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Correction: Acceptor–donor–acceptor-type molecules with large electrostatic potential difference for effective NIR photothermal therapy
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-02-03 DOI: 10.1039/D5TB90022K
Kexin Fan, Ludan Zhang, Qinqiu Zhong, Yanhe Xiang, Bowei Xu and Yuguang Wang

Correction for ‘Acceptor–donor–acceptor-type molecules with large electrostatic potential difference for effective NIR photothermal therapy’ by Kexin Fan et al., J. Mater. Chem. B, 2024, 12, 5140–5149, https://doi.org/10.1039/D4TB00187G.

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引用次数: 0
Correction: Synthesis and photophysical properties of a new push–pull pyrene dye with green-to-far-red emission and its application to human cellular and skin tissue imaging
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-01-31 DOI: 10.1039/D5TB90024G
Kazuki Inoue, Ryosuke Kawakami, Masamoto Murakami, Taku Nakayama, Shinkuro Yamamoto, Keiji Inoue, Teruko Tsuda, Koji Sayama, Takeshi Imamura, Daisuke Kaneno, Shingo Hadano, Shigeru Watanabe and Yosuke Niko

Correction for ‘Synthesis and photophysical properties of a new push–pull pyrene dye with green-to-far-red emission and its application to human cellular and skin tissue imaging’ by Kazuki Inoue et al., J. Mater. Chem. B, 2022, 10, 1641–1649, https://doi.org/10.1039/D1TB02728J.

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引用次数: 0
Correction: In vivo transplantation of intrahepatic cholangiocyte organoids with decellularized liver-derived hydrogels supports hepatic cellular proliferation and differentiation in chronic liver injury
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-01-23 DOI: 10.1039/D5TB90016F
Impreet Kaur, Ashwini Vasudevan, Natalia Sanchez-Romero, Arka Sanyal, Aarushi Sharma, Hamed Hemati, Pinky Juneja, Aarti Sharma, Iris Pla Palacin, Archana Rastogi, Pooja Vijayaraghavan, Sourabh Ghosh, Seeram Ramakrishna, Shiv K. Sarin, Pedro M. Baptista, Dinesh M. Tripathi and Savneet Kaur

Correction for ‘In vivo transplantation of intrahepatic cholangiocyte organoids with decellularized liver-derived hydrogels supports hepatic cellular proliferation and differentiation in chronic liver injury’ by Impreet Kaur et al., J. Mater. Chem. B, 2025, 13, 918–928, https://doi.org/10.1039/D4TB01503G.

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引用次数: 0
Capturing the dynamic integrity of carbocyanine fluorophore-based lipid nanoparticles using the FRET technique†
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-01-22 DOI: 10.1039/D4TB02653E
Siyu Long, David A. Turner, Kevin J. Hamill, Louise S. Natrajan and Tom O. McDonald

Nanoparticles capable of dynamically reporting their structural integrity in real-time are a powerful tool to guide the design of drug delivery technologies. Lipid nanoparticles (LNPs) offer multiple important advantages for drug delivery, including stability, protection of active substances, and sustained release capabilities. However, tracking their structural integrity and dynamic behaviour in complex biological environments remains challenging. Here, we report the development of a Förster resonance energy transfer (FRET)-enabled LNP platform that achieves unprecedented sensitivity and precision in monitoring nanoparticle disintegration. The FRET-based LNPs were prepared using nanoprecipitation, encapsulating high levels of 3,3′-dioctadecyloxacarbocyanine perchlorate (DiO) and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI) fluorophores as the donor and acceptors, respectively. The resulting LNPs had a mean diameter of 114 ± 19 nm with a distinct FRET signal. An optimal energy transfer efficiency of 0.98 and an emission quantum yield of 0.13 were achieved at 11.1% fluorophore loading in the LNPs, balancing efficient energy transfer and minimal aggregation-induced quenching. Using the FRET reporting, three dissociation stages of FRET LNPs were observed: solvation, indicated by an increased emission intensity; swelling and partial dissolution, evidenced by changes in emission maxima and mean size; and complete dissociation, confirmed by emission solely from DiO and the absence of particles. Testing the nanoparticles in live cells (telomerase-immortalised human corneal epithelial cells, hTCEpi cells) revealed a direct link to the disappearance of the FRET signal with the dissociation of FRET NPs. The nanoparticles initially exhibited a strong extracellular FRET signal, which diminished after cellular internalisation. This suggests that the LNPs disintegrate after entering the cells. These findings establish FRET-based LNPs as a robust tool for real-time nanoparticle tracking, offering insights into their integrity and release mechanisms, with potential applications in advanced drug delivery and diagnostics.

能够实时动态报告其结构完整性的纳米颗粒是指导给药技术设计的有力工具。脂质纳米颗粒(LNPs)具有多种重要的给药优势,包括稳定性、活性物质保护和持续释放能力。然而,跟踪它们在复杂生物环境中的结构完整性和动态行为仍然具有挑战性。在此,我们报告了一种支持佛斯特共振能量转移(FRET)的 LNP 平台的开发情况,该平台在监测纳米粒子崩解方面实现了前所未有的灵敏度和精确度。这种基于 FRET 的 LNPs 采用纳米沉淀法制备,分别封装了高浓度的 3,3'-双十八烷氧基羰花青高氯酸盐(DiO)和 1,1'-双十八烷基-3,3,3',3'-四甲基吲哚羰花青高氯酸盐(DiI)荧光团作为供体和受体。所得 LNPs 的平均直径为 114 ± 19 nm,具有明显的 FRET 信号。当 LNPs 中的荧光团含量为 11.1% 时,最佳能量传递效率为 0.98,发射量子产率为 0.13,实现了高效能量传递与最小聚集淬灭之间的平衡。利用 FRET 报告,可以观察到 FRET LNPs 的三个解离阶段:溶解,表现为发射强度增加;膨胀和部分溶解,表现为发射最大值和平均尺寸的变化;完全解离,表现为仅从 DiO 发射且没有颗粒。在活细胞(端粒酶凋亡的人角膜上皮细胞,hTCEpi 细胞)中测试纳米颗粒,发现 FRET 信号的消失与 FRET NPs 的解离有直接联系。纳米颗粒最初表现出很强的细胞外 FRET 信号,细胞内化后信号减弱。这表明 LNPs 在进入细胞后会解体。这些发现将基于 FRET 的 LNPs 确立为实时跟踪纳米粒子的可靠工具,有助于深入了解其完整性和释放机制,并有望应用于先进的药物输送和诊断。
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引用次数: 0
An ASGP-R-targeting magnetic resonance imaging contrast agent for liver cancer diagnosis† 一种靶向asgp - r的肝癌磁共振成像造影剂。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-01-22 DOI: 10.1039/D4TB02708F
Jie Chen, Xiaoming Wang, Yinan Bai, Zhiqian Li, Haonan Li, Bing Wang, Qiyong Gong and Kui Luo

Development of novel Gd-based contrast agents for targeted magnetic resonance imaging (MRI) of liver cancer remains a great challenge. Herein we reported a novel Gd-based MRI contrast agent with improved relaxivity for specifically diagnosing liver cancer. This GSH-responsive macromolecular contrast agent (mCA), POLDGd, was prepared by RAFT polymerization, and its lactic acid moiety could precisely target the ASGP-R surface protein on liver cancer cells, whereas PODGd without the lactic acid moiety was prepared as a control. POLDGd had a high molecular weight of 45 kDa and a particle size of 103 nm. Its longitudinal relaxivity (11.39 mM−1 s−1) measured via a 3.0 T MR scanner was three times that of the clinically used contrast agent DTPA-Gd. In comparison with the PODGd-treated group, the signal enhancement at the tumor site was significantly prolonged, with a maximum enhancement peak of about 190% after intravenous injection of POLDGd into tumor-bearing mice. A high accumulation level of POLDGd in the liver tumors observed via MRI was also confirmed by fluorescence imaging. POLDGd showed minimal side effects, which may be ascribed to its metabolism through the kidneys. Therefore, POLDGd may be used as a highly effective biosafe nanoscale contrast agent for targeted MRI of liver cancer.

开发用于肝癌靶向磁共振成像(MRI)的新型钆基造影剂仍然是一个巨大的挑战。在此,我们报道了一种新型的基于gd的MRI造影剂,它具有改进的弛豫性,可用于特异性诊断肝癌。采用RAFT聚合法制备gsh反应性大分子造影剂POLDGd,其乳酸片段可以精确靶向肝癌细胞上的ASGP-R表面蛋白,而不含乳酸片段的PODGd作为对照。POLDGd分子量为45 kDa,粒径为103 nm。3.0 T MR扫描仪测得其纵向弛缓度(11.39 mM-1 s-1)是临床使用造影剂DTPA-Gd的3倍。与podgd治疗组相比,肿瘤部位的信号增强明显延长,荷瘤小鼠静脉注射POLDGd后,最大增强峰约为190%。荧光成像也证实了肝脏肿瘤中POLDGd的高积累水平。POLDGd显示出最小的副作用,这可能归因于其通过肾脏的代谢。因此,POLDGd可作为一种高效的生物安全纳米造影剂用于肝癌的靶向MRI。
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引用次数: 0
Surface Bi-vacancy and corona polarization engineered nanosheets with sonopiezocatalytic antibacterial activity for wound healing 表面双空位和电晕极化工程纳米片具有声催化抗菌活性的伤口愈合。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-01-22 DOI: 10.1039/D4TB02489C
Mingbo Wu, Dong Li, Yao Liu, Xiaomiao Ruan, Jingwen Yang, Zegang Li, Siyi Chen, Xin Yang and Wenwu Ling

Piezocatalytic therapy is an emerging therapeutic strategy for eradicating drug-resistant bacteria, but suffers from insufficient piezoelectricity and catalytic active site availability. Herein, Bi-vacancies (BiV) and corona polarization were introduced to BiOBr nanosheets to create a BiOBr-BiVP nanoplatform for piezocatalytic antibacterial therapy. This meticulously tailored strategy strengthens the built-in electric field of nanosheets, enhancing piezoelectric potential and charge density and boosting charge separation and migration efficiency. Meanwhile, BiV adeptly adjust the band structure and increase reaction sites. Ultrasonication of nanosheets continuously enables the generation of reactive oxygen species (ROS) and CO, facilitating almost 100% broad-spectrum antibacterial efficacy. BiOBr-BiVP nanosheets demonstrate full bacterial eradication and accelerate wound healing through simultaneous regulation of inflammatory factors, facilitation of collagen deposition, and promotion of angiogenesis. Overall, this ultrasonic-triggered piezocatalytic nanoplatform combines BiV and the corona polarization strategy, providing a robust strategy for amplifying piezocatalytic mediated ROS/CO generation for drug-resistant bacterial eradication.

压电催化治疗是一种新兴的消除耐药细菌的治疗策略,但存在压电性和催化活性位点可用性不足的问题。本文将双空位(BiV)和电晕极化引入到BiOBr纳米片中,构建了一种用于压电催化抗菌的bibr - bivp纳米平台。这种精心定制的策略增强了纳米片的内置电场,增强了压电电位和电荷密度,提高了电荷分离和迁移效率。同时,BiV巧妙地调整了能带结构,增加了反应位点。纳米片的超声波持续使活性氧(ROS)和CO的产生,促进几乎100%的广谱抗菌效果。BiOBr-BiVP纳米片通过同时调节炎症因子、促进胶原沉积和促进血管生成,显示出完全的细菌根除和加速伤口愈合。总的来说,这种超声触发的压电催化纳米平台结合了BiV和电晕极化策略,为放大压电催化介导的ROS/CO生成提供了一种强大的策略,用于耐药细菌的根除。
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引用次数: 0
Correction: Preventing biofilm formation and eradicating pathogenic bacteria by Zn doped histidine derived carbon quantum dots 更正:通过锌掺杂组氨酸衍生的碳量子点防止生物膜形成和根除致病菌。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-01-22 DOI: 10.1039/D5TB90012C
Vijay Bhooshan Kumar, Maoz Lahav and Ehud Gazit

Correction for ‘Preventing biofilm formation and eradicating pathogenic bacteria by Zn doped histidine derived carbon quantum dots’ by Vijay Bhooshan Kumar et al., J. Mater. Chem. B, 2024, 12, 2855–2868, https://doi.org/10.1039/D3TB02488A.

更正Vijay Bhooshan Kumar等人的“通过锌掺杂组氨酸衍生的碳量子点防止生物膜形成并根除致病菌”,J. Mater。化学。B, 2024, 12, 2855-2868, https://doi.org/10.1039/D3TB02488A。
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引用次数: 0
Combination of adenosine blockade and ferroptosis for photo-immunotherapy of triple negative breast cancer with aptamer-modified copper sulfide† 腺苷阻断和铁下垂联合应用适配体修饰的硫化铜光免疫治疗三阴性乳腺癌。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-01-21 DOI: 10.1039/D4TB02125H
Xingyu Zhang, Chengyu Shi, Qiao Liu, Yuting Zhong, Lipeng Zhu and Yuetao Zhao

Combination of immunotherapy and photothermal therapy (PTT) provides a promising therapeutic performance for tumors. However, it still faces negative feedback from suppressive factors such as adenosine. Herein, we developed a new nanodrug that can combine adenosine blockade and ferroptosis to promote the photoimmunotherapy of triple negative breast cancer (TNBC). The nanodrug, named CuS-PEG@Apt, was constructed via the modification of copper sulfide (CuS) nanoparticles with adenosine aptamer and PEG. CuS-PEG@Apt could be effectively enriched in the tumor site and locally generate a strong photothermal effect, directly ablating tumors and inducing immunogenic death (ICD). On the other hand, the aptamers could block the adenosine pathway to inhibit the immune suppression by adenosine, which further promoted the anti-tumor immunity. Moreover, the CuS nanoparticles could consume GSH and inhibit GPX4 to cause the ferroptosis of tumor cells. Collectively, CuS-PEG@Apt achieved potent efficacy of tumor suppression via the combination of PTT, immune activation and ferroptosis, representing an appealing platform for TNBC treatment.

免疫疗法与光热疗法(PTT)联合治疗肿瘤具有良好的疗效。然而,它仍然面临来自腺苷等抑制因子的负反馈。在此,我们开发了一种新的纳米药物,可以联合腺苷阻断和铁下垂来促进三阴性乳腺癌(TNBC)的光免疫治疗。该纳米药物命名为CuS-PEG@Apt,是通过腺苷适配体和聚乙二醇修饰硫化铜纳米颗粒构建的。CuS-PEG@Apt可在肿瘤部位有效富集,局部产生强烈的光热效应,直接消融肿瘤,诱导免疫原性死亡(immunogenic death, ICD)。另一方面,适体可以阻断腺苷途径,抑制腺苷对免疫的抑制,进一步促进抗肿瘤免疫。此外,cu纳米颗粒可以消耗GSH,抑制GPX4,导致肿瘤细胞铁下垂。总的来说,CuS-PEG@Apt通过PTT、免疫激活和铁上睑松脱的结合获得了强有力的肿瘤抑制效果,代表了一个有吸引力的TNBC治疗平台。
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引用次数: 0
Metal–organic frameworks as anchors for giant unilamellar vesicle immobilization† 金属有机框架在巨型单层囊泡固定中的锚定作用。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-01-20 DOI: 10.1039/D4TB02055C
Aroosha Faheem, Mason C. Lawrence, Gazi A. Bushra, M.-Vicki Meli and Barry A. Blight

Giant unilamellar vesicles (GUVs) are ideal for studying cellular mechanisms due to their cell-mimicking morphology and size. The formation, stability, and immobilization of these vesicles are crucial for drug delivery and bioimaging studies. Separately, metal–organic frameworks (MOFs) are actively researched owing to their unique and varied properties, yet little is known about the interaction between MOFs and phospholipids. This study investigates the influence of the metal–phosphate interface on the formation, size distribution, and stability of GUVs with different lipid compositions. GUVs were electroformed in the presence of a series of MOFs. The results show Al, Zn, Cu, Fe, Zr, and Ca metal centers of MOFs can coordinate to phospholipids on the surface of GUVs, leading to the formation of functional GUV@MOF constructs, with stablilities over 12 hours. Macroscopically, society has seen biology (people, plants, microbes) interacting with inorganic materials regularly. We now explore how microscopic biological models behave in the presence of inorganic constructs. This research opens new avenues for advanced biomedical applications interacting tailored frameworks with liposomes.

巨型单层囊泡(GUVs)由于其细胞模拟的形态和大小而成为研究细胞机制的理想材料。这些囊泡的形成、稳定性和固定化对于药物传递和生物成像研究至关重要。另外,金属有机骨架(MOFs)由于其独特而多样的性质而受到积极的研究,但其与磷脂的相互作用知之甚少。本研究探讨了金属-磷酸盐界面对不同脂质组成的guv的形成、大小分布和稳定性的影响。在一系列mof存在下电铸guv。结果表明,mof的Al, Zn, Cu, Fe, Zr和Ca金属中心可以与guv表面的磷脂配合,形成功能性GUV@MOF结构,并具有超过12小时的稳定性。从宏观上看,社会已经看到生物(人、植物、微生物)与无机材料有规律地相互作用。我们现在探索微观生物模型在无机结构存在下的行为。这项研究为高级生物医学应用与脂质体相互作用的定制框架开辟了新的途径。
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引用次数: 0
Exploring the multifaceted roles of metal–organic frameworks in ecosystem regulation 探索金属有机框架在生态系统调节中的多方面作用。
IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-01-20 DOI: 10.1039/D4TB01882F
Wanjing Li, Jing Chen, Jian Guo, Ka Teng Chan, Yini Liang, Meixuan Chen, Jing Wang, Srinivas Gadipelli, Xuedong Zhou and Lei Cheng

Achieving microecological balance is a complex environmental challenge. This is because the equilibrium of microecological systems necessitates both the eradication of harmful microorganisms and preservation of the beneficial ones. Conventional materials predominantly target the elimination of pathogenic microorganisms and often neglect the protection of advantageous microbial species. Metal–organic frameworks (MOFs) with excellent physicochemical properties (such as crystalline particles of various dimensions with highly porous network topology, variable local networking structures, diverse compositions with functional groups, high specific surface areas and pore volumes for surface and porous guest molecular adsorption/adhesion/affinity/binding and separation) have been extensively studied as a type of bactericidal material. However, only recently, studies on using MOFs to protect microorganisms have been reported. This review provides a comprehensive analysis of the mechanisms and applications of various MOFs (such as ZIF-8, ZIF-90, HKUST-1, MOF-5, and MIL-101) in both microbial eradication and protection. Insights into previous studies on MOF development, the material-bacteria interaction mechanisms, and potential clinical and environmental applications are also elucidated. MOFs with different framework structures/topologies (zeolite, sodalite, scaffolding, diamond, one-dimensional, and spherical/cylindrical cavities/pore networks), particle dimensions, polyhedral, cubic, rod and open/uncoordinated metal centers or fully coordinated metal centers, and ligand functional groups are discussed to understand the varying degrees of activation and interaction of microorganisms. This review holds potential in guiding future research on the design, synthesis, utilization, and integration of MOFs for the targeted eradication and protection of microorganisms and generating novel MOFs with selective antimicrobial and protective properties. Moreover, this review delivers a timely update and outlines future prospects for MOFs and their interaction with microorganisms, emphasizing their potential as a promising candidate among the next generation of smart materials in the field of ecosystem regulation.

实现微生态平衡是一项复杂的环境挑战。这是因为微生态系统的平衡既需要消灭有害微生物,又需要保存有益微生物。传统材料主要针对病原微生物的消除,往往忽视了对有利微生物物种的保护。金属有机框架(MOFs)具有优异的物理化学性质(如具有高多孔网络拓扑的各种尺寸的晶体颗粒,可变的局部网络结构,具有功能基团的多种成分,具有表面和多孔客体分子吸附/粘附/亲和/结合和分离的高比表面积和孔体积),作为一种杀菌材料被广泛研究。然而,利用mof保护微生物的研究直到最近才有报道。本文综述了ZIF-8、ZIF-90、HKUST-1、MOF-5和MIL-101等MOF-5在微生物清除和保护方面的作用机制和应用。本文还对MOF的发展、材料-细菌相互作用机制以及潜在的临床和环境应用进行了综述。讨论了具有不同框架结构/拓扑结构(沸石、钠石、脚手架、金刚石、一维和球形/圆柱形空腔/孔网络)、颗粒尺寸、多面体、立方、棒状和开放/不配位金属中心或完全配位金属中心以及配体官能团的mof,以了解微生物的不同程度的活化和相互作用。这一综述对今后设计、合成、利用和整合mof用于靶向清除和保护微生物,以及产生具有选择性抗菌和保护性能的新型mof具有指导意义。此外,这篇综述提供了及时的更新,概述了mof及其与微生物相互作用的未来前景,强调了它们作为生态系统调节领域下一代智能材料的潜力。
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引用次数: 0
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Journal of Materials Chemistry B
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