Correction for ‘Acceptor–donor–acceptor-type molecules with large electrostatic potential difference for effective NIR photothermal therapy’ by Kexin Fan et al., J. Mater. Chem. B, 2024, 12, 5140–5149, https://doi.org/10.1039/D4TB00187G.
Correction for ‘Acceptor–donor–acceptor-type molecules with large electrostatic potential difference for effective NIR photothermal therapy’ by Kexin Fan et al., J. Mater. Chem. B, 2024, 12, 5140–5149, https://doi.org/10.1039/D4TB00187G.
Correction for ‘Synthesis and photophysical properties of a new push–pull pyrene dye with green-to-far-red emission and its application to human cellular and skin tissue imaging’ by Kazuki Inoue et al., J. Mater. Chem. B, 2022, 10, 1641–1649, https://doi.org/10.1039/D1TB02728J.
Correction for ‘In vivo transplantation of intrahepatic cholangiocyte organoids with decellularized liver-derived hydrogels supports hepatic cellular proliferation and differentiation in chronic liver injury’ by Impreet Kaur et al., J. Mater. Chem. B, 2025, 13, 918–928, https://doi.org/10.1039/D4TB01503G.
Nanoparticles capable of dynamically reporting their structural integrity in real-time are a powerful tool to guide the design of drug delivery technologies. Lipid nanoparticles (LNPs) offer multiple important advantages for drug delivery, including stability, protection of active substances, and sustained release capabilities. However, tracking their structural integrity and dynamic behaviour in complex biological environments remains challenging. Here, we report the development of a Förster resonance energy transfer (FRET)-enabled LNP platform that achieves unprecedented sensitivity and precision in monitoring nanoparticle disintegration. The FRET-based LNPs were prepared using nanoprecipitation, encapsulating high levels of 3,3′-dioctadecyloxacarbocyanine perchlorate (DiO) and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI) fluorophores as the donor and acceptors, respectively. The resulting LNPs had a mean diameter of 114 ± 19 nm with a distinct FRET signal. An optimal energy transfer efficiency of 0.98 and an emission quantum yield of 0.13 were achieved at 11.1% fluorophore loading in the LNPs, balancing efficient energy transfer and minimal aggregation-induced quenching. Using the FRET reporting, three dissociation stages of FRET LNPs were observed: solvation, indicated by an increased emission intensity; swelling and partial dissolution, evidenced by changes in emission maxima and mean size; and complete dissociation, confirmed by emission solely from DiO and the absence of particles. Testing the nanoparticles in live cells (telomerase-immortalised human corneal epithelial cells, hTCEpi cells) revealed a direct link to the disappearance of the FRET signal with the dissociation of FRET NPs. The nanoparticles initially exhibited a strong extracellular FRET signal, which diminished after cellular internalisation. This suggests that the LNPs disintegrate after entering the cells. These findings establish FRET-based LNPs as a robust tool for real-time nanoparticle tracking, offering insights into their integrity and release mechanisms, with potential applications in advanced drug delivery and diagnostics.
Development of novel Gd-based contrast agents for targeted magnetic resonance imaging (MRI) of liver cancer remains a great challenge. Herein we reported a novel Gd-based MRI contrast agent with improved relaxivity for specifically diagnosing liver cancer. This GSH-responsive macromolecular contrast agent (mCA), POLDGd, was prepared by RAFT polymerization, and its lactic acid moiety could precisely target the ASGP-R surface protein on liver cancer cells, whereas PODGd without the lactic acid moiety was prepared as a control. POLDGd had a high molecular weight of 45 kDa and a particle size of 103 nm. Its longitudinal relaxivity (11.39 mM−1 s−1) measured via a 3.0 T MR scanner was three times that of the clinically used contrast agent DTPA-Gd. In comparison with the PODGd-treated group, the signal enhancement at the tumor site was significantly prolonged, with a maximum enhancement peak of about 190% after intravenous injection of POLDGd into tumor-bearing mice. A high accumulation level of POLDGd in the liver tumors observed via MRI was also confirmed by fluorescence imaging. POLDGd showed minimal side effects, which may be ascribed to its metabolism through the kidneys. Therefore, POLDGd may be used as a highly effective biosafe nanoscale contrast agent for targeted MRI of liver cancer.
Piezocatalytic therapy is an emerging therapeutic strategy for eradicating drug-resistant bacteria, but suffers from insufficient piezoelectricity and catalytic active site availability. Herein, Bi-vacancies (BiV) and corona polarization were introduced to BiOBr nanosheets to create a BiOBr-BiVP nanoplatform for piezocatalytic antibacterial therapy. This meticulously tailored strategy strengthens the built-in electric field of nanosheets, enhancing piezoelectric potential and charge density and boosting charge separation and migration efficiency. Meanwhile, BiV adeptly adjust the band structure and increase reaction sites. Ultrasonication of nanosheets continuously enables the generation of reactive oxygen species (ROS) and CO, facilitating almost 100% broad-spectrum antibacterial efficacy. BiOBr-BiVP nanosheets demonstrate full bacterial eradication and accelerate wound healing through simultaneous regulation of inflammatory factors, facilitation of collagen deposition, and promotion of angiogenesis. Overall, this ultrasonic-triggered piezocatalytic nanoplatform combines BiV and the corona polarization strategy, providing a robust strategy for amplifying piezocatalytic mediated ROS/CO generation for drug-resistant bacterial eradication.
Correction for ‘Preventing biofilm formation and eradicating pathogenic bacteria by Zn doped histidine derived carbon quantum dots’ by Vijay Bhooshan Kumar et al., J. Mater. Chem. B, 2024, 12, 2855–2868, https://doi.org/10.1039/D3TB02488A.
Combination of immunotherapy and photothermal therapy (PTT) provides a promising therapeutic performance for tumors. However, it still faces negative feedback from suppressive factors such as adenosine. Herein, we developed a new nanodrug that can combine adenosine blockade and ferroptosis to promote the photoimmunotherapy of triple negative breast cancer (TNBC). The nanodrug, named CuS-PEG@Apt, was constructed via the modification of copper sulfide (CuS) nanoparticles with adenosine aptamer and PEG. CuS-PEG@Apt could be effectively enriched in the tumor site and locally generate a strong photothermal effect, directly ablating tumors and inducing immunogenic death (ICD). On the other hand, the aptamers could block the adenosine pathway to inhibit the immune suppression by adenosine, which further promoted the anti-tumor immunity. Moreover, the CuS nanoparticles could consume GSH and inhibit GPX4 to cause the ferroptosis of tumor cells. Collectively, CuS-PEG@Apt achieved potent efficacy of tumor suppression via the combination of PTT, immune activation and ferroptosis, representing an appealing platform for TNBC treatment.
Giant unilamellar vesicles (GUVs) are ideal for studying cellular mechanisms due to their cell-mimicking morphology and size. The formation, stability, and immobilization of these vesicles are crucial for drug delivery and bioimaging studies. Separately, metal–organic frameworks (MOFs) are actively researched owing to their unique and varied properties, yet little is known about the interaction between MOFs and phospholipids. This study investigates the influence of the metal–phosphate interface on the formation, size distribution, and stability of GUVs with different lipid compositions. GUVs were electroformed in the presence of a series of MOFs. The results show Al, Zn, Cu, Fe, Zr, and Ca metal centers of MOFs can coordinate to phospholipids on the surface of GUVs, leading to the formation of functional GUV@MOF constructs, with stablilities over 12 hours. Macroscopically, society has seen biology (people, plants, microbes) interacting with inorganic materials regularly. We now explore how microscopic biological models behave in the presence of inorganic constructs. This research opens new avenues for advanced biomedical applications interacting tailored frameworks with liposomes.
Achieving microecological balance is a complex environmental challenge. This is because the equilibrium of microecological systems necessitates both the eradication of harmful microorganisms and preservation of the beneficial ones. Conventional materials predominantly target the elimination of pathogenic microorganisms and often neglect the protection of advantageous microbial species. Metal–organic frameworks (MOFs) with excellent physicochemical properties (such as crystalline particles of various dimensions with highly porous network topology, variable local networking structures, diverse compositions with functional groups, high specific surface areas and pore volumes for surface and porous guest molecular adsorption/adhesion/affinity/binding and separation) have been extensively studied as a type of bactericidal material. However, only recently, studies on using MOFs to protect microorganisms have been reported. This review provides a comprehensive analysis of the mechanisms and applications of various MOFs (such as ZIF-8, ZIF-90, HKUST-1, MOF-5, and MIL-101) in both microbial eradication and protection. Insights into previous studies on MOF development, the material-bacteria interaction mechanisms, and potential clinical and environmental applications are also elucidated. MOFs with different framework structures/topologies (zeolite, sodalite, scaffolding, diamond, one-dimensional, and spherical/cylindrical cavities/pore networks), particle dimensions, polyhedral, cubic, rod and open/uncoordinated metal centers or fully coordinated metal centers, and ligand functional groups are discussed to understand the varying degrees of activation and interaction of microorganisms. This review holds potential in guiding future research on the design, synthesis, utilization, and integration of MOFs for the targeted eradication and protection of microorganisms and generating novel MOFs with selective antimicrobial and protective properties. Moreover, this review delivers a timely update and outlines future prospects for MOFs and their interaction with microorganisms, emphasizing their potential as a promising candidate among the next generation of smart materials in the field of ecosystem regulation.