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Correction: Portable smartphone-enabled dydrogesterone sensors based on biomimetic polymers for personalized gynecological care 更正:基于生物仿生聚合物的便携式智能手机氢化黄体酮传感器,用于个性化妇科护理。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2024-07-09 DOI: 10.1039/D4TB90115K
Sobia Ashraf, Tajamal Hussain, Sadia Zafar Bajwa, Adnan Mujahid and Adeel Afzal

Correction for ‘Portable smartphone-enabled dydrogesterone sensors based on biomimetic polymers for personalized gynecological care’ by Sobia Ashraf et al., J. Mater. Chem. B, 2024, https://doi.org/10.1039/D4TB00657G.

Sobia Ashraf 等人撰写的 "基于仿生聚合物的便携式智能手机氢孕酮传感器用于个性化妇科护理 "的更正,J. Mater.Chem.B,2024,https://doi.org/10.1039/D4TB00657G。
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引用次数: 0
Outstanding Reviewers for Journal of Materials Chemistry B in 2023 2023 年《材料化学杂志 B》优秀审稿人。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2024-07-01 DOI: 10.1039/D4TB90096K

We would like to take this opportunity to thank all of Journal of Materials Chemistry B's reviewers for helping to preserve quality and integrity in chemical science literature. We would also like to highlight the Outstanding Reviewers for Journal of Materials Chemistry B in 2023.

我们借此机会感谢《材料化学 B 辑》的所有审稿人,感谢他们帮助维护化学科学文献的质量和完整性。我们还想特别介绍一下 2023 年《材料化学 B 辑》的杰出审稿人。
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引用次数: 0
Surface functionalization of hydroxyapatite nanoparticles for biomedical applications 用于生物医学应用的羟基磷灰石纳米颗粒表面功能化。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2024-06-26 DOI: 10.1039/D4TB00551A
Takuya Kataoka, Zizhen Liu, Iori Yamada, Tania Guadalupe Peñaflor Galindo and Motohiro Tagaya

This review completely covers the various aspects of hydroxyapatite (HAp) nanoparticles and their role in different biological situations, and provides the surface and interface contents on (i) hydroxyapatite nanoparticles and their hybridization with organic molecules, (ii) surface designing of hydroxyapatite nanoparticles to provide their biocompatibility and photofunction, and (iii) coating technology of hydroxyapatite nanoparticles. In particular, we summarized how the HAp nanoparticles interact with the different ions and molecules and highlighted the potential for hybridization between HAp nanoparticles and organic molecules, which is driven by the interactions of the HAp nanoparticle surface ions with several functional groups of biological molecules. In addition, we highlighted the studies focusing on the interfacial interactions between the HAp nanoparticles and proteins for exploring the enhanced biocompatibility. Such studies focus on how these interactions affect the hydration layers and protein adsorption. However, the hydration layer state involves diverse molecular interactions that can alter the shape of the adsorbed proteins, thereby affecting cell adhesion and spreading on the surfaces. We also summarized the relationship between the surface properties of the HAp nanoparticles and the hydration layer. Furthermore, we spotlighted the cytocompatible photoluminescent probes that can be developed by designing HAp/organic nanohybrid structures. We then emphasized the importance of photofunctionalization in theranostics, which involves the integration of diagnostics and therapy based on the surface design of the HAp nanoparticles. Furthermore, the coating techniques using HAp nanoparticles and HAp nanoparticle/polymer composites were outlined for fusing base biomaterials with biological tissues. The advantages of HAp/biocompatible polymer composite coatings include the ability to effectively cover porous or irregularly shaped surfaces while controlling the thickness of the coating layer, and the addition of HAp nanoparticles to the polymer matrix improves the mechanical properties, increases the roughness, and forms the morphologies that mimic bone nanostructures. Therefore, the fundamental design of hydroxyapatite nanoparticles and their surfaces was suggested from various aspects for biomedical applications.

这篇综述完整地涵盖了羟基磷灰石(HAp)纳米粒子的各个方面及其在不同生物环境中的作用,并提供了以下方面的表面和界面内容:(i) 羟基磷灰石纳米粒子及其与有机分子的杂化;(ii) 羟基磷灰石纳米粒子的表面设计,以提供其生物相容性和光功能;(iii) 羟基磷灰石纳米粒子的涂层技术。我们特别总结了羟基磷灰石纳米粒子如何与不同的离子和分子相互作用,并强调了羟基磷灰石纳米粒子与有机分子杂交的潜力,这种潜力是由羟基磷灰石纳米粒子表面离子与生物分子的多个功能基团相互作用所驱动的。此外,我们还重点介绍了关于 HAp 纳米粒子与蛋白质之间界面相互作用的研究,以探索如何增强生物相容性。这些研究的重点是这些相互作用如何影响水合层和蛋白质吸附。然而,水合层状态涉及多种分子相互作用,会改变吸附蛋白质的形状,从而影响细胞在表面的粘附和扩散。我们还总结了 HAp 纳米颗粒的表面特性与水合层之间的关系。此外,我们还重点介绍了通过设计 HAp/有机纳米杂化结构可以开发的细胞相容性光致发光探针。然后,我们强调了光功能化在治疗学中的重要性,这涉及基于 HAp 纳米粒子表面设计的诊断与治疗一体化。此外,还概述了使用 HAp 纳米粒子和 HAp 纳米粒子/聚合物复合材料的涂层技术,以实现基础生物材料与生物组织的融合。HAp/生物相容性聚合物复合涂层的优点包括:能有效覆盖多孔或不规则形状的表面,同时控制涂层厚度;在聚合物基质中添加 HAp 纳米粒子能改善机械性能,增加粗糙度,并形成模仿骨纳米结构的形态。因此,从多方面提出了羟基磷灰石纳米粒子及其表面的基本设计,以应用于生物医学领域。
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引用次数: 0
Thermosensitive curcumin/silver/montmorillonite-F127 hydrogels with synergistic photodynamic/photothermal/silver ions antibacterial activity† 具有协同光动力/光热/银离子抗菌活性的热敏姜黄素/银/蒙脱石-F127 水凝胶。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2024-06-24 DOI: 10.1039/D4TB00431K
Jia Hui Liu, Xiao Lan Chen, Hui Min Yang, Yu Rong Yin, Alfin Kurniawan and Chun Hui Zhou

Bacterial infections and the emergence of super-resistant bacteria pose a significant risk to human health. Effective sterilization to prevent the development of bacterial drug resistance remains a challenge. Herein, curcumin/silver/montmorillonite (Cur/Ag/Mt) was prepared through a green chemical reduction method with montmorillonite as the carrier, curcumin as the reducing agent and the capping agent, and citric acid as the structure guide agent. Then, a novel dual light-responsive and thermosensitive Pluronic F127-based hydrogel (CAM-F) was prepared by encapsulating Cur/Ag/Mt within the F127 hydrogel. The Cur/Ag/Mt showed strong absorption in the near-infrared region that efficiently converts light into heat for photothermal therapy when the molar ratio of curcumin to silver nitrate was 2 : 1. Specifically, triangular silver nanoparticles reduced by curcumin were immobilized on the Mt layers, which could enhance photodynamic therapy by the metal-enhanced singlet oxygen and metal-enhanced fluorescence mechanisms. Upon combining 405 nm and 808 nm laser irradiation, the CAM-F hydrogel could simultaneously generate reactive oxygen species, increase the local temperature, and sustain the release of Ag+, thus displaying excellent bactericidal performance against Gram-negative and Gram-positive bacteria. The antibacterial rates of CAM-F hydrogels were 99.26 ± 0.95% and 99.95 ± 0.98% for Escherichia coli and Staphylococcus aureus, respectively. The findings suggest the potential of the CAM-F hydrogel as a stable, biologically safe, and broad-spectrum antimicrobial material. The thermosensitive CAM-F hydrogels for synergetic phototherapy may provide a promising strategy for solving clinical problems caused by pathogenic infections.

细菌感染和超级耐药细菌的出现对人类健康构成重大威胁。有效杀菌以防止细菌产生耐药性仍是一项挑战。本文以蒙脱石为载体,姜黄素为还原剂和封端剂,柠檬酸为结构引导剂,通过绿色化学还原法制备了姜黄素/银/蒙脱石(Cur/Ag/Mt)。然后,通过将姜黄素/Ag/Mt 包封在 F127 水凝胶中,制备了一种新型的基于 Pluronic F127 的双重光响应和热敏性水凝胶(CAM-F)。当姜黄素与硝酸银的摩尔比为 2 :1.具体来说,姜黄素还原的三角形银纳米颗粒被固定在 Mt 层上,可通过金属增强单线态氧和金属增强荧光机制增强光动力疗法。在 405 纳米和 808 纳米激光的联合照射下,CAM-F 水凝胶可同时产生活性氧、提高局部温度并持续释放 Ag+,从而对革兰氏阴性菌和革兰氏阳性菌表现出优异的杀菌性能。CAM-F 水凝胶对大肠杆菌和金黄色葡萄球菌的抗菌率分别为 99.26 ± 0.95% 和 99.95 ± 0.98%。研究结果表明,CAM-F 水凝胶具有作为一种稳定、生物安全和广谱抗菌材料的潜力。用于协同光疗的热敏 CAM-F 水凝胶可为解决病原体感染引起的临床问题提供一种前景广阔的策略。
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引用次数: 0
Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment† 将可调氧化还原反应白蛋白搭桥药物输送到肿瘤,用于癌症治疗。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2024-06-20 DOI: 10.1039/D4TB00751D
Shiwei Fu, Ajay Zheng, Lukun Wang, Jiuyan Chen, Bowen Zhao, Xiao Zhang, Victoria A. A. McKenzie, Zixin Yang, Roger M. Leblanc, Rajeev Prabhakar and Fuwu Zhang

This paper outlines a novel drug delivery system for highly cytotoxic mertansine (DM1) by conjugating to an albumin-binding Evans blue (EB) moiety through a tuneable responsive disulfide linker, providing valuable insights for the development of effective drug delivery systems toward cancer therapy.

本文概述了一种新型的高细胞毒性默坦新(DM1)给药系统,该系统通过可调节的响应性二硫键与白蛋白结合的伊文思蓝(EB)分子共轭,为开发有效的癌症治疗给药系统提供了宝贵的见解。
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引用次数: 0
A biocompatible pea protein isolate-derived bioink for 3D bioprinting and tissue engineering† 用于三维生物打印和组织工程的生物相容性豌豆蛋白分离衍生生物墨水。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2024-06-20 DOI: 10.1039/D4TB00781F
Xin Chen, Zheng Zhou, Mengni Yang, Shuai Zhu, Wenxiang Zhu, Jingjing Sun, Mengyi Yu, Jiaqian He, You Zuo, Wenxin Wang, Ning He, Xiaoxiao Han and Hairong Liu

Three-dimensional bioprinting is a potent biofabrication technique in tissue engineering but is limited by inadequate bioink availability. Plant-derived proteins are increasingly recognized as highly promising yet underutilized materials for biomedical product development and hold potential for use in bioink formulations. Herein, we report the development of a biocompatible plant protein bioink from pea protein isolate. Through pH shifting, ethanol precipitation, and lyophilization, the pea protein isolate (PPI) transformed from an insoluble to a soluble form. Next, it was modified with glycidyl methacrylate to obtain methacrylate-modified PPI (PPIGMA), which is photocurable and was used as the precursor of bioink. The mechanical and microstructural studies of the hydrogel containing 16% PPIGMA revealed a suitable compress modulus and a porous network with a pore size over 100 μm, which can facilitate nutrient and waste transportation. The PPIGMA bioink exhibited good 3D bioprinting performance in creating complex patterns and good biocompatibility as plenty of viable cells were observed in the printed samples after 3 days of incubation in the cell culture medium. No immunogenicity of the PPIGMA bioink was identified as no inflammation was observed for 4 weeks after implantation in Sprague Dawley rats. Compared with methacrylate-modified gelatin, the PPIGMA bioink significantly enhanced cartilage regeneration in vitro and in vivo, suggesting that it can be used in tissue engineering applications. In summary, the PPIGMA bioink can be potentially used for tissue engineering applications.

三维生物打印是组织工程中一种有效的生物制造技术,但由于生物墨水供应不足而受到限制。越来越多的人认识到,植物源蛋白质是一种极具潜力但尚未得到充分利用的生物医学产品开发材料,并具有用于生物墨水配方的潜力。在此,我们报告了利用豌豆蛋白分离物开发生物相容性植物蛋白生物墨水的情况。通过 pH 值转换、乙醇沉淀和冻干,豌豆蛋白分离物 (PPI) 从不溶物转变为可溶物。然后,用甲基丙烯酸缩水甘油酯对其进行改性,得到甲基丙烯酸酯改性豌豆蛋白(PPIGMA),它具有光固化性,可用作生物墨水的前体。对含 16% PPIGMA 的水凝胶进行的力学和微观结构研究表明,该水凝胶具有合适的压缩模量和孔径超过 100 μm 的多孔网络,可促进营养物质和废物的运输。PPIGMA 生物墨水在创建复杂图案方面表现出良好的三维生物打印性能,并且具有良好的生物相容性,在细胞培养基中培养 3 天后,打印样品中观察到大量存活细胞。在 Sprague Dawley 大鼠体内植入 PPIGMA 生物墨水 4 周后,没有发现炎症,因此 PPIGMA 生物墨水没有免疫原性。与甲基丙烯酸甲酯改性明胶相比,PPIGMA 生物墨水能显著提高软骨在体外和体内的再生能力,这表明它可用于组织工程应用。总之,PPIGMA 生物墨水可用于组织工程应用。
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引用次数: 0
Micropatterned shape-memory polymer substrate containing hydrogen bonds creates a long-term dynamic microenvironment for regulating nerve-cell fate† 含有氢键的微图案形状记忆聚合物基底为调节神经细胞命运创造了一个长期动态微环境。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2024-06-19 DOI: 10.1039/D4TB00593G
Yilei Wang, Hao Liu, Huan Wang, Hui Xie and Shaobing Zhou

Peripheral nerve injuries (PNIs) caused by mechanical contusion are frequently encountered in clinical practice, using nerve guidance conduits (NGCs) is now a promising therapy. An NGC creates a microenvironment for cell growth and differentiation, thus understanding physical and biochemical cues that can affect nerve-cell fate is a prerequisite for rationally designing NGCs. However, most of the previous works were focused on some static cues, the dynamic nature of the nerve microenvironment has not yet been well captured. Herein, we develop a micropatterned shape-memory polymer as a programmable substrate for providing a dynamic cue for nerve-cell growth. The shape-memory properties enable temporal programming of the substrate, and a dynamic microenvironment is created during standard cell culturing at 37 °C. Unlike most of the biomedical shape-memory polymers that recover rapidly at 37 °C, the proposed substrate shows a slow recovery process lasting 3–4 days and creates a long-term dynamic microenvironment. Results demonstrate that the vertically programmed substrates provide the most suitable dynamic microenvironment for PC12 cells as both the differentiation and maturity are promoted. Overall, this work provides a strategy for creating a long-term dynamic microenvironment for regulating nerve-cell fate and will inspire the rational design of NGCs for the treatment of PNIs.

由机械挫伤引起的周围神经损伤(PNIs)在临床实践中经常遇到,使用神经引导导管(NGCs)是目前一种很有前景的治疗方法。神经引导导管为细胞的生长和分化创造了微环境,因此了解影响神经细胞命运的物理和生化线索是合理设计神经引导导管的先决条件。然而,以往的研究大多集中在一些静态线索上,神经微环境的动态性质尚未被很好地捕捉到。在此,我们开发了一种微图案形状记忆聚合物,作为可编程基底,为神经细胞生长提供动态线索。形状记忆特性可对基底进行时间编程,并在 37 °C 的标准细胞培养过程中创建动态微环境。大多数生物医学形状记忆聚合物在 37 °C下会迅速恢复,与之不同的是,所提议的基底会在3-4天内缓慢恢复,并创造一个长期的动态微环境。结果表明,垂直编程基底为 PC12 细胞提供了最合适的动态微环境,因为它既能促进分化,又能促进成熟。总之,这项工作提供了一种为调节神经细胞命运创造长期动态微环境的策略,并将启发人们合理设计用于治疗 PNIs 的 NGCs。
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引用次数: 0
Injectable thermogel constructed from self-assembled polyurethane micelle networks for 3D cell culture and wound treatment† 由自组装聚氨酯胶束网络构建的可注射热凝胶,用于三维细胞培养和伤口治疗。
IF 6.1 3区 医学 Q1 Engineering Pub Date : 2024-06-18 DOI: 10.1039/D4TB00771A
Yanjun Wang, Nan Sheng, Ao Wang, Min Wang, Yuanyang Xu, Dan Lu, Wenkai Liu, Zhen Li, Jiehua Li, Jianhui Sun and Feng Luo

Injectable hydrogels have attracted significant interest in the biomedical field due to their minimal invasiveness and accommodation of intricate scenes. Herein, we developed an injectable polyurethane-based thermogel platform by modulating the hydrophilic–hydrophobic balance of the segmented components with pendant PEG. The thermogelling behavior is achieved by a combination of the bridging from the hydrophilic PEG and the percolated network from the hydrophobic micelle core. Firstly, the thermogelation mechanism of this system was demonstrated by both DPD simulation and experimental investigation. The gelling temperature could be modulated by varying the solid content, the component of soft segments, and the length of the pendant PEG. We further applied 3D printing technology to prepare personalized hydrogel structures. This integration highlights the adaptability of our thermogel for fabricating complex and patient-specific constructs, presenting a significant advance in the field of regenerative medicine and tissue engineering. Subsequently, in vitro cell experiments demonstrated that the thermogel had good cell compatibility and could promote the proliferation and migration of L929 cells. Impressively, A549 cells could be expediently in situ parceled in the thermogel for three-dimensional cultivation and gain lifeful 3D cell spheres after 7 days. Further, in vivo experiments demonstrated that the thermogel could promote wound healing with the regeneration of capillaries and hair follicles. Ultimately, our study demonstrates the potential of hydrogels to prepare personalized hydrogel structures via 3D printing technology, offering innovative solutions for complex biomedical applications. This work not only provides a fresh perspective for the design of injectable thermogels but also offers a promising avenue to develop thermoresponsive waterborne polyurethane for various medical applications.

可注射水凝胶因其微创性和可容纳复杂场景而在生物医学领域备受关注。在此,我们利用悬垂 PEG 调节分段成分的亲水-疏水平衡,开发出一种可注射的聚氨酯热凝胶平台。热凝胶行为是由亲水性 PEG 的桥接和疏水性胶束核心的渗流网络共同作用实现的。首先,通过 DPD 模拟和实验研究证明了该体系的热凝胶机制。胶凝温度可通过改变固体含量、软片段的成分和悬垂 PEG 的长度来调节。我们进一步应用三维打印技术制备了个性化的水凝胶结构。这种整合凸显了我们的热凝胶在制造复杂和患者特异性结构方面的适应性,在再生医学和组织工程领域取得了重大进展。随后的体外细胞实验表明,热凝胶具有良好的细胞相容性,能促进 L929 细胞的增殖和迁移。令人印象深刻的是,A549 细胞可以快速原位包裹在热凝胶中进行三维培养,并在 7 天后获得有生命力的三维细胞球。此外,体内实验表明,热凝胶可以促进伤口愈合,促进毛细血管和毛囊的再生。最终,我们的研究证明了水凝胶通过三维打印技术制备个性化水凝胶结构的潜力,为复杂的生物医学应用提供了创新解决方案。这项工作不仅为可注射热凝胶的设计提供了一个全新的视角,而且为开发用于各种医疗应用的热致伸缩性水性聚氨酯提供了一个前景广阔的途径。
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引用次数: 0
Liquid crystal polymer actuators with complex and multiple actuations 具有复杂和多重执行功能的液晶聚合物执行器。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2024-06-18 DOI: 10.1039/D4TB01055H
Xiaoyu Zhang, Jia Wei, Lang Qin and Yanlei Yu

Deformable liquid crystal polymers (LCPs), which exhibit both entropic elasticity of polymer networks and anisotropic properties originating from ordered mesogens, have gained more and more interest for use as biomedical soft actuators. Especially, LCP actuators with controllable mesogen alignment, sophisticated geometry and reprogrammability are a rising star on the horizon of soft actuators, since they enable complex and multiple actuations. This review focuses on two topics: (1) the regulation of mesogen alignment and geometry of LCP actuators for complex actuations; (2) newly designed reprogrammable LCP materials for multiple actuations. First, basic actuation mechanisms are briefly introduced. Then, LCP actuators with complex actuations are demonstrated. Special attention is devoted to the improvement of fabrication methods, which profoundly influence the available complexity of the mesogen alignment and geometry. Subsequently, reprogrammable LCP actuators featuring dynamic networks or shape memory effects are discussed, with an emphasis on their multiple actuations. Finally, perspectives on the current challenges and potential development trends toward more intelligent LCP actuators are discussed, which may shed light on future investigations in this field.

可变形液晶聚合物(LCP)既具有聚合物网络的熵弹性,又具有有序介质产生的各向异性,因此越来越多地被用作生物医学软致动器。尤其是具有可控介质排列、复杂几何形状和可重新编程性的 LCP 执行器,是软执行器地平线上一颗冉冉升起的新星,因为它们可以实现复杂的多重执行。本综述重点讨论两个主题:(1) 用于复杂致动器的 LCP 致动器的介质排列和几何形状的调节;(2) 用于多重致动器的新设计的可重新编程 LCP 材料。首先,简要介绍基本致动器机制。然后,演示了具有复杂致动器的 LCP 致动器。其中特别关注了制造方法的改进,因为这对介质排列和几何形状的可用复杂性有深远影响。随后,讨论了具有动态网络或形状记忆效应的可重新编程 LCP 激励器,重点是它们的多重激励。最后,还讨论了更智能的 LCP 执行器目前面临的挑战和潜在的发展趋势,这可能会对该领域未来的研究有所启发。
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引用次数: 0
Nanotube topography rejuvenates the senescence of mesenchymal stem cells by activating YAP signalling† 纳米管拓扑结构通过激活 YAP 信号使衰老的间充质干细胞恢复活力。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2024-06-18 DOI: 10.1039/D3TB02828C
Yanping Sun, Yejia Yu, Shixing Ma, Chengcheng Liao, Jian Yang, Yun Lyu, Xuanhao Zhang, Jingyi Zhang, Weidong Tian and Li Liao

Improving the regenerative ability of senescent stem cells is a critical issue in combating aging. The destiny and function of senescent stem cells are controlled by the niche, including the physical architecture of the surface of the extracellular matrix (ECM). In this study, we explored the functions of TiO2 nanotube topography on mesenchymal stem cells (MSCs) under senescence, as well as its mechanical effects on senescence. First, we created different nanotube topographies on the titanium samples. Next, we cultured senescent mesenchymal stem cells (S-MSCs) on samples with various nanotube topographies to determine suitable parameters. We found nanotube with a diameter of 10 nm significantly alleviated the cellular senescence of S-MSCs and improved the osteogenic differentiation of S-MSCs in vitro. Using an ectopic periodontium regeneration model, we confirmed that specific nanotube topography could promote tissue regeneration of S-MSCs in vivo. Moreover, we demonstrated that nanotube topography activated YAP in S-MSCs and reformed nuclear-cytoskeletal morphology to inhibit senescence. Taken together, our study establishes a bridge linking between nano-topography, mechanics, and senescence, suggesting a potential strategy to improve tissue regeneration in aged individuals by providing optimized surface topography on biomaterials.

提高衰老干细胞的再生能力是对抗衰老的关键问题。衰老干细胞的命运和功能受生态位控制,包括细胞外基质(ECM)表面的物理结构。在这项研究中,我们探讨了TiO2纳米管形貌对衰老间充质干细胞(MSCs)的功能及其对衰老的机械效应。首先,我们在钛样品上制作了不同的纳米管拓扑结构。接着,我们在具有不同纳米管拓扑结构的样品上培养衰老间充质干细胞(S-MSCs),以确定合适的参数。我们发现直径为 10 纳米的纳米管能明显缓解 S-MSCs 的细胞衰老,并改善 S-MSCs 的体外成骨分化。通过异位牙周再生模型,我们证实了特定的纳米管拓扑能促进 S-MSCs 在体内的组织再生。此外,我们还证明了纳米管拓扑能激活 S-MSCs 中的 YAP,并改变核-骨骼形态以抑制衰老。综上所述,我们的研究在纳米形貌、力学和衰老之间架起了一座桥梁,为通过优化生物材料的表面形貌来改善老年人的组织再生提出了一种潜在的策略。
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引用次数: 0
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