In the food sector, the problem of food fraud—which encompasses the more focused category of adulteration driven by economic gain—is becoming more widely acknowledged and is raising concerns. Both the government and the industry are accountable for avoiding food adulteration, regardless of where the food danger originated. Food adulteration can result from incidents concerning food safety, food fraud, and food defence, which poses serious risks to the general public's health. In contrast to inadvertent injury in food safety events and intentional harm in food defence incidents, food fraud entails intentional activities for financial gain. Although financially motivated adulteration may have financial motivations, the unusual nature of contaminants frequently makes the related public health hazards more dangerous than traditional food safety threats. Establishing and executing a database that aggregates reports of food component fraud available for publicly accessible sources is an essential task. For governments, agencies, and individual enterprises assessing the possible dangers associated with certain items created in specific regions and those disseminated and sold elsewhere, this database provides essential information and useful data. The paper also describes current analytical tools for identifying food fraud and highlights new developments and trends in the food production industry and the food production bad sector.
{"title":"Robust Chemical Testing for Food Safety: Assessing and Identifying Dye Adulterants in Blueberry Juice: A Comprehensive Case Study with Statistical Measures and Correlation Analysis","authors":"S. Bhandare","doi":"10.55121/fds.v1i1.145","DOIUrl":"https://doi.org/10.55121/fds.v1i1.145","url":null,"abstract":"In the food sector, the problem of food fraud—which encompasses the more focused category of adulteration driven by economic gain—is becoming more widely acknowledged and is raising concerns. Both the government and the industry are accountable for avoiding food adulteration, regardless of where the food danger originated. Food adulteration can result from incidents concerning food safety, food fraud, and food defence, which poses serious risks to the general public's health. In contrast to inadvertent injury in food safety events and intentional harm in food defence incidents, food fraud entails intentional activities for financial gain. Although financially motivated adulteration may have financial motivations, the unusual nature of contaminants frequently makes the related public health hazards more dangerous than traditional food safety threats. Establishing and executing a database that aggregates reports of food component fraud available for publicly accessible sources is an essential task. For governments, agencies, and individual enterprises assessing the possible dangers associated with certain items created in specific regions and those disseminated and sold elsewhere, this database provides essential information and useful data. The paper also describes current analytical tools for identifying food fraud and highlights new developments and trends in the food production industry and the food production bad sector.","PeriodicalId":514346,"journal":{"name":"Food and Drug Safety","volume":" 68","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This comprehensive study focus into various facets of food safety, covering controversial topics such as the bisphenol A (BPA) tolerable daily intake set by EFSA and challenges in aggregating data from food allergen immunotherapy trials. It also explores the evaluation of isomaltulose syrup as a novel food and emphasises the significance of a One Health perspective in addressing pathogenic Clostridia. Additionally, the study highlights the pivotal role of genomic resources in understanding persistence and virulence. Through a multidisciplinary lens, the study provides insights into current advancements, offering a scientific understanding of the evolving landscape of food safety.
这项综合研究关注食品安全的方方面面，涉及欧洲食品安全局（EFSA）设定的双酚 A (BPA) 每日耐受摄入量等有争议的话题，以及汇总食物过敏原免疫疗法试验数据所面临的挑战。研究还探讨了异麦芽糖浆作为新型食品的评估问题，并强调了 "一体健康 "观点在应对致病性梭状芽孢杆菌方面的重要意义。此外，该研究还强调了基因组资源在了解持久性和毒力方面的关键作用。通过多学科视角，该研究深入探讨了当前的进展，提供了对不断变化的食品安全状况的科学理解。
{"title":"Advancements in Food Safety: From Novel Approaches to Controversies and One Health Perspectives","authors":"S. Bhandare","doi":"10.55121/fds.v1i1.149","DOIUrl":"https://doi.org/10.55121/fds.v1i1.149","url":null,"abstract":"This comprehensive study focus into various facets of food safety, covering controversial topics such as the bisphenol A (BPA) tolerable daily intake set by EFSA and challenges in aggregating data from food allergen immunotherapy trials. It also explores the evaluation of isomaltulose syrup as a novel food and emphasises the significance of a One Health perspective in addressing pathogenic Clostridia. Additionally, the study highlights the pivotal role of genomic resources in understanding persistence and virulence. Through a multidisciplinary lens, the study provides insights into current advancements, offering a scientific understanding of the evolving landscape of food safety.","PeriodicalId":514346,"journal":{"name":"Food and Drug Safety","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141682671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gul-e-Saba Chaudhry, †. Zeenia, Abdah, Yeong Yik Sung, T. Sifzizul, Tengku Muhammad
Cancer remains a formidable global health challenge, necessitating sustained research efforts to develop innovative and efficacious therapeutic modalities. The exploration of alternative cancer therapies has gained prominence, given the adverse side effects associated with conventional treatments like chemotherapy. Natural medicines, particularly those derived from botanical sources, emerge as a potentially more viable option for cancer treatment within the confines of therapeutic and safe dosage parameters. This comprehensive review elucidates the effective mechanisms and safety profiles related to the dosage of these natural compounds. The literature under consideration spans and has been meticulously curated from reputable databases, including PubMed, Scopus, and Google Scholar. Noteworthy natural substances encompassed in this scrutiny include gossypol, curcumin, resveratrol, genistein, anthocyanin, and hispidulin. The review outlines their respective mechanisms, therapeutic dosages, and safety perspectives within the context of cancer treatment. These compounds manifest diverse anticancer effects, ranging from the induction of apoptosis and inhibition of cell proliferation to the modulation of crucial signaling pathways. These natural compounds exhibit promising anticancer potential by targeting key facets of cancer progression, notably by i) instigating apoptosis and ii) intervening in cell cycle checkpoints. However, a more strategic and nuanced investigation is imperative to fully elucidate their optimal dosages, modes of action, and potential synergies with existing cancer treatment modalities. This critical gap in our understanding underscores the necessity for further in-depth research to optimize the therapeutic potential of these plant-derived chemicals.
癌症仍然是一项严峻的全球健康挑战，因此需要持续开展研究工作，开发创新而有效的治疗方法。鉴于化疗等传统疗法的不良副作用，对癌症替代疗法的探索日益突出。在符合治疗和安全剂量参数的前提下，天然药物，尤其是那些从植物中提取的药物，有可能成为治疗癌症的一种更可行的选择。本综述阐明了这些天然化合物的有效机制以及与用量相关的安全性。本综述所涉及的文献跨度很大，而且是从 PubMed、Scopus 和 Google Scholar 等著名数据库中精心筛选出来的。值得注意的天然物质包括棉酚、姜黄素、白藜芦醇、染料木素、花青素和糙皮素。综述概述了它们各自的机制、治疗剂量以及在癌症治疗中的安全性。这些化合物具有多种抗癌作用，从诱导细胞凋亡、抑制细胞增殖到调节关键信号通路，不一而足。这些天然化合物针对癌症进展的关键环节，特别是通过 i) 诱导细胞凋亡和 ii) 干预细胞周期检查点，表现出了良好的抗癌潜力。然而，要充分阐明它们的最佳剂量、作用模式以及与现有癌症治疗方法的潜在协同作用，必须进行更具战略性和细致入微的研究。我们认识上的这一重大差距突出表明，有必要进一步深入研究，以优化这些植物源化学物质的治疗潜力。
{"title":"Comprehensive Review on Mechanistic Insights, Optimal Dosages, and Safety Prospective of Natural Products in Anticancer Therapeutics","authors":"Gul-e-Saba Chaudhry, †. Zeenia, Abdah, Yeong Yik Sung, T. Sifzizul, Tengku Muhammad","doi":"10.55121/fds.v1i1.137","DOIUrl":"https://doi.org/10.55121/fds.v1i1.137","url":null,"abstract":"Cancer remains a formidable global health challenge, necessitating sustained research efforts to develop innovative and efficacious therapeutic modalities. The exploration of alternative cancer therapies has gained prominence, given the adverse side effects associated with conventional treatments like chemotherapy. Natural medicines, particularly those derived from botanical sources, emerge as a potentially more viable option for cancer treatment within the confines of therapeutic and safe dosage parameters. This comprehensive review elucidates the effective mechanisms and safety profiles related to the dosage of these natural compounds. The literature under consideration spans and has been meticulously curated from reputable databases, including PubMed, Scopus, and Google Scholar. Noteworthy natural substances encompassed in this scrutiny include gossypol, curcumin, resveratrol, genistein, anthocyanin, and hispidulin. The review outlines their respective mechanisms, therapeutic dosages, and safety perspectives within the context of cancer treatment. These compounds manifest diverse anticancer effects, ranging from the induction of apoptosis and inhibition of cell proliferation to the modulation of crucial signaling pathways. These natural compounds exhibit promising anticancer potential by targeting key facets of cancer progression, notably by i) instigating apoptosis and ii) intervening in cell cycle checkpoints. However, a more strategic and nuanced investigation is imperative to fully elucidate their optimal dosages, modes of action, and potential synergies with existing cancer treatment modalities. This critical gap in our understanding underscores the necessity for further in-depth research to optimize the therapeutic potential of these plant-derived chemicals.","PeriodicalId":514346,"journal":{"name":"Food and Drug Safety","volume":"61 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139440848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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