Chemical Reviews最新文献

Thermally activated delayed fluorescence (TADF) in coinagemetalnanoclusters (CMNCs) has introduced new paradigms in the design ofoptoelectronic materials, uniting atomic precision with tunable quantumand photophysical properties. This review provides a critical andcomprehensive analysis of TADF mechanisms in gold, silver, copper,and doped/alloy nanoclusters, emphasizing quantum confinement, strongspin–orbit coupling, and engineered singlet–tripletenergy gaps that enable efficient reverse intersystem crossing andhigh photoluminescence quantum yields. Recent advances in TADF-activeCMNCs are highlighted, including ligand architecture, core composition,supramolecular assembly, and heterometallic doping, which collectivelyafford unprecedented control over emission color, dynamics, and stability.Comparative perspectives versus organic and metal–organic TADFemitters are presented, underscoring the distinctive advantages andongoing challenges of CMNCs. Current and emerging applications inOLEDs, X-ray scintillation, chiral photonics, and bioimaging are discussed,along with future research directions and critical barriers to therealization of CMNCs in next-generation optoelectronic devices.

Electrochemical energy conversion underpins the sustainableproductionof fuels and chemicals, with efficiency and selectivity governed byreactions at electrified solid–liquid interfaces. In supportedelectrocatalysts, metal–support interactions (MSIs) shape howcatalytic states form and persist under polarization. Yet a predictivedescription of MSI remains elusive. The as-prepared contact may reconstructunder operating conditions. Activity shifts, morphology, and chargeredistribution do not uniquely identify the current-carrying ensemble.These limitations motivate this review, which separates interfacialstructure, chemical bonding, and collective adhesion before relatingthem to catalytic function. The framework spans single atoms, clusters,nanoparticles, core–shell architectures, and reconstructedinterphases. We assess how atomic-resolution imaging, operando characterization, and potential-aware calculations constrain modelsof the working interface and relate them to electrocatalytic performance.Together, these analyses show that MSI effects depend on the workinginterfacial state and its reaction environment. Predictive designtherefore requires balancing interfacial stabilization with the active-siteaccessibility and structural adaptability needed for turnover.

Peptide-based therapeutics are gaining popularity asnext-generationdrugs because of their potent bioactivity, high specificity, and broadapplications in immunomodulatory, antiviral, anticancer, and antimicrobialtherapy. Membrane-active peptides (MAPs) are particularly promising,yet poor solubility, stability, pharmacokinetics, manufacturing complexity,and limited delivery options have restricted their clinical translation.This review focuses on computational approaches developed to addressthese challenges at the peptide-design stage and bridge the gap betweenpreclinical promise and clinical utility. The goal here is to providea broad overview of tools for in silico MAP design,prediction of functional structural ensembles and physicochemicalproperties, structure–function relationships, drug-target interactions,and formulation strategies for in vivo delivery.These approaches span bioinformatics, molecular dynamics and molecularmodeling, and emerging artificial intelligence and machine learningplatforms, including hybrid computational-experimental strategies,chemical modification and conjugation, and nanotechnology-based deliverysystems. These tools are improving key peptide–drug properties,including plasma stability, target specificity, efficacy, and delivery.Continued advances in computational design may enable MAPs to addresschallenging diseases, engage traditionally undruggable targets, andtranslate their substantial therapeutic potential into clinicallyeffective treatments.

Aqueous zinc–manganese batteries (ZMBs) representa compellingsolution for grid-scale energy storage due to their low cost, inherentsafety, and ease of manufacturing. However, conventional ion-intercalationZMBs (IZMBs) are often hindered by bottlenecks such as limited energydensity and poor cycling stability. Recently, electrolytic ZMBs (EZMBs),based on the two-electron Mn²⁺/MnO₂ deposition–dissolutionchemistry, have emerged with high operating voltages (∼1.99V) and exceptional theoretical capacities (616 mAh g^–1), paving a new way for performance breakthroughs in high-energyaqueous batteries. This review provides a deep dive into the mechanisticdivergence between IZMBs and EZMBs, clarifying the core significanceof EZMBs in enhancing energy density, longevity, and cost efficiency.By deconstructing critical challenges across cathode conversion, zincanode interfaces, and electrolyte environments, we synthesize recentbreakthroughs in cathode modification, anode protection, and electrolyteengineering to establish a unified design framework for high-performanceEZMBs. Furthermore, this review identifies emerging opportunitiesand future research directions, aiming to provide systematic theoreticalguidance and design inspiration for the development of next-generation,high-energy-density, and long-life EZMBs.