JFO Open Ophthalmology最新文献

英文中文

Effects of Sahaj Samadhi Meditation on health-related quality of life of glaucoma patients: A feasibility study 霎哈嘉三摩地冥想对青光眼患者健康相关生活质量影响的可行性研究

JFO Open Ophthalmology

Pub Date : 2025-06-01 Epub Date: 2025-03-22 DOI: 10.1016/j.jfop.2025.100164

Monali S. Malvankar-Mehta , Hyunsoo (Jason) Jang , Brian Yu , Cindy Hutnik

Background

Glaucoma is a leading cause of irreversible blindness, with a growing body of literature linking it to mental disorders. This study aimed to investigate the effects of Sahaj Samadhi Meditation (SSM) on depression, anxiety, sleep quality, and community integration in patients with glaucoma.

Methods

A prospective feasibility study was conducted with 28 participants aged 18 and older, including those with mild to severe glaucoma and glaucoma suspects. Participants were divided into two groups: one receiving treatment as usual (TAU) and the other receiving TAU plus Sahaj Samadhi Meditation (SSM). The SSM group participated in a structured 4-day group session and were instructed to meditate regularly on their own. Assessments were conducted on vision-related quality of life (VRQOL), depressive symptoms, anxiety, sleep quality, and community integration at baseline and at the 24-week follow-up. Feasibility outcomes were measured, and statistical analysis was performed using STATA 18.0.

Results

The SSM group showed a significant reduction in depression and improvement in sleep quality compared to the control group. Additionally, the SSM group experienced a reduction in anxiety symptoms. However, there were no significant differences in VRQOL, and community integration between the two groups. No adverse effects were reported.

Conclusions

SSM may help reduce depressive symptoms and improve sleep quality in glaucoma patients. It may also alleviate anxiety symptoms. Further studies with larger sample sizes and longer follow-up periods are needed to confirm these findings.

青光眼是不可逆失明的主要原因，越来越多的文献将其与精神障碍联系起来。本研究旨在探讨Sahaj Samadhi Meditation （SSM）对青光眼患者抑郁、焦虑、睡眠质量和社区融入的影响。方法对28例18岁及以上青光眼患者（轻至重度青光眼患者和青光眼疑似患者）进行前瞻性可行性研究。参与者被分为两组：一组接受常规治疗（TAU），另一组接受TAU加Sahaj三摩地冥想（SSM）。SSM组参加了一个为期4天的结构化小组会议，并被指示定期自己冥想。在基线和24周随访时对视力相关生活质量（VRQOL）、抑郁症状、焦虑、睡眠质量和社区融入进行评估。测量可行性结果，使用STATA 18.0进行统计分析。结果与对照组相比，SSM组抑郁症状明显减少，睡眠质量明显改善。此外，SSM组的焦虑症状有所减轻。然而，两组在VRQOL和社区整合方面无显著差异。无不良反应报告。结论sssm可减轻青光眼患者抑郁症状，改善睡眠质量。它还可以缓解焦虑症状。进一步的研究需要更大的样本量和更长的随访期来证实这些发现。

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引用次数: 0

Erratum regarding previously published articles 关于以前发表的文章的勘误

JFO Open Ophthalmology

Pub Date : 2025-06-01 Epub Date: 2025-04-12 DOI: 10.1016/j.jfop.2025.100165

引用次数: 0

Optic neuritis induced by Pembrolizumab treatment for recurrent vulvar cancer 派姆单抗治疗复发性外阴癌诱导视神经炎

JFO Open Ophthalmology

Pub Date : 2025-06-01 Epub Date: 2025-03-22 DOI: 10.1016/j.jfop.2025.100162

Ariel Cohen , Yonah Levy , Kristy Ward

Purpose

To describe a novel case of optic neuritis induced after pembrolizumab treatment for recurrent vulvar cancer.

Background

Immunotherapy is becoming increasingly important as a therapy for cases of vulvar cancer that are resistant to standard treatment.

Case presentation

A 53-year-old female with a history of recurrent vulvar cancer presented with sudden-onset progressive vision loss in both eyes for four weeks. Initially patient was thought to have brain metastases based on imaging, but after a thorough workup, the diagnosis of optic neuritis was made. Pembrolizumab therapy was immediately ceased, and high-dose corticosteroids were used to treat the patient effectively and reverse her symptoms.

Conclusions

Several cases of CNS toxicity and optic neuritis have been reported with the use of pembrolizumab immunotherapy but, to our knowledge, this is the first reported case to have occurred in the setting of recurrent vulvar cancer. In these cases it is important to have prompt discontinuation of the offending agent and treatment with high-dose corticosteroid course.

目的报道1例复发性外阴癌经派姆单抗治疗后引起视神经炎的新病例。背景免疫疗法作为一种对标准治疗有耐药性的外阴癌的治疗方法正变得越来越重要。患者53岁，女性，既往有外阴癌复发史，因突发性进行性双眼视力丧失4周。最初，根据影像学检查，患者被认为是脑转移，但经过彻底的检查，诊断为视神经炎。立即停止派姆单抗治疗，并使用大剂量皮质类固醇有效治疗患者并逆转其症状。结论：使用派姆单抗免疫治疗已报道了几例中枢神经系统毒性和视神经炎，但据我们所知，这是第一例发生在复发性外阴癌背景下的报道。在这些情况下，重要的是要及时停药，并用大剂量皮质类固醇治疗。

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引用次数: 0

Corneal innervation and neurotisation: a review of current concepts 角膜神经支配和神经化：当前概念的回顾

JFO Open Ophthalmology

Pub Date : 2025-03-22 DOI: 10.1016/j.jfop.2025.100163

Christian P. Pappas

The cornea is the most richly innervated tissue within the body, the complexity of which reflects the critical role of visual preservation to survival. Sensation is provided almost solely by innervation of the ophthalmic nerve, where any insult along the afferent sensory pathway may result in the development of neurotrophic keratopathy, a vision-threatening condition. We review the current model of corneal sensory and autonomic innervation and explore the typical aetiologic and pathogenic features of neurotrophic keratopathy. Special attention is given to corneal neurotisation, an effective microsurgical treatment for moderate to severe neurotrophic keratopathy refractory to non-surgical management techniques, and its role in the reinnervation of the asensate cornea by direct or indirect transplantation of healthy nerve tissue.

角膜是人体内神经支配最丰富的组织，其复杂性反映了视觉保护对生存的关键作用。感觉几乎完全由眼神经的神经支配提供，其中传入感觉通路的任何损伤都可能导致神经营养性角膜病变的发展，这是一种视力威胁疾病。我们回顾了目前角膜感觉和自主神经支配的模型，并探讨了神经营养性角膜病变的典型病因学和病原学特征。特别关注角膜神经化，这是一种对非手术治疗技术难以治愈的中度至重度神经营养性角膜病的有效显微外科治疗方法，以及它通过直接或间接移植健康神经组织在感觉性角膜的再神经支配中的作用。

引用次数: 0

Multiple stellate keratitis during immune checkpoint inhibitor therapy 免疫检查点抑制剂治疗期间多发性星状角膜炎

JFO Open Ophthalmology

Pub Date : 2025-03-01 Epub Date: 2025-01-31 DOI: 10.1016/j.jfop.2025.100157

Isana Nakajima, Hideki Tsuji

引用次数: 0

A rare case of lymphedema distichiasis syndrome 罕见的双支淋巴水肿综合征1例

JFO Open Ophthalmology

Pub Date : 2025-03-01 Epub Date: 2025-01-22 DOI: 10.1016/j.jfop.2025.100156

Deepsekhar Das, Sahil Agrawal, Manu Muraleekrishna, Poornima Chauhan

引用次数: 0

Cataract co-existing with glaucoma: A case of Klippel-Trénaunay Syndrome 白内障合并青光眼一例klippel - tramenaunay综合征

JFO Open Ophthalmology

Pub Date : 2025-03-01 Epub Date: 2025-01-31 DOI: 10.1016/j.jfop.2025.100158

Shubham Manchanda, Savleen Kaur, Sushmita Kaushik, Jaspreet Sukhija

引用次数: 0

Anti-nepotism policies and resident selection at Canadian medical schools 加拿大医学院的反裙带关系政策与住院医师选拔

JFO Open Ophthalmology

Pub Date : 2025-03-01 Epub Date: 2024-12-10 DOI: 10.1016/j.jfop.2024.100151

Edsel Ing , Michael Balas , Ahmed Al-Asmar

引用次数: 0

Long term outcomes of angle, filtering, and combined angle and filtering surgery for primary congenital glaucoma 原发性先天性青光眼的角度、滤过及角度与滤过联合手术的远期疗效

JFO Open Ophthalmology

Pub Date : 2025-03-01 Epub Date: 2024-11-28 DOI: 10.1016/j.jfop.2024.100145

Nader Bayoumi , Mahmoud Morsy , Mohamed Fouad , Eman Nabil Elsayed

Purpose

To report on long term follow-up of surgical results in primary congenital glaucoma (PCG).

Study design

Retrospective chart review.

Methods

The charts of all children presenting with and operated on for PCG in Alexandria Main University Hospital between 2005 and 2013 and completing at least 8 years of follow-up were reviewed. Data extracted included demographic characteristics, prenatal history, glaucoma diagnosis, preoperative, intraoperative and postoperative data. Success was defined as an IOP ≤ 16 mmHg with no vision-threatening complications and no signs of progression (progressive increase in corneal diameter, axial length (AL), or cup/disc (C/D) ratio).

Results

The records of 65 eyes of 41 children were reviewed. The mean ± standard deviation of the age at presentation was 5.9 ± 4.1 months and of follow-up was 128.3 ± 18.4 months. The most common presentation was cloudy cornea (53.7%). The total glaucoma surgical procedures were 96 (1.5 ± 0.8 procedures per eye, with 71% undergoing only 1 procedure). The most common initial glaucoma surgery was combined angle and filtering surgery with antimetabolite (56, 86.2%). At the final follow-up, IOP, AL and C/D ratio (12.4 ± 6.1 mmHg, 26.49 ± 3.5 mm and 0.3 ± 0.3) were statistically significantly different from preoperative values (19.0 ± 5.9 mmHg, 22.69 ± 1.86 mm and 0.5 ± 0.3) (p < 0.001, p < 0.001 and p = 0.001 respectively). The mean ± standard deviation best corrected visual acuity (BCVA) was 0.44 ± 0.3 decimal. The BCVA inter-eye difference was >0.2 in 56.25%. The mean ± standard deviation of the Mean Deviation (MD) and Pattern Standard Deviation (PSD) were -5.88 ± 2.9 and 3.22 ± 1.74 dB respectively. At the last follow-up, the success rate was 80%.

Conclusions

Combined angle and filtering surgery with antimetabolite was successful for long term control of PCG. Refractive errors and amblyopia occur in over half of the operated eyes.

目的报道原发性先天性青光眼（PCG）手术治疗的长期随访结果。研究设计回顾性图表回顾。方法回顾性分析2005 ~ 2013年在亚历山大大学附属医院就诊并行PCG手术的所有患儿随访8年以上的病历。提取的资料包括人口统计学特征、产前病史、青光眼诊断、术前、术中、术后资料。成功的定义是IOP≤16mmhg，无视力威胁并发症，无进展迹象（角膜直径、角膜轴长（AL）或角膜杯/椎间盘（C/D）比进行性增加）。结果回顾性分析41例患儿65只眼的手术记录。发病年龄平均±标准差为5.9±4.1个月，随访时间为128.3±18.4个月。最常见的表现是角膜混浊（53.7%）。青光眼手术总数为96例（每只眼1.5±0.8例，71%只接受1次手术）。最常见的青光眼初始手术是联合角滤手术和抗代谢物（56,86.2%）。末次随访时，IOP、AL、C/D比值（12.4±6.1 mmHg、26.49±3.5 mm、0.3±0.3）与术前（19.0±5.9 mmHg、22.69±1.86 mm、0.5±0.3）差异有统计学意义（p < 0.001、p < 0.001、p = 0.001）。最佳矫正视力（BCVA）平均值±标准差为0.44±0.3。56.25%的BCVA眼间差为0.2。平均偏差（MD）和模式标准差（PSD）的均值±标准差分别为-5.88±2.9和3.22±1.74 dB。最后一次随访时，成功率为80%。结论角滤手术联合抗代谢物治疗可长期控制PCG。一半以上的手术眼睛会出现屈光不正和弱视。

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引用次数: 0

Oxygen boost transepithelial corneal collagen crosslinking: 2-year ultrastructural results 氧促进经上皮角膜胶原交联：2年超微结构结果

JFO Open Ophthalmology

Pub Date : 2025-03-01 Epub Date: 2024-12-19 DOI: 10.1016/j.jfop.2024.100153

Valentine Saunier , Pierre Legout , Nathalie Thiery , Pierre Fournie , David Touboul

Purpose

To assess ultrastructural corneal changes induced by oxygen boost transepithelial crosslinking (OBXL) and its efficacy at 2 years.

Methods

This pilot cohort study was conducted at the French National Reference Keratoconus Center in patients with progressive keratoconus. Corneal transepithelial CXL with an additional source of oxygen delivered through the goggles was performed. All patients who underwent surgery had an evaluation preoperatively, between 1 and 3 mo postoperatively, and at 6, 12 and 24 mo postoperatively.

Biomechanical (Corvis ST), topographical (CASIA-2), and microstructural changes (using In Vivo Confocal Microscopy and Anterior Segment OCT) following this new technique were assessed. We also evaluated visual acuity and eye rubbing behavior.

Results

Ten eyes of ten patients were enrolled, with a mean age of 23.8 ± 4.9 years. A visible demarcation line was observed on AS-OCT with a mean depth of 414 μm ± 80.91 (89 % of the total thickness). We also noticed an anterior hyperreflective band with a mean depth of 214 ± 42.95 μm. At 6, 12 and 24 mo postoperatively, the Kmax, Kmin, Cyl and Corneal Thinnest Point were stable (p > 0.05). At 24 mo, there was significant improvement in BCVA. Compared to baseline, at the first postoperative visit, corneal sub-basal nerve density decreased, and keratocyte apoptosis was observed in all patients. Regarding eye rubbing, the number of patients who rubbed their eyes frequently decreased after CXL.

Conclusion

This study confirmed the histological effects of OBXL and a deep corneal interaction that is effective in stabilizing keratoconus.

目的观察氧促经上皮交联（OBXL）对角膜超微结构的影响及其2年疗效。方法在法国国家圆锥角膜参考中心对进行性圆锥角膜患者进行了前瞻性队列研究。通过护目镜提供额外的氧气源进行角膜上皮CXL。所有接受手术的患者术前、术后1至3个月、术后6、12和24个月进行评估。评估了新技术后的生物力学（Corvis ST）、地形学（CASIA-2）和显微结构变化（使用体内共聚焦显微镜和前段OCT）。我们还评估了视力和揉眼行为。结果入组10例患者10只眼，平均年龄23.8±4.9岁。在AS-OCT上观察到一条明显的分界线，平均深度为414 μm±80.91（占总厚度的89%）。我们还发现了一个平均深度为214±42.95 μm的前路高反射带。术后6、12、24月Kmax、Kmin、Cyl、角膜最薄点稳定（p > 0.05）。24个月时，BCVA有显著改善。与基线相比，术后第一次就诊时，所有患者的角膜基底下神经密度均下降，所有患者均观察到角膜细胞凋亡。在揉眼方面，CXL术后频繁揉眼的患者数量减少。结论本研究证实了OBXL的组织学作用和深层角膜相互作用对稳定圆锥角膜是有效的。

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引用次数: 0

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全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

JFO Open Ophthalmology

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