risk in most of the assessed WWTPs. The accumulative effects of antimicrobial classes and certain TPs might further aggravate adverse impacts on AMR development. Our study provides insights into the presence and AMR implications of antimicrobials in treated wastewater, aiming to safeguard public health and ecosystems.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"34 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143678071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Highly efficient molecular oxygen activation over transition metal oxides toward catalytic abatement of aromatic volatile organic compounds (AVOCs) is possible yet challenging due to the easily deactivated surface oxygen vacancy (VO). Herein, dynamic Mn–VO associates were crafted onto the Mn-incorporated CeO2 mesocrystal (Mn/meso-CeO2) surface with Mn substituting a Ce atom through an easy-to-handle precipitation strategy. Experiments and theoretical calculation demonstrated that the asymmetric surface Mn–O–Ce configuration induced electron delivery from the low-valent Mn to adjacent Ce, destabilizing the circumambient O atoms and facilitating the formation of dynamic Mn–VO associates. Compared to pristine meso-CeO2, the Mn/meso-CeO2 with dynamic Mn–VO associates could efficiently activate O2 into a superoxide radical and a peroxanion (O2•– and O22–) at higher reaction temperature (over 200 °C). Meanwhile, the O atom adjacent to Mn featuring substantially elevated Lewis acidity promoted the adsorption and activation of benzene. Consequently, the Mn/meso-CeO2 catalyst exhibited a superior catalytic oxidation reactivity (T90 = 215 °C) toward C6H6 combustion via a Langmuir–Hinshelwood mechanism. This work underlines the importance of rational design and regulation of catalytic sites over metal oxide surfaces for robust O2 activation and durable refractory AVOC combustion.
{"title":"Dynamic Mn–VO Associates Boosted Molecular Oxygen Activation for Benzene Combustion on Mn-Doped Mesocrystalline CeO2","authors":"Xupeng Liu, Yanbiao Shi, Linghao Yu, Biao Zhou, Ziyue Chen, Furong Guo, Hao Li, Xiao Liu, Lizhi Zhang, Zhihui Ai","doi":"10.1021/acs.est.4c14734","DOIUrl":"https://doi.org/10.1021/acs.est.4c14734","url":null,"abstract":"Highly efficient molecular oxygen activation over transition metal oxides toward catalytic abatement of aromatic volatile organic compounds (AVOCs) is possible yet challenging due to the easily deactivated surface oxygen vacancy (V<sub>O</sub>). Herein, dynamic Mn–V<sub>O</sub> associates were crafted onto the Mn-incorporated CeO<sub>2</sub> mesocrystal (Mn/meso-CeO<sub>2</sub>) surface with Mn substituting a Ce atom through an easy-to-handle precipitation strategy. Experiments and theoretical calculation demonstrated that the asymmetric surface Mn–O–Ce configuration induced electron delivery from the low-valent Mn to adjacent Ce, destabilizing the circumambient O atoms and facilitating the formation of dynamic Mn–V<sub>O</sub> associates. Compared to pristine meso-CeO<sub>2</sub>, the Mn/meso-CeO<sub>2</sub> with dynamic Mn–V<sub>O</sub> associates could efficiently activate O<sub>2</sub> into a superoxide radical and a peroxanion (O<sub>2</sub><sup>•</sup><sup>–</sup> and O<sub>2</sub><sup>2–</sup>) at higher reaction temperature (over 200 °C). Meanwhile, the O atom adjacent to Mn featuring substantially elevated Lewis acidity promoted the adsorption and activation of benzene. Consequently, the Mn/meso-CeO<sub>2</sub> catalyst exhibited a superior catalytic oxidation reactivity (<i>T</i><sub>90</sub> = 215 °C) toward C<sub>6</sub>H<sub>6</sub> combustion via a Langmuir–Hinshelwood mechanism. This work underlines the importance of rational design and regulation of catalytic sites over metal oxide surfaces for robust O<sub>2</sub> activation and durable refractory AVOC combustion.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"54 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143678070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rucheng Duan, Yu Fu, Zhuocan Li, Xin Wang, Meng Gao, Yunbo Yu, Guangzhi He, Hong He
Catalysts operating at low temperatures are imperative for the denitrification of flue gases from various non-electric industries. Current catalysts typically exhibit significant activity for the selective catalytic reduction of NOx with NH3 (NH3–SCR) at temperatures above 100 °C. Here, we observed for the first time remarkable room-temperature NH3–SCR activity on the surface of carbon-based catalysts. The oxidation of NO to NO2 by surface C–O–C groups at room temperature serves as a key initial step, triggering a fast SCR reaction. The C–OH groups, as active sites, directly participate in the elementary reaction pathways of the SCR through an H migration process, significantly reducing the energy barrier of the rate-determining step to below 1 eV, thereby enabling fast SCR to occur at room temperature. The room-temperature SCR and its novel reaction mechanism reported in this study would inevitably expand the research boundaries of NOx abatement.
在低温下运行的催化剂对于各种非电力行业的烟气脱硝至关重要。目前的催化剂通常在 100 °C 以上的温度条件下表现出显著的氮氧化物与 NH3 选择性催化还原（NH3-SCR）活性。在此，我们首次在碳基催化剂表面观察到显著的室温 NH3-SCR 活性。室温下，表面 C-O-C 基团将 NO 氧化成 NO2，这是引发快速 SCR 反应的关键第一步。作为活性位点的 C-OH 基团通过 H 迁移过程直接参与了 SCR 的基本反应途径，从而将决定速率步骤的能障显著降低到 1 eV 以下，从而使快速 SCR 在室温下发生。本研究中报道的室温 SCR 及其新颖的反应机理势必会拓展氮氧化物减排的研究领域。
{"title":"Unexpected Room-Temperature Selective Catalytic Reduction of NOx with NH3 over Metal-Free Carbon-Based Catalysts","authors":"Rucheng Duan, Yu Fu, Zhuocan Li, Xin Wang, Meng Gao, Yunbo Yu, Guangzhi He, Hong He","doi":"10.1021/acs.est.4c14482","DOIUrl":"https://doi.org/10.1021/acs.est.4c14482","url":null,"abstract":"Catalysts operating at low temperatures are imperative for the denitrification of flue gases from various non-electric industries. Current catalysts typically exhibit significant activity for the selective catalytic reduction of NO<sub><i>x</i></sub> with NH<sub>3</sub> (NH<sub>3</sub>–SCR) at temperatures above 100 °C. Here, we observed for the first time remarkable room-temperature NH<sub>3</sub>–SCR activity on the surface of carbon-based catalysts. The oxidation of NO to NO<sub>2</sub> by surface C–O–C groups at room temperature serves as a key initial step, triggering a fast SCR reaction. The C–OH groups, as active sites, directly participate in the elementary reaction pathways of the SCR through an H migration process, significantly reducing the energy barrier of the rate-determining step to below 1 eV, thereby enabling fast SCR to occur at room temperature. The room-temperature SCR and its novel reaction mechanism reported in this study would inevitably expand the research boundaries of NO<sub><i>x</i></sub> abatement.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"71 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143678092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Circadian rhythms regulate the timing of numerous biological functions in organisms. Besides well-known external stimuli like the light–dark cycle and temperature, circadian rhythms can also be modulated by environmental substances. However, this area remains largely underexplored. Here, we developed a robust Pattern Recognition-Driven Prediction Approach (PRD–PA) that enables the identification of circadian-disruptive compounds from large-scale zebrafish transcriptomic profiling. The approach utilizes a circadian gene panel consisting of over 270 Circadian-Indicating Genes (CIGs) with stable and robust periodicity and combines it with a predictive model, known as the Differential Gene Expression Values of an Individual Comparison Model (DGVICM), that can effectively predict internal circadian phases from transcriptomic samples. By analyzing 692 aggregated gene expression profiles across 40 environmental substances, several were identified as having significant circadian-disruptive potential. These include glucocorticoids (e.g., prednisone (PRE) and triamcinolone (TRI)), the antithyroid agent propylthiouracil (PTU), and the widely used UV filter benzophenone-3 (BP-3). Both glucocorticoids and PTU are well-documented disruptors of circadian rhythms, and BP-3’s circadian-disrupting properties were validated through experimental exposures. Moreover, BP-3 analogs, including 2,4-dihydroxybenzophenone (BP-1) and 2,2’-dihydroxy-4-methoxybenzophenone (BP-8), were also found to exhibit similar circadian-disruptive effects. Overall, the present findings demonstrated the reliability of the PRD–PA approach for circadian disruption screening and highlighted the presence of diverse circadian-disruptive substances in our environment.
{"title":"Pattern Recognition-Driven Detection of Circadian-Disruptive Compounds from Gene Expressions: High-Throughput Screening and Experimental Verification","authors":"Jierong Chen, Boyang Li, Shaoqi Zuo, Kun Zhang, Jiayin Dai, Lili Chen, Yanbin Zhao","doi":"10.1021/acs.est.4c12466","DOIUrl":"https://doi.org/10.1021/acs.est.4c12466","url":null,"abstract":"Circadian rhythms regulate the timing of numerous biological functions in organisms. Besides well-known external stimuli like the light–dark cycle and temperature, circadian rhythms can also be modulated by environmental substances. However, this area remains largely underexplored. Here, we developed a robust Pattern Recognition-Driven Prediction Approach (PRD–PA) that enables the identification of circadian-disruptive compounds from large-scale zebrafish transcriptomic profiling. The approach utilizes a circadian gene panel consisting of over 270 Circadian-Indicating Genes (CIGs) with stable and robust periodicity and combines it with a predictive model, known as the Differential Gene Expression Values of an Individual Comparison Model (DGVICM), that can effectively predict internal circadian phases from transcriptomic samples. By analyzing 692 aggregated gene expression profiles across 40 environmental substances, several were identified as having significant circadian-disruptive potential. These include glucocorticoids (e.g., prednisone (PRE) and triamcinolone (TRI)), the antithyroid agent propylthiouracil (PTU), and the widely used UV filter benzophenone-3 (BP-3). Both glucocorticoids and PTU are well-documented disruptors of circadian rhythms, and BP-3’s circadian-disrupting properties were validated through experimental exposures. Moreover, BP-3 analogs, including 2,4-dihydroxybenzophenone (BP-1) and 2,2’-dihydroxy-4-methoxybenzophenone (BP-8), were also found to exhibit similar circadian-disruptive effects. Overall, the present findings demonstrated the reliability of the PRD–PA approach for circadian disruption screening and highlighted the presence of diverse circadian-disruptive substances in our environment.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"125 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuangjia Xue, Matthew J. Broerman, Gillian C. Goobie, Daniel J. Kass, James P. Fabisiak, Sally E. Wenzel, Seyed Mehdi Nouraie
Gaseous pollutants such as CO, NO2, O3, and SO2 are linked to adverse clinical outcomes in patients with fibrotic interstitial lung diseases (fILDs), particularly idiopathic pulmonary fibrosis. However, the effect of various exposure estimation methods on these findings remains unclear. This study aims to evaluate three spatial approaches─nearest neighbor (NN), inverse distance weighting (IDW), and Kriging─for estimating gaseous pollutant exposures and to assess how these methods affect health outcome estimates in fILD patients. A 10-fold cross-validation showed that Kriging had the lowest prediction error compared to NN and IDW, with RMSE for CO = 0.43 ppm (11%), O3 = 5.9 ppb (14%), SO2 = 2.7 ppb (12%), and NO2 = 7.6 ppb (9%), respectively. Kriging also excelled over other methods across wide spatial and temporal ranges, showing the highest spatial R2 for CO and O3 and the highest temporal R2 for SO2 and NO2. In a large cohort of patients with fILD, higher levels of CO, SO2, and NO2 exposure were associated with lower pulmonary function. The magnitude of association and its precision were higher in SO2 and CO estimated by the Kriging method. This study underscores Kriging as a robust method for estimating gaseous pollutant levels and offers valuable insights for future epidemiological studies.
{"title":"Gaseous Air Pollutants and Lung Function in Fibrotic Interstitial Lung Disease (fILD): Evaluation of Different Spatial Analysis Approaches","authors":"Shuangjia Xue, Matthew J. Broerman, Gillian C. Goobie, Daniel J. Kass, James P. Fabisiak, Sally E. Wenzel, Seyed Mehdi Nouraie","doi":"10.1021/acs.est.4c11275","DOIUrl":"https://doi.org/10.1021/acs.est.4c11275","url":null,"abstract":"Gaseous pollutants such as CO, NO<sub>2</sub>, O<sub>3</sub>, and SO<sub>2</sub> are linked to adverse clinical outcomes in patients with fibrotic interstitial lung diseases (fILDs), particularly idiopathic pulmonary fibrosis. However, the effect of various exposure estimation methods on these findings remains unclear. This study aims to evaluate three spatial approaches─nearest neighbor (NN), inverse distance weighting (IDW), and Kriging─for estimating gaseous pollutant exposures and to assess how these methods affect health outcome estimates in fILD patients. A 10-fold cross-validation showed that Kriging had the lowest prediction error compared to NN and IDW, with RMSE for CO = 0.43 ppm (11%), O<sub>3</sub> = 5.9 ppb (14%), SO<sub>2</sub> = 2.7 ppb (12%), and NO<sub>2</sub> = 7.6 ppb (9%), respectively. Kriging also excelled over other methods across wide spatial and temporal ranges, showing the highest spatial <i>R</i><sup>2</sup> for CO and O<sub>3</sub> and the highest temporal R<sup>2</sup> for SO<sub>2</sub> and NO<sub>2</sub>. In a large cohort of patients with fILD, higher levels of CO, SO<sub>2</sub>, and NO<sub>2</sub> exposure were associated with lower pulmonary function. The magnitude of association and its precision were higher in SO<sub>2</sub> and CO estimated by the Kriging method. This study underscores Kriging as a robust method for estimating gaseous pollutant levels and offers valuable insights for future epidemiological studies.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"16 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biodegradable plastics (BPs) are promoted as eco-friendly alternatives to conventional plastics. However, compared to conventional microplastics (MPs), they degrade rapidly into biodegradable microplastics (BMPs), which may lead to a more significant accumulation of BMPs in the environment. This review systematically compares BMPs and MPs, summarizes current knowledge on their environmental behaviors and impacts on ecosystems and human health, and offers recommendations for future research. BMPs are detected in water, sediments, indoor dust, food, marine organisms, and human samples. Compared to MPs, BMPs are more prone to environmental transformations, such as photodegradation and biodegradation, which results in a shorter migration distance across different matrices. Like MPs, BMPs can adsorb pollutants and transport them into organisms, enhancing toxicity and health risks through the Trojan horse effect. Studies indicate that BMPs may negatively impact terrestrial and aquatic ecosystems more than MPs by disrupting nutrient cycling and inhibiting plant and animal growth. In vivo and in vitro research also shows that BMP degradation products increase bioavailability, exacerbating neurotoxicity and overall toxicity. However, findings on BMPs’ environmental and health effects remain inconsistent. Further evaluation of the trade-offs between BMP risks and their biodegradability is needed to address these uncertainties.
{"title":"Exploring Environmental Behaviors and Health Impacts of Biodegradable Microplastics","authors":"Yuhao Yan, Jiexia Cheng, Jie Gao, Yanna Liu, Haijiang Tian, Yaquan Liu, Xuehan Zheng, Guangxuan Wang, Jingtai Yao, Yun Ding, Aifeng Liu, Minghao Wang, Jing Zhao, Shunhao Wang, Chunzhen Shi, Li Zeng, Xinyue Yang, Hua Qin, Xiulan Zhao, Runzeng Liu, Liqun Chen, Guangbo Qu, Bing Yan, Guibin Jiang","doi":"10.1021/acs.est.4c14716","DOIUrl":"https://doi.org/10.1021/acs.est.4c14716","url":null,"abstract":"Biodegradable plastics (BPs) are promoted as eco-friendly alternatives to conventional plastics. However, compared to conventional microplastics (MPs), they degrade rapidly into biodegradable microplastics (BMPs), which may lead to a more significant accumulation of BMPs in the environment. This review systematically compares BMPs and MPs, summarizes current knowledge on their environmental behaviors and impacts on ecosystems and human health, and offers recommendations for future research. BMPs are detected in water, sediments, indoor dust, food, marine organisms, and human samples. Compared to MPs, BMPs are more prone to environmental transformations, such as photodegradation and biodegradation, which results in a shorter migration distance across different matrices. Like MPs, BMPs can adsorb pollutants and transport them into organisms, enhancing toxicity and health risks through the Trojan horse effect. Studies indicate that BMPs may negatively impact terrestrial and aquatic ecosystems more than MPs by disrupting nutrient cycling and inhibiting plant and animal growth. <i>In vivo</i> and <i>in vitro</i> research also shows that BMP degradation products increase bioavailability, exacerbating neurotoxicity and overall toxicity. However, findings on BMPs’ environmental and health effects remain inconsistent. Further evaluation of the trade-offs between BMP risks and their biodegradability is needed to address these uncertainties.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"45 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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