Pub Date : 2021-11-02DOI: 10.1002/9783527345939.ch9
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Pub Date : 2021-11-02DOI: 10.1002/9783527345939.ch10
R. Grubbs, D. J. O'Leary
About the Editors xxxiii Preface xxxvii List of Contributors of Volumes 1 and 2 xxxix Abbreviations and Acronyms xli Theory and instrumentation of mass spectrometry and its application to drug metabolism 393 Stacy L. Gelhaus and Ian A. Blair Mass spectral interpretation 419 Li-Kang Zhang and Birendra N. Pramanik Computational approaches in drug biotransformation studies: metabolite prediction 457 Nigel J. Waters and Michelle K. Dennehy High-throughput metabolite detection and quantitative qualitative bioanalysis 481 Donghui Cui and Sean Yu Metabolic stability screen in drug discovery 499 Chuang Lu Application of triple-quadrupole and its hybrid mass spectrometers for the identification of drug metabolites 523 Zhi-Yi Zhang, Chandra Prakash, and Lin Xu Role of ion trap LC-MS techniques for the identification of drug metabolites 553 Robert D. Pelletier and W. George Lai Drug metabolite identification with high-resolution mass spectrometry 567 Haiying Zhang and Mingshe Zhu Strategies for the identification of unusual and novel metabolites using derivatization, hydrogen deuterium exchange (HDX), and liquid chromatography-nuclear magnetic resonance (LC-NMR) spectroscopy techniques 591 Amin Kamel, Shawn Harriman, and Chandra Prakash The use of nanoelectrospray mass spectrometry for the quantitation of metabolites in the absence of synthetic standards 619 Jing-Tao Wu Quantitation of drug metabolites by radioactivity detection including accelerator mass spectrometry (AMS) 633 Angus N.R. Nedderman and Mark E. Savage Application of quantitative NMR in drug metabolism studies 661 Abdul E. Mutlib Early assessment of exposure of drug metabolites in humans using mass spectrometry 693 Natalia A. Penner, Joanna Zgoda-Pols, and Chandra Prakash Profiling and characterization of bioactive substances of herbal medicine and their metabolites using mass spectrometry 723 Xiaoyan Chen Application of in silico metabolism and environmental degradation data to support chemical PBT assessment 787 Sabcho Dimitrov, Gilman Veith, and Ovanes Mekenyan
编者简介xxxiii前言xxxvii第1卷和第2卷编者名单xxxix缩语和首字母缩略词xli质谱理论和仪器及其在药物代谢中的应用393 Stacy L. Gelhaus和Ian A. Blair质谱解释419张利康和Birendra N. Pramanik药物生物转化研究中的计算方法:代谢物预测457 Nigel J. Waters and Michelle K. Dennehy高通量代谢物检测与定量定性生物分析481崔东辉Yu Sean药物发现中的代谢稳定性筛选499路创523三重四极杆及其混合质谱在药物代谢物鉴定中的应用离子阱LC-MS技术在药物代谢物鉴定中的作用553 Robert D. Pelletier和W. George Lai高分辨率质谱鉴定药物代谢物567张海英朱明设衍生化、氢氘交换(HDX)和液相色谱-核磁共振(LC-NMR)光谱技术鉴定罕见和新型代谢物的策略591 Amin Kamel, Shawn Harriman，纳米电喷雾质谱法在没有合成标准物的情况下对代谢物进行定量分析吴景涛用放射性检测包括加速器质谱法(AMS)对药物代谢物进行定量分析633 Angus N.R. nederman和Mark E. Savage定量核磁共振在药物代谢研究中的应用661 Abdul E. Mutlib质谱法对人体药物代谢物暴露的早期评估693 Natalia A. Penner中草药生物活性物质及其代谢物的质谱分析与表征[23]陈晓燕。硅代谢和环境降解数据支持化学PBT评价的应用[7]Sabcho Dimitrov, Gilman Veith, Ovanes me肯亚
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