Emerging and promising tools against cancer are theranosticnnanoplatformsnthat combine imaging and therapy. A major challenge is unsatisfactorynantitumor efficiency, which is accompanied by a great risk of tumornrelapse. Therefore, a multimodal therapeutic functional strategy isnhighly desirable that can eradicate tumors, preventing tumor relapsesnand impeding the metastases. Therefore, a combination of photoimmunotherapynin a single therapeutic nanoplatform for efficient tumor-targetedntherapy is an efficient task. Herein, we designed a theranostic conjugatednpolymer polyaniline (PANi)-based synergistic therapeutic model fornphotothermal immunotherapy (PIT)composed of the EA-PANi@ICG/CpG-FAnnanocomposite (NC). This nanosystem was combined with a phototheranosticnagent (ICG) with immunomodulation (CpG). On the one hand, PANi promotesnphotothermal immunogenic cell death (ICD) upon NIR-light irradiation;ndying tumors discharge damage-associated molecular pattern signalsnsuch as HMBG1, CRT, and ATP, thereby encouraging DC maturation andnactivation of cytotoxic T lymphocytes. Furthermore, to improve thenimmune response, CpG promotes the TLR-9 activation in the tumor microenvironment.nTherefore, the combinatorial action of NC with CpG leads to completeninhibition of tumor regression by a strong antitumor immune memoryneffect. We explore that the synergistic effect of the NC in targetedntumor cells improves excellent antitumor effects that have been achievednby photoimmunotherapeutic tactics of cancer therapy.
{"title":"Tumor-Targeted ConjugatednPolymer Promotes PhotothermalnImmunogenic Cell Death and Release of the TLR‑9 ImmunostimulantnInduced Efficient Cancer Immunotherapy","authors":"Laxmanan Karthikeyan (10834872), Pathath Abdul Rasheed (16846898), Yuvaraj Haldorai (2584951), Raju Vivek (1419283)","doi":"10.1021/acsapm.3c01148.s001","DOIUrl":"https://doi.org/10.1021/acsapm.3c01148.s001","url":null,"abstract":"Emerging and promising tools against cancer are theranosticnnanoplatformsnthat combine imaging and therapy. A major challenge is unsatisfactorynantitumor efficiency, which is accompanied by a great risk of tumornrelapse. Therefore, a multimodal therapeutic functional strategy isnhighly desirable that can eradicate tumors, preventing tumor relapsesnand impeding the metastases. Therefore, a combination of photoimmunotherapynin a single therapeutic nanoplatform for efficient tumor-targetedntherapy is an efficient task. Herein, we designed a theranostic conjugatednpolymer polyaniline (PANi)-based synergistic therapeutic model fornphotothermal immunotherapy (PIT)composed of the EA-PANi@ICG/CpG-FAnnanocomposite (NC). This nanosystem was combined with a phototheranosticnagent (ICG) with immunomodulation (CpG). On the one hand, PANi promotesnphotothermal immunogenic cell death (ICD) upon NIR-light irradiation;ndying tumors discharge damage-associated molecular pattern signalsnsuch as HMBG1, CRT, and ATP, thereby encouraging DC maturation andnactivation of cytotoxic T lymphocytes. Furthermore, to improve thenimmune response, CpG promotes the TLR-9 activation in the tumor microenvironment.nTherefore, the combinatorial action of NC with CpG leads to completeninhibition of tumor regression by a strong antitumor immune memoryneffect. We explore that the synergistic effect of the NC in targetedntumor cells improves excellent antitumor effects that have been achievednby photoimmunotherapeutic tactics of cancer therapy.","PeriodicalId":522802,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：