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The invisible tax of US visa bureaucracy on international scholars 美国签证制度对国际学者的无形税收
IF 44.5 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2026-08-11 DOI: 10.1038/s41587-026-03252-8
Michel Nofal, Raquel Ferrer-Espada, Payel Ganguly, Mayank Chugh
Survey data document US visa types and burdens of time, cost and mental health among international postdocs.
调查数据记录了美国签证的种类、时间负担、成本和国际博士后的心理健康状况。
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引用次数: 0
AI-assisted design of synthetic gene editors 人工智能辅助合成基因编辑器的设计
IF 44.5 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2026-08-11 DOI: 10.1038/s41587-026-03273-3
Dario Ummarino
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引用次数: 0
Prime prevails in Beam dispute 在Beam之争中，Prime占上风
IF 44.5 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2026-08-11 DOI: 10.1038/s41587-026-03276-0
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引用次数: 0
Biotech news from around the world 来自世界各地的生物技术新闻
IF 44.5 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2026-08-11 DOI: 10.1038/s41587-026-03268-0
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引用次数: 0
Five questions with Elham Azizi Elham Azizi的五个问题
IF 44.5 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2026-08-11 DOI: 10.1038/s41587-026-03255-5
Michael Francisco
This multidisciplinary biomedical engineer hopes to bridge data-driven discovery and mechanistic understanding, advancing precision oncology through interpretable, biologically grounded machine learning and artificial intelligence.
这位多学科生物医学工程师希望在数据驱动的发现和机制理解之间架起桥梁，通过可解释的、基于生物学的机器学习和人工智能推进精确肿瘤学。
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引用次数: 0
Microbiomics Microbiomics
IF 44.5 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2026-08-11 DOI: 10.1038/s41587-026-03250-w
Recent patents relating to microbiome-associated identification, modulation and treatment of diseases.
最近的专利涉及与微生物组相关的疾病鉴定、调节和治疗。
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引用次数: 0
Magnetic microrobots for gastrointestinal drug delivery 用于胃肠道给药的磁性微型机器人
IF 44.5 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2026-08-11 DOI: 10.1038/s41587-026-03274-2
Dario Ummarino
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引用次数: 0
Light up your space with glowing houseplants 用发光的室内植物照亮你的空间
IF 44.5 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2026-08-11 DOI: 10.1038/s41587-026-03270-6
Claire Turrell
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引用次数: 0
FDA approves glue to repair severed nerves 美国食品药品监督管理局批准用胶水修复切断的神经
IF 44.5 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2026-08-11 DOI: 10.1038/s41587-026-03279-x
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引用次数: 0
Non-invasive nanoparticle barcoding in nonhuman primates. 非人类灵长类动物的非侵入性纳米粒子条形码。
IF 44.5 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2026-08-11 DOI: 10.1038/s41587-026-03262-6
Bora Jang, Ryan Zenhausern, Liming Lian, Kara Gentry, Abdulraouf M Abbas, Sebastian Rudden, Yoon-Joo Shin, Jessie Doan, David Loughrey, Elizabeth H Curran, Jennifer S Wood, Rachelle L Stammen, R Paul Johnson, Hyejin Kim, James E Dahlman

The clinical relevance of a lipid nanoparticle (LNP)-mRNA drug candidate is often dictated by its behavior in nonhuman primates. Yet, evaluating how chemically distinct LNPs behave in nonhuman primates remains difficult, in part because nanoparticle barcoding assays require euthanasia and difficult downstream tissue processing. Here we report non-invasive nanoparticle barcoding, which quantifies functional mRNA delivery mediated by several LNPs in a single nonhuman primate using 30 µl of serum. This method is enabled by snapCodes, benzylguanine-modified DNA barcodes that covalently bind an mRNA-encoded nanoluciferase-SNAP-tag fusion protein in vivo. The resulting DNA-fusion protein complexes are exported from cells, isolated from serum and sequenced. After validating snapCode and fusion protein activity, we intravenously administer six snapCoded LNPs to mice and nonhuman primates, thereby comparing LNP delivery across species. Measuring mRNA delivery from multiple LNPs using a low-volume blood draw reduces animal use and may help identify promising nanoparticle formulations.

脂质纳米颗粒(LNP)-mRNA候选药物的临床相关性通常由其在非人灵长类动物中的行为决定。然而，评估LNPs在非人类灵长类动物中的化学特性仍然很困难，部分原因是纳米颗粒条形码检测需要安乐死和困难的下游组织处理。在这里，我们报道了非侵入性纳米颗粒条形码技术，该技术使用30µl血清定量了单个非人灵长类动物中几种LNPs介导的功能性mRNA传递。该方法是通过snapCodes实现的，snapCodes是一种苯基鸟嘌呤修饰的DNA条形码，在体内共价结合mrna编码的纳米荧光素- snap标签融合蛋白。由此产生的dna融合蛋白复合物从细胞中输出，从血清中分离并测序。在验证了snapCode和融合蛋白的活性后，我们将6个snapCode LNPs静脉注射到小鼠和非人灵长类动物中，从而比较LNP在物种间的传递。通过小体积抽血测量多个LNPs的mRNA传递量，减少了动物使用，并可能有助于确定有前途的纳米颗粒配方。
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引用次数: 0
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