American Journal of Transplantation最新文献

{"title":"Reply to “Reassessing the evidence for elevated deficient mismatch repair colorectal cancer risk after kidney transplantation”","authors":"Koen Zwart, Rob C.M. van Kruijsdijk, Iris D. Nagtegaal, Guus M. Bol","doi":"10.1016/j.ajt.2026.05.716","DOIUrl":"10.1016/j.ajt.2026.05.716","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"26 10","pages":"Pages 2408-2409"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148215697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Comment on “A comparative study of once-daily versus twice-daily tacrolimus in deceased donor kidney transplant recipients: a national cohort analysis”","authors":"Bekir Tanriover,Gaurav Gupta,Ahmet B. Gungor","doi":"10.1016/j.ajt.2026.10.010","DOIUrl":"https://doi.org/10.1016/j.ajt.2026.10.010","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"53 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to West Nile virus encephalitis posttransplantation: A case report and literature review [American Journal of Transplantation, Date: January 2026, Page: S15, Volume: Volume 26, Issue 1, Supplement 1]","authors":"Michael Irby,Paulo Martins,Narendra Battula,Maheshwaran Pitchaimuthu,Jose Henao-Cordero","doi":"10.1016/j.ajt.2026.09.034","DOIUrl":"https://doi.org/10.1016/j.ajt.2026.09.034","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"162 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normothermic regional perfusion and donation after circulatory death kidney transplantation: Essential intervention or unnecessary complexity?","authors":"James A. Richards, Gavin J. Pettigrew","doi":"10.1016/j.ajt.2026.07.006","DOIUrl":"10.1016/j.ajt.2026.07.006","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"26 10","pages":"Pages 2234-2236"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dying on the waitlist: Mexico’s kidney allocation system as a public health scandal","authors":"Magdalena Madero","doi":"10.1016/j.ajt.2026.06.010","DOIUrl":"10.1016/j.ajt.2026.06.010","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"26 10","pages":"Pages 2232-2233"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathomic analysis of 5-year surveillance biopsies as predictors of kidney allograft loss","authors":"Pinaki Sarder,&nbsp;Aleksandar Denic,&nbsp;Byron H. Smith,&nbsp;Anindya S. Paul,&nbsp;Akshita Gupta,&nbsp;Harishwar Reddy Kasireddy,&nbsp;Sumanth Devarasetty,&nbsp;Samuel P. Border,&nbsp;Walter D. Park,&nbsp;Mark D. Stegall","doi":"10.1016/j.ajt.2026.05.727","DOIUrl":"10.1016/j.ajt.2026.05.727","url":null,"abstract":"<div><div>This study aimed to assess whether various pathomic features in automatically segmented glomeruli and tubules were associated with death-censored graft loss in kidney transplant recipients. We studied 906 patients who were transplanted between 2000 and 2013, returned to Mayo Clinic for a 5-year surveillance biopsy, and had available subsequent follow-up. Banff scores were obtained from the pathology reports and clinical characteristics from the patients’ charts. A multicompartment segmentation model segmented nonsclerotic glomeruli and tubules, and within these compartments, morphometric and textural (pathomic) features were computed. There were 70 death-censored graft losses that occurred during the 5 years of follow-up, and Cox models were used to assess the risk of death-censored graft failure with all Banff scores, with 2 composite pathomic features (glomeruli and tubules), and with Banff scores and pathomic features combined. The composite pathomic score model had similar performance to the Banff score model (c-statistics 0.845 vs 0.823, <em>P</em> = .47). A model combining the Banff scores and pathomic scores showed the best performance (c-statistic 0.897). We conclude that multicompartment segmentation models can identify pathomic features which can complement Banff scoring and are associated with future graft loss.</div></div><div>This study aimed to assess whether various pathomic features in automatically segmented glomeruli and tubules were associated with death-censored graft loss in kidney transplant recipients. We studied 906 patients who were transplanted between 2000 and 2013, returned to Mayo Clinic for a 5-year surveillance biopsy, and had available subsequent follow-up. Banff scores were obtained from the pathology reports and clinical characteristics from the patients’ charts. A multicompartment segmentation model segmented nonsclerotic glomeruli and tubules, and within these compartments, morphometric and textural (pathomic) features were computed. There were 70 death-censored graft losses that occurred during the 5 years of follow-up, and Cox models were used to assess the risk of death-censored graft failure with all Banff scores, with 2 composite pathomic features (glomeruli and tubules), and with Banff scores and pathomic features combined. The composite pathomic score model had similar performance to the Banff score model (c-statistics 0.845 vs 0.823, <em>P</em> = .47). A model combining the Banff scores and pathomic scores showed the best performance (c-statistic 0.897). We conclude that multicompartment segmentation models can identify pathomic features which can complement Banff scoring and are associated with future graft loss.</div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"26 10","pages":"Pages 2345-2355"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147985705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of donor-transmitted Strongyloides stercoralis infections in solid organ transplant recipients, United States, 2012-2024","authors":"Marcus R. Pereira","doi":"10.1016/j.ajt.2026.07.027","DOIUrl":"10.1016/j.ajt.2026.07.027","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"26 10","pages":"Pages 2230-2231"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148576154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low blood pressure alone in the posterior brain circulation during thoraco-abdominal normothermic regional perfusion does not assure brain circulatory arrest","authors":"Johan P.C. Sonneveld,&nbsp;Michael A. Kuiper,&nbsp;Niels P. van der Kaaij","doi":"10.1016/j.ajt.2026.06.016","DOIUrl":"10.1016/j.ajt.2026.06.016","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"26 10","pages":"Pages 2416-2418"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148322749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor macrophage depletion permits posttransplant tolerance induction in a murine islet transplant model","authors":"Miriam Dilts,&nbsp;Olivia K. Fay,&nbsp;Yang Yu,&nbsp;Collin Z. Jordan,&nbsp;Xunrong Luo","doi":"10.1016/j.ajt.2026.05.2296","DOIUrl":"10.1016/j.ajt.2026.05.2296","url":null,"abstract":"<div><div>Current strategies for experimental tolerance induction for allogeneic transplantation typically require recipient preparation days to weeks prior to transplantation, making them not applicable to deceased-donor transplantation. Developing tolerance strategies feasible for deceased-donor transplantation would greatly increase the pool of eligible patients for tolerance induction. Here, we aimed to induce tolerance with posttransplant-only interventions in a murine pancreatic islet transplant model. We demonstrated that transplant tolerance induction by recipient infusions of ethylcarbodiimide-treated donor splenocytes could be reliably delayed to the posttransplant timeframe, provided that donor islets were depleted of intraislet macrophages prior to transplantation. Mechanistically, islet production of C-C chemokine ligand (CCL)3, CCL4, and CCL5 was significantly reduced by intraislet macrophage depletion. On postoperative day +1, islet allografts depleted of donor intraislet macrophages exhibited significantly reduced infiltration of recipient innate immune cells, including monocytes, macrophages, and neutrophils. Interestingly, perioperative inhibition of C-C chemokine receptor 5, the receptor for CCL3, CCL4, and CCL5, also reduced postoperative day +1 innate immune cell infiltration, and similarly permitted tolerance induction by posttransplant donor ethylcarbodiimide-treated splenocyte infusions. This study, thus, demonstrates the efficacy of a strategy that would allow transplant tolerance induction by posttransplant-only interventions, thereby expanding the applicability of tolerance induction regimens to additional clinically relevant settings.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"26 10","pages":"Pages 2265-2277"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148154338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normothermic regional perfusion in kidney transplants with donors after controlled circulatory death: Functional benefits and safety in older recipients","authors":"Néstor Toapanta,&nbsp;Jordi Comas,&nbsp;Fritz Diekmann,&nbsp;Edoardo Melilli,&nbsp;María José Pérez-Saez,&nbsp;Anna Vila,&nbsp;Carme Facundo,&nbsp;Emma Arcos,&nbsp;Jaume Tort,&nbsp;Alberto Sandiumenge,&nbsp;Francesc Moreso,&nbsp;Oriol Bestard","doi":"10.1016/j.ajt.2026.04.027","DOIUrl":"10.1016/j.ajt.2026.04.027","url":null,"abstract":"<div><div>Normothermic regional perfusion (NRP) is increasingly used in controlled donation after circulatory death (cDCD) to mitigate ischemia-reperfusion injury. While NRP reduces delayed graft function (DGF), its impact on long-term outcomes, particularly in elderly recipients, remains uncertain. We retrospectively analyzed first kidney transplants from cDCD donors in a national registry (2015-2023). Outcomes after NRP were compared with rapid recovery (RR) using 1:1 propensity score matching based on donor/recipient age, comorbidities, and transplant year. A predefined subcohort analysis focused on recipients aged ≥65 years. Endpoints included DGF, hospital stay, renal function, and 5-year graft and patient survival. Among 1414 transplants, 1153 were eligible, and 410 matched pairs were analyzed. DGF and median hospital stay were significantly lower with NRP than with RR (19% vs 34%; odds ratio for RR vs NRP 2.87; 95% CI, 2.1-4.0; <em>P</em> &lt; .001 and 11 vs 13 days; difference −2.0 days; 95% CI, −3.6 to −0.4; <em>P</em> = .012, respectively). No significant differences were observed in estimated glomerular filtration rate trajectories or 5-year overall graft survival (P = .896), death-censored graft survival (<em>P</em> = .666), and patient survival (P = .981). Results were consistent in recipients ≥65 years. In this large real-world cDCD cohort, NRP improved early posttransplant outcomes without influencing midterm graft or patient survival.</div></div><div>Normothermic regional perfusion (NRP) is increasingly used in controlled donation after circulatory death (cDCD) to mitigate ischemia-reperfusion injury. While NRP reduces delayed graft function (DGF), its impact on long-term outcomes, particularly in elderly recipients, remains uncertain. We retrospectively analyzed first kidney transplants from cDCD donors in a national registry (2015-2023). Outcomes after NRP were compared with rapid recovery (RR) using 1:1 propensity score matching based on donor/recipient age, comorbidities, and transplant year. A predefined subcohort analysis focused on recipients aged ≥65 years. Endpoints included DGF, hospital stay, renal function, and 5-year graft and patient survival. Among 1414 transplants, 1153 were eligible, and 410 matched pairs were analyzed. DGF and median hospital stay were significantly lower with NRP than with RR (19% vs 34%; odds ratio for RR vs NRP 2.87; 95% CI, 2.1-4.0; <em>P</em> &lt; .001 and 11 vs 13 days; difference −2.0 days; 95% CI, −3.6 to −0.4; <em>P</em> = .012, respectively). No significant differences were observed in estimated glomerular filtration rate trajectories or 5-year overall graft survival (P = .896), death-censored graft survival (<em>P</em> = .666), and patient survival (P = .981). Results were consistent in recipients ≥65 years. In this large real-world cDCD cohort, NRP improved early posttransplant outcomes without influencing midterm graft or patient survival.</div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"26 10","pages":"Pages 2327-2335"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}