Pub Date : 2025-12-01Epub Date: 2025-02-01DOI: 10.1016/j.inv.2025.100038
Shengwei Sun
Screening and mining efficient polyethylene terephthalate (PET)-degrading enzyme is a promising strategy for plastic waste treatment and recycling. This invention provides a novel transcription factor-based biosensor method for identifying potential PET-degrading enzymes from the microorganisms. When PET is degraded by a specific enzyme to produce terephthalic acid (TPA), the transcription factor TphR recognizes the TPA substrate and then activates the transcription of downstream green fluorescent protein (GFP) reporter, generating measurable fluorescence signals in bacterial cells.
{"title":"A transcription factor-based biosensor for identification of the polyethylene terephthalate-degrading enzyme","authors":"Shengwei Sun","doi":"10.1016/j.inv.2025.100038","DOIUrl":"10.1016/j.inv.2025.100038","url":null,"abstract":"<div><div>Screening and mining efficient polyethylene terephthalate (PET)-degrading enzyme is a promising strategy for plastic waste treatment and recycling. This invention provides a novel transcription factor-based biosensor method for identifying potential PET-degrading enzymes from the microorganisms. When PET is degraded by a specific enzyme to produce terephthalic acid (TPA), the transcription factor TphR recognizes the TPA substrate and then activates the transcription of downstream green fluorescent protein (GFP) reporter, generating measurable fluorescence signals in bacterial cells.</div></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"5 ","pages":"Article 100038"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143182586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2024-12-24DOI: 10.1016/j.inv.2024.100036
K.P. Lijesh, M.M. Khonsari
The present work proposes a novel in-situ measurement technology to monitor the complex evolution of consistency during grease manufacturing. Variations in raw materials, environmental conditions, and human errors often lead to inconsistencies in the final grease consistency across production batches, causing product wastage, rework, higher costs, and production delays. To guide grease manufacturers in achieving consistent final products, a technology was developed and patented to enable real-time monitoring of rheological properties using accumulated entropy generation (AEG), a parameter derived from the principles of irreversible thermodynamics. A process sensor unit (PSU) was developed to measure AEG by recording real-time current, voltage, and process temperatures in a 5000 kg grease kettle. Tests on NLGI grade 2 and grade 1.5 grease batches demonstrated a strong linear correlation between AEG values and grease consistency, enabling a predictive model for consistency control for future batches.
{"title":"In-situ monitoring of grease consistency","authors":"K.P. Lijesh, M.M. Khonsari","doi":"10.1016/j.inv.2024.100036","DOIUrl":"10.1016/j.inv.2024.100036","url":null,"abstract":"<div><div>The present work proposes a novel in-situ measurement technology to monitor the complex evolution of consistency during grease manufacturing. Variations in raw materials, environmental conditions, and human errors often lead to inconsistencies in the final grease consistency across production batches, causing product wastage, rework, higher costs, and production delays. To guide grease manufacturers in achieving consistent final products, a technology was developed and patented to enable real-time monitoring of rheological properties using accumulated entropy generation (AEG), a parameter derived from the principles of irreversible thermodynamics. A process sensor unit (PSU) was developed to measure AEG by recording real-time current, voltage, and process temperatures in a 5000 kg grease kettle. Tests on NLGI grade 2 and grade 1.5 grease batches demonstrated a strong linear correlation between AEG values and grease consistency, enabling a predictive model for consistency control for future batches.</div></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"5 ","pages":"Article 100036"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143182584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-14DOI: 10.1016/j.inv.2025.100047
Daroel M. Fuentebella
The invention discloses a method for the Centralized Vehicle Information and Document Repository System, which comprises a mobile, tablet, and computer device and a server connected to a network. The system is mainly intended to provide transportation companies with a system that will protect the vehicles’ important documents to avoid operational disruption with quick access, notification of registration’s validity, and quick search of specific or volume information. The server computer will verify all incoming requests from the query parsing application, and the query parsing application should be registered by connecting the device to the network and keying in the registration details submitted to the server through its network. The admin either approves or rejects the registration. If approved, the admin can later manage the user (activate/deactivate). The approved user logs in with credentials, and a 2FA code is sent to the registered mobile number for confirmation. If the 2FA check succeeds, the user gains access to the system dashboard; if it fails, access is denied. The user can perform CRUD (Create, Read, Update, Delete) operations on vehicle records, such as uploading files or entering vehicle data. The invention is best for micro and macro wherein companies indulged to invested in technological infrastructure and focused mainly on operational functions in the transportation industry. Moreover, the potential when you try to understand the idea of the invention is that it can minimize, if not eliminate, the duplication of data, overspending in document registration and renewal, and mainly avoid excess penalties for smooth everyday transport operation.
{"title":"Centralized vehicle information and document repository system","authors":"Daroel M. Fuentebella","doi":"10.1016/j.inv.2025.100047","DOIUrl":"10.1016/j.inv.2025.100047","url":null,"abstract":"<div><div>The invention discloses a method for the Centralized Vehicle Information and Document Repository System, which comprises a mobile, tablet, and computer device and a server connected to a network. The system is mainly intended to provide transportation companies with a system that will protect the vehicles’ important documents to avoid operational disruption with quick access, notification of registration’s validity, and quick search of specific or volume information. The server computer will verify all incoming requests from the query parsing application, and the query parsing application should be registered by connecting the device to the network and keying in the registration details submitted to the server through its network. The admin either approves or rejects the registration. If approved, the admin can later manage the user (activate/deactivate). The approved user logs in with credentials, and a 2FA code is sent to the registered mobile number for confirmation. If the 2FA check succeeds, the user gains access to the system dashboard; if it fails, access is denied. The user can perform CRUD (Create, Read, Update, Delete) operations on vehicle records, such as uploading files or entering vehicle data. The invention is best for micro and macro wherein companies indulged to invested in technological infrastructure and focused mainly on operational functions in the transportation industry. Moreover, the potential when you try to understand the idea of the invention is that it can minimize, if not eliminate, the duplication of data, overspending in document registration and renewal, and mainly avoid excess penalties for smooth everyday transport operation.</div></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"5 ","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2024-12-25DOI: 10.1016/j.inv.2024.100035
Stuart Licht
Due to significant CO2 emissions, atmospheric CO2 levels have surpassed 423 ppm for the first time in recorded history, nearly doubling its level from that over the past few hundred thousand years. The primary contributor to this accumulation is anthropogenic release of CO2. Addressing the challenge of reducing atmospheric CO2 requires developing carbon-neutral industrial processes to replace current CO2-intensive methods and innovating low-cost technologies for capturing and converting CO2, and exploring its potential as a feedstock for fuels and societal staples. In pursuit of these goals, efforts have focused on sustainable methods for industrial production without a high carbon footprint, for which the Solar Thermal Electrochemical Process (STEP) was developed. In STEP, solar UV–visible energy powers a photovoltaic device for high temperature electrolysis, while solar thermal energy heats another system crucial for the electrolytic processes for carbon capture and to generate societal staples, such as H2 or syngas, iron, aluminum, lithium, magnesium, oxygen and chlorine at low energy and without CO2. This comprehensive use of sunlight enhances the overall efficiency of solar energy conversion compared to other methods. Applications of STEP include CO2-free synthesis of iron, bleach and fuels.
{"title":"STEP carbon dioxide free production of societal staples","authors":"Stuart Licht","doi":"10.1016/j.inv.2024.100035","DOIUrl":"10.1016/j.inv.2024.100035","url":null,"abstract":"<div><div>Due to significant CO<sub>2</sub> emissions, atmospheric CO<sub>2</sub> levels have surpassed 423 ppm for the first time in recorded history, nearly doubling its level from that over the past few hundred thousand years. The primary contributor to this accumulation is anthropogenic release of CO<sub>2</sub>. Addressing the challenge of reducing atmospheric CO<sub>2</sub> requires developing carbon-neutral industrial processes to replace current CO<sub>2</sub>-intensive methods and innovating low-cost technologies for capturing and converting CO<sub>2</sub>, and exploring its potential as a feedstock for fuels and societal staples. In pursuit of these goals, efforts have focused on sustainable methods for industrial production without a high carbon footprint, for which the Solar Thermal Electrochemical Process (STEP) was developed. In STEP, solar UV–visible energy powers a photovoltaic device for high temperature electrolysis, while solar thermal energy heats another system crucial for the electrolytic processes for carbon capture and to generate societal staples, such as H<sub>2</sub> or syngas, iron, aluminum, lithium, magnesium, oxygen and chlorine at low energy and without CO<sub>2</sub>. This comprehensive use of sunlight enhances the overall efficiency of solar energy conversion compared to other methods. Applications of STEP include CO<sub>2</sub>-free synthesis of iron, bleach and fuels.</div></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"5 ","pages":"Article 100035"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143182585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-03-15DOI: 10.1016/j.inv.2025.100039
S. Codony , E. Valverde , C. Galdeano , A.L. Turcu , R. Leiva , S. Vázquez
In this invention, a novel family of benzohomoadamantane-based soluble epoxide hydrolase inhibitors is disclosed. The benzohomoadamantane scaffold is a polycyclic, readily accessible, system that features a homoadamantane unit fused with an aromatic ring. Although it has been scarcely used in medicinal chemistry, it is very versatile and permits several chemical derivatizations in its structure in order to improve the inhibitory activity and/or the DMPK properties of the compounds. This invention encompasses ureas, amides, carbamates and thioureas. The compounds are of interest for the broad range of therapeutic indications related to the inhibition of soluble epoxide hydrolase, including inflammatory diseases, pain and neurodegeneration. This invention has been licensed to a US-based start-up that is actively recruiting investors and strategic partners for advancing a selected candidate to regulatory studies.
{"title":"Polycyclic compounds as soluble epoxide hydrolase inhibitors","authors":"S. Codony , E. Valverde , C. Galdeano , A.L. Turcu , R. Leiva , S. Vázquez","doi":"10.1016/j.inv.2025.100039","DOIUrl":"10.1016/j.inv.2025.100039","url":null,"abstract":"<div><div>In this invention, a novel family of benzohomoadamantane-based soluble epoxide hydrolase inhibitors is disclosed. The benzohomoadamantane scaffold is a polycyclic, readily accessible, system that features a homoadamantane unit fused with an aromatic ring. Although it has been scarcely used in medicinal chemistry, it is very versatile and permits several chemical derivatizations in its structure in order to improve the inhibitory activity and/or the DMPK properties of the compounds. This invention encompasses ureas, amides, carbamates and thioureas. The compounds are of interest for the broad range of therapeutic indications related to the inhibition of soluble epoxide hydrolase, including inflammatory diseases, pain and neurodegeneration. This invention has been licensed to a US-based start-up that is actively recruiting investors and strategic partners for advancing a selected candidate to regulatory studies.</div></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"5 ","pages":"Article 100039"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-07-17DOI: 10.1016/j.inv.2025.100041
Yee Wei Foong
The invention embodies a method to incorporate nanoparticles in an energy storage device, more specifically batteries and supercapacitors, to enable quantized capacitance energy storage mechanism. It operates on the principle of quantization in nanoscale, also referred to as the solvated Coulomb blockade mechanism, rather than the classical intercalation mechanism, allowing greater electron storage potential within the nanoparticles relative to classical energy storage devices. This enables pseudocapacitive battery to theoretically store as much energy as lithium-ion batteries while all its other properties resemble ultracapacitors, including the theoretical ability to have long cycle life and can be charged and discharged at very high rates, a significant departure from lithium-ion battery technology which are well known to have long charging times. This invention also enables electrochemical storage devices to be designed with sustainable materials (e.g., carbon), transitioning from the heavy reliance on precious metals (e.g., lithium, manganese, cobalt, and nickel).
{"title":"Pseudocapacitive batteries: Methods of activating quantized capacitance energy storage mechanism","authors":"Yee Wei Foong","doi":"10.1016/j.inv.2025.100041","DOIUrl":"10.1016/j.inv.2025.100041","url":null,"abstract":"<div><div>The invention embodies a method to incorporate nanoparticles in an energy storage device, more specifically batteries and supercapacitors, to enable quantized capacitance energy storage mechanism. It operates on the principle of quantization in nanoscale, also referred to as the solvated Coulomb blockade mechanism, rather than the classical intercalation mechanism, allowing greater electron storage potential within the nanoparticles relative to classical energy storage devices. This enables pseudocapacitive battery to theoretically store as much energy as lithium-ion batteries while all its other properties resemble ultracapacitors, including the theoretical ability to have long cycle life and can be charged and discharged at very high rates, a significant departure from lithium-ion battery technology which are well known to have long charging times. This invention also enables electrochemical storage devices to be designed with sustainable materials (e.g., carbon), transitioning from the heavy reliance on precious metals (e.g., lithium, manganese, cobalt, and nickel).</div></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"5 ","pages":"Article 100041"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-14DOI: 10.1016/j.inv.2025.100046
Peshraw Ahmed Abdalla, Bander Sidiq Mahmood, Nawzad Rasul Hama
MyKidney is an accessible, web-based software platform designed to assist in the automated detection of kidney stones from axial computed tomography (CT) images. By leveraging a custom convolutional neural network (CNN), the system classifies CT slices and visually highlights potential stone regions, aiding in preliminary diagnosis. The model achieved a classification accuracy of 98.80 %, demonstrating a superior balance between sensitivity and specificity when compared to established architectures like ResNet-18 and VGG19. The platform provides a cost-effective, real-time solution for clinics, particularly in under-resourced or rural areas where access to radiology expertise may be limited. Users can upload images directly via the web interface, and the system processes the data using a trained deep-learning model hosted on a secure backend. This software provides a potential entry point for further Artificial Intelligence (AI) assisted diagnostic tools and can be integrated into telehealth systems. We welcome potential collaborators interested in further validating or extending this tool for broader medical imaging applications.
•
Provides a low-cost, accessible tool for automated kidney stone detection using CT imaging, supporting early identification and reducing diagnostic delays in clinical settings.
•
Healthcare professionals in rural or resource-limited environments, academic researchers in medical imaging, and developers of telehealth platforms can benefit from its deployment.
•
The modular architecture and open-source nature allow the software to be reused, extended, or adapted for additional diagnostic tasks or integrated into broader AI-driven radiology systems.
•
Offers real-time visual feedback with interactive elements, making it suitable for training, demonstration, and patient education in medical institutions.
•
Bridges the gap between technical deep learning models and practical clinical tools through a browser-based interface that requires no installation or specialist hardware.
•
Supports the ongoing development of explainable AI tools by providing interpretable predictions and confidence indicators, contributing to transparency in clinical AI adoption.
{"title":"MyKidney: A Web-based AI tool for automated kidney stone detection from CT imaging","authors":"Peshraw Ahmed Abdalla, Bander Sidiq Mahmood, Nawzad Rasul Hama","doi":"10.1016/j.inv.2025.100046","DOIUrl":"10.1016/j.inv.2025.100046","url":null,"abstract":"<div><div>MyKidney is an accessible, web-based software platform designed to assist in the automated detection of kidney stones from axial computed tomography (CT) images. By leveraging a custom convolutional neural network (CNN), the system classifies CT slices and visually highlights potential stone regions, aiding in preliminary diagnosis. The model achieved a classification accuracy of 98.80 %, demonstrating a superior balance between sensitivity and specificity when compared to established architectures like ResNet-18 and VGG19. The platform provides a cost-effective, real-time solution for clinics, particularly in under-resourced or rural areas where access to radiology expertise may be limited. Users can upload images directly via the web interface, and the system processes the data using a trained deep-learning model hosted on a secure backend. This software provides a potential entry point for further Artificial Intelligence (AI) assisted diagnostic tools and can be integrated into telehealth systems. We welcome potential collaborators interested in further validating or extending this tool for broader medical imaging applications.<ul><li><span>•</span><span><div>Provides a low-cost, accessible tool for automated kidney stone detection using CT imaging, supporting early identification and reducing diagnostic delays in clinical settings.</div></span></li><li><span>•</span><span><div>Healthcare professionals in rural or resource-limited environments, academic researchers in medical imaging, and developers of telehealth platforms can benefit from its deployment.</div></span></li><li><span>•</span><span><div>The modular architecture and open-source nature allow the software to be reused, extended, or adapted for additional diagnostic tasks or integrated into broader AI-driven radiology systems.</div></span></li><li><span>•</span><span><div>Offers real-time visual feedback with interactive elements, making it suitable for training, demonstration, and patient education in medical institutions.</div></span></li><li><span>•</span><span><div>Bridges the gap between technical deep learning models and practical clinical tools through a browser-based interface that requires no installation or specialist hardware.</div></span></li><li><span>•</span><span><div>Supports the ongoing development of explainable AI tools by providing interpretable predictions and confidence indicators, contributing to transparency in clinical AI adoption.</div></span></li></ul></div></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"5 ","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-09-07DOI: 10.1016/j.inv.2025.100043
Torsten Berning , Diogo Loureiro Martinho
Alkaline electrolyzer technology is widely considered the most mature and cost-effective way of producing green hydrogen, provided the electricity to operate the electrolyzer is generated via renewable energies. These electrolyzers typically consist of two electrodes, anode and cathode, separated by a diaphragm which is often Zirfon™, a porous composite separator material composed of a polysulfone matrix and ZrO in powder form. This porous membrane allows for the ion transport in the electrolyte and separates the product gases hydrogen and oxygen from each other. However, there are dissolved product gases in the liquid electrolyte that cross the porous membrane via diffusion. The main reason for this crossover rate is the fact that the aqueous liquid electrolyte phase is supersaturated with hydrogen on one side and oxygen on the other. We are proposing to add a layer of coating to the outside faces of the Zirfon membrane to promote the formation of hydrogen/oxygen bubbles outside of the membrane and thus reduce the hydrogen and oxygen crossover.
{"title":"An alkaline electrolyzer having a diaphragm surface coating to enable bubble formation and thus reduce the crossover rates of the product gases","authors":"Torsten Berning , Diogo Loureiro Martinho","doi":"10.1016/j.inv.2025.100043","DOIUrl":"10.1016/j.inv.2025.100043","url":null,"abstract":"<div><div>Alkaline electrolyzer technology is widely considered the most mature and cost-effective way of producing green hydrogen, provided the electricity to operate the electrolyzer is generated via renewable energies. These electrolyzers typically consist of two electrodes, anode and cathode, separated by a diaphragm which is often Zirfon™, a porous composite separator material composed of a polysulfone matrix and ZrO in powder form. This porous membrane allows for the ion transport in the electrolyte and separates the product gases hydrogen and oxygen from each other. However, there are dissolved product gases in the liquid electrolyte that cross the porous membrane via diffusion. The main reason for this crossover rate is the fact that the aqueous liquid electrolyte phase is supersaturated with hydrogen on one side and oxygen on the other. We are proposing to add a layer of coating to the outside faces of the Zirfon membrane to promote the formation of hydrogen/oxygen bubbles outside of the membrane and thus reduce the hydrogen and oxygen crossover.</div></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"5 ","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-02-01DOI: 10.1016/j.inv.2025.100037
Yu Chyuan Heng, Sandra Kittelmann
Hydroxy fatty acids are an emerging class of compounds with growing industrial and medicinal significance, yet their chemical synthesis remains challenging. Consequently, biological synthesis has been explored as an alternative approach, with fatty acid hydratases gaining considerable interest due to their mild reaction conditions and broad substrate and product ranges. The present invention introduces 21 fatty acid hydratases with varied regio-selectivity, substrate, and product scopes, and discloses methods of producing hydroxy fatty acids from unsaturated fatty acids using individual or combinations of these enzymes. The present invention offers a foundation for industrial-scale hydroxy fatty acid bioproduction, paving the way to broaden the availability and application of hydroxy fatty acids across various sectors.
{"title":"Fatty acid hydratases for hydroxy fatty acid bioproduction","authors":"Yu Chyuan Heng, Sandra Kittelmann","doi":"10.1016/j.inv.2025.100037","DOIUrl":"10.1016/j.inv.2025.100037","url":null,"abstract":"<div><div>Hydroxy fatty acids are an emerging class of compounds with growing industrial and medicinal significance, yet their chemical synthesis remains challenging. Consequently, biological synthesis has been explored as an alternative approach, with fatty acid hydratases gaining considerable interest due to their mild reaction conditions and broad substrate and product ranges. The present invention introduces 21 fatty acid hydratases with varied regio-selectivity, substrate, and product scopes, and discloses methods of producing hydroxy fatty acids from unsaturated fatty acids using individual or combinations of these enzymes. The present invention offers a foundation for industrial-scale hydroxy fatty acid bioproduction, paving the way to broaden the availability and application of hydroxy fatty acids across various sectors.</div></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"5 ","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-09-06DOI: 10.1016/j.inv.2025.100044
Carla Flores-Rodriguez , Oscar Fernando Herrera Adarme , Gustavo Mockaitis
This invention presents an innovative anaerobic bioreactor prototype, called the electrostimulated anaerobic bioreactor (EAB), consisting of a tubular container with conductive and non-conductive supports, arranged radially and alternately around the circular cross-section and aligned with the longitudinal axis. Electrical stimulation applied to the conductive supports facilitates direct microbial electron transfer, enhancing reaction kinetics. In combination with non-conductive supports, which provide micro-niches that promote diverse microbial attachment and metabolic activity, the system fosters syntrophic interactions, accelerates substrate conversion, ensures rapid process stabilization, and maintains sustained long-term performance, thereby increasing the overall efficiency of anaerobic digestion. The EAB provides an adaptable platform for treating organic-based substrates and generating renewable energy. It enables the production of methane, hydrogen, and recoverable chemicals. It can be integrated with other bioprocesses for process optimization, testing of alternative substrates, or inclusion in biorefineries for the development of new bio-based products.
{"title":"Revolutionizing fixed-film anaerobic bioreactors: An innovative electrostimulated system for superior biomethane and biohydrogen production","authors":"Carla Flores-Rodriguez , Oscar Fernando Herrera Adarme , Gustavo Mockaitis","doi":"10.1016/j.inv.2025.100044","DOIUrl":"10.1016/j.inv.2025.100044","url":null,"abstract":"<div><div>This invention presents an innovative anaerobic bioreactor prototype, called the electrostimulated anaerobic bioreactor (EAB), consisting of a tubular container with conductive and non-conductive supports, arranged radially and alternately around the circular cross-section and aligned with the longitudinal axis. Electrical stimulation applied to the conductive supports facilitates direct microbial electron transfer, enhancing reaction kinetics. In combination with non-conductive supports, which provide micro-niches that promote diverse microbial attachment and metabolic activity, the system fosters syntrophic interactions, accelerates substrate conversion, ensures rapid process stabilization, and maintains sustained long-term performance, thereby increasing the overall efficiency of anaerobic digestion. The EAB provides an adaptable platform for treating organic-based substrates and generating renewable energy. It enables the production of methane, hydrogen, and recoverable chemicals. It can be integrated with other bioprocesses for process optimization, testing of alternative substrates, or inclusion in biorefineries for the development of new bio-based products.</div></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"5 ","pages":"Article 100044"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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