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Role of “NAFLAN” Immune (Nasal/ Oral) Spray in Prevention of Respiratory Virus Infections (Including COVID 19) in Indian Volunteers: The Preliminary Report of a Phase 1 Clinical Trial “NAFLAN”免疫(鼻/口服)喷雾剂在预防印度志愿者呼吸道病毒感染(包括COVID - 19)中的作用:一项1期临床试验的初步报告
Pub Date : 1900-01-01 DOI: 10.37179/rijcmph.000011
S. Davey
Background & Object൴ves: The Immune-modulat൴ng Nutr൴t൴onal Supplements based on Grapeseeds r൴ch ൴n Sterols and V൴tam൴ns can be useful ൴n Management of Resp൴ratory V൴ral ൴nfect൴ons ൴nclud൴ng COVID 19, but stud൴es reveal൴ng the൴r comb൴ned eff ects are lack൴ng ൴n l൴terature. Therefore the German manufactured Oro-Nasal Immune spray (NAFLAN- A Nutr൴t൴onal Supplements Product) based on comb൴nat൴on of Plant Sterols & V൴tam൴n, B, D, E needs urgent explorat൴on ൴n context of Preva൴l൴ng COVID 19 Pandem൴c across the world ൴nclud൴ng Ind൴a. Methods: Th൴s cl൴n൴cal tr൴al was done on 40 healthy Volunteers, as part of a Phase 1 tr൴al Project of Pure Derm GmBH, Germany for ൴ts evaluat൴on ൴n Management of Resp൴ratory Infect൴ons ൴nclud൴ng COVID 19. The volunteers were selected from an NGO Hosp൴tal and th൴s tr൴al was enrolled at CTRI ICMR Ind൴a and conducted accord൴ng to WHO, PATH & CONSORT gu൴del൴nes . Tr൴al was done from 15th March 2021- 15th June 2021 ൴n wh൴ch th൴s Immune spray was used for 1 month (1st May 2021- 31st May). Th൴s Cl൴n൴cal tr൴al ൴ncluded all types of COVID 19 ൴nclud൴ng Ind൴an Mutat൴on Delta Var൴ant. Results: Symptoms such as Cough and D൴arrhoea were reduced s൴gn൴f൴cantly after use of Immune( Nafl an Spray) [χ2 =9.25 (Yates Correct൴on), P <0.05, RR Adjusted=1.8, 95% C.I=1.5-2.1], but no eff ect on h൴gh fever, headache, and Common cold were seen. Interpretation & Conclusions: Nafalan Spray can be useful in Prevention of Cough in Respiratory Infections (possibly also COVID 19). However Large scale Multicentric trial is however advocated by authors before reaching a more defi nite conclusion of role of Nafalan Spray in Prevention of COVID 19 Infection.
背景和对象类型൴:Immune-modulat൴ng减轻൴t൴补充传统基于葡萄籽r൴ch൴n固醇和V൴tam൴ns可能有用൴n Resp൴管理室内V൴、൴nfect൴ons൴nclud൴ng COVID 19日,但螺栓൴es揭示൴ng൴r梳子൴ned颜色缺少൴ng൴n l൴terature。因此德国制造Oro-Nasal免疫喷雾(NAFLAN——减轻൴t൴传统补充剂产品)基于梳൴nat൴植物固醇& V൴tam൴n, B, D, E迫切需要工作൴൴n的Preva൴l൴ng COVID 19 Pandem൴c全世界൴nclud൴ng印第安纳൴。方法:Th൴s cl൴n൴卡尔tr൴al是40个健康的志愿者,作为第一阶段的一部分,tr൴al项目纯真皮GmBH德国൴ts evaluat൴൴n管理职责൴室内感染൴ons൴nclud൴ng COVID 19。志愿者是从一家非政府组织医院൴tal中挑选出来的,而这些志愿者则是在CTRI ICMR Ind൴a中注册的,并在൴del൴nes中与世卫组织、PATH和CONSORT进行了协议൴。试验൴于2021年3月15日至2021年6月15日进行൴n,其中൴ch൴的免疫喷雾使用了一个月(2021年5月1日至5月31日)。Th൴s Cl൴n൴卡尔tr൴al൴ncluded所有类型的COVID 19൴nclud൴ng印第安纳൴一个Mutat൴三角洲Var൴ant。结果:使用免疫(Nafl和Spray)后,患者咳嗽、൴腹泻等症状明显减轻(൴gn൴൴)[χ2 =9.25 (Yates Correct൴on), P <0.05, RR调整=1.8,95% ci =1.5 ~ 2.1],但对൴高热、头痛、普通感冒无明显影响。解释和结论:纳夫兰喷雾剂可用于预防呼吸道感染(可能也包括COVID - 19)的咳嗽。然而,作者主张在Nafalan Spray预防COVID - 19感染的作用得到更明确的结论之前,进行大规模的多中心试验。
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引用次数: 0
Evaluate the Effectiveness of Virtual Health Education Program on Covid-19 Vaccination 评估Covid-19疫苗虚拟健康教育项目的有效性
Pub Date : 1900-01-01 DOI: 10.37179/rijcmph.000012
X. S. Blessing NimaSajai
The Kingdom of Saudi Arabia (KSA) was one of the very fi rst countries in the world to grant emergency use authorization to the BNT162b2 vaccine, a new type of modifi ed RNA vaccine developed by Pfi zer-BioNTech. Here, we review various COVID-19 vaccines and the success of the vaccine rollout in KSA. Pfi zer/ BioNTech is currently being used at all vaccination centers in the KSA. Kingdom Of Saudi Arabia aim is to make the COVID-19 vaccine available to all citizens and residents within the coming months, based on a phased strategic plan to limit the impact the COVID-19 virus on our community and our critical infrastructure. People should get knowledge regarding vaccination and get benefi t of it. So, it was important to create awareness among the people residing inside the Kingdom to safeguard themselves and others, due to current pandemic situation physical gathering to give group health education is not applicable and only way to impart knowledge through online (virtual), therefore as the faculty of Applied Medical Science College For Females At Alnamas, University Of Bisha I selected this study to Evaluate The Eff ectiveness Of Virtual Health Education Program On Covid-19 Vaccination Among The People Residing At Selected Areas In Alnamas. The tool used for the research study was demographic data, virtual health education program, semi structured awareness scale and knowledge online questionnaire to assess the knowledge on Covid-19 vaccination. Before conducting the study, formal permission was obtained. Informed consent was obtained from the participants. The period of data collection was done for 4 weeks. The researcher introduced self to each subject and explained the purpose of the study and assessed the knowledge level before conducting virtual health education program on Covid-19 vaccination. After fi nishing virtual health education program again, the knowledge level was assessed. Data analysis was done according to the objectives of the study using descriptive statistics and inferential statistics. Frequency percentage mean and standard deviation were used for the analysis. Study fi ndings reveals that the virtual health education program is eff ective, and which was evidenced by the gain in posttest knowledge score was signifi cant at 0.05 level of signifi cant and the value of z is-7.2477. and the value of p is <. 00001.. The result is signifi cant at p < .05. Findings revealed that virtual health education program on Covid -19 vaccination among people age between 18 years to 65 years and above was an eff ective teaching strategy in gaining knowledge among the people. The fi ndings also revealed that there was signifi cant association between knowledge level and education of the participant, received any information before regarding Covid-19 vaccination. But there is no association between knowledge level and age, citizenship, family income per –month. Health care professionals can create awareness among general public regarding Covid-
沙特阿拉伯王国(KSA)是世界上最早授予BNT162b2疫苗紧急使用授权的国家之一,BNT162b2疫苗是Pfi - biontech开发的一种新型修饰RNA疫苗。在这里,我们回顾了各种COVID-19疫苗以及疫苗在沙特的成功推广。目前,KSA的所有疫苗接种中心都在使用Pfi / BioNTech。沙特阿拉伯王国的目标是根据一项分阶段战略计划,在未来几个月内向所有公民和居民提供COVID-19疫苗,以限制COVID-19病毒对我们社区和关键基础设施的影响。人们应该获得有关疫苗接种的知识并从中受益。因此,重要的是要在居住在王国境内的人们中建立保护自己和他人的意识,由于目前的大流行情况,通过物理聚集进行群体健康教育是不适用的,唯一的方式是通过在线(虚拟)传授知识,因此,作为阿尔纳马斯女子应用医学学院的教师,Bisha大学选择本研究来评估Alnamas选定地区居住人群中Covid-19疫苗虚拟健康教育计划的有效性。研究工具采用人口统计数据、虚拟健康教育计划、半结构化认知量表和知识在线问卷来评估Covid-19疫苗接种知识。在进行研究之前,已获得正式许可。获得了参与者的知情同意。数据收集期为4周。研究人员在进行新冠病毒疫苗虚拟健康教育之前,向每位研究对象进行了自我介绍,解释了研究目的,并评估了知识水平。再次完成虚拟健康教育项目后,评估知识水平。根据研究目的,采用描述性统计和推理统计对数据进行分析。使用频率百分比平均值和标准差进行分析。研究结果表明,虚拟健康教育计划是有效的,测试后知识得分的增加在显著性水平0.05和z -7.2477的值上显著。p的值是<。00001 . .p < 0.05,差异有统计学意义。结果表明,在18岁至65岁及以上人群中开展Covid -19疫苗虚拟健康教育是一种有效的教育策略。研究结果还显示,参与者的知识水平与受教育程度之间存在显着关联,他们在接种新冠病毒疫苗之前接受了任何信息。但知识水平与年龄、国籍、家庭月收入之间没有关联。卫生保健专业人员可以提高公众对Covid-19疫苗接种的认识,澄清他们对Covid-19疫苗接种的疑虑,并使社区免受Covid-19大流行的影响。
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引用次数: 0
Aerobic Capacity and Regular Physical Exercise among Tobacco Smokers 吸烟者的有氧能力与定期体育锻炼
Pub Date : 1900-01-01 DOI: 10.37179/rijcmph.000010
Anees Alyafei
Background: The Aerobic capacity is a well-recognized indicator for cardiopulmonary fi tness, which is aff ected by many factors, including tobacco use. Tobacco smoking is also known for its toxic eff ects on the cardiopulmonary system. Thus, aerobic capacity change is an exciting area for discussion among tobacco smokers, parallel to the cardiopulmonary eff ect. There is signifi cant agreement that aerobic capacity is reduced in tobacco smokers and improves by regular physical exercise in a dose-related manner. Few scattered studies showed minimal or no eff ect of physical exercise on aerobic capacity. Further clinical trials need to assess the impact of physical exercise and related improving & suppresser factors on the aerobic capacity among tobacco smokers.
背景:有氧能力是一个公认的心肺健康指标,它受到许多因素的影响,包括烟草使用。吸烟也因其对心肺系统的毒性作用而闻名。因此,有氧能力的变化是吸烟者讨论的一个令人兴奋的领域,与心肺效应平行。有一项重要的共识是,吸烟者的有氧能力会降低,而定期体育锻炼会以剂量相关的方式提高有氧能力。一些零散的研究表明,体育锻炼对有氧能力的影响很小或没有影响。进一步的临床试验需要评估体育锻炼和相关的改善和抑制因素对吸烟者有氧能力的影响。
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引用次数: 3
期刊
Research International Journal of Community Medicine and Public Health
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