Pub Date : 2026-05-03Epub Date: 2025-03-03DOI: 10.1080/14786419.2025.2475510
Jiajia Lu , Ronghui Kuang , Jingjing Ye , Zhenyi Liang , Jing Xu
An undescribed fusaric acid derivative, fusaricate L (1) was isolated together with eight known compounds (2-9) from mangrove plant Rhizophora apiculata rhizosphere soil-derived Streptomyces angustmyceticus J-71. The structures of these compounds were established by extensive NMR spectroscopic data and comparison with the data of literature. Moreover, all isolated metabolites were tested for antifungal and antibacterial activities against a panel of plant and human pathogens. Compounds 4, 6, 7 and 9 showed modest antimicrobial activities towards methicillin- susceptible Staphylococcus aureus.
{"title":"Fusaricate L, a new fusaric acid derivative from mangrove rhizosphere soil-derived Streptomyces angustmyceticus J-71","authors":"Jiajia Lu , Ronghui Kuang , Jingjing Ye , Zhenyi Liang , Jing Xu","doi":"10.1080/14786419.2025.2475510","DOIUrl":"10.1080/14786419.2025.2475510","url":null,"abstract":"<div><div>An undescribed fusaric acid derivative, fusaricate L (<strong>1</strong>) was isolated together with eight known compounds (<strong>2</strong>-<strong>9</strong>) from mangrove plant <em>Rhizophora apiculata</em> rhizosphere soil-derived <em>Streptomyces angustmyceticus</em> J-71. The structures of these compounds were established by extensive NMR spectroscopic data and comparison with the data of literature. Moreover, all isolated metabolites were tested for antifungal and antibacterial activities against a panel of plant and human pathogens. Compounds <strong>4</strong>, <strong>6</strong>, <strong>7</strong> and <strong>9</strong> showed modest antimicrobial activities towards methicillin- susceptible <em>Staphylococcus aureus</em>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2473-2477"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phytochemical investigation of the flowers of Acronychia pedunculata led to the isolation of eight compounds. They consist of one undescribed polyphenolic isoprenylated acetophenone benzofuran, acronyculatin S (1), and seven known compounds: demethylacrovestone (2), acrovestone (3), acroflavone A (4), 3,5,4′-trihydroxy-3′,8-dimethoxy-7-(3-methylbut-2-enyloxy)flavone (5), xanthotoxin (6), isopimpinellin (7) and N-methylflindersine (8). The structures of the isolated compounds were elucidated by thorough analysis of spectroscopic (IR, NMR and ECD) and spectrometric (MS) data. Compounds 1 and 2 were tested against seven bacterial strains. They displayed significant activities against methicillin-resistant Staphylococcus aureus and Bacillus subtilis with MIC values in the range of 2–8 µg/mL.
{"title":"Acronyculatin S, a polyphenolic isoprenylated acetophenone benzofuran with antibacterial properties from the flowers of Acronychia pedunculata","authors":"Ratsami Lekphrom , Phornnapa Saentao , Wasan Seemakram , Sophon Boonlue , Florian T. Schevenels","doi":"10.1080/14786419.2025.2477221","DOIUrl":"10.1080/14786419.2025.2477221","url":null,"abstract":"<div><div>Phytochemical investigation of the flowers of <em>Acronychia pedunculata</em> led to the isolation of eight compounds. They consist of one undescribed polyphenolic isoprenylated acetophenone benzofuran, acronyculatin S (<strong>1</strong>), and seven known compounds: demethylacrovestone (<strong>2</strong>), acrovestone (<strong>3</strong>), acroflavone A (<strong>4</strong>), 3,5,4′-trihydroxy-3′,8-dimethoxy-7-(3-methylbut-2-enyloxy)flavone (<strong>5</strong>), xanthotoxin (<strong>6</strong>), isopimpinellin (<strong>7</strong>) and <em>N</em>-methylflindersine (<strong>8</strong>). The structures of the isolated compounds were elucidated by thorough analysis of spectroscopic (IR, NMR and ECD) and spectrometric (MS) data. Compounds <strong>1</strong> and <strong>2</strong> were tested against seven bacterial strains. They displayed significant activities against methicillin-resistant <em>Staphylococcus aureus</em> and <em>Bacillus subtilis</em> with MIC values in the range of 2–8 µg/mL.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2532-2537"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-05-03Epub Date: 2025-02-26DOI: 10.1080/14786419.2025.2473573
Yi-huan Li , Yi-hang Ba , Jian-fen Xiao , Shuai Chen , Tian-qing Zhu , Kai-xiang Liu , Hong-ping He , Hua-yi Jiang , Rui Yang
One new diterpenoid possessing a rare 14,15-dinor-neo-clerodane framework, ajugamacrin H (1), and one new neo-clerodane diterpenoid, ajugamacrin I (2), along with seven known analogues (3–9), were obtained from Ajuga macrosperma Wall. ex Benth.. Structures of compounds 1 and 2 were elucidated primarily based on NMR and MS methods, and their absolute configurations were identified via ECD calculations. 3, 7, and 8 exhibited inhibitory activities on NO production in LPS-stimulated RAW 264.7 cells at 50 μM. Moreover, compounds 1–9 were evaluated for their antibacterial effects against four strains of bacteria.
{"title":"New 14,15-dinor-neo-clerodane and neo-clerodane diterpenoids from Ajuga macrosperma Wall. ex benth","authors":"Yi-huan Li , Yi-hang Ba , Jian-fen Xiao , Shuai Chen , Tian-qing Zhu , Kai-xiang Liu , Hong-ping He , Hua-yi Jiang , Rui Yang","doi":"10.1080/14786419.2025.2473573","DOIUrl":"10.1080/14786419.2025.2473573","url":null,"abstract":"<div><div>One new diterpenoid possessing a rare 14,15-dinor-<em>neo</em>-clerodane framework, ajugamacrin H (<strong>1</strong>), and one new <em>neo</em>-clerodane diterpenoid, ajugamacrin I (<strong>2</strong>), along with seven known analogues (<strong>3</strong>–<strong>9</strong>), were obtained from <em>Ajuga macrosperma</em> Wall. ex Benth.. Structures of compounds <strong>1</strong> and <strong>2</strong> were elucidated primarily based on NMR and MS methods, and their absolute configurations were identified via ECD calculations. <strong>3</strong>, <strong>7</strong>, and <strong>8</strong> exhibited inhibitory activities on NO production in LPS-stimulated RAW 264.7 cells at 50 <em>μ</em>M. Moreover, compounds <strong>1</strong>–<strong>9</strong> were evaluated for their antibacterial effects against four strains of bacteria.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2457-2461"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The extraction of vinca alkaloids, such as vinblastine and vincristine, has traditionally been a challenge due to their low concentrations in natural sources and lengthy, low-yielding procedures. In this study, we explored a high-yield, efficient method for extracting vinblastine and vincristine from Catharanthus roseus using deep eutectic solvents (DES). We prepared various choline chloride (ChCl) based DESs with different hydrogen bond donors (HBD) and used them to extract leaves and flowers of C. roseus under ultrasonication. The extracts were evaluated for vinblastine and vincristine content using UV-spectroscopic analysis. Using response surface methodology, various parameters were optimised, including water content, sonication time, and solid-to-liquid ratio. Under optimised conditions, DES based on organic acids was found to extract 27.94 μg/ml of vinblastine in Choline chloride: citric acid DES and 30.84 μg/ml of vincristine in Choline chloride: oxalic acid. These results highlight the eco-friendliness of Choline chloride: citric acid and Choline chloride: oxalic acid DESs, which are effective, sustainable alternatives to conventional solvents for extracting these alkaloids from C. roseus, contributing to our collective environmental consciousness.
{"title":"Optimisation and utilization of deep eutectic solvents for the green extraction of anticancer alkaloids from Catharanthus roseus","authors":"Avjot Kaur , Ramandeep Kaur , Urvashi Bhardwaj , Parul Sharma","doi":"10.1080/14786419.2025.2476199","DOIUrl":"10.1080/14786419.2025.2476199","url":null,"abstract":"<div><div>The extraction of vinca alkaloids, such as vinblastine and vincristine, has traditionally been a challenge due to their low concentrations in natural sources and lengthy, low-yielding procedures. In this study, we explored a high-yield, efficient method for extracting vinblastine and vincristine from <em>Catharanthus roseus</em> using deep eutectic solvents (DES). We prepared various choline chloride (ChCl) based DESs with different hydrogen bond donors (HBD) and used them to extract leaves and flowers of <em>C. roseus</em> under ultrasonication. The extracts were evaluated for vinblastine and vincristine content using UV-spectroscopic analysis. Using response surface methodology, various parameters were optimised, including water content, sonication time, and solid-to-liquid ratio. Under optimised conditions, DES based on organic acids was found to extract 27.94 μg/ml of vinblastine in Choline chloride: citric acid DES and 30.84 μg/ml of vincristine in Choline chloride: oxalic acid. These results highlight the eco-friendliness of Choline chloride: citric acid and Choline chloride: oxalic acid DESs, which are effective, sustainable alternatives to conventional solvents for extracting these alkaloids from <em>C. roseus</em>, contributing to our collective environmental consciousness.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2493-2501"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cassane furanoditerpenoids were isolated along with oil from n-hexane (1-3) and chloroform (4-8) extracts from the seeds of Caesalpinia bonducella. These compounds were identified by means of comparison of spectroscopic data with literature data. The insecticidal activity of the major compound, 2-acetoxy caesaldekarin E (5), oil and three formulations of both were evaluated against the fall armyworm. Formulation of seed oil and compound (5) in 1:1 exhibited a potent insecticidal activity (LC50 = 255.31 ppm) than compound 5 and seed oil against fall armyworm, while compound 5 showed a higher activity (LC50 =549.69 ppm) than oil. Our study suggests that formulations of 5 and oil could be beneficial to control S. frugiperda.
{"title":"Pesticidal efficacy of 2-acetoxy caesaldekarin E and oil from the seeds of <i>Caesalpinia bonducella</i>.","authors":"Umme Ummarah Fariha, Sainath Gamayolla, Hemendra Kumar Patel, Kariyanna Bheeranna, Mangala Gowri Ponnapalli","doi":"10.1080/14786419.2026.2663510","DOIUrl":"https://doi.org/10.1080/14786419.2026.2663510","url":null,"abstract":"<p><p>Cassane furanoditerpenoids were isolated along with oil from <i>n</i>-hexane (1-3) and chloroform (4-8) extracts from the seeds of <i>Caesalpinia bonducella</i>. These compounds were identified by means of comparison of spectroscopic data with literature data. The insecticidal activity of the major compound, 2-acetoxy caesaldekarin E (<b>5</b>), oil and three formulations of both were evaluated against the fall armyworm. Formulation of seed oil and compound (<b>5</b>) in 1:1 exhibited a potent insecticidal activity (LC<sub>5</sub><sub>0</sub> = 255.31 ppm) than compound <b>5</b> and seed oil against fall armyworm, while compound <b>5</b> showed a higher activity (LC<sub>5</sub><sub>0</sub> =549.69 ppm) than oil. Our study suggests that formulations of <b>5</b> and oil could be beneficial to control <i>S. frugiperda</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alpinia calcicola Q.B.Nguyen & M.F.Newman (Zingiberaceae Martinov) remains an underexplored species despite its pharmacological potential. This study provides the first comprehensive investigation of the chemical profile and antibacterial properties of A. calcicola leaf essential oil and methanol extract. GC-MS analysis of the essential oil revealed a dominance of sesquiterpenoids, with tricyclo[5.2.2.0(1,6)]undecan-3-ol and isoshyobunone identified as the major components. Meanwhile, LC-MS/MS molecular networking of the methanol extract annotated 19 diverse metabolites, including distinct flavonoid derivates. In antibacterial assays against Staphyloccoccus aureus, the samples exhibited moderate activity: the methanol extract displayed a consistent MIC of 0.5 mg/mL (MBC: 2 mg/mL), while the essential oil showed MIC values ranging from 0.05 to 0.2% (v/v). Molecular docking and dynamics simulations predicted stable interactions between key identified terpenoids and flavonoids with bacterial enzymes, suggesting a putative multicomponent mechanism. These findings establish the chemical baseline for A. calcicola and highlight its potential for further pharmacological exploration within the Zingiberaceae family.
{"title":"GC-MS and LC-MS/MS profiling, antibacterial activity against <i>Staphylococcus aureus</i>, and docking study of <i>Alpinia calcicola</i> Q.B.Nguyen & M.F.Newman.","authors":"Thanh-Tung Nguyen, Phuong-Thao Nguyen Thi, Khac-Tiep Nguyen, Nhu-Quynh Nguyen Thi, Ngoc-Thac Pham, Ngoc-Anh Luu Dam, Huong-Giang Le","doi":"10.1080/14786419.2026.2658146","DOIUrl":"https://doi.org/10.1080/14786419.2026.2658146","url":null,"abstract":"<p><p><i>Alpinia calcicola</i> Q.B.Nguyen & M.F.Newman (Zingiberaceae Martinov) remains an underexplored species despite its pharmacological potential. This study provides the first comprehensive investigation of the chemical profile and antibacterial properties of <i>A. calcicola</i> leaf essential oil and methanol extract. GC-MS analysis of the essential oil revealed a dominance of sesquiterpenoids, with tricyclo[5.2.2.0(1,6)]undecan-3-ol and isoshyobunone identified as the major components. Meanwhile, LC-MS/MS molecular networking of the methanol extract annotated 19 diverse metabolites, including distinct flavonoid derivates. In antibacterial assays against <i>Staphyloccoccus aureus</i>, the samples exhibited moderate activity: the methanol extract displayed a consistent MIC of 0.5 mg/mL (MBC: 2 mg/mL), while the essential oil showed MIC values ranging from 0.05 to 0.2% (v/v). Molecular docking and dynamics simulations predicted stable interactions between key identified terpenoids and flavonoids with bacterial enzymes, suggesting a putative multicomponent mechanism. These findings establish the chemical baseline for <i>A. calcicola</i> and highlight its potential for further pharmacological exploration within the Zingiberaceae family.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-05-03Epub Date: 2025-03-01DOI: 10.1080/14786419.2025.2473567
Perumal Govindhan
Plants have served as the foundation of traditional medicine since the earliest civilisations. In light of this, it is crucial to study the phytochemical and physicochemical properties of Bauhinia variegata seed oil to discover novel secondary metabolites. Seed extracts were obtained through successive Soxhlet extraction using methanol and petroleum ether. The particle size of 0.25 mm achieved the highest bio-oil yield at 24.8%. The bio-oil was characterised using various techniques, including FTIR, GC–MS, and 1H & 13C NMR. Elemental analysis revealed the presence of Pd (0.03 ± 0.01 ppm), Cd (0.003 ± 0.007 ppm), Cr (0.02 ± 0.05 ppm), Zn (0.02 ± 0.008 ppm), Mg (0.04 ± 0.01 ppm) and Na (0.45 ± 0.05 ppm). The bio-oil was further analysed for basic properties, and phytochemical compounds, revealing the presence of alkaloids, glycosides, carbohydrates, phenolics, tannins, saponins, flavonoids and terpenoids. The study highlights the biomedical, biodiesel and industrial applications of bio-oil.
{"title":"Phytochemical screening, elemental analysis and physicochemical properties of the oil from Bauhinia variegata seeds","authors":"Perumal Govindhan","doi":"10.1080/14786419.2025.2473567","DOIUrl":"10.1080/14786419.2025.2473567","url":null,"abstract":"<div><div>Plants have served as the foundation of traditional medicine since the earliest civilisations. In light of this, it is crucial to study the phytochemical and physicochemical properties of <em>Bauhinia variegata</em> seed oil to discover novel secondary metabolites. Seed extracts were obtained through successive Soxhlet extraction using methanol and petroleum ether. The particle size of 0.25 mm achieved the highest bio-oil yield at 24.8%. The bio-oil was characterised using various techniques, including FTIR, GC–MS, and <sup>1</sup>H & <sup>13</sup>C NMR. Elemental analysis revealed the presence of Pd (0.03 ± 0.01 ppm), Cd (0.003 ± 0.007 ppm), Cr (0.02 ± 0.05 ppm), Zn (0.02 ± 0.008 ppm), Mg (0.04 ± 0.01 ppm) and Na (0.45 ± 0.05 ppm). The bio-oil was further analysed for basic properties, and phytochemical compounds, revealing the presence of alkaloids, glycosides, carbohydrates, phenolics, tannins, saponins, flavonoids and terpenoids. The study highlights the biomedical, biodiesel and industrial applications of bio-oil.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2446-2456"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The formal divergent synthesis of natural products (−)-warburganal and synthesis of (+)-isodrimenin has been developed from α-hydroxy β,γ-unsaturated aldehyde I, which was easily prepared from available (+)-sclareolide in 5 steps. Reduction of intermediate I to II via an aldehyde reduction provides a 10-step access to (−)-warburganal, while oxidation of I to III via allylic oxidation and in situ hemiacetalization facilitates a 9-step synthesis of (+)-isodrimenin.
{"title":"Formal synthesis of (-)-warburganal and synthesis of (+)-isodrimenin","authors":"Xian-Hui Zhao , Liang Zhao , Yue-Cheng Wu , Ya-Jing Bian , Hui-Jing Li , Yan-Chao Wu","doi":"10.1080/14786419.2025.2477813","DOIUrl":"10.1080/14786419.2025.2477813","url":null,"abstract":"<div><div>The formal divergent synthesis of natural products (−)-warburganal and synthesis of (+)-isodrimenin has been developed from α-hydroxy β,γ-unsaturated aldehyde I, which was easily prepared from available (+)-sclareolide in 5 steps. Reduction of intermediate I to II <em>via</em> an aldehyde reduction provides a 10-step access to (−)-warburganal, while oxidation of I to III <em>via</em> allylic oxidation and <em>in situ</em> hemiacetalization facilitates a 9-step synthesis of (+)-isodrimenin.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2573-2577"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-05-03Epub Date: 2025-05-19DOI: 10.1080/14786419.2025.2509142
C. S. Keerthana , Rozy Kumari , Muskan Beura , Sumit Sharan , Susheel Kumar Sharma , Ananta Ganjoo , Anil Dahuja , Veda Krishnan
Mushrooms are rich in bioactive polysaccharides, particularly α- and β-glucans, renowned for their immunomodulatory properties. The present study optimised the cultivation methods and quantified α-, β-, and total glucan from Hericium erinaceus (Lion’s Mane) and Lentinula edodes (Shiitake) mushrooms. Shiitake exhibited an α-glucan content ranging from 0.806% to 5.521%, with the highest at 5.521% (DMRO-356), approximately 8.2 times higher than Lion’s Mane (HE-TC), which had 0.673%. For β-glucans, Shiitake strains showed a range of 13.433–26.190%, with the highest value at 26.190% (DMRX-2022) which was 1.5-fold higher than HE-TC at 17.442%. The findings emphasise Indian Shiitake strains’ remarkable α and β-glucan content and their potential as immune-boosting supplements. Incorporating these mushrooms into commercial products and health supplements requires more research on their bioavailability and health advantages.
{"title":"Unveiling the glucan profile: a comparative study of Lion’s Mane and Shiitake mushrooms","authors":"C. S. Keerthana , Rozy Kumari , Muskan Beura , Sumit Sharan , Susheel Kumar Sharma , Ananta Ganjoo , Anil Dahuja , Veda Krishnan","doi":"10.1080/14786419.2025.2509142","DOIUrl":"10.1080/14786419.2025.2509142","url":null,"abstract":"<div><div>Mushrooms are rich in bioactive polysaccharides, particularly α- and β-glucans, renowned for their immunomodulatory properties. The present study optimised the cultivation methods and quantified α-, β-, and total glucan from <em>Hericium erinaceus</em> (Lion’s Mane) and <em>Lentinula edodes</em> (Shiitake) mushrooms. Shiitake exhibited an α-glucan content ranging from 0.806% to 5.521%, with the highest at 5.521% (DMRO-356), approximately 8.2 times higher than Lion’s Mane (HE-TC), which had 0.673%. For β-glucans, Shiitake strains showed a range of 13.433–26.190%, with the highest value at 26.190% (DMRX-2022) which was 1.5-fold higher than HE-TC at 17.442%. The findings emphasise Indian Shiitake strains’ remarkable α and β-glucan content and their potential as immune-boosting supplements. Incorporating these mushrooms into commercial products and health supplements requires more research on their bioavailability and health advantages.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2627-2630"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-05-03Epub Date: 2025-02-26DOI: 10.1080/14786419.2025.2473563
Raylane Rocha da Mata , Rainara Ribeiro Oliveira , Sinval Garcia Pereira , Thiara Lopes Rocha , João Vitor Castro Aguiar , Raissa Rachel Salustriano da Silva-Matos
This article discusses the synthesis of secondary metabolites in the plant Ipomoea asarifolia, known for its traditional use in medicine. Phytochemical analysis revealed the presence of tannins, flavonoids, anthocyanins and saponins in the flowers and roots, highlighting variations between extracts. These compounds have allelopathic potential and defensive activity. The biochemical diversity highlights the importance of continuous research for applications in agriculture and sustainable therapeutic applications in the pharmaceutical industry, guaranteeing safe and effective benefits. The study highlights the connection between plant biochemistry and practical application in agriculture and the pharmaceutical industry, emphasising the need to understand these compounds.
{"title":"Phytochemical analysis of secondary metabolites from the flowers and roots of the plant Ipomoea asarifolia","authors":"Raylane Rocha da Mata , Rainara Ribeiro Oliveira , Sinval Garcia Pereira , Thiara Lopes Rocha , João Vitor Castro Aguiar , Raissa Rachel Salustriano da Silva-Matos","doi":"10.1080/14786419.2025.2473563","DOIUrl":"10.1080/14786419.2025.2473563","url":null,"abstract":"<div><div>This article discusses the synthesis of secondary metabolites in the plant <em>Ipomoea asarifolia</em>, known for its traditional use in medicine. Phytochemical analysis revealed the presence of tannins, flavonoids, anthocyanins and saponins in the flowers and roots, highlighting variations between extracts. These compounds have allelopathic potential and defensive activity. The biochemical diversity highlights the importance of continuous research for applications in agriculture and sustainable therapeutic applications in the pharmaceutical industry, guaranteeing safe and effective benefits. The study highlights the connection between plant biochemistry and practical application in agriculture and the pharmaceutical industry, emphasising the need to understand these compounds.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2441-2445"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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