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A coumarin-nicotinic hydrazone probe for chromofluorogenic detection of toxic cyanide ions and its application in molecular logic gate and real water samples analysis.
IF 2.7 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2025-04-01 DOI: 10.1007/s43630-025-00704-z
Denzil Britto Christopher Leslee, Logapriya Shanmugam, Narmatha Venkatesan, Bharathi Madheswaran, Venkatesh Ravula, Sekar Karuppannan, Shanmuga Bharathi Kuppannan

This report develops a coumarin-nicotinic hydrazide-based sensor for detection of CN- ions. The ligand is prepared by simple method and has been characterized by 1H NMR, 13C NMR, FTIR, and mass spectral analyses. The sensing behavior of coumarin-nicotinic hydrazide (CNH) probe was investigated in the presence of different anions using UV-visible and fluorescence methods. The sensor showed a selective naked-eye, colorimetric, and fluorescence detection particularly in the presence of CN- ions over the other anions. The sensing involves a ratiometric red shift in absorption and photoluminescence profile in presence of incremental addition of CN- ions. This provides a multi-detection point at two different wavelengths. This sensor involves a displacement type approach through a nucleophilic substitution-based chemodosimeter sensor proposed based on 1H and 13C NMR along with D2O exchange experiment, and mass and photophysical studies. Interestingly, the sensor affords the lowest limit of detection up to 5.97 × 10-7 M. The practical utility of the sensor is illustrated in molecular logic gate operation and real water analysis.

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引用次数: 0
The virucidal potential effects of violet-blue light on influenza D virus.
IF 2.7 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2025-03-26 DOI: 10.1007/s43630-025-00708-9
Serena Marchi, Davide Amodeo, Benedetta Peccetti, Isa De Palma, Gabriele Messina, Emanuele Montomoli, Claudia Maria Trombetta

Influenza D virus (IDV) is a novel influenza virus, first isolated from swine with influenza-like symptoms in the USA in 2011. To date, IDV circulation has been reported in various animal species such as cattle, pigs, horses with the ability to expand its range of hosts. UV radiation has been widely used for the disinfection of various sources such as water, air, and surfaces, especially in places at greater risk of contamination by viruses and bacteria, such as hospitals and health facilities. The aim of this study was to evaluate the potential virucidal effect of a violet-blue light against IDV. Viral suspension of IDV was exposed to a violet-blue light (405 nm) for different times (radiant exposures): 22 min and 30 s (5.4 J/cm2), 45 min (10.8 J/cm2), 90 min (21.6 J/cm2), 180 min (43.2 J/cm2), and 360 min (86.4 J/cm2), and different temperatures (room temperature, 4 and 37 °C). At the end of exposure, virus titration was performed on MDCK cells. After violet-blue light exposure, a viral titre reduction proportional to exposure time was observed: 0.228 log10 after 22 min and 30 s, 0.668 log10 after 45 min, 0.940 log10 after 90 min, 1.375 log10 after 180 min and 2.293 log10 after 360 min. Differences were observed among temperatures of exposure, with the greatest virucidal effect observed at room temperature. As reported for other respiratory viruses, this violet-blue light can potentially be used to reduce IDV spread in potentially hotspot areas for animals and humans.

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引用次数: 0
The wound healing effects of linearly polarized irradiation in photobiomodulation.
IF 2.7 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2025-03-01 Epub Date: 2025-03-07 DOI: 10.1007/s43630-025-00696-w
You-Rim Park, Yoo-Kyoung Shin, Joo Beom Eom

We report the fabrication of a polarization-based photobiomodulation (PBM) system and its performance on wound healing effects. The light source for PBM was a 625 nm LED and two different linear polarizations (P-wave and S-wave) were generated using the wire grid linear polarizers. To confirm the effect of PBM on polarization, wounds were created on hairless mice, and the healing process was compared. The light source conditions for comparison were control, two linearly polarized light, and unpolarized light. The light irradiation conditions for each group were based on the energy settings (energy 18 J/cm2, power density 30 mW/cm2, exposure time 600 sec) commonly used in LED masks. After creating the wound, the light was irradiated only once. To confirm the wound healing effect over time, it was evaluated through wound surface area measurements, self-made optical coherence tomography images, and histological images. In the group irradiated with S-wave polarized light, the percentage from the initial wound size was reduced to 70.73%, and the epithelial tongue ratio reached 58.36% on day 7 after PBM, indicating the fastest recovery. In this way, the potential of a new product that can increase the effect of wound healing or skin regeneration by adjusting the polarization state without irradiating high energy was confirmed.

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引用次数: 0
Baicalein prevents skin damage, tumorigenesis and tumor growth in chronic ultraviolet B-irradiated hairless mice.
IF 2.7 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2025-03-01 Epub Date: 2025-03-17 DOI: 10.1007/s43630-025-00700-3
Yoshiyuki Kimura, Maho Sumiyoshi, Masahiko Taniguchi

Non-melanoma skin cancer accounted for over one million new cases, according to the Global Cancer Statistics 2020 report. Moreover, UV radiation causes photodamage (skin inflammation and angiogenesis), photoaging (increases in skin wrinkle and reduction in skin elasticity). This study investigated the preventive effects of baicalein against skin damage, aging, tumorigenesis and tumor growth in long-term UVB irradiated hairless mice. Five-week-old male mice were divided into the following groups: a non-UVB group (control), vehicle-treated UVB group (UVB control), and UVB groups treated with two different doses of baicalein (10 and 30 mg/kg, twice daily). The mice were exposed to UVB irradiation (36-192 mJ/cm2) three times per week for 23 weeks. Baicalein was orally administered at the specified doses for the same duration. Skin cytokine, chemokine, and vascular endothelial growth factor (VEGF) levels were measured using ELISA kits. Baicalein (at doses of 10 and 30 mg/kg) suppressed UVB-induced increases in skin thickness, improved skin elasticity, and reduced the number and growth of skin tumors. Additionally, baicalein inhibited UVB-induced increases in IL-1β, IL-6, MCP-1, MIF, VEGF, p53, COX-2, total/phospho-NF-κB expression levels in the skin. Immunohistochemical analysis revealed that baicalein attenuated UVB-induced increases in the number of Ki-67-, and HIF-1α-positive cells. The preventive effects of baicalein on skin damage and skin tumor growth in chronically UVB-irradiated mice were associated with reduced skin cytokine levels through the down-regulation of COX-2, phosphorylated NF-κB p65, and HIF-1α expression.

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引用次数: 0
Environmental consequences of interacting effects of changes in stratospheric ozone, ultraviolet radiation, and climate: UNEP Environmental Effects Assessment Panel, Update 2024.
IF 2.7 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2025-03-01 Epub Date: 2025-03-17 DOI: 10.1007/s43630-025-00687-x
Patrick J Neale, Samuel Hylander, Anastazia T Banaszak, Donat-P Häder, Kevin C Rose, Davide Vione, Sten-Åke Wängberg, Marcel A K Jansen, Rosa Busquets, Mads P Sulbæk Andersen, Sasha Madronich, Mark L Hanson, Tamara Schikowski, Keith R Solomon, Barbara Sulzberger, Timothy J Wallington, Anu M Heikkilä, Krishna K Pandey, Anthony L Andrady, Laura S Bruckman, Christopher C White, Liping Zhu, Germar H Bernhard, Alkiviadis Bais, Pieter J Aucamp, Gabriel Chiodo, Raúl R Cordero, Irina Petropavlovskikh, Rachel E Neale, Catherine M Olsen, Simon Hales, Aparna Lal, Gareth Lingham, Lesley E Rhodes, Antony R Young, T Matthew Robson, Sharon A Robinson, Paul W Barnes, Janet F Bornman, Anna B Harper, Hanna Lee, Roy Mackenzie Calderón, Rachele Ossola, Nigel D Paul, Laura E Revell, Qing-Wei Wang, Richard G Zepp
<p><p>This Assessment Update by the Environmental Effects Assessment Panel (EEAP) of the United Nations Environment Programme (UNEP) addresses the interacting effects of changes in stratospheric ozone, solar ultraviolet (UV) radiation, and climate on the environment and human health. These include new modelling studies that confirm the benefits of the Montreal Protocol in protecting the stratospheric ozone layer and its role in maintaining a stable climate, both at low and high latitudes. We also provide an update on projected levels of solar UV-radiation during the twenty-first century. Potential environmental consequences of climate intervention scenarios are also briefly discussed, illustrating the large uncertainties of, for example, Stratospheric Aerosol Injection (SAI). Modelling studies predict that, although SAI would cool the Earth's surface, other climate factors would be affected, including stratospheric ozone depletion and precipitation patterns. The contribution to global warming of replacements for ozone-depleting substances (ODS) are assessed. With respect to the breakdown products of chemicals under the purview of the Montreal Protocol, the risks to ecosystem and human health from the formation of trifluoroacetic acid (TFA) as a degradation product of ODS replacements are currently de minimis. UV-radiation and climate change continue to have complex interactive effects on the environment due largely to human activities. UV-radiation, other weathering factors, and microbial action contribute significantly to the breakdown of plastic waste in the environment, and in affecting transport, fate, and toxicity of the plastics in terrestrial and aquatic ecosystems, and the atmosphere. Sustainability demands continue to drive industry innovations to mitigate environmental consequences of the use and disposal of plastic and plastic-containing materials. Terrestrial ecosystems in alpine and polar environments are increasingly being exposed to enhanced UV-radiation due to earlier seasonal snow and ice melt because of climate warming and extended periods of ozone depletion. Solar radiation, including UV-radiation, also contributes to the decomposition of dead plant material, which affects nutrient cycling, carbon storage, emission of greenhouse gases, and soil fertility. In aquatic ecosystems, loss of ice cover is increasing the area of polar oceans exposed to UV-radiation with possible negative effects on phytoplankton productivity. However, modelling studies of Arctic Ocean circulation suggests that phytoplankton are circulating to progressively deeper ocean layers with less UV irradiation. Human health is also modified by climate change and behaviour patterns, resulting in changes in exposure to UV-radiation with harmful or beneficial effects depending on conditions and skin type. For example, incidence of melanoma has been associated with increased air temperature, which affects time spent outdoors and thus exposure to UV-radiation. Overal
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引用次数: 0
A pyrene-based fluorescent probe for H2S detection and cellular imaging.
IF 2.7 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2025-03-01 DOI: 10.1007/s43630-025-00695-x
Said Alam, Xuanzuo Tao, Yanxia Mao, Shaojun Zheng, Chunhui Jiang, Shu-Yang Chen, Hongfei Lu

Hydrogen sulfide (H2S) is a significant reactive sulfur species (RSS) involved in various human diseases, also playing an important role in many physiological and pathological processes. Thus, the development of an effective method for detecting H2S in mammalian cells is of great importance. In this study, we present the synthesis of a novel pyrene-based fluorescent probe, DPP, specifically designed for the selective detection of H2S. The DPP exhibits remarkable sensitivity, with a low detection limit of 0.63 µM, and demonstrates high selectivity for H2S in the presence of various interfering species. Additionally, the probe has demonstrated rapid detection of H2S in less than 6 min. The detection mechanism was thoroughly validated using 1H NMR, FT-IR, UV and fluorescence spectra. Moreover, the applicability of DPP was successfully demonstrated in both in vitro and in vivo settings using HeLa cells, confirming its potential as a powerful tool for monitoring H2S in biological systems. Additionally, the probe exhibited excellent performance in detecting H2S in water samples and in paper strip-based assays, further highlighting its versatility and practical utility for environmental monitoring and on-site applications.

硫化氢(H2S)是一种重要的活性硫物种(RSS),与多种人类疾病有关,在许多生理和病理过程中也发挥着重要作用。因此,开发一种有效的方法来检测哺乳动物细胞中的 H2S 至关重要。在本研究中,我们合成了一种新型芘基荧光探针 DPP,专门用于选择性检测 H2S。DPP 具有极高的灵敏度,检测限低至 0.63 µM,并且在存在各种干扰物的情况下对 H2S 具有高选择性。此外,该探针还能在 6 分钟内快速检测到 H2S。使用 1H NMR、FT-IR、UV 和荧光光谱对检测机制进行了全面验证。此外,还利用 HeLa 细胞成功地在体外和体内环境中证明了 DPP 的适用性,从而证实了它作为监测生物系统中 H2S 的强大工具的潜力。此外,该探针在检测水样中的 H2S 和纸带检测中表现出卓越的性能,进一步突出了其在环境监测和现场应用中的多功能性和实用性。
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引用次数: 0
Targeted photodynamic elimination of HER2 + breast cancer cells mediated by antibody-photosensitizer fusion proteins.
IF 2.7 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2025-03-01 Epub Date: 2025-03-09 DOI: 10.1007/s43630-025-00689-9
Yi Li, Jian Hou, Jun Wan, Qinglian Liu, Lei Zhou

Breast cancer has emerged as the leading cause of cancer death in women worldwide. The high recurrence and metastasis rates of malignant tumors impose significant limitations on existing mainstream treatments, including surgery, chemotherapy, and radiotherapy. Photodynamic therapy (PDT) is a clinically validated approach for cancer treatment. PDT requires three elements, photosensitizer, light, and oxygen, and mainly relies on the production of singlet oxygen (1O2) to elicit damage to the cancer tissue. In this study, we explored targeted photodynamic elimination of breast cancer cells overexpressing human epidermal growth factor receptor 2 (HER2). HER2 is enriched on the surface of certain cancer cells and targeted by commercially available monoclonal antibodies, including Trastuzumab, in the treatment of breast and stomach cancers. We engineered chimeric fusion proteins composed of Trastuzumab and genetically encoded photosensitizers, including SOPP3 and miniSOG. The production of 1O2 by these fusion proteins was directly measured by near-infrared spectroscopy centered at 1270 nm and further evaluated in the assay of targeted photodynamic neutralizations of SARS-CoV-2 pseudoviruses. To enhance the internalization of the antibody-photosensitizer fusion protein, cell-penetrating peptides (CPPs) were added to the fusion protein. HER2-positive (HER2+) cancer cells were incubated with the antibody-photosensitizer fusion protein and then exposed to light illumination. Cell viability assays revealed an over 50% reduction in cancer cell survival, with minimal impacts on the cells from the control group. In addition, we observed a long-lasting, over 24-h inhibition of the growth of the cancer cells after photodynamic treatment. Thus, based on these assays at the molecular and cellular levels, this study established a targeted photodynamic approach that can potentially be developed as an effective PDT for cancer treatment.

{"title":"Targeted photodynamic elimination of HER2 <sup>+</sup> breast cancer cells mediated by antibody-photosensitizer fusion proteins.","authors":"Yi Li, Jian Hou, Jun Wan, Qinglian Liu, Lei Zhou","doi":"10.1007/s43630-025-00689-9","DOIUrl":"10.1007/s43630-025-00689-9","url":null,"abstract":"<p><p>Breast cancer has emerged as the leading cause of cancer death in women worldwide. The high recurrence and metastasis rates of malignant tumors impose significant limitations on existing mainstream treatments, including surgery, chemotherapy, and radiotherapy. Photodynamic therapy (PDT) is a clinically validated approach for cancer treatment. PDT requires three elements, photosensitizer, light, and oxygen, and mainly relies on the production of singlet oxygen (<sup>1</sup>O<sub>2</sub>) to elicit damage to the cancer tissue. In this study, we explored targeted photodynamic elimination of breast cancer cells overexpressing human epidermal growth factor receptor 2 (HER2). HER2 is enriched on the surface of certain cancer cells and targeted by commercially available monoclonal antibodies, including Trastuzumab, in the treatment of breast and stomach cancers. We engineered chimeric fusion proteins composed of Trastuzumab and genetically encoded photosensitizers, including SOPP3 and miniSOG. The production of <sup>1</sup>O<sub>2</sub> by these fusion proteins was directly measured by near-infrared spectroscopy centered at 1270 nm and further evaluated in the assay of targeted photodynamic neutralizations of SARS-CoV-2 pseudoviruses. To enhance the internalization of the antibody-photosensitizer fusion protein, cell-penetrating peptides (CPPs) were added to the fusion protein. HER2-positive (HER2<sup>+</sup>) cancer cells were incubated with the antibody-photosensitizer fusion protein and then exposed to light illumination. Cell viability assays revealed an over 50% reduction in cancer cell survival, with minimal impacts on the cells from the control group. In addition, we observed a long-lasting, over 24-h inhibition of the growth of the cancer cells after photodynamic treatment. Thus, based on these assays at the molecular and cellular levels, this study established a targeted photodynamic approach that can potentially be developed as an effective PDT for cancer treatment.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"393-403"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergic anti-tumor effects of photodynamic therapy and resveratrol on triple-negative breast cancer cells.
IF 2.7 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2025-03-01 Epub Date: 2025-03-17 DOI: 10.1007/s43630-025-00698-8
Masta Ghazizadeh, Khatereh Khorsandi, SMahmoud A Najafi

Introduction: Breast cancer is a widespread type of cancer found across the world. The use of chemotherapy in breast cancer treatment may result in side effects and the emergence of drug resistance. Hence, seeking new and efficient therapies that reduce adverse reactions is imperative. Recently, combination therapy has emerged as a fresh and innovative strategy in contrast to conventional treatment methods. Photodynamic therapy (PDT) serves as a highly effective and minimally invasive technique for addressing breast cancer, providing the option to be utilized either concurrently or in conjunction with other therapeutic approaches. Resveratrol (RES) is a polyphenol found in several food sources. Research has demonstrated that RES can inhibit cell proliferation and metastasis and trigger apoptosis in tumor cells. This research aimed to assess the impact of combining RES and photodynamic therapy on MDA-MB-231 breast cancer cells.

Methods: MDA-MB-231 cells were grown in culture and subsequently exposed to different methylene blue (MB) doses while subjected to laser irradiation (PDT). Following this treatment, the cells were exposed to different RES concentrations. Cell viability was assessed utilizing the MTT assay. Light and fluorescence microscopy (AO/EB staining) were employed to observe cell morphological alterations following exposure to RES and MB-PDT. Additionally, flow cytometry was utilized to investigate cell cycle progression and apoptosis induction.

Results: The findings indicated that the co-administration of MB-PDT and RES resulted in increased cytotoxic effects on MDA-MB-231 breast cancer cells compared to the individual application of either treatment.

Discussion: The results of this study suggest that MB-PDT can reduce the dose and time of RES treatment and, therefore, can be indicated as a new approach for treating breast cancer cells.

{"title":"Synergic anti-tumor effects of photodynamic therapy and resveratrol on triple-negative breast cancer cells.","authors":"Masta Ghazizadeh, Khatereh Khorsandi, SMahmoud A Najafi","doi":"10.1007/s43630-025-00698-8","DOIUrl":"10.1007/s43630-025-00698-8","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer is a widespread type of cancer found across the world. The use of chemotherapy in breast cancer treatment may result in side effects and the emergence of drug resistance. Hence, seeking new and efficient therapies that reduce adverse reactions is imperative. Recently, combination therapy has emerged as a fresh and innovative strategy in contrast to conventional treatment methods. Photodynamic therapy (PDT) serves as a highly effective and minimally invasive technique for addressing breast cancer, providing the option to be utilized either concurrently or in conjunction with other therapeutic approaches. Resveratrol (RES) is a polyphenol found in several food sources. Research has demonstrated that RES can inhibit cell proliferation and metastasis and trigger apoptosis in tumor cells. This research aimed to assess the impact of combining RES and photodynamic therapy on MDA-MB-231 breast cancer cells.</p><p><strong>Methods: </strong>MDA-MB-231 cells were grown in culture and subsequently exposed to different methylene blue (MB) doses while subjected to laser irradiation (PDT). Following this treatment, the cells were exposed to different RES concentrations. Cell viability was assessed utilizing the MTT assay. Light and fluorescence microscopy (AO/EB staining) were employed to observe cell morphological alterations following exposure to RES and MB-PDT. Additionally, flow cytometry was utilized to investigate cell cycle progression and apoptosis induction.</p><p><strong>Results: </strong>The findings indicated that the co-administration of MB-PDT and RES resulted in increased cytotoxic effects on MDA-MB-231 breast cancer cells compared to the individual application of either treatment.</p><p><strong>Discussion: </strong>The results of this study suggest that MB-PDT can reduce the dose and time of RES treatment and, therefore, can be indicated as a new approach for treating breast cancer cells.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"451-465"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silk fibroin protein-templated gold nanoclusters for in vivo fluorescence imaging.
IF 2.7 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2025-03-01 Epub Date: 2025-03-20 DOI: 10.1007/s43630-025-00699-7
Shanshan He, Baozhu Wang, Huixin Hou, Yueyue Zhang, Zhijun Zhang, Feng Zhao, Miao Su

Protein-templated synthesis has been proved to be an effective approach for building high-performance fluorescent bioimaging agents. Nevertheless, the high cost of proteins has restricted its wide application. Silk fibroin is a low cost natural protein with superior properties, which holds significant application prospects in many biomedical fields. However, its application potential in the biomedical imaging field remains to be explored. Herein, we report a one-pot green synthesis of high performance gold nanoclusters (AuNCs) using silk fibroin as stabilizer. The SF-AuNCs (~ 1.8 nm) shows a red emission around 600 nm with a large Stokes shift of 200 nm and a quantum yield of 5.42% which is comparable with that of fluorescence proteins. Meanwhile, the lifetime is as high as 3.47 μs which is about three magnitude orders higher than that of most molecular dyes and fluorescence proteins. Moreover, the stability is also greatly enhanced than that of the classical GSH-AuNCs. The SF-AuNCs is also well performed in cell labeling and in vivo imaging in zebrafish. This work not only provides a promising high performance protein fluorescence nano agent for bioimaging, but also expands the potential of the silk fibroin application in the biomedical imaging field.

{"title":"Silk fibroin protein-templated gold nanoclusters for in vivo fluorescence imaging.","authors":"Shanshan He, Baozhu Wang, Huixin Hou, Yueyue Zhang, Zhijun Zhang, Feng Zhao, Miao Su","doi":"10.1007/s43630-025-00699-7","DOIUrl":"10.1007/s43630-025-00699-7","url":null,"abstract":"<p><p>Protein-templated synthesis has been proved to be an effective approach for building high-performance fluorescent bioimaging agents. Nevertheless, the high cost of proteins has restricted its wide application. Silk fibroin is a low cost natural protein with superior properties, which holds significant application prospects in many biomedical fields. However, its application potential in the biomedical imaging field remains to be explored. Herein, we report a one-pot green synthesis of high performance gold nanoclusters (AuNCs) using silk fibroin as stabilizer. The SF-AuNCs (~ 1.8 nm) shows a red emission around 600 nm with a large Stokes shift of 200 nm and a quantum yield of 5.42% which is comparable with that of fluorescence proteins. Meanwhile, the lifetime is as high as 3.47 μs which is about three magnitude orders higher than that of most molecular dyes and fluorescence proteins. Moreover, the stability is also greatly enhanced than that of the classical GSH-AuNCs. The SF-AuNCs is also well performed in cell labeling and in vivo imaging in zebrafish. This work not only provides a promising high performance protein fluorescence nano agent for bioimaging, but also expands the potential of the silk fibroin application in the biomedical imaging field.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"467-477"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UVA-light-induced mutagenesis in the exome of human nucleotide excision repair-deficient cells.
IF 2.7 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2025-03-01 Epub Date: 2025-03-10 DOI: 10.1007/s43630-025-00697-9
Nathalia Quintero-Ruiz, Camila Corradi, Natália Cestari Moreno, Tiago Antonio de Souza, Carlos Frederico Martins Menck

Skin cancer is associated with genetic mutations caused by sunlight exposure, primarily through ultraviolet (UV) radiation that damages DNA. While UVA is less energetic, it is the predominant solar UV component reaching the Earth's surface. However, the mechanisms of UVA-induced mutagenesis and its role in skin cancer development remain poorly understood. This study employed whole exome sequencing of clones from human XP-C cells, which lack nucleotide excision repair (NER), to characterize somatic mutations induced by UVA exposure. DNA sequence analysis of UVA-irradiated XP-C cells revealed a marked increase in mutation frequency across nearly all types of base substitutions, with particular enrichment in C > T transitions within the CCN and TCN trinucleotide context-potential sites for pyrimidine dimer formation. The C > T mutation primarily occurred at the 3' base of the 5'TC dimer, and an enrichment of CC > TT tandem mutations. We also identified the SBS7b COSMIC mutational signature within irradiated cells, which has been associated with tumors in sun-exposed skin. C > A transversions, often linked to oxidized guanine, were the second most frequently induced mutation, although a specific context for this base substitution was not identified. Moreover, C > T mutations were significantly increased in unirradiated XP-C compared to NER-proficient cells, which may be caused by unrepaired spontaneous DNA damage. Thus, this study indicates that pyrimidine dimers are the primary lesions contributing to UVA-induced mutagenesis in NER-deficient human cells and demonstrates that UVA generates mutational signatures similar to those of UVB irradiation.

{"title":"UVA-light-induced mutagenesis in the exome of human nucleotide excision repair-deficient cells.","authors":"Nathalia Quintero-Ruiz, Camila Corradi, Natália Cestari Moreno, Tiago Antonio de Souza, Carlos Frederico Martins Menck","doi":"10.1007/s43630-025-00697-9","DOIUrl":"10.1007/s43630-025-00697-9","url":null,"abstract":"<p><p>Skin cancer is associated with genetic mutations caused by sunlight exposure, primarily through ultraviolet (UV) radiation that damages DNA. While UVA is less energetic, it is the predominant solar UV component reaching the Earth's surface. However, the mechanisms of UVA-induced mutagenesis and its role in skin cancer development remain poorly understood. This study employed whole exome sequencing of clones from human XP-C cells, which lack nucleotide excision repair (NER), to characterize somatic mutations induced by UVA exposure. DNA sequence analysis of UVA-irradiated XP-C cells revealed a marked increase in mutation frequency across nearly all types of base substitutions, with particular enrichment in C > T transitions within the CCN and TCN trinucleotide context-potential sites for pyrimidine dimer formation. The C > T mutation primarily occurred at the 3' base of the 5'TC dimer, and an enrichment of CC > TT tandem mutations. We also identified the SBS7b COSMIC mutational signature within irradiated cells, which has been associated with tumors in sun-exposed skin. C > A transversions, often linked to oxidized guanine, were the second most frequently induced mutation, although a specific context for this base substitution was not identified. Moreover, C > T mutations were significantly increased in unirradiated XP-C compared to NER-proficient cells, which may be caused by unrepaired spontaneous DNA damage. Thus, this study indicates that pyrimidine dimers are the primary lesions contributing to UVA-induced mutagenesis in NER-deficient human cells and demonstrates that UVA generates mutational signatures similar to those of UVB irradiation.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"429-449"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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