International Journal of Mass Spectrometry最新文献

A membrane deposition - laser ablation - inductively coupled plasma mass spectrometry approach for the trace determination of dysprosium, gadolinium, and ytterbium in high-purity cerium oxide 膜沉积-激光烧蚀-电感耦合等离子体质谱法测定高纯氧化铈中痕量镝、钆和镱

IF 1.7 3区化学 Q3 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

International Journal of Mass Spectrometry

Pub Date : 2026-04-01 Epub Date: 2026-01-08 DOI: 10.1016/j.ijms.2026.117579

Zhe Fang , Lei Wang , Kai Li , Chaogang Wang , Lizhi Ren , Yaqiang Li , Yihui Wang , Ming Chen , Haizhou Wang

A membrane deposition–laser ablation sampling system was developed, in which the generated dry aerosol was introduced into an inductively coupled plasma mass spectrometer (ICP-MS). Based on this system, a micro-sampling method was established for the determination of gadolinium (Gd), dysprosium (Dy), and ytterbium (Yb) in high-purity cerium oxide. The gas composition in the ablation cell, carrier-gas flow rates, and laser spot sizes were systematically optimized. Carrier gas 1 was argon (Ar) at 1.0 L/min, and carrier gas 2 was helium (He) at 1.1 L/min. An optical aperture diameter of 2.75 mm was found to provide optimal performance. The membrane-deposition efficiency was evaluated from the ratio of the generated analyte mass to the mass determined post-deposition by ICP-MS/MS. Results showed that when the sampling volume was 100 μL and the cerium (Ce) matrix concentration exceeded 100 mg/L, the deposition efficiency approached 100 %. Internal-standard correction was applied to minimize fractionation and matrix effects, and the most suitable internal standards were identified. Under these optimized conditions, the detection limits for Gd, Dy, and Yb were 0.52, 0.18, and 0.21 ng/g, respectively. Analysis of three high-purity CeO₂ samples showed that this method produced significantly lower Gd and Yb values than conventional ICP-MS, effectively eliminated hydroxide and oxide interferences, exhibited superior resistance to spectral interference, and provided results consistent with those from ICP-MS/MS.

研制了一种膜沉积-激光烧蚀取样系统，将生成的干气溶胶引入电感耦合等离子体质谱仪（ICP-MS）。在此基础上，建立了测定高纯氧化铈中钆（Gd）、镝（Dy）、镱（Yb）的微进样方法。系统优化了烧蚀池内气体组成、载气流速和激光光斑尺寸。载气1为1.0 L/min的氩（Ar），载气2为1.1 L/min的氦（He）。光学孔径直径为2.75 mm可提供最佳性能。通过生成的分析物质量与ICP-MS/MS沉积后测定的质量之比来评估膜沉积效率。结果表明，当样品体积为100 μL，铈（Ce）基质浓度超过100 mg/L时，沉积效率接近100%。采用内标校正以减少分馏和基质效应，确定最合适的内标。在此优化条件下，Gd、Dy和Yb的检出限分别为0.52、0.18和0.21 ng/g。对3个高纯度CeO2样品的分析表明，该方法的Gd和Yb值明显低于常规的ICP-MS，有效地消除了氢氧化物和氧化物的干扰，具有较好的抗光谱干扰能力，与ICP-MS/MS的结果一致。

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引用次数: 0

An improved single-column separating procedure of copper, iron, and zinc from geological samples for their isotopic measurements by MC-ICP-MS 用MC-ICP-MS从地质样品中分离铜、铁和锌的改进单柱分离程序

IF 1.7 3区化学 Q3 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

International Journal of Mass Spectrometry

Pub Date : 2026-04-01 Epub Date: 2026-01-31 DOI: 10.1016/j.ijms.2026.117592

Wenwu Yang , Can You , Xiaofei Qiu , Xirun Tong , Shansong Lu , Guiling Duan , Yingxiong Cai , Hanyu Deng , Hongmei Yang

It can provide valuable information about geological and environmental processes that study Cu, Fe, and Zn isotopic compositions in natural samples. Generally, the chemical separation of Cu, Fe, and Zn from a matrix was achieved by independent methods, but only a few methods could simultaneously separate all three elements through a single anion-exchange column. In this study, we present an optimized method for combined separation of Cu, Fe and Zn from geological samples by the anion exchange chromatography. It required only one pass-through the resin to produce the quantitative and pure Cu, Fe and Zn isolate, respectively, which can minimize the handling time, reagent consumption and total analytical blanks. The isobaric interferences from matrix elements were virtually eliminated for the consequent multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) analysis of the isotopic compositions of these Cu, Fe and Zn isolates. The accuracy and precision of Cu, Fe and Zn isotopic analyses were evaluated by replicate measurements of the reference materials. The isotopic results demonstrate fully-reproducible, accurate and precise analyses. The long-term external reproducibility is better than ±0.05‰, ±0.06‰ and ±0.06‰ (2SD) for δ⁶⁵Cu, δ⁵⁶Fe and δ⁶⁶Zn, respectively. Employing these techniques, we report Cu, Fe and Zn isotopic compositions of fourteen commercially accessible geological reference materials with a wide range of matrices. This dataset can serve as a reference for Cu, Fe and Zn isotopic studies for both the quality assurance and inter-laboratory calibration.

对自然样品中Cu、Fe、Zn同位素组成的研究可以提供有价值的地质和环境过程信息。一般来说，Cu、Fe和Zn的化学分离是通过独立的方法实现的，但只有少数方法可以通过单个阴离子交换柱同时分离这三种元素。在这项研究中，我们提出了一种优化的阴离子交换色谱法从地质样品中联合分离铜、铁和锌的方法。只需要一次通过树脂，就可以分别获得定量和纯的Cu、Fe和Zn分离物，从而最大限度地减少处理时间、试剂消耗和总分析空白。在随后的多收集器电感耦合等离子体质谱（MC-ICP-MS）分析这些Cu、Fe和Zn分离物的同位素组成时，基体元素的等压干扰几乎被消除了。通过对参比物质的重复测量，评价了铜、铁和锌同位素分析的准确度和精密度。同位素分析结果可完全重现、准确、精确。δ65Cu、δ56Fe和δ66Zn的长期外重复性分别优于±0.05‰、±0.06‰和±0.06‰（2SD）。利用这些技术，我们报告了14种商业上可获得的具有广泛基质的地质参考物质的Cu， Fe和Zn同位素组成。该数据集可作为Cu， Fe和Zn同位素研究的质量保证和实验室间校准的参考。

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引用次数: 0

Welcoming “Protocols in Mass Spectrometry” 欢迎“质谱分析规程”

IF 1.7 3区化学 Q3 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

International Journal of Mass Spectrometry

Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1016/j.ijms.2026.117585

Julia Laskin, Stephen Blanksby, Isabelle Fournier

引用次数: 0

Identification of microplastics and additives from the Lake Erie watershed and the Cuyahoga River via MALDI-MS and DART-MS 利用MALDI-MS和DART-MS鉴定伊利湖流域和凯霍加河的微塑料及其添加剂

IF 1.7 3区化学 Q3 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

International Journal of Mass Spectrometry

Pub Date : 2026-03-01 Epub Date: 2026-01-09 DOI: 10.1016/j.ijms.2026.117581

Luciana Rivera Molina , Robert Brand , Calum Bochenek , Chrys Wesdemiotis

Micro(nano)plastics have received increased attention as environmental contaminants due to their harmful effects on ecosystems and human health. Conventional extraction methods for microplastic analysis are often lengthy and complicated, resulting in the loss of important chemical components such as additives. In this study, we provide a complementary approach, utilizing matrix-assisted laser desorption/ionization (MALDI) and direct analysis in real time (DART) mass spectrometry (MS) techniques, with minimal extraction and sample preparation to preserve both polymer and additive information. MALDI-MS was applied to aqueous samples collected along the shores of Lake Erie and the Cuyahoga River, successfully identifying the base polymer(s) in the micro(nano)plastics content of these samples, which included polyethylene oxide (PEO), polypropylene oxide (PPO), polyethylene (PE), and polymethylmethacrylate (PMMA). Simultaneously, DART-MS was used to analyze macroplastics debris collected from the same locations, enabling sensitive detection of the additives and plasticizers that are likely leaching into the aquatic environment. DART-MS macroplastics analysis additionally revealed the presence of PE and PEO chains in the plastic litter, corroborating the MALDI-MS data from the water samples and providing strong evidence for contaminant transfer from discarded plastics to the aquatic environment. Finally, DART-MS analysis of the water samples showed additives and plasticizers matching those present in the litter. This study combined both MALDI-MS and DART-MS analysis for the first time, offering a more comprehensive assessment of the base polymer composition and associated additives. By minimizing extraction steps, this approach improves the detection of compounds often lost by conventional methods, ultimately providing deeper insight into microplastic pollution and its toxicological implications.

由于微（纳米）塑料对生态系统和人类健康的有害影响，其作为环境污染物受到越来越多的关注。传统的微塑性分析提取方法往往冗长而复杂，导致添加剂等重要化学成分的损失。在这项研究中，我们提供了一种互补的方法，利用基质辅助激光解吸/电离（MALDI）和实时直接分析（DART）质谱（MS）技术，以最少的提取和样品制备来保存聚合物和添加剂信息。MALDI-MS应用于伊利湖和凯霍加河沿岸的水样，成功地鉴定了这些样品中微（纳米）塑料含量的基础聚合物，包括聚乙烯氧化物（PEO）、聚丙烯氧化物（PPO）、聚乙烯（PE）和聚甲基丙烯酸甲酯（PMMA）。同时，DART-MS用于分析从同一地点收集的宏观塑料碎片，能够灵敏地检测可能浸出到水生环境中的添加剂和增塑剂。DART-MS宏观塑料分析还揭示了塑料垃圾中PE和PEO链的存在，证实了来自水样的MALDI-MS数据，并为污染物从废弃塑料转移到水生环境提供了强有力的证据。最后，对水样的DART-MS分析显示，添加剂和增塑剂与凋落物中的添加剂和增塑剂相匹配。该研究首次结合了MALDI-MS和DART-MS分析，对基础聚合物组成和相关添加剂进行了更全面的评估。通过最大限度地减少提取步骤，这种方法提高了对传统方法经常丢失的化合物的检测，最终提供了对微塑料污染及其毒理学影响的更深入了解。

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引用次数: 0

The review of time of flight secondary ion mass spectrometry technology in LIBs LIBs飞行时间二次离子质谱技术研究进展

IF 1.7 3区化学 Q3 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

International Journal of Mass Spectrometry

Pub Date : 2026-03-01 Epub Date: 2026-01-15 DOI: 10.1016/j.ijms.2026.117584

Zixuan Huang, Ran Tian, Yun Gao

Lithium-ion batteries (LIBs) are pivotal in advancing electronic technology and sustainable energy systems. However, characterizing lithium, the central element in LIBs, remains challenging due to its low atomic mass, which limits its detection by conventional techniques like energy-dispersive X-ray spectroscopy (EDS). Time-of-flight secondary ion mass spectrometry (TOF-SIMS) emerges as a powerful solution, leveraging its high surface sensitivity and capability to detect all elements, including lithium. This review outlines the fundamental principles of TOF-SIMS and highlights its pivotal applications in analyzing LIB components, including anodes, cathodes, and solid-state electrolytes.We critically assess specific testing methodologies and operational modes, providing a clear perspective on how TOF-SIMS elucidates interfacial phenomena and component distribution. Finally, we offer an outlook on the future utilization of TOF-SIMS to deepen the understanding of electrochemical mechanisms in LIBs. This review aims to establish a new pathway for lithium characterization, thereby accelerating the development of high-performance LIBs.

锂离子电池（LIBs）是推动电子技术和可持续能源系统发展的关键。然而，锂作为lib中的核心元素，由于其低原子质量，对其进行表征仍然具有挑战性，这限制了像能量色散x射线光谱（EDS）这样的传统技术的检测。飞行时间二次离子质谱法（TOF-SIMS）作为一种强大的解决方案出现，利用其高表面灵敏度和检测所有元素的能力，包括锂。本文概述了TOF-SIMS的基本原理，并强调了其在分析锂电池组件（包括阳极、阴极和固态电解质）方面的关键应用。我们批判性地评估了特定的测试方法和操作模式，为TOF-SIMS如何阐明界面现象和组件分布提供了清晰的视角。最后，我们展望了TOF-SIMS的未来应用，以加深对lib电化学机制的理解。本文旨在为锂的表征开辟一条新的途径，从而加速高性能锂离子电池的发展。

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引用次数: 0

Evaluation of cleavable crosslinking for characterization of proteoform structural differences by top-down mass spectrometry 自顶向下质谱法评价可切割交联对蛋白质形态结构差异表征的影响

IF 1.7 3区化学 Q3 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

International Journal of Mass Spectrometry

Pub Date : 2026-03-01 Epub Date: 2026-01-03 DOI: 10.1016/j.ijms.2026.117570

Erika A. Renbarger , Ian K. Webb

Cleavable crosslinking has traditionally been employed in bottom-up mass spectrometry to elucidate protein structure and protein-protein interactions through identification of peptides bearing characteristic mass adducts. Here, we demonstrate the application of cleavable crosslinking in top-down mass spectrometry to enhance fragmentation efficiency and enable precise localization of crosslink sites. We first validated this approach using cytochrome c, a well-characterized model protein. Subsequently, we extended top-down cleavable crosslinking to transthyretin, a natively homotetrameric protein exhibiting extensive proteoform heterogeneity, to investigate whether proteoform variations induce structural changes detectable by this method. Our results confirm that cleavable crosslinks can be detected and characterized by top-down mass spectrometry, with crosslinker cleavage under collisional activation significantly enhancing fragmentation. Application to transthyretin (intramolecular crosslinks) yielded complex crosslinking patterns that precluded complete identification of crosslinks. However, the crosslinking data provided valuable information on solvent-accessible residues, functioning effectively as a covalent labeling strategy. This work establishes cleavable crosslinking as a viable chemical crosslinking approach for top-down mass spectrometry applications.

可切割交联传统上用于自下而上的质谱分析，通过鉴定具有特征质量加合物的肽来阐明蛋白质结构和蛋白质相互作用。在这里，我们展示了可切割交联在自上而下质谱中的应用，以提高裂解效率并实现交联位点的精确定位。我们首先使用细胞色素c（一种表征良好的模型蛋白）验证了这种方法。随后，我们将自顶向下可切割交联扩展到转甲状腺素，一种具有广泛蛋白质形态异质性的天然四聚体蛋白，以研究蛋白质形态变异是否会诱导通过该方法检测到的结构变化。我们的研究结果证实，可切割的交联可以通过自上而下的质谱检测和表征，交联剂在碰撞激活下的裂解显著增强了碎片化。应用于转甲状腺素（分子内交联）产生了复杂的交联模式，阻碍了交联的完全鉴定。然而，交联数据提供了有价值的信息，溶剂可接近的残留物，有效地作为一种共价标记策略。这项工作建立了可切割交联作为一种可行的化学交联方法，自上而下的质谱应用。

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引用次数: 0

Identification and analysis of resolution-limiting factors in an alpha time-of-flight spectrometer 飞行时间光谱仪分辨率限制因素的识别与分析

IF 1.7 3区化学 Q3 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

International Journal of Mass Spectrometry

Pub Date : 2026-03-01 Epub Date: 2026-01-09 DOI: 10.1016/j.ijms.2026.117571

M. Azizi , B. Ghasemi , O. Kakuee , A. Biganeh

High-energy resolution alpha spectrometry is essential for accurate nuclear decay data. The Time-Of-Flight (TOF) technique offers high-resolution measurements of alpha particle energy, but several factors can impact spectral resolution, leading to spectral broadening. This study examines the primary sources of uncertainty in TOF alpha spectrometry, assessing the effect of each factor through computational and experimental methods. Results show that energy loss and straggling of alpha particles in the foil, as well as the transit time spread of secondary electrons to the electron detector, significantly affect spectrum broadening. Mitigating these effects through optimized carbon foils and transmission detector design can enhance resolution and measurement precision.

高能分辨率α光谱法对于精确的核衰变数据是必不可少的。飞行时间（TOF）技术提供了α粒子能量的高分辨率测量，但有几个因素会影响光谱分辨率，导致光谱展宽。本研究考察了TOF α光谱法不确定度的主要来源，通过计算和实验方法评估了每个因素的影响。结果表明，箔中α粒子的能量损失和散列，以及二次电子到电子探测器的传递时间扩展，对光谱展宽有显著影响。通过优化碳箔和透射检测器设计来减轻这些影响，可以提高分辨率和测量精度。

引用次数: 0

Impact of supercharging on top-down characterization of monoclonal antibodies by collision induced dissociation 增压对碰撞诱导解离单克隆抗体自上而下表征的影响

IF 1.7 3区化学 Q3 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

International Journal of Mass Spectrometry

Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.ijms.2026.117578

Lasini Amunugama, Jared B. Shaw

Native top-down characterization of monoclonal antibodies (mAbs) is an attractive approach due to the narrow charge state distribution of the intact mAb and the spectral decongestion afforded by relatively low charge product ions being spread over a broad m/z range. However, low precursor charge and extensive disulfide bonding together greatly limit characterization by collision induced dissociation (CID). This study evaluates solution phase supercharging in ammonium acetate electrospray solutions to produce charge state distributions with intermediate charge, i.e., somewhere between native and fully denatured. Sequence coverage and interchain disulfide bond cleavage were evaluated as a function of precursor charge and collision energy for denatured, native, and supercharged “native” mAb precursor ions. Native ESI produced low charge precursors (z∼22–23) that required high collision energies (∼200–225 eV/q) for interchain disulfide cleavages (i.e., light chain (LC) release) and yielded modest sequence coverage. Formic acid, 50:50 acetonitrile/water with formic acid, dimethyl sulfoxide, propylene carbonate, and sulfolane were compared as additives; many increased precursors charge states but produced broader envelopes and degraded spectral quality. In contrast 3 % sulfolane in 100 mM ammonium acetate increased average charges to ∼39 for Infliximab and ∼42 for SigmaMAb and reduced the dissociation threshold to 125 eV/q as expected for higher charge precursor ions. Optimized conditions produced abundant [LC-S]/[LC]/[LC+S] triplets and extended b/y ions into CDR3 regions. Overall, adding 3 % sulfolane in ammonium acetate provides a practical way to overcome key CID limitations for intact mAbs and enables more extensive sequence characterization.

单克隆抗体（mAb）的天然自顶向下表征是一种有吸引力的方法，因为完整的mAb的电荷状态分布较窄，并且相对低电荷的产物离子在较宽的m/z范围内分布，从而使光谱去拥挤。然而，低前体电荷和广泛的二硫键一起极大地限制了碰撞诱导解离（CID）的表征。本研究评估了醋酸铵电喷雾溶液的液相增压，以产生中间电荷的电荷态分布，即介于天然和完全变性之间。序列覆盖率和链间二硫键劈裂作为前体电荷和碰撞能量对变性、原生和超充电的“原生”mAb前体离子进行了评估。原生ESI产生低电荷前体（z ~ 22-23），需要高碰撞能量（~ 200-225 eV/q）进行链间二硫化物裂解（即轻链（LC）释放），并产生适度的序列覆盖。比较了甲酸、乙腈/水50:50与甲酸、二甲基亚砜、碳酸丙烯和亚砜作为添加剂；许多前驱体增加了电荷状态，但产生了更宽的包层和降低的光谱质量。相比之下，在100 mM醋酸铵中加入3%的亚砜将英夫利昔单抗的平均电荷增加到~ 39，SigmaMAb的平均电荷增加到~ 42，并将高电荷前体离子的解离阈值降低到125 eV/q。优化后的条件产生了丰富的[LC-S]/[LC]/[LC+S]三重态，并将b/y离子扩展到CDR3区域。总的来说，在乙酸铵中添加3%的亚砜，为克服完整单抗的关键CID限制提供了实用的方法，并能够进行更广泛的序列表征。

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引用次数: 0

Advances in tapping-mode scanning probe electrospray ionization (t-SPESI): Instrumental development for high-spatial-resolution ambient mass spectrometry imaging 挖掘模式扫描探针电喷雾电离（t-SPESI）的研究进展：高空间分辨率环境质谱成像仪器的开发

IF 1.7 3区化学 Q3 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

International Journal of Mass Spectrometry

Pub Date : 2026-03-01 Epub Date: 2025-12-29 DOI: 10.1016/j.ijms.2025.117569

Yoichi Otsuka

Mass spectrometry imaging (MSI) is an essential technique for visualizing the distribution of molecules in biological tissues. Ambient sampling ionization-based MSI has attracted attention for its ability to analyze samples directly; however, improving spatial resolution remains a major technical challenge. Young Scientist developed a tapping-mode scanning probe electrospray ionization (t-SPESI) method that uniquely combines the core technologies of electrospray ionization (ESI) and atomic force microscopy (AFM). By using an oscillating capillary probe to periodically supply minute amounts of solvent to the sample surface, t-SPESI enables spatiotemporal separation of the extraction and ionization processes, allowing rapid, soft ionization of analytes in micro-regions of the sample. In addition, the oscillating probe senses the sample surface, minimizing the influence of surface topography on extraction and ionization during MSI. Young Scientist has further advanced high-spatial-resolution t-SPESI-MSI through the development of feedback-control methods, probe fabrication techniques, and miniaturization of t-SPESI units. This paper provides an overview of the progress made in the development of t-SPESI instrumentation and highlights MSI results obtained from tissues and single cells.

质谱成像（MSI）是可视化生物组织中分子分布的重要技术。基于环境采样电离的MSI因其直接分析样品的能力而受到关注；然而，提高空间分辨率仍然是一个主要的技术挑战。Young Scientist开发了一种独特地结合了电喷雾电离（ESI）和原子力显微镜（AFM）核心技术的轻敲模式扫描探针电喷雾电离（t-SPESI）方法。通过使用振荡毛细管探针定期向样品表面提供微量溶剂，t-SPESI实现了萃取和电离过程的时空分离，允许样品微区域的分析物快速、软电离。此外，振荡探针感知样品表面，最大限度地减少表面形貌对MSI过程中提取和电离的影响。通过反馈控制方法、探针制造技术和t-SPESI单元小型化的发展，进一步推进了高空间分辨率t-SPESI- msi的发展。本文概述了t-SPESI仪器的发展进展，并重点介绍了从组织和单细胞中获得的MSI结果。

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引用次数: 0

Paper spray analysis of crude oil samples: comparing traditional characterization schemes with mass spectrometric outcomes 原油样品的纸喷分析：传统表征方案与质谱结果的比较

IF 1.7 3区化学 Q3 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

International Journal of Mass Spectrometry

Pub Date : 2026-02-01 Epub Date: 2025-11-25 DOI: 10.1016/j.ijms.2025.117554

Theis I. Solling , Nathan F. Dalleska , Syed S. Hussain , J.L. Beauchamp

Crude oil constitutes one of the most complex mixtures in the world and its characterization is challenging yet absolutely essential in any upstream related production context. Traditionally, this has been addressed in fractionation of the oil into saturates, aromatics, resins and asphaltenes; the SARA protocol. We have employed this conventional approach on three crude oils to compare results with mass spectrometric analysis in paper spray ionization mode where the crude does not enter inlets nor does it adhere to interfaces and therefore leaves no memory effects. Thus, it has proven to be an extremely convenient method for oil characterization as crude normally tends to damage analytical equipment by contamination. We have found that the densities of the three crude oils align very well with their SARA analyses in the sense that more saturates (alkanes) correspond to less dense oils. The paper spray ionization mass spectrometry handles the oil that consists of mostly saturates poorly and results in ill-defined peak shapes. A few peaks stand out and are most likely highly polar production compounds that are more easily ionized. On the other hand, the oils with aromatic components result in nice spectra and coupling the paper spray to HRMS clearly reveals the alkyl-aromatics. The combined results show that paper spray provides a fast valuable, non-contaminating route to oil characterization that provides actual structural insights; something that the traditional oil characterization methods can never be brought to do. We also show that production-relevant surfactants are readily characterized with paper spray. Thus, with some development it will facilitate the characterization of residual production chemicals in light crudes and guide the refining process.

原油是世界上最复杂的混合物之一，其特性具有挑战性，但在任何上游相关生产环境中都是绝对必要的。传统上，这是通过将油分馏成饱和油、芳烃、树脂和沥青质来解决的；SARA协议。我们对三种原油采用了这种常规方法，并将结果与纸喷雾电离模式下的质谱分析结果进行了比较。在纸喷雾电离模式下，原油不会进入进口，也不会粘附在界面上，因此不会留下记忆效应。因此，它已被证明是一种非常方便的石油表征方法，因为原油通常容易因污染而损坏分析设备。我们发现，这三种原油的密度与他们的SARA分析结果非常吻合，因为饱和烃（烷烃）越多，油的密度就越低。纸喷雾电离质谱法处理的油大部分是饱和的，导致峰形不明确。有几个峰很突出，很可能是极性很强的产物，更容易电离。另一方面，含有芳香族成分的油具有良好的光谱，将纸喷雾与HRMS耦合可以清晰地显示烷基芳香族。综合结果表明，纸喷为油品表征提供了一种快速、有价值、无污染的途径，可以提供实际的结构洞察；这是传统的油品表征方法永远无法做到的。我们还表明，与生产相关的表面活性剂很容易用纸喷雾表征。因此，随着一些发展，它将有助于表征轻质原油中残留的生产化学品，并指导炼油过程。

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引用次数: 0