Pub Date : 2024-03-22DOI: 10.1177/09732179241234519
Pragya Mishra, Shalini Tripathi, Akhil Sharma, G. Sonkar, Mala Kumar, S.N. Singh
Background: Bronchopulmonary dysplasia (BPD) in preterm neonates is a dreadful complication that increases the length of neonatal intensive care unit (NICU) stay, increases the cost of treatment, and poses long-term respiratory morbidity. Methods: This was a case-control study to determine risk factors for BPD among preterm neonates (gestational age <32 weeks). Also, the proportion of BPD neonates developing secondary pulmonary arterial hypertension (PAH), vitamin D levels, and their outcomes were studied. Results: Of 70 neonates with a mean birth weight of 1392 ± 544.28 grams and a mean gestational age of 30.14 ± 1.12 weeks, 35 cases of BPD (mild 42%, moderate 27%, severe 31%) and 35 controls were enrolled. After multivariate analysis, SGA (adjusted odds ratio [AOR] 12.6 with 95% CI 1.5-109.3; 0.022), lack of antenatal steroids (AOR 9.4 with 95% CI 1.8-50.7; 0.009), mechanical ventilation [MV] within the first 48 hours of life (AOR 8.7 with 95% CI 1.4-54.1; 0.021), and lack of surfactant administration (AOR 16.5% CI 3-89.1; 0.005) were independent risk factors. No significant difference was reported in vitamin D levels between BPD and non-BPD neonates (33.89 ± 22.50 ng/mL vs. 27.00 ± 8.17 ng/mL; 0.356). 14.3 % of BPD neonates expired, and 23% developed PAH. Neonates had a longer NICU stay than controls (46.66 ± 7.96 vs. 21 ± 8.82 days; <0.001) Conclusion: We found SGA, lack of antenatal steroids, MV, and lack of surfactant administration to be independent risk factors for BPD. BPD neonates had dismal outcomes (one-fourth expired and left against medical advice), and one-fifth had PAH among survivors, increasing the length of their NICU stay.
{"title":"Bronchopulmonary Dysplasia in a Tertiary Level Neonatal Unit of North India: Risk Factors and Outcome: A Case-control Study","authors":"Pragya Mishra, Shalini Tripathi, Akhil Sharma, G. Sonkar, Mala Kumar, S.N. Singh","doi":"10.1177/09732179241234519","DOIUrl":"https://doi.org/10.1177/09732179241234519","url":null,"abstract":"Background: Bronchopulmonary dysplasia (BPD) in preterm neonates is a dreadful complication that increases the length of neonatal intensive care unit (NICU) stay, increases the cost of treatment, and poses long-term respiratory morbidity. Methods: This was a case-control study to determine risk factors for BPD among preterm neonates (gestational age <32 weeks). Also, the proportion of BPD neonates developing secondary pulmonary arterial hypertension (PAH), vitamin D levels, and their outcomes were studied. Results: Of 70 neonates with a mean birth weight of 1392 ± 544.28 grams and a mean gestational age of 30.14 ± 1.12 weeks, 35 cases of BPD (mild 42%, moderate 27%, severe 31%) and 35 controls were enrolled. After multivariate analysis, SGA (adjusted odds ratio [AOR] 12.6 with 95% CI 1.5-109.3; 0.022), lack of antenatal steroids (AOR 9.4 with 95% CI 1.8-50.7; 0.009), mechanical ventilation [MV] within the first 48 hours of life (AOR 8.7 with 95% CI 1.4-54.1; 0.021), and lack of surfactant administration (AOR 16.5% CI 3-89.1; 0.005) were independent risk factors. No significant difference was reported in vitamin D levels between BPD and non-BPD neonates (33.89 ± 22.50 ng/mL vs. 27.00 ± 8.17 ng/mL; 0.356). 14.3 % of BPD neonates expired, and 23% developed PAH. Neonates had a longer NICU stay than controls (46.66 ± 7.96 vs. 21 ± 8.82 days; <0.001) Conclusion: We found SGA, lack of antenatal steroids, MV, and lack of surfactant administration to be independent risk factors for BPD. BPD neonates had dismal outcomes (one-fourth expired and left against medical advice), and one-fifth had PAH among survivors, increasing the length of their NICU stay.","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140216764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: In the middle of 2018, we noticed an outbreak of sepsis due to Burkholderia cepacia complex among inborn babies, and this continued till December 2020. These babies were not responding to conventional antibiotic therapy. Aim: To study the clinical profile of neonates with Burkholderia septicemia, to determine its antimicrobial susceptibility patterns, and to identify the source of infection. Materials and methods: This was a retrospective descriptive study conducted in the inborn nursery of the Government Medical College, Thiruvananthapuram for a period of 30 months, from June 2018 to December 2020. All babies whose blood culture was positive for Burkholderia were identified from the records. Microbiological surveillance was done for source identification. Results: Out of the total 2264 neonates admitted during the study period, 84 (3.7%) had Burkholderia cepacia sepsis. The mean gestational age was 31(2) weeks. The most common clinical presentation was feed intolerance (64%) and 12% had a liver abscess. The highest antimicrobial sensitivity was observed for ceftazidime and cotrimoxazole (100%) followed by cefoperazone-sulbactam (98%) and meropenem (94%). The outbreak was controlled by the withdrawal of contaminated muti-use USG gel and the implementation of the practice of single-use sterile USG gel. Conclusions: Gastrointestinal manifestations are predominantly a manifestation in Burkholderia cepacia sepsis and a strong suspicion of liver abscess should be kept in mind. cotrimoxazole and ceftazidime are the best choice of antibiotics. Unsterile ultrasound gel use in the labor room and NICU can be a source of infection
{"title":"Ultrasound Gel as a Source of Burkholderia cepacia Sepsis Outbreak in Preterm Neonates","authors":"Raunak Raj, Radhika Sujatha, Sahira Haneefa, Vishnu Vasantha Sundaresan, Aswathy Rahul","doi":"10.1177/09732179241234188","DOIUrl":"https://doi.org/10.1177/09732179241234188","url":null,"abstract":"Background: In the middle of 2018, we noticed an outbreak of sepsis due to Burkholderia cepacia complex among inborn babies, and this continued till December 2020. These babies were not responding to conventional antibiotic therapy. Aim: To study the clinical profile of neonates with Burkholderia septicemia, to determine its antimicrobial susceptibility patterns, and to identify the source of infection. Materials and methods: This was a retrospective descriptive study conducted in the inborn nursery of the Government Medical College, Thiruvananthapuram for a period of 30 months, from June 2018 to December 2020. All babies whose blood culture was positive for Burkholderia were identified from the records. Microbiological surveillance was done for source identification. Results: Out of the total 2264 neonates admitted during the study period, 84 (3.7%) had Burkholderia cepacia sepsis. The mean gestational age was 31(2) weeks. The most common clinical presentation was feed intolerance (64%) and 12% had a liver abscess. The highest antimicrobial sensitivity was observed for ceftazidime and cotrimoxazole (100%) followed by cefoperazone-sulbactam (98%) and meropenem (94%). The outbreak was controlled by the withdrawal of contaminated muti-use USG gel and the implementation of the practice of single-use sterile USG gel. Conclusions: Gastrointestinal manifestations are predominantly a manifestation in Burkholderia cepacia sepsis and a strong suspicion of liver abscess should be kept in mind. cotrimoxazole and ceftazidime are the best choice of antibiotics. Unsterile ultrasound gel use in the labor room and NICU can be a source of infection","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"3 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-19DOI: 10.1177/09732179241234182
Lalitha Rajalakshmi S, Lakshmi Venugopalan, Gnanasambandam Subramaniyam, N. Krishnamoorthy
Aim: To assess the value of perfusion index (PI) and arrive at the ideal cut-off value of delta PI (DPI) (pre and postductal difference in PI) in identifying hemodynamically significant patent ductus arteriosus (HsPDA). Methods: Prospective observational study was conducted on 156 preterm newborns of <37 weeks in the NICU of tertiary care center, from August 2019 to March 2020 after ethical clearance. 156 preterm babies were classified into noPDA, HsPDA and Non-HsPDA based on echocardiogram findings and compared with DPI value on Day 1 to 3 of life. Receiver operating characteristic (ROC) curve was constructed to establish cut-offs for DPI in diagnosing HsPDA. A P value <.05 is considered for statistical significance. Results: There was a significantly lower PI in both preductal and post ductal limbs with HsPDA compared to other groups. A DPI Cut-off of 0.75 on day 2 of life has a sensitivity of 75%, specificity of 100% and positive predictive value (PPV) of 100% and a negative predictive value of 89%. Conclusion: PI is a simple non-invasive bedside index predict the presence of a HsPDA in preterm newborns and DPI of >0.75 indicates for presence of HsPDA.
目的：评估灌注指数（PI）的价值，并确定δPI（DPI）（导管前和导管后的 PI 差值）的理想临界值，以识别血流动力学意义上的动脉导管未闭（HsPDA）。研究方法对 156 名 0.75 指征的早产新生儿进行了前瞻性观察研究，以确定是否存在 HsPDA。
{"title":"Perfusion Index as a Predictor of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Newborns","authors":"Lalitha Rajalakshmi S, Lakshmi Venugopalan, Gnanasambandam Subramaniyam, N. Krishnamoorthy","doi":"10.1177/09732179241234182","DOIUrl":"https://doi.org/10.1177/09732179241234182","url":null,"abstract":"Aim: To assess the value of perfusion index (PI) and arrive at the ideal cut-off value of delta PI (DPI) (pre and postductal difference in PI) in identifying hemodynamically significant patent ductus arteriosus (HsPDA). Methods: Prospective observational study was conducted on 156 preterm newborns of <37 weeks in the NICU of tertiary care center, from August 2019 to March 2020 after ethical clearance. 156 preterm babies were classified into noPDA, HsPDA and Non-HsPDA based on echocardiogram findings and compared with DPI value on Day 1 to 3 of life. Receiver operating characteristic (ROC) curve was constructed to establish cut-offs for DPI in diagnosing HsPDA. A P value <.05 is considered for statistical significance. Results: There was a significantly lower PI in both preductal and post ductal limbs with HsPDA compared to other groups. A DPI Cut-off of 0.75 on day 2 of life has a sensitivity of 75%, specificity of 100% and positive predictive value (PPV) of 100% and a negative predictive value of 89%. Conclusion: PI is a simple non-invasive bedside index predict the presence of a HsPDA in preterm newborns and DPI of >0.75 indicates for presence of HsPDA.","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140228572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-19DOI: 10.1177/09732179241234177
Geethanjali Rupnagudi, Anil Mathew, P. Bendapudi
Here we report a case of a late preterm baby, noted to have asymptomatic hypoglycemia and developed transient metabolic acidosis with hyponatremia and hyperkalemia whilst being treated with continuous infusion of glucagon.
{"title":"Unveiling the Downside of Glucagon Therapy for Neonatal Hypoglycemia: A Case Report","authors":"Geethanjali Rupnagudi, Anil Mathew, P. Bendapudi","doi":"10.1177/09732179241234177","DOIUrl":"https://doi.org/10.1177/09732179241234177","url":null,"abstract":"Here we report a case of a late preterm baby, noted to have asymptomatic hypoglycemia and developed transient metabolic acidosis with hyponatremia and hyperkalemia whilst being treated with continuous infusion of glucagon.","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"72 S103","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140229722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-19DOI: 10.1177/09732179241234515
Jennifer Webb, Sian Elliott, W. J. Watkins, Laura Stuttaford, Sujoy Banerjee, Babatunde Kayode-Adedeji, Gautam Bagga, Neha Sharma, M. Chakraborty
Objective: Current formulae used by clinicians to estimate the insertion length of umbilical catheters are inaccurate. We aimed to derive a new model that could improve accuracy in estimating the insertion length of umbilical catheters. Study design: This was a multi-centre prospective observational study of neonates admitted to neonatal units and needing umbilical line(s) inserted for clinical reasons. Demographic data, catheter-related measurements and a new external length measurement—sternal notch to the umbilicus, were collected at three tertiary-level neonatal units in South Wales, UK. Generalised linear models were used to estimate the fit of the external length, birthweight, gestation and head circumference with catheter length and to derive a formula. The best fit was estimated by comparing r 2 values for each equation. Results: Data from 113 infants for each venous and arterial line were analysed for the new mathematical formulae. For both umbilical arterial catheterisation [[Formula: see text] and umbilical venous catheter (UVC) [[Formula: see text]], a quadratic model based on birthweight was found to have the best fit for predicting the insertion length of the catheters. However, the overall fit for UVCs was poorer for all explanatory variables ( y = estimated insertion length of the umbilical catheter in cm, x = birthweight in kg). Conclusion: Our prospective multi-centre observational study identified a quadratic model based on birthweight as the best fit for estimating the insertion length of umbilical lines in neonates. This is a new finding and further development on earlier birthweight-based linear models.
目的：临床医生目前用于估算脐部导管插入长度的公式并不准确。我们的目的是建立一个新模型，以提高估计脐部导管插入长度的准确性。研究设计：这是一项多中心前瞻性观察研究，研究对象是新生儿病房收治的因临床原因需要插入脐导管的新生儿。在英国南威尔士的三个三级新生儿科室收集了人口统计学数据、导管相关测量数据和新的外部长度测量数据--到脐部的胸骨切迹。我们使用广义线性模型来估计外部长度、出生体重、妊娠和头围与导管长度的拟合度，并得出一个公式。通过比较每个等式的 r 2 值来估计最佳拟合度。结果：根据新的数学公式分析了 113 名婴儿的静脉和动脉导管数据。对于脐动脉导管插入术[[公式：见正文]]和脐静脉导管插入术（UVC）[[公式：见正文]]，基于出生体重的二次模型被认为是预测导管插入长度的最佳拟合模型。然而，在所有解释变量中，脐静脉导管的总体拟合效果较差（y = 脐静脉导管的估计插入长度，单位为厘米；x = 出生体重，单位为千克）。结论我们的前瞻性多中心观察研究发现，基于出生体重的二次模型是估计新生儿脐管插入长度的最佳拟合模型。这是一项新发现，是对早期基于出生体重的线性模型的进一步发展。
{"title":"A New Formula for Estimating Insertion Length of Umbilical Catheters in Neonates: An Observational Study","authors":"Jennifer Webb, Sian Elliott, W. J. Watkins, Laura Stuttaford, Sujoy Banerjee, Babatunde Kayode-Adedeji, Gautam Bagga, Neha Sharma, M. Chakraborty","doi":"10.1177/09732179241234515","DOIUrl":"https://doi.org/10.1177/09732179241234515","url":null,"abstract":"Objective: Current formulae used by clinicians to estimate the insertion length of umbilical catheters are inaccurate. We aimed to derive a new model that could improve accuracy in estimating the insertion length of umbilical catheters. Study design: This was a multi-centre prospective observational study of neonates admitted to neonatal units and needing umbilical line(s) inserted for clinical reasons. Demographic data, catheter-related measurements and a new external length measurement—sternal notch to the umbilicus, were collected at three tertiary-level neonatal units in South Wales, UK. Generalised linear models were used to estimate the fit of the external length, birthweight, gestation and head circumference with catheter length and to derive a formula. The best fit was estimated by comparing r 2 values for each equation. Results: Data from 113 infants for each venous and arterial line were analysed for the new mathematical formulae. For both umbilical arterial catheterisation [[Formula: see text] and umbilical venous catheter (UVC) [[Formula: see text]], a quadratic model based on birthweight was found to have the best fit for predicting the insertion length of the catheters. However, the overall fit for UVCs was poorer for all explanatory variables ( y = estimated insertion length of the umbilical catheter in cm, x = birthweight in kg). Conclusion: Our prospective multi-centre observational study identified a quadratic model based on birthweight as the best fit for estimating the insertion length of umbilical lines in neonates. This is a new finding and further development on earlier birthweight-based linear models.","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"59 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-14DOI: 10.1177/09732179241234520
Priyanka Tank, Suraj Chawla, Rakesh Tank, A. Dhingra, Jyoti Sangwan
Background: The recent novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) pandemic has been responsible for millions of deaths globally. Several vaccines against the SARS-CoV-2 virus have been developed. Objective: To estimate the proportion of newborns who acquire IgG anti-SARS-CoV-2 antibodies from mothers vaccinated against COVID-19. Methods: Eligible study subjects seeking care in the Obstetrics & Gynecology department for delivery were recruited in this cross-sectional analytic study. Demographic and clinical characteristics of the study subjects were noted and around 3–5 mL venous blood was collected from each study participant duo (mother and newborn) to detect IgG antibodies to SARS-CoV2 “S” protein. Results: Over the entire study period, 125 pregnant ladies who were vaccinated with two doses of any COVID-19 vaccine were included in the study. A sizeable proportion (44.0%) of vaccinated pregnant women were seropositive for IgG antibodies to SARS-CoV2 “S” protein. A significantly high number of seropositive newborns (82.8%) were delivered to seropositive mothers as compared to seronegative mothers (OR 41.1; 95% confidence interval 14.6–116.1, p < .0001). Conclusions: The present study reveals that a substantial proportion of newborns acquired SARS-CoV-2 antibodies from their vaccinated seropositive mothers through transplacental transfer.
{"title":"SARS CoV-2 Antibodies in Cord Blood of Neonates Delivered to Pregnant Mothers Vaccinated for COVID-19","authors":"Priyanka Tank, Suraj Chawla, Rakesh Tank, A. Dhingra, Jyoti Sangwan","doi":"10.1177/09732179241234520","DOIUrl":"https://doi.org/10.1177/09732179241234520","url":null,"abstract":"Background: The recent novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) pandemic has been responsible for millions of deaths globally. Several vaccines against the SARS-CoV-2 virus have been developed. Objective: To estimate the proportion of newborns who acquire IgG anti-SARS-CoV-2 antibodies from mothers vaccinated against COVID-19. Methods: Eligible study subjects seeking care in the Obstetrics & Gynecology department for delivery were recruited in this cross-sectional analytic study. Demographic and clinical characteristics of the study subjects were noted and around 3–5 mL venous blood was collected from each study participant duo (mother and newborn) to detect IgG antibodies to SARS-CoV2 “S” protein. Results: Over the entire study period, 125 pregnant ladies who were vaccinated with two doses of any COVID-19 vaccine were included in the study. A sizeable proportion (44.0%) of vaccinated pregnant women were seropositive for IgG antibodies to SARS-CoV2 “S” protein. A significantly high number of seropositive newborns (82.8%) were delivered to seropositive mothers as compared to seronegative mothers (OR 41.1; 95% confidence interval 14.6–116.1, p < .0001). Conclusions: The present study reveals that a substantial proportion of newborns acquired SARS-CoV-2 antibodies from their vaccinated seropositive mothers through transplacental transfer.","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"18 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140244278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1177/09732179241236661
Sushma Nangia
{"title":"From the pen of the President NNF…","authors":"Sushma Nangia","doi":"10.1177/09732179241236661","DOIUrl":"https://doi.org/10.1177/09732179241236661","url":null,"abstract":"","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"290 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140278140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1177/09732179231215887
Vijayanand Jamalpuri
{"title":"Ma Ka Doodh Amrut [मां का दूध अमृत]","authors":"Vijayanand Jamalpuri","doi":"10.1177/09732179231215887","DOIUrl":"https://doi.org/10.1177/09732179231215887","url":null,"abstract":"","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"37 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140271551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-18DOI: 10.1177/09732179241228065
S. Nimbalkar, Anish Sinha, Purvi Patel, Reshma Pujara, Dipti Shah, Jaimin Patel, Swati Sethi, Rashmi Aradhya, Mayur K Shinde, D. Patel
Background: Neonatalie Live (NL) was developed as a part of the Safer Births project with collaboration between Laerdal Global Health and Tanzanian, Norwegian, and international research institutions. Its features allow instructors to determine the time of starting ventilation, the percentage of valid ventilations, etc. NL generated real-time data during the assessment. Aim: To evaluate whether undergraduate students trained on Neonatalie and NL manikins had equivalent ventilation skills on NL. Study design: Randomized Control Trial. Methods: Final-year MBBS students were randomly assigned to Neonatalie (72 students) or NL (71 students) groups after providing written and informed consent and assessed on NL. Live data generated by NL was analyzed. Outcome: To assess the success rate at bag and mask ventilation (BMV), as evidenced by objective data from NL. Results: A total of 142 students (assessed only on NL) participated in the study before and after four months. Total time from initiation of BMV to spontaneous breathing did not differ significantly between the Neonatalie and NL [127.6 sec (57.4) vs. 115.1 sec (48.3), p = .16]. “Try to ventilate the baby continuously without pauses” was the most common feedback to all students 70 (49.2%), but no statistical significance between the Neonatalie and NL groups [34 (47.2%) vs. 36 (51.43%)] was found. Conclusion: Undergraduate students trained on either manikin had similar success at BMV, as evidenced by independent objective data generated from within the manikin.
{"title":"Pressure Data from Neonatalie Live Manikin to Determine Appropriate Ventilation During Simulation Training of Undergraduate Students in Neonatal Resuscitation","authors":"S. Nimbalkar, Anish Sinha, Purvi Patel, Reshma Pujara, Dipti Shah, Jaimin Patel, Swati Sethi, Rashmi Aradhya, Mayur K Shinde, D. Patel","doi":"10.1177/09732179241228065","DOIUrl":"https://doi.org/10.1177/09732179241228065","url":null,"abstract":"Background: Neonatalie Live (NL) was developed as a part of the Safer Births project with collaboration between Laerdal Global Health and Tanzanian, Norwegian, and international research institutions. Its features allow instructors to determine the time of starting ventilation, the percentage of valid ventilations, etc. NL generated real-time data during the assessment. Aim: To evaluate whether undergraduate students trained on Neonatalie and NL manikins had equivalent ventilation skills on NL. Study design: Randomized Control Trial. Methods: Final-year MBBS students were randomly assigned to Neonatalie (72 students) or NL (71 students) groups after providing written and informed consent and assessed on NL. Live data generated by NL was analyzed. Outcome: To assess the success rate at bag and mask ventilation (BMV), as evidenced by objective data from NL. Results: A total of 142 students (assessed only on NL) participated in the study before and after four months. Total time from initiation of BMV to spontaneous breathing did not differ significantly between the Neonatalie and NL [127.6 sec (57.4) vs. 115.1 sec (48.3), p = .16]. “Try to ventilate the baby continuously without pauses” was the most common feedback to all students 70 (49.2%), but no statistical significance between the Neonatalie and NL groups [34 (47.2%) vs. 36 (51.43%)] was found. Conclusion: Undergraduate students trained on either manikin had similar success at BMV, as evidenced by independent objective data generated from within the manikin.","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"7 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139959565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-16DOI: 10.1177/09732179241228421
Lena F. Olgun, Andrea S. Weintraub, Robert S. Green
Aim: Extrauterine growth restriction (EUGR) is common in premature infants, but the progression after neonatal intensive care unit (NICU) discharge is not well described. We aimed to assess EUGR after NICU discharge and to identify factors associated with catch-up growth (CUG) and neurodevelopmental outcomes at 2 years of age. Methods: Growth parameters at birth, 36 weeks postmenstrual age (PMA), and two neurodevelopmental follow-up visits for preterm graduates of our NICU were reviewed. EUGR was assessed using Fenton and Intergrowth-21 standards. Factors associated with outpatient growth and neurodevelopmental outcomes at 2 years of age were evaluated using logistic and linear regression. Results: 369 infants born at 24–32 weeks gestation comprised the cohort. EUGR prevalence was 14.9% for Intergrowth-21 versus 56.4% for Fenton ( p < .001). Although there was a significant decrease in weight z-score from birth to 36 weeks PMA, weight z-scores returned to their birth weight values at the second clinic visit (86 weeks PMA). Infants who received formula as opposed to human milk (HM) showed faster CUG. Higher scores in the Bayley-III scale at 2 years of age were associated with HM feeding. Discussion/Conclusion: Fewer infants were identified as EUGR when Intergrowth-21 versus Fenton growth standards were used, which categorizes infants with adverse clinical courses and poorer neurodevelopmental outcomes more distinctly. While growth failure during the birth hospitalization is common in preterm infants, outpatient CUG was demonstrated, with return to birth weight z-score. Our findings suggest that HM feeding may have a positive impact on cognitive, language, and motor developmental outcomes for preterm infants despite less rapid CUG.
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