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Precise, Sensitive Detection of Viable Foodborne Pathogenic Bacteria with a 6-Order Dynamic Range via Digital Rolling Circle Amplification 通过数字滚圆放大技术精确、灵敏地检测可存活的食源性致病细菌,动态范围达 6 级
IF 8.9 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-07-19 DOI: 10.1021/acssensors.4c01069
Ruijie Deng, Yachen Shi, Yong Zhang, Xinlei Zhang, Sha Deng, Xuhan Xia
The presence of viable pathogenic bacteria in food can lead to serious foodborne diseases, thus posing a risk to human health. Here, we develop a digital rolling circle amplification (dRCA) assay that enables the precise and sensitive quantification of viable foodborne pathogenic bacteria. Directly targeting pathogenic RNAs via a ligation-based padlock probe allows for precisely discriminating viable bacteria from dead one. The one-target-one-amplicon characteristic of dRCA enables high sensitivity and a broad quantitative detection range, conferring a detection limit of 10 CFU/mL and a dynamic range of 6 orders. dRCA can detect rare viable bacteria, even at a proportion as low as 0.1%, which is 50 times more sensitive than the live/dead staining method. The high sensitivity for detecting viable bacteria accommodates dRCA for assessing sterilization efficiency. Based on the assay, we found that, for pasteurization, slightly elevating the temperature to 68 °C can reduce the heating time to 10 min, which may minimize nutrient degradation caused by high-temperature exposure. The assay can serve as a precise tool for estimating the contamination by viable pathogenic bacteria and assessing sterilization, which facilitates food safety control.
食品中存活的致病菌可导致严重的食源性疾病,从而对人类健康造成危害。在这里,我们开发了一种数字滚动圈扩增(dRCA)检测方法,可以精确、灵敏地定量检测食源性致病菌。通过基于连接的挂锁探针直接靶向致病性 RNA,可精确区分存活细菌和死亡细菌。dRCA 的一靶标一扩增子特性实现了高灵敏度和宽定量检测范围,使其检测限达到 10 CFU/mL,动态范围达到 6 阶。检测存活细菌的高灵敏度使 dRCA 可用于评估灭菌效率。根据该检测方法,我们发现在巴氏杀菌过程中,将温度稍稍升高至 68 ℃,可将加热时间缩短至 10 分钟,从而最大限度地减少高温暴露造成的营养物质降解。该检测方法可作为一种精确的工具,用于估算存活致病菌的污染程度和评估灭菌效果,从而促进食品安全控制。
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引用次数: 0
Vaginal Sensors. 阴道传感器
IF 8.2 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-07-18 DOI: 10.1021/acssensors.4c00567
Kourosh Kalantar-Zadeh, Daniella Susic, Jon Hyett

The development and market emergence of vaginal sensors have begun to demonstrate their impact on women's healthcare. Until recently, in limited cases, these sensors have exhibited their capabilities in diagnosing and monitoring disorders of the vaginal tract during different stages of women's lives. This Perspective is a compilation of what has been accomplished so far in the landscape of vaginal sensors. The text explores the diverse types of vaginal sensor technologies, their applications, and their potential impact on women's healthcare. The review introduces the anatomy of the vagina and cervix and categorizes vaginal sensors that have been developed, highlighting the technologies and potential applications. The paper covers biomarkers of the vaginal tract and discusses their importance in maintaining the overall characteristics of the vaginal system. The text also explores the clinical implications of vaginal sensors in pregnancy monitoring, disease detection, and sexual health management. In the final step, the manuscript provides future perspectives and possibilities that can be incorporated in the emerging field of vaginal sensors.

阴道传感器的开发和市场兴起已开始证明其对妇女保健的影响。直到最近,这些传感器才在有限的案例中展示了它们在妇女生命的不同阶段诊断和监测阴道疾病的能力。本视角汇编了迄今为止在阴道传感器领域所取得的成就。文中探讨了各种类型的阴道传感器技术、其应用及其对妇女医疗保健的潜在影响。综述介绍了阴道和宫颈的解剖结构,并对已开发的阴道传感器进行了分类,重点介绍了相关技术和潜在应用。论文介绍了阴道的生物标志物,并讨论了它们在保持阴道系统整体特性方面的重要性。文中还探讨了阴道传感器在怀孕监测、疾病检测和性健康管理方面的临床意义。最后,手稿提出了阴道传感器这一新兴领域的未来前景和可能性。
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引用次数: 0
Facile Fabrication of Lilac-Like Multiple Self-Supporting WO3 Nanoneedle Arrays with Cubic/Hexagonal Phase Junctions for Highly Sensitive Ethylene Glycol Gas Sensors. 简易制备具有立方/六方相结的丁香花状多重自支撑 WO3 纳米针阵列,用于高灵敏度乙二醇气体传感器。
IF 8.2 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-07-17 DOI: 10.1021/acssensors.4c00600
Xiaohan Qu, Mingchun Li, Hanlin Mu, Bingbing Jin, Minggao Song, Kunlong Zhang, Yusheng Wu, Laishi Li, Yan Yu

Metal oxides with nanoarray structures have been demonstrated to be prospective materials for the design of gas sensors with high sensitivity. In this work, the WO3 nanoneedle array structures were synthesized by a one-step hydrothermal method and subsequent calcination. It was demonstrated that the calcination of the sample at 400 °C facilitated the construction of lilac-like multiple self-supporting WO3 arrays, with appropriate c/h-WO3 heterophase junction and highly oriented nanoneedles. Sensors with this structure exhibited the highest sensitivity (2305) to 100 ppm ethylene glycol at 160 °C and outstanding selectivity. The enhanced ethylene glycol gas sensing can be attributed to the abundant transport channels and active sites provided by this unique structure. In addition, the more oxygen adsorption caused by the heterophase junction and the aggregation of reaction medium induced by tip effect are both in favor of the improvement on the gas sensing performance.

具有纳米阵列结构的金属氧化物已被证明是设计高灵敏度气体传感器的前瞻性材料。本研究采用一步水热法合成了 WO3 纳米针状阵列结构,随后进行了煅烧。结果表明,在 400 °C 下煅烧样品有助于构建丁香状多自支撑 WO3 阵列,该阵列具有适当的 c/h-WO3 异相交界和高度取向的纳米针。具有这种结构的传感器对 160 °C 时的 100 ppm 乙二醇具有最高的灵敏度(2305)和出色的选择性。乙二醇气体传感的增强可归功于这种独特结构所提供的丰富传输通道和活性位点。此外,异相交界处产生的更多氧气吸附和尖端效应引起的反应介质聚集都有利于提高气体传感性能。
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引用次数: 0
Deep Learning Enabled Universal Multiplexed Fluorescence Detection for Point-of-Care Applications. 用于护理点应用的深度学习通用多路复用荧光检测。
IF 8.2 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-07-15 DOI: 10.1021/acssensors.4c00860
Aneesh Kshirsagar, Anthony J Politza, Weihua Guan

There is a significant demand for multiplexed fluorescence sensing and detection across a range of applications. Yet, the development of portable and compact multiplexable systems remains a substantial challenge. This difficulty largely stems from the inherent need for spectrum separation, which typically requires sophisticated and expensive optical components. Here, we demonstrate a compact, lens-free, and cost-effective fluorescence sensing setup that incorporates machine learning for scalable multiplexed fluorescence detection. This method utilizes low-cost optical components and a pretrained machine learning (ML) model to enable multiplexed fluorescence sensing without optical adjustments. Its multiplexing capability can be easily scaled up through updates to the machine learning model without altering the hardware. We demonstrate its real-world application in a probe-based multiplexed Loop-Mediated Isothermal Amplification (LAMP) assay designed to simultaneously detect three common respiratory viruses within a single reaction. The effectiveness of this approach highlights the system's potential for point-of-care applications that require cost-effective and scalable solutions. The machine learning-enabled multiplexed fluorescence sensing demonstrated in this work would pave the way for widespread adoption in diverse settings, from clinical laboratories to field diagnostics.

在一系列应用中,对多重荧光传感和检测的需求量很大。然而,开发便携式紧凑型多路复用系统仍然是一项巨大的挑战。这种困难主要源于光谱分离的内在需求,而光谱分离通常需要复杂而昂贵的光学元件。在这里,我们展示了一种结构紧凑、无需透镜且经济高效的荧光传感装置,该装置结合了机器学习技术,可用于可扩展的多路复用荧光检测。该方法利用低成本光学元件和预训练机器学习(ML)模型,无需光学调整即可实现多路复用荧光传感。通过对机器学习模型的更新,它的复用能力可以轻松扩展,而无需改变硬件。我们在基于探针的多路复用环路介导等温扩增(LAMP)检测中演示了它在现实世界中的应用,该检测旨在一次反应中同时检测三种常见的呼吸道病毒。这种方法的有效性凸显了该系统在需要具有成本效益和可扩展解决方案的护理点应用中的潜力。这项工作中展示的支持机器学习的多重荧光传感技术将为广泛应用于从临床实验室到现场诊断等各种环境铺平道路。
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引用次数: 0
Visible Light-Activated Room Temperature NO2 Gas Sensing Based on the In2O3@ZnO Heterostructure with a Hollow Microtube Structure. 基于具有空心微管结构的 In2O3@ZnO 异质结构的可见光激活型室温二氧化氮气体传感。
IF 8.2 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-07-12 DOI: 10.1021/acssensors.4c00919
Ying Li, Xiangyang Wei, Qingyuan Liu, Diming Zang, Rui You

The persistent challenge of poor recovery characteristics of NO2 sensors operated at room temperature remains significant. However, the development of In2O3-based gas sensing materials provides a promising approach to accelerate response and recovery for sub-ppm of NO2 detection at room temperature. Herein, we propose a simple two-step method to synthesize a one-dimensional (1D) In2O3@ZnO heterostructure material with hollow microtubes, by coupling metal-organic frameworks (MOFs) (MIL-68 (In)) and zinc ions. Meanwhile, the In2O3@ZnO composite-based gas sensor exhibits superior sensitivity performance to NO2 under visible light activation. The response value to 5 ppm of NO2 at room temperature is as high as 1800, which is 35 times higher than that of the pure In2O3-based sensor. Additionally, the gas sensor based on the In2O3@ZnO heterostructure demonstrates a significantly reduced response/recovery time of 30 s/67 s compared to the sensor based on pure In2O3 (74 s/235 s). The outstanding gas sensing properties of the In2O3@ZnO heterostructure-based sensors can be attributed to the enhanced photogenerated charge separation efficiency resulting from the heterostructure effect, and the improved receptor function toward NO2, which can increase the reactive sites and gas adsorption capacity. In summary, this work proposes a low-cost and efficient method to synthesize a 1D heterostructure material with microtube structures, which can serve as a fundamental technique for developing high-performance room-temperature gas sensors.

在室温下工作的二氧化氮传感器一直面临着恢复特性差的挑战。然而,基于 In2O3 的气体传感材料的开发为室温下检测亚ppm 二氧化氮提供了一种有望加快响应和恢复的方法。在此,我们提出了一种简单的两步法,通过耦合金属有机框架(MOFs)(MIL-68 (In))和锌离子,合成具有空心微管的一维(1D)In2O3@ZnO 异质结构材料。同时,基于 In2O3@ZnO 复合材料的气体传感器在可见光激活条件下对二氧化氮表现出卓越的灵敏度。室温下对 5 ppm 二氧化氮的响应值高达 1800,是纯 In2O3 传感器的 35 倍。此外,与基于纯 In2O3 的传感器(74 秒/235 秒)相比,基于 In2O3@ZnO 异质结构的气体传感器的响应/恢复时间大大缩短,分别为 30 秒/67 秒。基于 In2O3@ZnO 异质结构的传感器之所以具有出色的气体传感性能,是因为异质结构效应提高了光生电荷分离效率,并改善了对 NO2 的受体功能,从而增加了反应位点和气体吸附能力。综上所述,本研究提出了一种低成本、高效率合成微管结构一维异质结构材料的方法,可作为开发高性能室温气体传感器的基础技术。
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引用次数: 0
Ultradense Array of On-Chip Sensors for High-Throughput Electrochemical Analyses. 用于高通量电化学分析的超密集片上传感器阵列
IF 8.2 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-07-12 DOI: 10.1021/acssensors.4c01026
Lucas B Ayres, Gabriel J C Pimentel, Juliana N Y Costa, Maria H O Piazzetta, Angelo L Gobbi, Flávio M Shimizu, Carlos D Garcia, Renato S Lima

High-throughput sensors are valuable tools for enabling massive, fast, and accurate diagnostics. To yield this type of electrochemical device in a simple and low-cost way, high-density arrays of vertical gold thin-film microelectrode-based sensors are demonstrated, leading to the rapid and serial interrogation of dozens of samples (10 μL droplets). Based on 16 working ultramicroelectrodes (UMEs) and 3 quasi-reference electrodes (QREs), a total of 48 sensors were engineered in a 3D crossbar arrangement that devised a low number of conductive lines. By exploiting this design, a compact chip (75 × 35 mm) can enable performing 16 sequential analyses without intersensor interferences by dropping one sample per UME finger. In practice, the electrical connection to the sensors was achieved by simply switching the contact among WE adjacent fingers. Importantly, a short analysis time was ensured by interrogating the UMEs with chronoamperometry or square wave voltammetry using a low-cost and hand-held one-channel potentiostat. As a proof of concept, the detection of Staphylococcus aureus in 15 samples was performed within 14 min (20 min incubation and 225 s reading). Additionally, the implementation of peptide-tethered immunosensors in these chips allowed the screening of COVID-19 from patient serum samples with 100% accuracy. Our experiments also revealed that dispensing additional droplets on the array (in certain patterns) results in the overestimation of the faradaic current signals, a phenomenon referred to as crosstalk. To address this interference, a set of analyses was conducted to design a corrective strategy that boosted the testing capacity by allowing using all on-chip sensors to address subsequent analyses (i.e., 48 samples simultaneously dispensed on the chip). This strategy only required grounding the unused rows of QRE and can be broadly adopted to develop high-throughput UME-based sensors. In practice, we could analyze 48 droplets (with [Fe(CN)6]4-) within ∼8 min using amperometry.

高通量传感器是实现大规模、快速和准确诊断的重要工具。为了以简单、低成本的方式生产这种类型的电化学装置,我们展示了基于垂直金薄膜微电极的高密度传感器阵列,可对数十个样品(10 μL 液滴)进行快速、连续的检测。基于 16 个工作超微电极 (UME) 和 3 个准参比电极 (QRE),共设计了 48 个传感器,采用三维横杆排列,导电线数量较少。利用这种设计,一个紧凑型芯片(75 × 35 毫米)就能在每个 UME 手指上放置一个样本,从而在没有传感器干扰的情况下进行 16 次连续分析。在实际操作中,只需在相邻的 WE 指之间切换触点,即可实现与传感器的电气连接。重要的是,通过使用低成本的手持式单通道恒电位仪,用计时安培法或方波伏安法询问 UME,确保了较短的分析时间。作为概念验证,15 份样品中金黄色葡萄球菌的检测在 14 分钟内完成(培养 20 分钟,读数 225 秒)。此外,在这些芯片中实施肽系免疫传感器后,从患者血清样本中筛选 COVID-19 的准确率达到了 100%。我们的实验还发现,在阵列上分配额外的液滴(以特定的模式)会导致高估法拉第电流信号,这种现象被称为串扰。为了解决这种干扰,我们进行了一系列分析,设计出一种纠正策略,通过使用所有芯片上的传感器来处理后续分析(即在芯片上同时分配 48 个样品),从而提高测试能力。这种策略只需将 QRE 未使用的行接地,可广泛用于开发基于 UME 的高通量传感器。实际上,我们可以在 8 分钟内利用安培法分析 48 个液滴(含[Fe(CN)6]4-)。
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引用次数: 0
Multipressure Sampling for Improving the Performance of MOF-based Electronic Noses. 多压力取样技术用于提高基于 MOF 的电子鼻的性能。
IF 8.2 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-07-12 DOI: 10.1021/acssensors.4c00199
Brian A Day, Nicolas I Ahualli, Christopher E Wilmer

Metal-organic frameworks (MOFs) are a promising class of porous materials for the design of gas sensing arrays, which are often called electronic noses. Due to their chemical and structural tunability, MOFs are a highly diverse class of materials that align well with the similarly diverse class of volatile organic compounds (VOCs) of interest in many gas detection applications. In principle, by choosing the right combination of cross-sensitive MOFs, layered on appropriate signal transducers, one can design an array that yields detailed information about the composition of a complex gas mixture. However, despite the vast number of MOFs from which one can choose, gas sensing arrays that rely too heavily on distinct chemistries can be impractical from the cost and complexity perspective. On the other hand, it is difficult for small arrays to have the desired selectivity and sensitivity for challenging sensing applications, such as detecting weakly adsorbing gases with weak signals, or conversely, strongly adsorbing gases that readily saturate MOF pores. In this work, we employed gas adsorption simulations to explore the use of a variable pressure sensing array as a means of improving both sensitivity and selectivity as well as increasing the information content provided by each array. We studied nine different MOFs (HKUST-1, IRMOF-1, MgMOF-74, MOF-177, MOF-801, NU-100, NU-125, UiO-66, and ZIF-8) and four different gas mixtures, each containing nitrogen, oxygen, carbon dioxide, and exactly one of the hydrogen, methane, hydrogen sulfide, or benzene. We found that by lowering the pressure, we can limit the saturation of MOFs, and by raising the pressure, we can concentrate weakly adsorbing gases, in both cases, improving gas detection with the resulting arrays. In many cases, changing the system pressure yielded a better improvement in performance (as measured by the Kullback-Liebler divergence of gas composition probability distributions) than including additional MOFs. We thus demonstrated and quantified how sensing at multiple pressures can increase information content and cross-sensitivity in MOF-based arrays while limiting the number of unique materials needed in the device.

金属有机框架(MOFs)是一类很有前途的多孔材料,可用于设计气体传感阵列,这种阵列通常被称为 "电子鼻"。由于其化学和结构的可调性,MOFs 是一类高度多样化的材料,与许多气体检测应用中所关注的同样多样化的挥发性有机化合物 (VOC) 非常吻合。原则上,通过选择交叉敏感 MOFs 的正确组合,并在适当的信号传感器上分层,就可以设计出一个阵列,提供有关复杂气体混合物成分的详细信息。然而,尽管可以选择的 MOF 种类繁多,但从成本和复杂性的角度来看,过于依赖不同化学成分的气体传感阵列是不切实际的。另一方面,对于具有挑战性的传感应用来说,小型阵列很难具有所需的选择性和灵敏度,例如检测弱吸附性气体时信号很弱,或者相反,强吸附性气体很容易使 MOF 孔隙饱和。在这项研究中,我们利用气体吸附模拟来探索如何使用可变压力传感阵列来提高灵敏度和选择性,并增加每个阵列提供的信息含量。我们研究了九种不同的 MOF(HKUST-1、IRMOF-1、MgMOF-74、MOF-177、MOF-801、NU-100、NU-125、UiO-66 和 ZIF-8)和四种不同的气体混合物,每种混合物都含有氮气、氧气、二氧化碳以及氢气、甲烷、硫化氢或苯中的一种。我们发现,通过降低压力,我们可以限制 MOF 的饱和度,而通过提高压力,我们可以集中弱吸附气体。在许多情况下,改变系统压力比添加额外的 MOFs 更能提高性能(以气体成分概率分布的库尔贝克-李布勒发散度来衡量)。因此,我们展示并量化了在多种压力下进行传感如何提高基于 MOF 阵列的信息含量和交叉灵敏度,同时限制装置中所需独特材料的数量。
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引用次数: 0
From Organ-on-a-Chip to Human-on-a-Chip: A Review of Research Progress and Latest Applications. 从芯片上的器官到芯片上的人:研究进展和最新应用综述。
IF 8.2 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-07-11 DOI: 10.1021/acssensors.4c00004
Yisha Huang, Tong Liu, Qi Huang, Yuxi Wang

Organ-on-a-Chip (OOC) technology, which emulates the physiological environment and functionality of human organs on a microfluidic chip, is undergoing significant technological advancements. Despite its rapid evolution, this technology is also facing notable challenges, such as the lack of vascularization, the development of multiorgan-on-a-chip systems, and the replication of the human body on a single chip. The progress of microfluidic technology has played a crucial role in steering OOC toward mimicking the human microenvironment, including vascularization, microenvironment replication, and the development of multiorgan microphysiological systems. Additionally, advancements in detection, analysis, and organoid imaging technologies have enhanced the functionality and efficiency of Organs-on-Chips (OOCs). In particular, the integration of artificial intelligence has revolutionized organoid imaging, significantly enhancing high-throughput drug screening. Consequently, this review covers the research progress of OOC toward Human-on-a-chip, the integration of sensors in OOCs, and the latest applications of organoid imaging technologies in the biomedical field.

芯片上器官(OOC)技术是在微流控芯片上模拟人体器官的生理环境和功能,目前正在经历重大的技术进步。尽管该技术发展迅速,但也面临着明显的挑战,如缺乏血管化、多器官芯片系统的开发以及在单个芯片上复制人体等。微流控技术的进步在引导 OOC 模拟人体微环境方面发挥了至关重要的作用,包括血管化、微环境复制和多器官微生理系统的开发。此外,检测、分析和类器官成像技术的进步也提高了片上器官(OOC)的功能和效率。特别是,人工智能的集成彻底改变了类器官成像技术,大大提高了高通量药物筛选的能力。因此,本综述涵盖了 OOC 走向片上人体的研究进展、传感器在 OOC 中的集成以及类器官成像技术在生物医学领域的最新应用。
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引用次数: 0
Pt Loading of Phosphorus-Doped Carbon Nanotube Aerogels in Fuel Cell-Type Gas Sensors for Ultrasensitive H2 Detection. 燃料电池型气体传感器中掺磷碳纳米管气凝胶的铂负载,用于超灵敏 H2 检测。
IF 8.2 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-07-10 DOI: 10.1021/acssensors.4c00948
Lingchu Huang, Huaiyuan Sun, Weijia Li, Jianyu Zhang, Sitong Feng, Qi Lu, Tong Wang, Xishuang Liang, Fangmeng Liu, Fengmin Liu, Geyu Lu

A phosphorus-doped carbon nanotube (CNT) aerogel as the support material was loaded with Pt nanoparticles in fuel cell-type gas sensors for ultrasensitive H2 detection. The high surface area of the CNT scaffold is favorable to providing abundant active sites, and the high electrical conductivity facilitates the transport of carriers generated by electrochemical reactions. In addition, the CNT aerogel was doped with phosphorus (P) to further enhance the conductivity and electrochemical catalytic activity. As a result, the fuel cell-type gas sensor using the Pt/CNT aerogel doped with the optimal P content as the sensing material shows considerable performance for H2 detection at room temperature. The sensor exhibits an ultrahigh response of -921.9 μA to 15,000 ppm of H2. The sensitivity is -0.063 μA/ppm, which is 21 times higher than that of the conventional Pt/CF counterpart. The sensor also exhibits excellent repeatability and humidity resistance, as well as fast response/recovery; the response/recovery times are 31 and 4 s to 3000 ppm of H2, respectively. The modulation of the structure and catalytic properties of the support material is responsible for the improvement of the sensor performance, thus providing a feasible solution for optimizing the performance of fuel cell-type gas sensors.

以掺磷碳纳米管(CNT)气凝胶为支撑材料,在燃料电池型气体传感器中负载铂纳米粒子,用于超灵敏 H2 检测。碳纳米管支架的高表面积有利于提供丰富的活性位点,而高导电性则有利于电化学反应产生的载流子的传输。此外,为了进一步提高导电性和电化学催化活性,还在 CNT 气凝胶中掺入了磷(P)。因此,使用掺杂了最佳磷含量的铂/CNT 气凝胶作为传感材料的燃料电池型气体传感器在室温下检测 H2 方面表现出了相当高的性能。该传感器对 15,000 ppm 的 H2 具有 -921.9 μA 的超高响应。灵敏度为 -0.063 μA/ppm,是传统 Pt/CF 同等材料的 21 倍。该传感器还具有出色的重复性和耐湿性,以及快速响应/恢复能力;对 3000 ppm H2 的响应/恢复时间分别为 31 秒和 4 秒。对支撑材料的结构和催化特性进行调节是提高传感器性能的关键,从而为优化燃料电池型气体传感器的性能提供了可行的解决方案。
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引用次数: 0
Ambipolar Heterojunction Sensors: Another Way to Detect Polluting Gases Ambipolar 异质结传感器:检测污染气体的另一种方法
IF 8.9 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-07-10 DOI: 10.1021/acssensors.4c00900
Sujithkumar Ganesh Moorthy, Seydou Ouedraogo, Marcel Bouvet
Gas sensors based on ambipolar materials offer significant advantages in reducing the size of the analytical system and enhancing its efficiency. Here, bilayer heterojunction devices are constructed using different octafluorinated phthalocyanine complexes, with Zn and Co as metal centers, combined with a lutetium bisphthalocyanine complex (LuPc2). Stable p-type behavior is observed for the ZnF8Pc/LuPc2 device under both electron-donating (NH3) and -oxidizing (NO2 and O3) gaseous species, while the CoF8Pc/LuPc2 device exhibits n-type behavior under reducing gases and p-type behavior under oxidizing gases. The nature of majority of the charge carriers of Co-based devices varies depending on the nature of target gases, displaying an ambipolar behavior. Both heterojunction devices demonstrate stable and observable response toward all three toxic gases in the sub-ppm range. Remarkably, the Co-based device is highly sensitive toward ammonia with a limit of detection (LOD) of 200 ppb, whereas the Zn-based device demonstrates exceptional sensitivity toward oxidizing gases, with excellent LOD values of 4.9 and 0.75 ppb toward NO2 and O3, respectively, which makes it one of the most effective organic heterojunction sensors reported so far for oxidizing gases.
基于双极材料的气体传感器在缩小分析系统尺寸和提高分析系统效率方面具有显著优势。本文利用不同的八氟酞菁配合物(以 Zn 和 Co 为金属中心),结合双酞菁镥配合物(LuPc2),构建了双层异质结器件。ZnF8Pc/LuPc2 器件在电子捐献(NH3)和氧化(NO2 和 O3)两种气体中均表现出稳定的 p 型行为,而 CoF8Pc/LuPc2 器件在还原气体中表现出 n 型行为,在氧化气体中表现出 p 型行为。Co 基器件的大部分电荷载流子的性质因目标气体的性质而异,表现出一种两极行为。这两种异质结器件在亚ppm范围内对所有三种有毒气体都表现出稳定和可观察的响应。值得注意的是,钴基器件对氨气高度敏感,检测限(LOD)为 200 ppb,而锌基器件对氧化性气体异常敏感,对 NO2 和 O3 的检测限分别为 4.9 和 0.75 ppb,这使其成为迄今为止报道的对氧化性气体最有效的有机异质结传感器之一。
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