Pub Date : 2022-06-06DOI: 10.1101/2022.06.06.22276034
A. Dubé, K. McCall, Kirsten Stickney, A. Gelinas, K. McCall
Background: Rheumatoid arthritis and psoriasis are inflammatory diseases which require frequent monitoring to optimize therapy. Specialty pharmacists are in the unique position to assist in the screening and monitoring of patients with complex, chronic diseases. Objectives: The study objective is to describe the impact of pharmacist screening services in two patient populations. In patients with rheumatoid arthritis, the goal is to describe outcome monitoring through disease severity, therapeutic switches, and adherence rates. In patients with psoriasis, the aim is to describe the utilization of a screening for psoriatic arthritis and the resulting number of potential referrals to medical providers. Methods: The retrospective study patient population consisted of rheumatoid arthritis (RA) patients who filled one or more prescriptions at a specialty pharmacy between 8/22/2017 and 9/26/2018, and psoriasis patients who filled between 6/1/2021 to 9/1/2021. A Routine Assessment of Patient Index Data 3 (RAPID3) score was collected during a refill coordination call every three months throughout the 13-month period for RA patients, and a Psoriasis Epidemiology Screening Tool (PEST) scores reported throughout the stated timeline. Data was imported from the pharmacy electronic medical record into an Excel spreadsheet with each row representing a unique patient. Following data validation, descriptive statistics including means, standard deviations, and percentages were calculated to characterize the sample. Statistical significance was determined at an alpha of 0.05. Results: Of the patients who had 4 assessments for RAPID3, the disease severity category significantly improved from assessment 1 to assessment 4 (p=0.021) when analyzed using a chi-square test. The RAPID3 assessment of patients with RA by pharmacists in a specialty setting identified responders (n=21, 25.6%) and stable patients (n=51, 63%), which reinforces current therapy, and non-responders (n=10, 12.2%), who may benefit from referral to their provider for reevaluation of their therapeutic plan. The PEST screening of patients with psoriasis by pharmacists in a specialty setting identified 11 of 32 patients (34%) who scored a 3 or higher and who may benefit from a referral to a rheumatologist for further assessment of psoriatic arthritis activity. Conclusion: Specialty pharmacists are an essential part of ongoing assessment and management of patients with chronic inflammatory conditions such as rheumatoid arthritis and psoriasis. Screening and monitoring of patients by pharmacists can identify the need for referral to a medical provider.
{"title":"Specialty pharmacy disease screening and routine assessments for patients with rheumatoid arthritis and psoriasis","authors":"A. Dubé, K. McCall, Kirsten Stickney, A. Gelinas, K. McCall","doi":"10.1101/2022.06.06.22276034","DOIUrl":"https://doi.org/10.1101/2022.06.06.22276034","url":null,"abstract":"Background: Rheumatoid arthritis and psoriasis are inflammatory diseases which require frequent monitoring to optimize therapy. Specialty pharmacists are in the unique position to assist in the screening and monitoring of patients with complex, chronic diseases. Objectives: The study objective is to describe the impact of pharmacist screening services in two patient populations. In patients with rheumatoid arthritis, the goal is to describe outcome monitoring through disease severity, therapeutic switches, and adherence rates. In patients with psoriasis, the aim is to describe the utilization of a screening for psoriatic arthritis and the resulting number of potential referrals to medical providers. Methods: The retrospective study patient population consisted of rheumatoid arthritis (RA) patients who filled one or more prescriptions at a specialty pharmacy between 8/22/2017 and 9/26/2018, and psoriasis patients who filled between 6/1/2021 to 9/1/2021. A Routine Assessment of Patient Index Data 3 (RAPID3) score was collected during a refill coordination call every three months throughout the 13-month period for RA patients, and a Psoriasis Epidemiology Screening Tool (PEST) scores reported throughout the stated timeline. Data was imported from the pharmacy electronic medical record into an Excel spreadsheet with each row representing a unique patient. Following data validation, descriptive statistics including means, standard deviations, and percentages were calculated to characterize the sample. Statistical significance was determined at an alpha of 0.05. Results: Of the patients who had 4 assessments for RAPID3, the disease severity category significantly improved from assessment 1 to assessment 4 (p=0.021) when analyzed using a chi-square test. The RAPID3 assessment of patients with RA by pharmacists in a specialty setting identified responders (n=21, 25.6%) and stable patients (n=51, 63%), which reinforces current therapy, and non-responders (n=10, 12.2%), who may benefit from referral to their provider for reevaluation of their therapeutic plan. The PEST screening of patients with psoriasis by pharmacists in a specialty setting identified 11 of 32 patients (34%) who scored a 3 or higher and who may benefit from a referral to a rheumatologist for further assessment of psoriatic arthritis activity. Conclusion: Specialty pharmacists are an essential part of ongoing assessment and management of patients with chronic inflammatory conditions such as rheumatoid arthritis and psoriasis. Screening and monitoring of patients by pharmacists can identify the need for referral to a medical provider.","PeriodicalId":291908,"journal":{"name":"International Journal of Clinical & Experimental Dermatology","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131548135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aphthous ulcer occurs as a frequent, idiopathic, painful, singular, multiple or reoccurring oral ulceration. Of obscure aetiology, oral trauma, stress, anxiety, diverse systemic diseases as coeliac disease, Crohn’s disease, Behçet’s syndrome, reactive arthritis or infection with human immune deficiency virus (HIV), drugs such NSAIDs, β-blockers, angiotensin converting enzyme (ACE) inhibitors, deficiencies of vitamins and trace elements as zinc, iron, B12, folate or sensitivity to food and chemicals may engender the ulcer. Contingent to magnitude, aphthous ulcer is subcategorized into minor ulcer, major ulcer or herpetiform ulcer. Aphthous ulcer manifests upon non-keratinized oral mucosa as a well circumscribed, centric, necrotic ulcer circumscribed by a grey, fibrinous exudate and an erythematous halo. The ulcer requires a segregation from contact dermatitis, lichen planus, oral carcinoma, infection with herpes simplex virus (HSV), various drug induced lesions or autoimmune diseases. Aphthous ulcer can be evaluated with clinical examination, complete blood count with nutritional deficiencies of iron, folate or vitamin B12, neutropenia, serum anti-endomysial antibodies and transglutaminase (tTg-IgA) for coeliac disease and investigations for HIV. Cogent therapeutic options are local anaesthetics, coating or occlusive agents as bismuth subsalicylate, sucralfate, 2-octyl cyanoacrylate, bio-adherent emollient pastes, oral antiseptics as chlorhexidine gluconate, hydrogen peroxide, antiinflammatory agents as glucocorticoids, metalloprotease inhibitors, antimicrobials as tetracycline, doxycycline, minocycline, honey, immunomodulatory agents as amlexanox, colchicine, cyclosporine, cyclophosphamide, dapsone, methotrexate, montelukast, thalidomide or retinoids.
{"title":"The Articulate Canker-Aphthous Ulcer","authors":"","doi":"10.33140/ijced.07.01.04","DOIUrl":"https://doi.org/10.33140/ijced.07.01.04","url":null,"abstract":"Aphthous ulcer occurs as a frequent, idiopathic, painful, singular, multiple or reoccurring oral ulceration. Of obscure aetiology, oral trauma, stress, anxiety, diverse systemic diseases as coeliac disease, Crohn’s disease, Behçet’s syndrome, reactive arthritis or infection with human immune deficiency virus (HIV), drugs such NSAIDs, β-blockers, angiotensin converting enzyme (ACE) inhibitors, deficiencies of vitamins and trace elements as zinc, iron, B12, folate or sensitivity to food and chemicals may engender the ulcer. Contingent to magnitude, aphthous ulcer is subcategorized into minor ulcer, major ulcer or herpetiform ulcer. Aphthous ulcer manifests upon non-keratinized oral mucosa as a well circumscribed, centric, necrotic ulcer circumscribed by a grey, fibrinous exudate and an erythematous halo. The ulcer requires a segregation from contact dermatitis, lichen planus, oral carcinoma, infection with herpes simplex virus (HSV), various drug induced lesions or autoimmune diseases. Aphthous ulcer can be evaluated with clinical examination, complete blood count with nutritional deficiencies of iron, folate or vitamin B12, neutropenia, serum anti-endomysial antibodies and transglutaminase (tTg-IgA) for coeliac disease and investigations for HIV. Cogent therapeutic options are local anaesthetics, coating or occlusive agents as bismuth subsalicylate, sucralfate, 2-octyl cyanoacrylate, bio-adherent emollient pastes, oral antiseptics as chlorhexidine gluconate, hydrogen peroxide, antiinflammatory agents as glucocorticoids, metalloprotease inhibitors, antimicrobials as tetracycline, doxycycline, minocycline, honey, immunomodulatory agents as amlexanox, colchicine, cyclosporine, cyclophosphamide, dapsone, methotrexate, montelukast, thalidomide or retinoids.","PeriodicalId":291908,"journal":{"name":"International Journal of Clinical & Experimental Dermatology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126615245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Chemical peels are used to treat photoaging and skin discoloration. Ferulic peel is a non-exfoliating peel having antioxidant properties. The aim of this study is to validate the efficacy of ferulic acid peel as a monotherapy for photoaging. It is a technique-sensitive procedure, and injury must be in a proper tissue plane to achieve the desired results. Materials and Methods: This is a prospective study from Feb 2018 to Feb 2020 in which 55 patients were treated with Ferulic acid peel 12 % (hydro alcohol base) with L-ascorbic acid 15% as a monotherapy. The patients were followed up for 6 months. Data were summarised in Mean ± SD. Pre and post data were compared by paired t test. A two-tailed (α=2) p<0.05 was considered statistically significant. Two scales were used for assessing the results; Allergan Skin Roughness Scale (ASRS) and Allergan Fine Line Scale (AFLS). Results: The scores were assessed at pre-treatment (pre) and post treatment (post). The results achieved were highly satisfactory as measured using the ASRS and AFLS Scale with p-value <0.001(statistically significant). No complications were observed in our study. Conclusion: Ferulic Peel with L-Ascorbic Acid is very useful as a monotherapy in Photoaging cases; initial results of our six-month follow-up study have yielded promising results.
{"title":"Efficacy of Ferulic Acid Peel as a Monotherapy for Photoaging.","authors":"Sukhbir Singh, Dr. Ashish Chauhan","doi":"10.33140/ijced.07.01.06","DOIUrl":"https://doi.org/10.33140/ijced.07.01.06","url":null,"abstract":"Objectives: Chemical peels are used to treat photoaging and skin discoloration. Ferulic peel is a non-exfoliating peel having antioxidant properties. The aim of this study is to validate the efficacy of ferulic acid peel as a monotherapy for photoaging. It is a technique-sensitive procedure, and injury must be in a proper tissue plane to achieve the desired results. Materials and Methods: This is a prospective study from Feb 2018 to Feb 2020 in which 55 patients were treated with Ferulic acid peel 12 % (hydro alcohol base) with L-ascorbic acid 15% as a monotherapy. The patients were followed up for 6 months. Data were summarised in Mean ± SD. Pre and post data were compared by paired t test. A two-tailed (α=2) p<0.05 was considered statistically significant. Two scales were used for assessing the results; Allergan Skin Roughness Scale (ASRS) and Allergan Fine Line Scale (AFLS). Results: The scores were assessed at pre-treatment (pre) and post treatment (post). The results achieved were highly satisfactory as measured using the ASRS and AFLS Scale with p-value <0.001(statistically significant). No complications were observed in our study. Conclusion: Ferulic Peel with L-Ascorbic Acid is very useful as a monotherapy in Photoaging cases; initial results of our six-month follow-up study have yielded promising results.","PeriodicalId":291908,"journal":{"name":"International Journal of Clinical & Experimental Dermatology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129989320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meditation is a popular practice used to bring awareness and attention to calm the mind. It involves using techniques like mindfulness to help achieve a mentally clear state. Meditation derives from Hindu and Buddhist traditions. It involves bringing one’s attention to the present moment without negative thinking. Meditation allows our brain to focus its attention and calm down active stressors. This is achieved through the deep breathing techniques practiced in daily meditation routines. But did you know there are different types of meditation you can practice? Trying different styles of meditation will help you find the one that works best for you. Thus Meditation has the power to transform the well-being of your body. Through mantras or simple breathing exercises, meditating can help promote a healthy lifestyle. Embracing daily meditation routine means embracing a healthy, glowing body, voice and mind. Think of meditation as your mind’s armor against the many stressors of life. It improves our lives by changing the way we handle and process our emotions and stress. Meditation is transformative. It has the power to change the way we look, feel, and act. Thus maintain your stressed, our bodies produce cortisol and adrenaline in abundance.
{"title":"Meditation for Skin Aging, Reduces Wrinkles and Change Your Appearance?","authors":"","doi":"10.33140/ijced.07.01.05","DOIUrl":"https://doi.org/10.33140/ijced.07.01.05","url":null,"abstract":"Meditation is a popular practice used to bring awareness and attention to calm the mind. It involves using techniques like mindfulness to help achieve a mentally clear state. Meditation derives from Hindu and Buddhist traditions. It involves bringing one’s attention to the present moment without negative thinking. Meditation allows our brain to focus its attention and calm down active stressors. This is achieved through the deep breathing techniques practiced in daily meditation routines. But did you know there are different types of meditation you can practice? Trying different styles of meditation will help you find the one that works best for you. Thus Meditation has the power to transform the well-being of your body. Through mantras or simple breathing exercises, meditating can help promote a healthy lifestyle. Embracing daily meditation routine means embracing a healthy, glowing body, voice and mind. Think of meditation as your mind’s armor against the many stressors of life. It improves our lives by changing the way we handle and process our emotions and stress. Meditation is transformative. It has the power to change the way we look, feel, and act. Thus maintain your stressed, our bodies produce cortisol and adrenaline in abundance.","PeriodicalId":291908,"journal":{"name":"International Journal of Clinical & Experimental Dermatology","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124111004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erythema multiforme arises as a spectrum of reactive muco-cutaneous disorders exhibiting maculopapular or vesiculo-bullous eruptions. The condition may be designated as erythema multiforme (major or minor), toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS). Aforesaid disorders exhibit significant involvement oforal mucosa along with epidermal necrosis. Erythema multiforme is an acute, self limiting, immune mediated disorder which emerges as a hypersensitivity reactionto pertinent antigenic stimuli. The condition may arise due to diverse carcinomas, collagen vascular diseases, drugs or bacterial and viral infections and is associated with a favourable prognosis [1,2].
{"title":"The Prototypal Utricle-Erythema Multiforme","authors":"","doi":"10.33140/ijced.07.01.07","DOIUrl":"https://doi.org/10.33140/ijced.07.01.07","url":null,"abstract":"Erythema multiforme arises as a spectrum of reactive muco-cutaneous disorders exhibiting maculopapular or vesiculo-bullous eruptions. The condition may be designated as erythema multiforme (major or minor), toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS). Aforesaid disorders exhibit significant involvement oforal mucosa along with epidermal necrosis. Erythema multiforme is an acute, self limiting, immune mediated disorder which emerges as a hypersensitivity reactionto pertinent antigenic stimuli. The condition may arise due to diverse carcinomas, collagen vascular diseases, drugs or bacterial and viral infections and is associated with a favourable prognosis [1,2].","PeriodicalId":291908,"journal":{"name":"International Journal of Clinical & Experimental Dermatology","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125851833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Impetigo herpetiformis is a rare life threatening pustular dermatoses of pregnancy. The etiology is unclear but is usually steroid responsive. A case of impetigo herpetiformis in a multiparous 40 years old lady in her 30 weeks of gestation is presented. She was on the topical corticosteroids.
{"title":"Third Trimester Impetigo Herpetiformis In Multiparous Female","authors":"Saad R. Abed","doi":"10.33140/ijced.07.01.03","DOIUrl":"https://doi.org/10.33140/ijced.07.01.03","url":null,"abstract":"Impetigo herpetiformis is a rare life threatening pustular dermatoses of pregnancy. The etiology is unclear but is usually steroid responsive. A case of impetigo herpetiformis in a multiparous 40 years old lady in her 30 weeks of gestation is presented. She was on the topical corticosteroids.","PeriodicalId":291908,"journal":{"name":"International Journal of Clinical & Experimental Dermatology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116799960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyper-Ig E syndrome (HIES) includes a rare group of primary immunodeficiency conditions with frequently recurrent lung and skin infections. The respiratory system is affected by acute and chronic bronchitis, otitis, recurrent pneumonia, pneumocele, pleurisy, severe and prolonged sinusitis. Cutaneous manifestations are presented with “cold abscesses” and eczema/dermatitis. A pathognomic feature for the syndrome is the increased level of serum Ig E. The etiology of HIES still remains unclear. HIES occurs sporadically or is inherited - as an autosomal dominant HIES or autosomal recessive HIES. The type of inheritance determines the variable clinical picture of the syndrome. The pathogenetic diversity, the absence of specific clinical criteria as well as the presentation of few or minor symptoms in some patients complicate the diagnosis. We report а clinical case of a sporadic hyper-Ig E syndrome in an adult man suffering from atopic dermatitis since childhood presented with recurrent bacterial, viral, fungal and protozoan infections of the respiratory tract, gastrointestinal tract, skin and mucosal surfaces. A brief review of the scientific literature is also included.
{"title":"Hyper-Ig E syndrome in adult patient: a clinical case and a review of the literature","authors":"","doi":"10.33140/ijced.07.01.01","DOIUrl":"https://doi.org/10.33140/ijced.07.01.01","url":null,"abstract":"Hyper-Ig E syndrome (HIES) includes a rare group of primary immunodeficiency conditions with frequently recurrent lung and skin infections. The respiratory system is affected by acute and chronic bronchitis, otitis, recurrent pneumonia, pneumocele, pleurisy, severe and prolonged sinusitis. Cutaneous manifestations are presented with “cold abscesses” and eczema/dermatitis. A pathognomic feature for the syndrome is the increased level of serum Ig E. The etiology of HIES still remains unclear. HIES occurs sporadically or is inherited - as an autosomal dominant HIES or autosomal recessive HIES. The type of inheritance determines the variable clinical picture of the syndrome. The pathogenetic diversity, the absence of specific clinical criteria as well as the presentation of few or minor symptoms in some patients complicate the diagnosis. We report а clinical case of a sporadic hyper-Ig E syndrome in an adult man suffering from atopic dermatitis since childhood presented with recurrent bacterial, viral, fungal and protozoan infections of the respiratory tract, gastrointestinal tract, skin and mucosal surfaces. A brief review of the scientific literature is also included.","PeriodicalId":291908,"journal":{"name":"International Journal of Clinical & Experimental Dermatology","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116285315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
When the Physician Assistant profession was begun in the United States half a century ago, there were two pathways. There was the MEDEX [Medical Extender] pathway and the PA [Physician Assistant] pathway. [1-3] Those who graduated from the physician assistant pathway affixed the postnominals PA after their names and those who graduated via the medical extender pathway affixed the postnominals MX after their names. The bloated egos of the doctors preferred the PA designation because it implied a practitioner that was subservient to them. If only the MEDEX School had prevailed, doctors and Pas in America would have a far more harmonious relationship than they have today. But which word, “extender” or “assistant” better describes what PAs do? The New 8th Edition of The Oxford Advanced Learners Dictionary defines an assistant as a person who helps or supports somebody in their job. On the other hand, to extend is defined as to make an idea or influence cover more areas or operate in more places. The latter better defines the profession. Let the founders of the profession speak for themselves
{"title":"If only the Medex School Had Prevailed","authors":"","doi":"10.33140/ijced.07.01.02","DOIUrl":"https://doi.org/10.33140/ijced.07.01.02","url":null,"abstract":"When the Physician Assistant profession was begun in the United States half a century ago, there were two pathways. There was the MEDEX [Medical Extender] pathway and the PA [Physician Assistant] pathway. [1-3] Those who graduated from the physician assistant pathway affixed the postnominals PA after their names and those who graduated via the medical extender pathway affixed the postnominals MX after their names. The bloated egos of the doctors preferred the PA designation because it implied a practitioner that was subservient to them. If only the MEDEX School had prevailed, doctors and Pas in America would have a far more harmonious relationship than they have today. But which word, “extender” or “assistant” better describes what PAs do? The New 8th Edition of The Oxford Advanced Learners Dictionary defines an assistant as a person who helps or supports somebody in their job. On the other hand, to extend is defined as to make an idea or influence cover more areas or operate in more places. The latter better defines the profession. Let the founders of the profession speak for themselves","PeriodicalId":291908,"journal":{"name":"International Journal of Clinical & Experimental Dermatology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127923718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amelanotic /Hypomelanotic melanoma is a form of melanoma in which the malignant cells have little to no pigment. The term ‘amelanotic’ is often used to indicate lesions that are only partially devoid of pigment while truly amelanotic melanoma where lesions lack all pigment is rare [1]. Most Amelanotic/Hypomelanotic melanomas are Nodular. Thus combining the clinical features with the dermatoscopic image features the diagnosis is Nodular Melanoma [2]
{"title":"Dermoscopic Image of Amelanotic Nodular Melanoma","authors":"Saad R. Abed","doi":"10.33140/ijced.06.02.09","DOIUrl":"https://doi.org/10.33140/ijced.06.02.09","url":null,"abstract":"Amelanotic /Hypomelanotic melanoma is a form of melanoma in which the malignant cells have little to no pigment. The term ‘amelanotic’ is often used to indicate lesions that are only partially devoid of pigment while truly amelanotic melanoma where lesions lack all pigment is rare [1]. Most Amelanotic/Hypomelanotic melanomas are Nodular. Thus combining the clinical features with the dermatoscopic image features the diagnosis is Nodular Melanoma [2]","PeriodicalId":291908,"journal":{"name":"International Journal of Clinical & Experimental Dermatology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123414074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The tireless search for therapeutic options that alleviate the signs of skin aging is a challenge for the aesthetic practitioner. Objective: To evaluate the efficacy and safety of autologous platelet concentrate (APC) in the treatment of facial cutaneous aging (FCA). Method: Between March 1, 2017 and March 31, 2021 at the “Hermanos Ameijeiras” hospital, a randomized, singlecenter, double-blind and controlled clinical trial was carried out in 164 patients with FCA. A group treated with APC was compared to another treated with fresh autologous plasma (FAP). The treatment was applied monthly for 1 year. Results: Three months after the end of the treatment, there were significant differences between the patients treated with APC compared to those treated with FAP in terms of improvement in the texture, tone, elasticity, hydration, pores, homogeneity of the skin, the global aesthetic improvement scale (GAIS) and degree of satisfaction (p <0.001). All adverse events were of mild intensity, did not imply changes before the intervention and were completely resolved. Conclusions: The autologous platelet concentrate proved to be effective and safe in reducing the signs of skin aging, associated with a high degree of patient satisfaction.
{"title":"Facial Skin Changes Produced by Treatment with Autologous Platelet Concentrate","authors":"","doi":"10.33140/ijced.06.02.08","DOIUrl":"https://doi.org/10.33140/ijced.06.02.08","url":null,"abstract":"Background: The tireless search for therapeutic options that alleviate the signs of skin aging is a challenge for the aesthetic practitioner. Objective: To evaluate the efficacy and safety of autologous platelet concentrate (APC) in the treatment of facial cutaneous aging (FCA). Method: Between March 1, 2017 and March 31, 2021 at the “Hermanos Ameijeiras” hospital, a randomized, singlecenter, double-blind and controlled clinical trial was carried out in 164 patients with FCA. A group treated with APC was compared to another treated with fresh autologous plasma (FAP). The treatment was applied monthly for 1 year. Results: Three months after the end of the treatment, there were significant differences between the patients treated with APC compared to those treated with FAP in terms of improvement in the texture, tone, elasticity, hydration, pores, homogeneity of the skin, the global aesthetic improvement scale (GAIS) and degree of satisfaction (p <0.001). All adverse events were of mild intensity, did not imply changes before the intervention and were completely resolved. Conclusions: The autologous platelet concentrate proved to be effective and safe in reducing the signs of skin aging, associated with a high degree of patient satisfaction.","PeriodicalId":291908,"journal":{"name":"International Journal of Clinical & Experimental Dermatology","volume":"137 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131428139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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