首页 > 最新文献

Journal of Medical Physics / Association of Medical Physicists of India最新文献

英文 中文
News and Events 新闻及活动
Pub Date : 2018-09-01 DOI: 10.1057/udi.1997.28
T. Ganesh
{"title":"News and Events","authors":"T. Ganesh","doi":"10.1057/udi.1997.28","DOIUrl":"https://doi.org/10.1057/udi.1997.28","url":null,"abstract":"","PeriodicalId":143694,"journal":{"name":"Journal of Medical Physics / Association of Medical Physicists of India","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115715206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gamma Putty dosimetric studies in electron beam 电子束中伽马腻子剂量学研究
Pub Date : 2016-07-01 DOI: 10.4103/0971-6203.189480
Aime M. Gloi
Traditionally, lead has been used for field shaping in megavoltage electron beams in radiation therapy. In this study, we analyze the dosimetric parameters of a nontoxic, high atomic number (Z = 83), bismuth-loaded material called Gamma Putty that is malleable and can be easily molded to any desired shape. First, we placed an ionization chamber at different depths in a solid water phantom under a Gamma Putty shield of thickness (t = 0, 3, 5, 10, 15, 20, and 25 mm, respectively) and measured the ionizing radiation on the central axis (CAX) for electron beam ranging in energies from 6 to 20 MeV. Next, we investigated the relationship between the relative ionization (RI) measured at a fixed depth for several Gamma Putty shield at different cutout diameters ranging from 2 to 5 cm for various beam energies and derived an exponential fitting equation for clinical purposes. The dose profiles along the CAX show that bremsstrahlung dominates for Gamma Putty thickness >15 mm. For high-energy beams (12-20 MeV) and all Gamma Putty thicknesses up to 25 mm, RI below 5% could not be achieved due to the strong bremsstrahlung component. However, Gamma Putty is a very suitable material for reducing the transmission factor below 5% and protecting underlying normal tissues for low-energy electron beams (6-9 MeV).
传统上,铅被用于在放射治疗中的超高压电子束的场整形。在这项研究中,我们分析了一种无毒、高原子序数(Z = 83)、铋负载材料Gamma腻子的剂量学参数,这种材料具有延展性,可以很容易地塑造成任何所需的形状。首先,在伽玛腻子屏蔽层(t分别为0、3、5、10、15、20和25 mm)下,我们将电离室放置在固体水模体的不同深度,并测量了能量为6至20 MeV的电子束在中心轴(CAX)上的电离辐射。接下来,我们研究了几种Gamma腻子屏蔽在固定深度测量的相对电离(RI)之间的关系,在不同的切口直径范围从2到5厘米,不同的光束能量,并推导了一个指数拟合方程,用于临床目的。沿CAX方向的剂量分布表明,当γ腻子厚度>15 mm时,韧致辐射占主导地位。对于高能光束(12-20 MeV)和所有Gamma腻子厚度达25 mm,由于强韧致辐射成分,RI无法达到5%以下。然而,Gamma腻子是一种非常合适的材料,可以将透射系数降低到5%以下,并在低能量电子束(6-9 MeV)下保护底层正常组织。
{"title":"Gamma Putty dosimetric studies in electron beam","authors":"Aime M. Gloi","doi":"10.4103/0971-6203.189480","DOIUrl":"https://doi.org/10.4103/0971-6203.189480","url":null,"abstract":"Traditionally, lead has been used for field shaping in megavoltage electron beams in radiation therapy. In this study, we analyze the dosimetric parameters of a nontoxic, high atomic number (Z = 83), bismuth-loaded material called Gamma Putty that is malleable and can be easily molded to any desired shape. First, we placed an ionization chamber at different depths in a solid water phantom under a Gamma Putty shield of thickness (t = 0, 3, 5, 10, 15, 20, and 25 mm, respectively) and measured the ionizing radiation on the central axis (CAX) for electron beam ranging in energies from 6 to 20 MeV. Next, we investigated the relationship between the relative ionization (RI) measured at a fixed depth for several Gamma Putty shield at different cutout diameters ranging from 2 to 5 cm for various beam energies and derived an exponential fitting equation for clinical purposes. The dose profiles along the CAX show that bremsstrahlung dominates for Gamma Putty thickness >15 mm. For high-energy beams (12-20 MeV) and all Gamma Putty thicknesses up to 25 mm, RI below 5% could not be achieved due to the strong bremsstrahlung component. However, Gamma Putty is a very suitable material for reducing the transmission factor below 5% and protecting underlying normal tissues for low-energy electron beams (6-9 MeV).","PeriodicalId":143694,"journal":{"name":"Journal of Medical Physics / Association of Medical Physicists of India","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122395361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dosimetric and radiobiological characterizations of prostate intensity-modulated radiotherapy and volumetric-modulated arc therapy: A single-institution review of ninety cases 前列腺调强放疗和体积调节电弧治疗的剂量学和放射生物学特征:一项对90例病例的单一机构回顾
Pub Date : 2016-07-01 DOI: 10.4103/0971-6203.189479
Muhammad Isa Khan, R. Jiang, A. Kiciak, Jalil ur Rehman, M. Afzal, J. Chow
This study reviewed prostate volumetric-modulated arc therapy (VMAT) plans with intensity-modulated radiotherapy (IMRT) plans after prostate IMRT technique was replaced by VMAT in an institution. Characterizations of dosimetry and radiobiological variation in prostate were determined based on treatment plans of 40 prostate IMRT patients (planning target volume = 77.8-335 cm 3 ) and 50 VMAT patients (planning target volume = 120-351 cm 3 ) treated before and after 2013, respectively. Both IMRT and VMAT plans used the same dose-volume criteria in the inverse planning optimization. Dose-volume histogram, mean doses of target and normal tissues (rectum, bladder and femoral heads), dose-volume points (D 99% of planning target volume; D 30% , D 50% , V 30 Gy and V 35 Gy of rectum and bladder; D 5% , V 14 Gy , V 22 Gy of femoral heads), conformity index (CI), homogeneity index (HI), gradient index (GI), prostate tumor control probability (TCP), and rectal normal tissue complication probability (NTCP) based on the Lyman-Burman-Kutcher algorithm were calculated for each IMRT and VMAT plan. From our results, VMAT plan was found better due to its higher (1.05%) CI, lower (0.83%) HI and (0.75%) GI than IMRT. Comparing doses in normal tissues between IMRT and VMAT, it was found that IMRT mostly delivered higher doses of about 1.05% to the normal tissues than VMAT. Prostate TCP and rectal NTCP were found increased (1%) for VMAT than IMRT. It is seen that VMAT technique can decrease the dose-volume evaluation criteria for the normal tissues. Based on our dosimetric and radiobiological results in treatment plans, it is concluded that our VMAT implementation could produce comparable or slightly better target coverage and normal tissue sparing with a faster treatment time in prostate radiotherapy.
本研究回顾了某机构在前列腺体积调节弧线治疗(VMAT)和调强放疗(IMRT)技术被VMAT取代后的治疗方案。根据2013年前后治疗的40例前列腺IMRT患者(计划靶体积= 77.8-335 cm 3)和50例VMAT患者(计划靶体积= 120-351 cm 3)的治疗方案,确定前列腺剂量学特征和放射生物学变化。IMRT和VMAT计划在逆向规划优化中使用相同的剂量-体积标准。剂量-体积直方图,靶组织和正常组织(直肠、膀胱和股骨头)的平均剂量,剂量-体积点(计划靶体积的d99%;D为30%,D为50%,V为30 Gy, V为35 Gy;以Lyman-Burman-Kutcher算法计算各IMRT和VMAT方案的D 5%、V 14 Gy、V 22 Gy、一致性指数(CI)、均匀性指数(HI)、梯度指数(GI)、前列腺肿瘤控制概率(TCP)和直肠正常组织并发症概率(NTCP)。从我们的结果来看,VMAT计划比IMRT有更高(1.05%)的CI,更低(0.83%)的HI和更低(0.75%)的GI。比较IMRT和VMAT在正常组织中的剂量,发现IMRT对正常组织的剂量大多高于VMAT,约为1.05%。VMAT组前列腺TCP和直肠NTCP较IMRT组增加(1%)。可见VMAT技术可以降低正常组织的剂量-体积评价标准。根据我们在治疗方案中的剂量学和放射生物学结果,我们得出结论,我们的VMAT实施可以在前列腺放疗中以更快的治疗时间产生相当或稍好的靶标覆盖和正常组织保留。
{"title":"Dosimetric and radiobiological characterizations of prostate intensity-modulated radiotherapy and volumetric-modulated arc therapy: A single-institution review of ninety cases","authors":"Muhammad Isa Khan, R. Jiang, A. Kiciak, Jalil ur Rehman, M. Afzal, J. Chow","doi":"10.4103/0971-6203.189479","DOIUrl":"https://doi.org/10.4103/0971-6203.189479","url":null,"abstract":"This study reviewed prostate volumetric-modulated arc therapy (VMAT) plans with intensity-modulated radiotherapy (IMRT) plans after prostate IMRT technique was replaced by VMAT in an institution. Characterizations of dosimetry and radiobiological variation in prostate were determined based on treatment plans of 40 prostate IMRT patients (planning target volume = 77.8-335 cm 3 ) and 50 VMAT patients (planning target volume = 120-351 cm 3 ) treated before and after 2013, respectively. Both IMRT and VMAT plans used the same dose-volume criteria in the inverse planning optimization. Dose-volume histogram, mean doses of target and normal tissues (rectum, bladder and femoral heads), dose-volume points (D 99% of planning target volume; D 30% , D 50% , V 30 Gy and V 35 Gy of rectum and bladder; D 5% , V 14 Gy , V 22 Gy of femoral heads), conformity index (CI), homogeneity index (HI), gradient index (GI), prostate tumor control probability (TCP), and rectal normal tissue complication probability (NTCP) based on the Lyman-Burman-Kutcher algorithm were calculated for each IMRT and VMAT plan. From our results, VMAT plan was found better due to its higher (1.05%) CI, lower (0.83%) HI and (0.75%) GI than IMRT. Comparing doses in normal tissues between IMRT and VMAT, it was found that IMRT mostly delivered higher doses of about 1.05% to the normal tissues than VMAT. Prostate TCP and rectal NTCP were found increased (1%) for VMAT than IMRT. It is seen that VMAT technique can decrease the dose-volume evaluation criteria for the normal tissues. Based on our dosimetric and radiobiological results in treatment plans, it is concluded that our VMAT implementation could produce comparable or slightly better target coverage and normal tissue sparing with a faster treatment time in prostate radiotherapy.","PeriodicalId":143694,"journal":{"name":"Journal of Medical Physics / Association of Medical Physicists of India","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122571156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Comparative study of old and new versions of treatment planning system using dose volume histogram indices of clinical plans 应用临床计划剂量体积直方图指标的新旧治疗计划系统比较研究
Pub Date : 2016-07-01 DOI: 10.4103/0971-6203.189489
G. S. Krishna, V. Srinivas, K. Ayyangar, P. Y. Reddy
Recently, Eclipse treatment planning system (TPS) version 8.8 was upgraded to the latest version 13.6. It is customary that the vendor gives training on how to upgrade the existing software to the new version. However, the customer is provided less inner details about changes in the new software version. According to manufacturer, accuracy of point dose calculations and irregular treatment planning is better in the new version (13.6) compared to the old version (8.8). Furthermore, the new version uses voxel-based calculations while the earlier version used point dose calculations. Major difference in intensity-modulated radiation therapy (IMRT) plans was observed between the two versions after re-optimization and re-calculations. However, minor difference was observed for IMRT cases after performing only re-calculations. It is recommended TPS quality assurance to be performed after any major upgrade of software. This can be done by performing dose calculation comparisons in TPS. To assess the difference between the versions, 25 clinical cases from the old version were compared keeping all the patient data intact including the monitor units and comparing the differences in dose calculations using dose volume histogram (DVH) analysis. Along with DVH analysis, uniformity index, conformity index, homogeneity index, and dose spillage index were also compared for both versions. The results of comparative study are presented in this paper.
最近,Eclipse治疗计划系统(TPS)版本8.8升级到最新版本13.6。通常,供应商会提供如何将现有软件升级到新版本的培训。但是,向客户提供的关于新软件版本更改的内部细节较少。据生产厂家反映,新版(13.6)在点剂量计算和不规则治疗计划方面的准确性优于旧版(8.8)。此外,新版本使用基于体素的计算,而早期版本使用点剂量计算。在重新优化和重新计算后,观察到两个版本之间调强放射治疗(IMRT)计划的主要差异。然而,在仅重新计算IMRT病例后,观察到的差异较小。建议在任何重大软件升级后执行TPS质量保证。这可以通过在TPS中进行剂量计算比较来实现。为了评估两个版本之间的差异,我们比较了旧版本的25例临床病例,保留了包括监护单元在内的所有患者数据,并使用剂量-体积直方图(DVH)分析比较了剂量计算的差异。在进行DVH分析的同时,还比较了两种版本的均匀性指数、一致性指数、均匀性指数和剂量溢出指数。本文给出了比较研究的结果。
{"title":"Comparative study of old and new versions of treatment planning system using dose volume histogram indices of clinical plans","authors":"G. S. Krishna, V. Srinivas, K. Ayyangar, P. Y. Reddy","doi":"10.4103/0971-6203.189489","DOIUrl":"https://doi.org/10.4103/0971-6203.189489","url":null,"abstract":"Recently, Eclipse treatment planning system (TPS) version 8.8 was upgraded to the latest version 13.6. It is customary that the vendor gives training on how to upgrade the existing software to the new version. However, the customer is provided less inner details about changes in the new software version. According to manufacturer, accuracy of point dose calculations and irregular treatment planning is better in the new version (13.6) compared to the old version (8.8). Furthermore, the new version uses voxel-based calculations while the earlier version used point dose calculations. Major difference in intensity-modulated radiation therapy (IMRT) plans was observed between the two versions after re-optimization and re-calculations. However, minor difference was observed for IMRT cases after performing only re-calculations. It is recommended TPS quality assurance to be performed after any major upgrade of software. This can be done by performing dose calculation comparisons in TPS. To assess the difference between the versions, 25 clinical cases from the old version were compared keeping all the patient data intact including the monitor units and comparing the differences in dose calculations using dose volume histogram (DVH) analysis. Along with DVH analysis, uniformity index, conformity index, homogeneity index, and dose spillage index were also compared for both versions. The results of comparative study are presented in this paper.","PeriodicalId":143694,"journal":{"name":"Journal of Medical Physics / Association of Medical Physicists of India","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124803530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Radiological risk assessment of cosmic radiation at aviation altitudes (a trip from Houston Intercontinental Airport to Lagos International Airport) 航空高度宇宙辐射的辐射风险评估(从休斯顿洲际机场到拉各斯国际机场的行程)
Pub Date : 2016-07-01 DOI: 10.4103/0971-6203.189491
P. Enyinna
Radiological risk parameters associated with aircrew members traveling from Houston Intercontinental Airport to Lagos International Airport have been computed using computer software called EPCARD (version 3.2). The mean annual effective dose of radiation was computed to be 2.94 mSv/year. This result is above the standard permissible limit of 1 mSv/year set for the public and pregnant aircrew members but below the limit set for occupationally exposed workers. The Risk of cancer mortality and excess career time cancer risk computed ranged from 3.5 × 10−5 to 24.5 × 10−5 (with average of 14.7 × 10−5 ) and 7 × 10−4 to 49 × 10−4 (with average of 29.4 × 10−4 ). Passengers and aircrew members should be aware of the extra cosmic radiation doses taken in during flights. All aircraft operators should monitor radiation doses incurred during aviation trips.
使用名为EPCARD(3.2版)的计算机软件计算了从休斯顿洲际机场飞往拉各斯国际机场的机组人员的辐射风险参数。计算得出年平均有效辐射剂量为2.94毫西弗/年。这一结果高于为公众和怀孕机组人员设定的每年1毫西弗的标准允许限值,但低于职业暴露工人设定的限值。计算得出的癌症死亡风险和超长职业时间癌症风险范围为3.5 × 10 - 5 ~ 24.5 × 10 - 5(平均值为14.7 × 10 - 5)和7 × 10 - 4 ~ 49 × 10 - 4(平均值为29.4 × 10 - 4)。乘客和机组人员应该注意在飞行过程中摄入的额外宇宙辐射剂量。所有飞机操作员都应监测航空旅行期间产生的辐射剂量。
{"title":"Radiological risk assessment of cosmic radiation at aviation altitudes (a trip from Houston Intercontinental Airport to Lagos International Airport)","authors":"P. Enyinna","doi":"10.4103/0971-6203.189491","DOIUrl":"https://doi.org/10.4103/0971-6203.189491","url":null,"abstract":"Radiological risk parameters associated with aircrew members traveling from Houston Intercontinental Airport to Lagos International Airport have been computed using computer software called EPCARD (version 3.2). The mean annual effective dose of radiation was computed to be 2.94 mSv/year. This result is above the standard permissible limit of 1 mSv/year set for the public and pregnant aircrew members but below the limit set for occupationally exposed workers. The Risk of cancer mortality and excess career time cancer risk computed ranged from 3.5 × 10−5 to 24.5 × 10−5 (with average of 14.7 × 10−5 ) and 7 × 10−4 to 49 × 10−4 (with average of 29.4 × 10−4 ). Passengers and aircrew members should be aware of the extra cosmic radiation doses taken in during flights. All aircraft operators should monitor radiation doses incurred during aviation trips.","PeriodicalId":143694,"journal":{"name":"Journal of Medical Physics / Association of Medical Physicists of India","volume":"65 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124218186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Radioprotective effects of hesperidin on oxidative damages and histopathological changes induced by X-irradiation in rats heart tissue 橙皮苷对x射线致大鼠心脏组织氧化损伤及组织病理改变的辐射防护作用
Pub Date : 2016-07-01 DOI: 10.4103/0971-6203.189482
A. Rezaeyan, G. Haddadi, Massood Hosseinzadeh, M. Moradi, M. Najafi
This study was carried out to evaluate radioprotective effects of hesperidin (HES) administration before the irradiation on the cardiac oxidative stress and histopathological changes in an experimental rat model. The cardiovascular complications of radiation exposure cause morbidity and mortality in patients who received radiotherapy. HES, an antioxidant flavonoid found in citrus fruits, suggests the protection against the tissue damage. Fifty-eight rats were divided into four groups: Group 1 received phosphate buffered saline (PBS) and sham radiation; Group 2, HES and sham radiation; Group 3, PBS and radiation; and Group 4, HES and radiation. The rats were exposed to single dose of 18 Gy of 6 MV X-ray. One hundred milligrams per kilogram doses of HES was administered for 7 days before irradiation. The estimation of superoxide dismutase (SOD), malondialdehyde (MDA), and histopathological analyses was performed at 24 h and 8 weeks after radiation exposure. The irradiation of chest area resulted in an elevated MDA level and decreased SOD activity. Moreover, long-term pathological lesions of radiation were inflammation, fibrosis, the increased number of mast cells and macrophages, and development of plaque, vascular leakage, myocardial degeneration, and myocyte necrosis. Although the administration of HES decreases inflammation, fibrosis, mast cell and macrophage numbers, and myocyte necrosis, it did not result in reduced thrombus, myocardium degeneration, and vascular leakage. In conclusion, these results suggest that HES can perform a radioprotection action. The protective effect of HES may be attributable to its immunomodulatory effects and free radical-scavenging properties.
本研究旨在评价辐照前给药橙皮苷(HES)对实验性大鼠心脏氧化应激和组织病理学改变的辐射防护作用。在接受放射治疗的患者中,辐射暴露的心血管并发症引起发病率和死亡率。HES是一种在柑橘类水果中发现的抗氧化剂类黄酮,它可以防止组织损伤。58只大鼠分为4组:1组给予磷酸盐缓冲盐水(PBS)和假放疗;第2组,HES与假放疗;第3组,PBS和辐射;第4组,HES和辐射。大鼠接受单次剂量18 Gy、6 MV x射线照射。辐照前7天给予每公斤100毫克的HES剂量。在辐射暴露后24小时和8周进行超氧化物歧化酶(SOD)、丙二醛(MDA)的测定和组织病理学分析。胸部照射导致大鼠MDA水平升高,SOD活性降低。长期病理病变表现为炎症、纤维化、肥大细胞和巨噬细胞增多、斑块形成、血管渗漏、心肌变性、肌细胞坏死。虽然HES可以减少炎症、纤维化、肥大细胞和巨噬细胞数量以及心肌细胞坏死,但它并没有减少血栓、心肌变性和血管渗漏。综上所述,这些结果表明HES具有一定的辐射防护作用。HES的保护作用可能与其免疫调节作用和自由基清除作用有关。
{"title":"Radioprotective effects of hesperidin on oxidative damages and histopathological changes induced by X-irradiation in rats heart tissue","authors":"A. Rezaeyan, G. Haddadi, Massood Hosseinzadeh, M. Moradi, M. Najafi","doi":"10.4103/0971-6203.189482","DOIUrl":"https://doi.org/10.4103/0971-6203.189482","url":null,"abstract":"This study was carried out to evaluate radioprotective effects of hesperidin (HES) administration before the irradiation on the cardiac oxidative stress and histopathological changes in an experimental rat model. The cardiovascular complications of radiation exposure cause morbidity and mortality in patients who received radiotherapy. HES, an antioxidant flavonoid found in citrus fruits, suggests the protection against the tissue damage. Fifty-eight rats were divided into four groups: Group 1 received phosphate buffered saline (PBS) and sham radiation; Group 2, HES and sham radiation; Group 3, PBS and radiation; and Group 4, HES and radiation. The rats were exposed to single dose of 18 Gy of 6 MV X-ray. One hundred milligrams per kilogram doses of HES was administered for 7 days before irradiation. The estimation of superoxide dismutase (SOD), malondialdehyde (MDA), and histopathological analyses was performed at 24 h and 8 weeks after radiation exposure. The irradiation of chest area resulted in an elevated MDA level and decreased SOD activity. Moreover, long-term pathological lesions of radiation were inflammation, fibrosis, the increased number of mast cells and macrophages, and development of plaque, vascular leakage, myocardial degeneration, and myocyte necrosis. Although the administration of HES decreases inflammation, fibrosis, mast cell and macrophage numbers, and myocyte necrosis, it did not result in reduced thrombus, myocardium degeneration, and vascular leakage. In conclusion, these results suggest that HES can perform a radioprotection action. The protective effect of HES may be attributable to its immunomodulatory effects and free radical-scavenging properties.","PeriodicalId":143694,"journal":{"name":"Journal of Medical Physics / Association of Medical Physicists of India","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134576274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 42
Analysis of dose distribution in organs at risk in patients with prostate cancer treated with the intensity-modulated radiation therapy and arc technique 调强放疗和电弧技术治疗前列腺癌患者危险器官的剂量分布分析
Pub Date : 2016-07-01 DOI: 10.4103/0971-6203.189490
Michał Biegała, A. Hydzik
This study describes a comparative analysis of treatment plans in 48 patients with prostate cancer treated with ionizing radiation. Each patient was subjected to the intensity-modulated radiation therapy (IMRT) and arc technique. In each treatment plan, the organs at risk were assessed: the urinary bladder, rectum and heads of the femur, as well as the volume of normal tissue. The following features were compared: treatment time, conformity indices for the planning target volume, mean doses and standard deviation in organs at risk, and organ volumes for each particular dose. The treatment period in the arc technique is 13.7% shorter than in the IMRT technique. Comparing the results of the IMRT and arc techniques (arc vs. IMRT), the mean values were 29.21 ± 12.91 Gy versus 28.36 ± 13.79 Gy for the bladder, 20.36 ± 3.16 Gy versus 18.17 ± 5.11 Gy for the right femoral head, and 18.98 ± 3.28 Gy versus 16.67 ± 5.15 Gy for the left femoral head. For the rectum, lower values were obtained after application of the arc technique, not the IMRT technique: 35.84 ± 12.28 Gy versus 35.90 ± 13.05 Gy. The results indicate that the applied therapy has a statistically significant influence on the volume for a particular dose with regard to the urinary bladder. It is advisable to apply the IMRT technique to patients who need the femur heads and urinary bladder protected by exposing them to low irradiation doses.
本研究对48例接受电离辐射治疗的前列腺癌患者的治疗方案进行比较分析。每位患者均接受调强放射治疗(IMRT)和电弧技术。在每个治疗方案中,评估了有风险的器官:膀胱、直肠和股骨头,以及正常组织的体积。比较治疗时间、计划靶体积符合性指标、危及器官的平均剂量和标准差、各特定剂量下的器官体积。电弧技术的治疗周期比IMRT技术短13.7%。比较IMRT和arc技术(arc vs IMRT)的结果,膀胱的平均值为29.21±12.91 Gy对28.36±13.79 Gy,右侧股骨头的平均值为20.36±3.16 Gy对18.17±5.11 Gy,左侧股骨头的平均值为18.98±3.28 Gy对16.67±5.15 Gy。对于直肠,应用电弧技术获得的数值较低,而非IMRT技术:35.84±12.28 Gy和35.90±13.05 Gy。结果表明,在特定剂量下,应用的治疗对膀胱的体积有统计学上显著的影响。对于需要在低剂量照射下保护股骨头和膀胱的患者,建议应用IMRT技术。
{"title":"Analysis of dose distribution in organs at risk in patients with prostate cancer treated with the intensity-modulated radiation therapy and arc technique","authors":"Michał Biegała, A. Hydzik","doi":"10.4103/0971-6203.189490","DOIUrl":"https://doi.org/10.4103/0971-6203.189490","url":null,"abstract":"This study describes a comparative analysis of treatment plans in 48 patients with prostate cancer treated with ionizing radiation. Each patient was subjected to the intensity-modulated radiation therapy (IMRT) and arc technique. In each treatment plan, the organs at risk were assessed: the urinary bladder, rectum and heads of the femur, as well as the volume of normal tissue. The following features were compared: treatment time, conformity indices for the planning target volume, mean doses and standard deviation in organs at risk, and organ volumes for each particular dose. The treatment period in the arc technique is 13.7% shorter than in the IMRT technique. Comparing the results of the IMRT and arc techniques (arc vs. IMRT), the mean values were 29.21 ± 12.91 Gy versus 28.36 ± 13.79 Gy for the bladder, 20.36 ± 3.16 Gy versus 18.17 ± 5.11 Gy for the right femoral head, and 18.98 ± 3.28 Gy versus 16.67 ± 5.15 Gy for the left femoral head. For the rectum, lower values were obtained after application of the arc technique, not the IMRT technique: 35.84 ± 12.28 Gy versus 35.90 ± 13.05 Gy. The results indicate that the applied therapy has a statistically significant influence on the volume for a particular dose with regard to the urinary bladder. It is advisable to apply the IMRT technique to patients who need the femur heads and urinary bladder protected by exposing them to low irradiation doses.","PeriodicalId":143694,"journal":{"name":"Journal of Medical Physics / Association of Medical Physicists of India","volume":"224 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114428210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Medical physics aspects in accreditation of radiation oncology practice 放射肿瘤学实践认证的医学物理方面
Pub Date : 2016-07-01 DOI: 10.4103/0971-6203.189452
S. Rustgi
Diagnosis of cancer is usually a life‐changing experience for patients and their loved ones. As they seek treatment for their disease, cancer patients need to know that they are receiving safe and appropriate care. When the cancer patient receives radiation treatment at an accredited radiation oncology facility, he can rest assured that his treatment will be done at a facility that has met the highest level of quality and radiation safety. Therefore, it is important to understand that every aspect of the accreditation process is overseen by certified, expert radiation oncologists and medical physicists.
对于患者和他们的亲人来说,癌症的诊断通常是改变他们一生的经历。当癌症患者寻求治疗时,他们需要知道他们正在接受安全和适当的护理。当癌症患者在认可的放射肿瘤学设施接受放射治疗时,他可以放心,他的治疗将在符合最高质量和辐射安全水平的设施中进行。因此,重要的是要明白,认证过程的每一个方面都是由经过认证的放射肿瘤学专家和医学物理学家监督的。
{"title":"Medical physics aspects in accreditation of radiation oncology practice","authors":"S. Rustgi","doi":"10.4103/0971-6203.189452","DOIUrl":"https://doi.org/10.4103/0971-6203.189452","url":null,"abstract":"Diagnosis of cancer is usually a life‐changing experience for patients and their loved ones. As they seek treatment for their disease, cancer patients need to know that they are receiving safe and appropriate care. When the cancer patient receives radiation treatment at an accredited radiation oncology facility, he can rest assured that his treatment will be done at a facility that has met the highest level of quality and radiation safety. Therefore, it is important to understand that every aspect of the accreditation process is overseen by certified, expert radiation oncologists and medical physicists.","PeriodicalId":143694,"journal":{"name":"Journal of Medical Physics / Association of Medical Physicists of India","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125767272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Investigation of grid performance using simple image quality tests 使用简单的图像质量测试调查网格性能
Pub Date : 2016-01-01 DOI: 10.4103/0971-6203.177280
D. Bor, O. Birgul, Umran Onal, T. Olgar
Antiscatter grids improve the X-ray image contrast at a cost of patient radiation doses. The choice of appropriate grid or its removal requires a good knowledge of grid characteristics, especially for pediatric digital imaging. The aim of this work is to understand the relation between grid performance parameters and some numerical image quality metrics for digital radiological examinations. The grid parameters such as bucky factor (BF), selectivity (Σ), Contrast improvement factor (CIF), and signal-to-noise improvement factor (SIF) were determined following the measurements of primary, scatter, and total radiations with a digital fluoroscopic system for the thicknesses of 5, 10, 15, 20, and 25 cm polymethyl methacrylate blocks at the tube voltages of 70, 90, and 120 kVp. Image contrast for low- and high-contrast objects and high-contrast spatial resolution were measured with simple phantoms using the same scatter thicknesses and tube voltages. BF and SIF values were also calculated from the images obtained with and without grids. The correlation coefficients between BF values obtained using two approaches (grid parameters and image quality metrics) were in good agreement. Proposed approach provides a quick and practical way of estimating grid performance for different digital fluoroscopic examinations.
反散射网格以病人的辐射剂量为代价提高x射线图像的对比度。选择合适的网格或去除网格需要对网格特性有很好的了解,特别是对于儿科数字成像。这项工作的目的是了解网格性能参数和数字放射学检查的一些数值图像质量指标之间的关系。网格参数,如bucky factor (BF)、选择性(Σ)、对比度改善因子(CIF)和信噪比改善因子(SIF),是在用数字荧光系统测量5、10、15、20和25 cm厚度的聚甲基丙烯酸甲酯块在70、90和120 kVp的管电压下的初级、散射和总辐射后确定的。使用相同的散射厚度和管电压,用简单的模型测量了低对比度和高对比度物体的图像对比度和高对比度空间分辨率。同时计算了带网格和不带网格图像的BF和SIF值。两种方法(网格参数和图像质量度量)得到的BF值之间的相关系数是一致的。该方法提供了一种快速实用的方法来估计不同数字透视检查的网格性能。
{"title":"Investigation of grid performance using simple image quality tests","authors":"D. Bor, O. Birgul, Umran Onal, T. Olgar","doi":"10.4103/0971-6203.177280","DOIUrl":"https://doi.org/10.4103/0971-6203.177280","url":null,"abstract":"Antiscatter grids improve the X-ray image contrast at a cost of patient radiation doses. The choice of appropriate grid or its removal requires a good knowledge of grid characteristics, especially for pediatric digital imaging. The aim of this work is to understand the relation between grid performance parameters and some numerical image quality metrics for digital radiological examinations. The grid parameters such as bucky factor (BF), selectivity (Σ), Contrast improvement factor (CIF), and signal-to-noise improvement factor (SIF) were determined following the measurements of primary, scatter, and total radiations with a digital fluoroscopic system for the thicknesses of 5, 10, 15, 20, and 25 cm polymethyl methacrylate blocks at the tube voltages of 70, 90, and 120 kVp. Image contrast for low- and high-contrast objects and high-contrast spatial resolution were measured with simple phantoms using the same scatter thicknesses and tube voltages. BF and SIF values were also calculated from the images obtained with and without grids. The correlation coefficients between BF values obtained using two approaches (grid parameters and image quality metrics) were in good agreement. Proposed approach provides a quick and practical way of estimating grid performance for different digital fluoroscopic examinations.","PeriodicalId":143694,"journal":{"name":"Journal of Medical Physics / Association of Medical Physicists of India","volume":"208 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114757516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Evaluation of various boluses in dose distribution for electron therapy of the chest wall with an inward defect 胸壁内缺陷电子治疗不同剂量分布的评价
Pub Date : 2016-01-01 DOI: 10.4103/0971-6203.177288
Hoda Mahdavi, K. Jabbari, M. Roayaei
Delivering radiotherapy to the postmastectomy chest wall can be achieved using matched electron fields. Surgical defects of the chest wall change the dose distribution of electrons. In this study, the improvement of dose homogeneity using simple, nonconformal techniques of thermoplastic bolus application on a defect is evaluated. The proposed phantom design improves the capability of film dosimetry for obtaining dose profiles of a patient's anatomical condition. A modeled electron field of a patient with a postmastectomy inward surgical defect was planned. High energy electrons were delivered to the phantom in various settings, including no bolus, a bolus that filled the inward defect (PB0), a uniform thickness bolus of 5 mm (PB1), and two 5 mm boluses (PB2). A reduction of mean doses at the base of the defect was observed by any bolus application. PB0 increased the dose at central parts of the defect, reduced hot areas at the base of steep edges, and reduced dose to the lung and heart. Thermoplastic boluses that compensate a defect (PB0) increased the homogeneity of dose in a fixed depth from the surface; adversely, PB2 increased the dose heterogeneity. This study shows that it is practical to investigate dose homogeneity profiles inside a target volume for various techniques of electron therapy.
乳房切除术后胸壁放射治疗可以使用匹配的电子场来实现。胸壁的手术缺陷改变了电子的剂量分布。在这项研究中,使用简单的,非保形技术热塑性弹丸应用于缺陷的剂量均匀性的改善进行了评估。提出的模体设计提高了胶片剂量学的能力,以获得患者解剖状况的剂量谱。一个模型的电子场的病人乳房切除术后向内手术缺陷计划。在不同的设置下,高能电子被输送到幻体,包括不输送,一个填充向内缺陷的输送(PB0),一个均匀厚度为5毫米的输送(PB1)和两个5毫米的输送(PB2)。在缺陷底部的平均剂量的减少,观察到任何丸的应用。PB0增加了缺损中心部位的剂量,减少了陡峭边缘基部的热区,减少了肺和心脏的剂量。补偿缺陷(PB0)的热塑性微丸增加了距离表面一定深度的剂量均匀性;相反,PB2增加了剂量异质性。这项研究表明,在不同的电子治疗技术中,研究靶体积内的剂量均匀性曲线是可行的。
{"title":"Evaluation of various boluses in dose distribution for electron therapy of the chest wall with an inward defect","authors":"Hoda Mahdavi, K. Jabbari, M. Roayaei","doi":"10.4103/0971-6203.177288","DOIUrl":"https://doi.org/10.4103/0971-6203.177288","url":null,"abstract":"Delivering radiotherapy to the postmastectomy chest wall can be achieved using matched electron fields. Surgical defects of the chest wall change the dose distribution of electrons. In this study, the improvement of dose homogeneity using simple, nonconformal techniques of thermoplastic bolus application on a defect is evaluated. The proposed phantom design improves the capability of film dosimetry for obtaining dose profiles of a patient's anatomical condition. A modeled electron field of a patient with a postmastectomy inward surgical defect was planned. High energy electrons were delivered to the phantom in various settings, including no bolus, a bolus that filled the inward defect (PB0), a uniform thickness bolus of 5 mm (PB1), and two 5 mm boluses (PB2). A reduction of mean doses at the base of the defect was observed by any bolus application. PB0 increased the dose at central parts of the defect, reduced hot areas at the base of steep edges, and reduced dose to the lung and heart. Thermoplastic boluses that compensate a defect (PB0) increased the homogeneity of dose in a fixed depth from the surface; adversely, PB2 increased the dose heterogeneity. This study shows that it is practical to investigate dose homogeneity profiles inside a target volume for various techniques of electron therapy.","PeriodicalId":143694,"journal":{"name":"Journal of Medical Physics / Association of Medical Physicists of India","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122456349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
期刊
Journal of Medical Physics / Association of Medical Physicists of India
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1