The accessible chemical space of second-generation crystalline sponges (2G-CSs) is extended to low-polarity small molecules via a modulator-enabled strategy. The key is the size compensation between guest and modulator to achieve a snug fit within the cage cavity.
{"title":"Expanding the Chemical Space of Analytes in the 2G Crystalline Sponge Method: Size-Compensation Strategy for the Structural Analysis of Low-Polarity Small Molecules","authors":"Wei He,Luc Soliman,Hiroki Takezawa,Makoto Fujita","doi":"10.1002/anie.4748505","DOIUrl":"https://doi.org/10.1002/anie.4748505","url":null,"abstract":"The accessible chemical space of second-generation crystalline sponges (2G-CSs) is extended to low-polarity small molecules via a modulator-enabled strategy. The key is the size compensation between guest and modulator to achieve a snug fit within the cage cavity.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weijian Yang,Jing-Ao Fan,Limei Tian,Zijian Zhao,Tinghao Wu,Dan-Dan Zhai,Zhang-Jie Shi,Chi Zhang,Ke Hu
A one-pot cascade electrochemical strategy directly links N2 fixation with C─N/S─N bond formation. By suppressing ammonia formation, electrochemically generated Li3N is preserved as the cascade intermediate and intercepted by acyl/sulfonyl chlorides, enabling value-added imide and sulfonimide synthesis from N2.
{"title":"Cascade Electrosynthesis of Aryl Imides and Sulfonimides From N2 via Integrated Nitrogen Fixation and C─N/S─N Bond Formation","authors":"Weijian Yang,Jing-Ao Fan,Limei Tian,Zijian Zhao,Tinghao Wu,Dan-Dan Zhai,Zhang-Jie Shi,Chi Zhang,Ke Hu","doi":"10.1002/anie.9766022","DOIUrl":"https://doi.org/10.1002/anie.9766022","url":null,"abstract":"A one-pot cascade electrochemical strategy directly links N2 fixation with C─N/S─N bond formation. By suppressing ammonia formation, electrochemically generated Li3N is preserved as the cascade intermediate and intercepted by acyl/sulfonyl chlorides, enabling value-added imide and sulfonimide synthesis from N2.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zihao Gao,Hui Huang,Qiaomei Chen,Haisheng Fang,Mengdi Li,Jieyang Li,Chenglong Long,Yinhua Zhou,Weiwei Li
Zwitterionic TMG regulates 2PACz self-assembly through partial proton transfer and local electrostatic interactions, simultaneously suppressing molecular aggregation and strengthening P–O–M anchoring on ITO. The resulting uniform, robust, and electrostatically homogeneous SAM improves hole extraction, reduces interfacial recombination, and enables efficient, stable organic solar cells with 21.07% efficiency and large-area compatibility.
{"title":"Zwitterion-Regulated Carbazole Phosphonic Acid Self-Assembled Monolayers via Proton Transfer and Electrostatic Interactions for 21% Organic Solar Cells","authors":"Zihao Gao,Hui Huang,Qiaomei Chen,Haisheng Fang,Mengdi Li,Jieyang Li,Chenglong Long,Yinhua Zhou,Weiwei Li","doi":"10.1002/anie.1010721","DOIUrl":"https://doi.org/10.1002/anie.1010721","url":null,"abstract":"Zwitterionic TMG regulates 2PACz self-assembly through partial proton transfer and local electrostatic interactions, simultaneously suppressing molecular aggregation and strengthening P–O–M anchoring on ITO. The resulting uniform, robust, and electrostatically homogeneous SAM improves hole extraction, reduces interfacial recombination, and enables efficient, stable organic solar cells with 21.07% efficiency and large-area compatibility.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"11 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A hyperbranched topology strategy employs imide-containing dual-functional macromolecules as toughening and coupling agents, forming covalent interphases via thiol-ene click chemistry and a “penetration-locking” topology through network interpenetration, thereby elevating low-cost T300 fibers beyond T800-grade composites with full recovery of fibers and resin.
Dan Meng,Yan Yu,Rui Gao,Ming Li,Qiuhong Zhang,Youju Huang
Chiral gold superlattice films amplify the chirality-induced spin selectivity (CISS) effect and confined ion-transport signals for ultrasensitive enantiomer recognition. A CISS-recognition efficiency relationship is revealed, enabling high-performance chiral sensing and clinical medical monitoring.
{"title":"Tunable Spin-Polarized Chiral Plasmonic Films for Dual-Mode Enantiomer Recognition","authors":"Dan Meng,Yan Yu,Rui Gao,Ming Li,Qiuhong Zhang,Youju Huang","doi":"10.1002/anie.5841922","DOIUrl":"https://doi.org/10.1002/anie.5841922","url":null,"abstract":"Chiral gold superlattice films amplify the chirality-induced spin selectivity (CISS) effect and confined ion-transport signals for ultrasensitive enantiomer recognition. A CISS-recognition efficiency relationship is revealed, enabling high-performance chiral sensing and clinical medical monitoring.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"55 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuxing Lin,Yifan Zhou,Jiaqi Sang,Bihao Hu,Jikai Sun,Chao Yang,Yuhua Wen,Lei Wang,Pengfei Ou
Potassium concentration opens an optimal selectivity window for urea electrosynthesis on Cu. At an intermediate K+ concentration, favorable precursor geometry alignment and balanced electronic activation minimize the *CO–*NO coupling barrier and enhance urea selectivity. Molecular simulations and infrared spectroscopy link this response to changes in reaction energetics and the interfacial environment, guiding electrolyte design for selective urea formation.
{"title":"Potassium-Concentration-Gated C–N Coupling Enables a Volcano-Shaped Selectivity Window for Electrocatalytic Urea Synthesis","authors":"Yuxing Lin,Yifan Zhou,Jiaqi Sang,Bihao Hu,Jikai Sun,Chao Yang,Yuhua Wen,Lei Wang,Pengfei Ou","doi":"10.1002/anie.4817510","DOIUrl":"https://doi.org/10.1002/anie.4817510","url":null,"abstract":"Potassium concentration opens an optimal selectivity window for urea electrosynthesis on Cu. At an intermediate K+ concentration, favorable precursor geometry alignment and balanced electronic activation minimize the *CO–*NO coupling barrier and enhance urea selectivity. Molecular simulations and infrared spectroscopy link this response to changes in reaction energetics and the interfacial environment, guiding electrolyte design for selective urea formation.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"234 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aline Dantas de Araujo,Lei Luo,Mahan Azad,Miao Yu,Jody M. Mason,Junxian Lim,Timothy A. Hill,David P. Fairlie
Oncogenic MYC is a transcription factor that is difficult to inhibit. However, precise positioning of an acrylamide electrophile in MAX to covalently bond to the unique Cys438 in MYC, enabled shortening and optimizing of MAX-derived, helix-constrained peptides with high-affinity and selectivity. These covalent inhibitors block MAX-MYC interaction, while ester prodrugs trigger MYC degradation, suppressing cancer cell migration and proliferation.
{"title":"Downsizing Electrophilic MAX-Derived Helical Zipper Peptides to Covalently Bind and Degrade Oncogenic MYC","authors":"Aline Dantas de Araujo,Lei Luo,Mahan Azad,Miao Yu,Jody M. Mason,Junxian Lim,Timothy A. Hill,David P. Fairlie","doi":"10.1002/anie.4950007","DOIUrl":"https://doi.org/10.1002/anie.4950007","url":null,"abstract":"Oncogenic MYC is a transcription factor that is difficult to inhibit. However, precise positioning of an acrylamide electrophile in MAX to covalently bond to the unique Cys438 in MYC, enabled shortening and optimizing of MAX-derived, helix-constrained peptides with high-affinity and selectivity. These covalent inhibitors block MAX-MYC interaction, while ester prodrugs trigger MYC degradation, suppressing cancer cell migration and proliferation.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"4 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lei Hua,Zekun Xia,Kai Huang,Xinyi Qian,Weiguo Zhu,Yafei Wang
A centrosymmetric molecular strategy with quadruple boron–nitrogen heteroarenes yields highly rigid multi-resonance thermally activated delayed fluorescence (MR-TADF) emitters. Full width at half-maxima (FWHM) of 8.2 and 14.2 nm in hexane are achieved for green and yellow emission, respectively. A maximum EQE of 24.8% is obtained for the solution processable OLED.
{"title":"Centrosymmetric Molecular Strategy With Quadruple Boron–Nitrogen Heteroarenes Enabling Efficient Ultra-Narrowband Emission","authors":"Lei Hua,Zekun Xia,Kai Huang,Xinyi Qian,Weiguo Zhu,Yafei Wang","doi":"10.1002/anie.9341082","DOIUrl":"https://doi.org/10.1002/anie.9341082","url":null,"abstract":"A centrosymmetric molecular strategy with quadruple boron–nitrogen heteroarenes yields highly rigid multi-resonance thermally activated delayed fluorescence (MR-TADF) emitters. Full width at half-maxima (FWHM) of 8.2 and 14.2 nm in hexane are achieved for green and yellow emission, respectively. A maximum EQE of 24.8% is obtained for the solution processable OLED.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"26 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Synergistic high-entropy and N/O anchoring stabilization of ultrasmall PtPdIrRuCu alloy nanoparticles suppresses Ostwald ripening and migration, enabling durable and selective PET upcycling to glycolic acid with 7.66 A mgPt−1, 95.8% FE, and >240 h stability.
超小型PtPdIrRuCu合金纳米颗粒的协同高熵和N/O锚定稳定抑制了Ostwald成熟和迁移，实现了持久和选择性的PET升级为乙醇酸，具有7.66 A mgPt - 1, 95.8% FE和>240 h的稳定性。
{"title":"Synergistic High-Entropy and Anchoring Stabilization of PtPdIrRuCu Alloy Nanoparticles on N, O-Doped Carbon Cage Fibers for Durable and Selective PET Upcycling","authors":"Tong Zuo,Zhenle Hu,Jiahao Zhu,Zhanpeng Qi,Fujie Li,Zhenxi Xu,Ning Dai,Guojun Zhang,Zhiyao Gu,Zimeng Tian,Yanting Cheng,Chao Zhi,Jiaguang Meng,Xiang Li,Jingnan Wang,Yaming Liu","doi":"10.1002/anie.3049389","DOIUrl":"https://doi.org/10.1002/anie.3049389","url":null,"abstract":"Synergistic high-entropy and N/O anchoring stabilization of ultrasmall PtPdIrRuCu alloy nanoparticles suppresses Ostwald ripening and migration, enabling durable and selective PET upcycling to glycolic acid with 7.66 A mgPt−1, 95.8% FE, and >240 h stability.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"33 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xingtao Zheng,Zanjiao Liu,Jia-Hong Wu,Fan Wang,Siqiang Fang,Xingjie Luo,Jingxuan Wei,Tianli Wang
An organocatalytic dynamic kinetic resolution merges reversible Pudovik addition with stereoselective phospha-Brook rearrangement, converting racemic diastereomers into N–N axially chiral compounds. Bioinspired peptide-phosphonium salt catalysis enables catalyst-accelerated racemization and epimerization, affording good yields and high enantioselectivities. Mechanistic studies identify the rearrangement as stereodetermining and reveal synergistic hydrogen-bonding/ion-pairing control over asymmetric induction, establishing a new paradigm for axially chiral molecule synthesis.
{"title":"Organocatalytic Dynamic Kinetic Resolution for the Stereoconvergent Synthesis of N–N Axially Chiral Compounds","authors":"Xingtao Zheng,Zanjiao Liu,Jia-Hong Wu,Fan Wang,Siqiang Fang,Xingjie Luo,Jingxuan Wei,Tianli Wang","doi":"10.1002/anie.6151948","DOIUrl":"https://doi.org/10.1002/anie.6151948","url":null,"abstract":"An organocatalytic dynamic kinetic resolution merges reversible Pudovik addition with stereoselective phospha-Brook rearrangement, converting racemic diastereomers into N–N axially chiral compounds. Bioinspired peptide-phosphonium salt catalysis enables catalyst-accelerated racemization and epimerization, affording good yields and high enantioselectivities. Mechanistic studies identify the rearrangement as stereodetermining and reveal synergistic hydrogen-bonding/ion-pairing control over asymmetric induction, establishing a new paradigm for axially chiral molecule synthesis.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"42 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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