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El citomegalovirus como modulador profibrótico en esclerosis sistémica: evidencia experimental 巨细胞病毒作为全身性硬化症profibrotic modulator:实验证据
IF 0.5 Q3 Health Professions Pub Date : 2026-07-01 Epub Date: 2026-05-27 DOI: 10.1016/j.rcreu.2026.504913
Victoria E. Butrón-Verástegui, José M. Vela-Ruiz, Sacha Barrios Healey
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引用次数: 0
Inyección intraarticular de glucocorticoides guiada por ultrasonido. Una revisión sistemática de la literatura 超声引导关节内糖皮质激素注射。系统的文献审查
IF 0.5 Q3 Health Professions Pub Date : 2026-07-01 Epub Date: 2026-06-18 DOI: 10.1016/j.rcreu.2026.504920
Luis Pereira Sarduy, Alida Ricardo Marzo
Ultrasound-guided intra-articular glucocorticoid (IA-GC) injection has transformed local management of various rheumatic diseases by improving procedural accuracy and safety. This systematic review analyzed evidence published between 2010 and 2024 on the efficacy, safety, optimal dosing, and controversies surrounding ultrasound-guided IA-GC, including original articles, systematic reviews, meta-analyses, and clinical practice guidelines. The studies showed that ultrasound guidance significantly increased injection accuracy (86.7% vs 26.7% with landmark guidance; p < 0.05) and reduced procedural pain by 48% (VAS: 3.0 ± 2.8 cm vs 5.8 ± 3.0 cm; p < 0.001). It also improved short-term therapeutic outcomes (VAS at 2 weeks: 1.5 ± 1.9 cm vs 2.8 ± 2.4 cm; p = 0.034), with significant improvements in pain and joint function. In knee osteoarthritis, pain reduction (VAS) was approximately 4.4 points (95% CI: 4.1-4.7), with a short-term success rate of 78.6%. In the acromioclavicular joint, ultrasound guidance yielded greater pain relief (mean difference [MD] 1.9, 95% CI: 1.2-2.6; p < 0.00001) and functional improvement (Constant score MD 10.9, 95% CI: 6.57-15.23; p < 0.00001) compared with landmark-guided injection. The most supported regimen was triamcinolone 40 mg for large joints and 10-20 mg for small joints, although dosing varied considerably. Serious complications were uncommon, but systematic safety assessment was insufficient. Ultrasound-guided IA-GC is a valuable tool, although multicenter, standardized studies are needed to strengthen clinical recommendations.
超声引导关节内糖皮质激素(IA-GC)注射通过提高手术准确性和安全性,改变了各种风湿性疾病的局部管理。本系统综述分析了2010年至2024年间发表的关于超声引导IA-GC的疗效、安全性、最佳剂量和争议的证据,包括原创文章、系统综述、荟萃分析和临床实践指南。研究表明,超声引导可显著提高注射精度(86.7% vs .地标引导26.7%;p < 0.05),并可减少48%的手术疼痛(VAS: 3.0±2.8 cm vs . 5.8±3.0 cm; p < 0.001)。它还改善了短期治疗结果(2周VAS: 1.5±1.9 cm vs 2.8±2.4 cm; p = 0.034),疼痛和关节功能显著改善。在膝关节骨关节炎中,疼痛减轻(VAS)约为4.4分(95% CI: 4.1-4.7),短期成功率为78.6%。在肩锁关节,超声引导比路标引导注射更能缓解疼痛(平均差值[MD] 1.9, 95% CI: 1.2-2.6; p < 0.00001)和改善功能(恒定评分MD 10.9, 95% CI: 6.57-15.23; p < 0.00001)。最支持的方案是曲安奈德大关节40毫克,小关节10-20毫克,尽管剂量变化很大。严重并发症不常见,但缺乏系统的安全性评价。超声引导下的IA-GC是一种有价值的工具,尽管需要多中心、标准化的研究来加强临床推荐。
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引用次数: 0
Sex hormones in psoriasis and psoriatic arthritis: Unraveling a complex immunoendocrine dialogue 银屑病和银屑病关节炎中的性激素:解开一个复杂的免疫内分泌对话
IF 0.5 Q3 Health Professions Pub Date : 2026-07-01 Epub Date: 2026-06-23 DOI: 10.1016/j.rcreu.2026.504964
Daniela B. Tovar-Bastidas, Enrique R. Soriano
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引用次数: 0
Renal ultrasound in rheumatic diseases 肾超声在风湿病中的应用
IF 0.5 Q3 Health Professions Pub Date : 2026-07-01 Epub Date: 2026-04-23 DOI: 10.1016/j.rcreu.2026.504931
Fabiola Pazos-Pérez, Carlos Enrique Méndez-Landa, María Ines Gil-Arredondo, Yessyca López-Cabrera, Estefanía Garduño-Hernández, Francisco Román Soto-Zuñiga, Ivan Jese Casas-Romero, Jesús Iván Lara-Prado, Dulce Paola Grajales-García
Ultrasound (US) is the imaging study of choice in patients with systemic autoimmune rheumatic diseases with clinical suspicion of kidney damage, as it requires no radiation, is non-invasive, and provides real-time imaging. It has become more accessible, and currently, bedside US can be performed with portable devices. US allows evaluation of the structural (shape and size) and functional (perfusion and permeability) aspects of the kidneys, which are particularly important as rheumatological diseases progress. There are no specific ultrasonographic findings in these diseases; consequently, interpretation often depends on clinical correlation. This review describes the most frequent indications and findings in conventional US and Doppler US in various systemic rheumatological diseases.
超声(US)是临床怀疑肾脏损害的系统性自身免疫性风湿病患者的首选影像学研究,因为它不需要放射,无创,并提供实时成像。它已经变得更容易获得,目前,床边检查可以用便携式设备进行。US允许评估肾脏的结构(形状和大小)和功能(灌注和通透性)方面,这在风湿病的进展中尤为重要。这些疾病没有特殊的超声表现;因此,解释往往取决于临床相关性。本综述描述了常规超声和多普勒超声在各种系统性风湿病中的最常见适应症和发现。
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引用次数: 0
Sleep quality in rheumatoid arthritis: A cross sectional study 类风湿性关节炎患者的睡眠质量:一项横断面研究
IF 0.5 Q3 Health Professions Pub Date : 2026-07-01 Epub Date: 2025-06-12 DOI: 10.1016/j.rcreu.2025.04.002
Sonia Rekik, Faïza Ben Messaoud, Safa Rahmouni, Khaoula Zouaoui, Lobna Ben Ammar, Maïssa Abbes, Soumaya Boussaid, Hela Sahli

Introduction

While numerous studies have examined the physical consequences of rheumatoid arthritis (RA), its impact on sleep quality remains relatively understudied.

Objective

This study aims to specifically assess the effect of RA on patients’ sleep quality.

Materials and methods

We conducted a cross-sectional study. Patient characteristics were assessed. The patients’ sleep quality was assessed using the Medical Outcomes Study Sleep Scale (MOS-Sleep scale) in its validated Arabic version.

Results

The study included n = 49 patients with RA. Their mean age was 54.1 ± 12.06 years [24–83]. The mean diagnostic delay was 2.35 years [.5–13]. The RA was erosive in 46 cases (93.8%), two patients (4.1%) had atlantoaxial subluxation, and coxitis was noted in four cases (8.2%). A longer diagnostic delay was associated with a higher sleep problem index score. A significant positive association was found between VAS pain and all sleep disturbance scores (p = .00 and r = .518). The presence of comorbidities was associated with a higher index (p = .03). This was also true in case of coxitis and/or atlantoaxial subluxation (p = .03). For therapeutic management, we did not find a statistically significant association between the use of NSAIDs or corticosteroids, or methotrexate (MTX), and the sleep problem index. However, weekly dosage of MTX was positively correlated with the sleep problem index (p = .03, r = .358). The multivariate analysis found global patient assessment (GPA) (p = .000), presence of comorbidities (p = .007), and presence of atlantoaxial subluxation and/or coxitis (p = .05) were significant factors influencing sleep quality.

Conclusion

Diagnostic delay and the global management of RA patients, including co-morbidities could impact sleep quality. Therefore, early treatment and holistic management of patients are necessary.
虽然许多研究已经检查了类风湿性关节炎(RA)的生理后果,但其对睡眠质量的影响仍相对缺乏研究。目的探讨类风湿关节炎对患者睡眠质量的影响。材料与方法我们进行了横断面研究。评估患者特征。使用经验证的阿拉伯语版本的医学结果研究睡眠量表(MOS-Sleep Scale)评估患者的睡眠质量。结果纳入49例RA患者。平均年龄54.1±12.06岁[24-83]。平均诊断延迟为2.35年[.5 - 13]。RA糜烂46例(93.8%),2例(4.1%)出现寰枢椎半脱位,4例(8.2%)出现肩关节炎。诊断延迟越长,睡眠问题指数得分越高。VAS疼痛与所有睡眠障碍评分之间存在显著正相关(p = .00, r = .518)。合并症的存在与较高的指数相关(p = .03)。在肩关节炎和/或寰枢椎半脱位的情况下也是如此(p = .03)。对于治疗性管理,我们没有发现非甾体抗炎药、皮质类固醇或甲氨蝶呤(MTX)的使用与睡眠问题指数之间有统计学上显著的关联。MTX周剂量与睡眠问题指数呈正相关(p = .03, r = .358)。多因素分析发现,总体患者评估(GPA) (p = 0.000)、合并症的存在(p = 0.007)、寰枢椎半脱位和/或肩关节炎的存在(p = 0.05)是影响睡眠质量的重要因素。结论RA患者的诊断延迟和整体管理(包括合并症)可能影响睡眠质量。因此,患者的早期治疗和综合管理是必要的。
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引用次数: 0
Exploring the potential link between vitamin D receptor Cdx2 gene polymorphism and rheumatoid arthritis in female patients: A study in Erbil, Kurdistan Region-Iraq 探索维生素D受体Cdx2基因多态性与女性患者类风湿关节炎之间的潜在联系:一项来自伊拉克库尔德斯坦地区埃尔比勒的研究
IF 0.5 Q3 Health Professions Pub Date : 2026-07-01 Epub Date: 2025-07-01 DOI: 10.1016/j.rcreu.2025.03.004
Raghda R. Qadir, Bushra H. Shnawa, Mukhtar H. Ahmed

Introduction

In recent decades, vitamin D has been extensively researched in relation to several autoimmune diseases, including Rheumatoid Arthritis (RA).

Objective

The primary objective of this study is to investigate the relationship between RA and polymorphism in vitamin D receptor gene Cdx2 in a sample of women.

Methods

Eighty females (60 with RA and 20 controls) participated in this case–control investigation. The Cdx2 single nucleotide polymorphism (SNP) of the VDR gene was genotyped using the tetra-primer amplification refractory mutation system-polymerase chain reaction technique (ARMS-PCR).

Results

The current study found that 51 RA patients have the heterozygous GA genotype of the Cdx2 polymorphism despite non-significant values. Although the present findings showed no significant association between Cdx2 gene polymorphism and the risk of RA, this genotype still represents the majority among the study's RA patients. Moreover, vitamin D3 serum was significantly lower in RA with the GA genotype compared to healthy controls (HC) with a similar genotype (p = .0002). Also, RA patients with heterozygote GA genotype for Cdx2 had a relatively lower mean VD3 serum level than those with homozygote GG genotype.

Conclusion

The novelty of this study is to discover the probable association of Vitamin D receptor, caudal-related homeobox 2 (VDR-Cdx2) polymorphism with RA in the given study group for the first time in our society using a tetra primer ARMS-PCR. Additionally, the tetra-primer ARMS-PCR technique is simple, reliable, and cost-effective, making it a potentially valuable alternative to Restriction Fragment Length Polymorphism-Polymerase Chain Reaction (RFLP-PCR) for (SNP) genotyping.
近几十年来,维生素D已被广泛研究与几种自身免疫性疾病,包括类风湿性关节炎(RA)的关系。目的本研究的主要目的是探讨RA与女性维生素D受体基因Cdx2多态性的关系。方法80例女性(RA患者60例,对照组20例)参与病例-对照调查。采用四引物扩增难解突变系统-聚合酶链反应技术(ARMS-PCR)对VDR基因Cdx2单核苷酸多态性(SNP)进行基因分型。结果本研究发现51例RA患者存在Cdx2多态性的杂合GA基因型,但值不显著。虽然目前的研究结果显示Cdx2基因多态性与RA的风险之间没有显著的相关性,但该基因型在研究的RA患者中仍然占多数。此外,与具有相似基因型的健康对照组(HC)相比,GA基因型RA的维生素D3血清显著降低(p = 0.0002)。同时,Cdx2基因型为GA杂合子的RA患者血清VD3平均水平相对于基因型为GG纯合子的RA患者较低。结论本研究的新颖之处在于,利用四引物ARMS-PCR技术,在国内首次发现了维生素D受体尾侧相关同源盒2 (VDR-Cdx2)多态性与RA的相关性。此外,四引物ARMS-PCR技术简单,可靠,成本效益高,使其成为限制性片段长度多态性-聚合酶链反应(RFLP-PCR)基因分型的潜在有价值的替代方法。
{"title":"Exploring the potential link between vitamin D receptor Cdx2 gene polymorphism and rheumatoid arthritis in female patients: A study in Erbil, Kurdistan Region-Iraq","authors":"Raghda R. Qadir,&nbsp;Bushra H. Shnawa,&nbsp;Mukhtar H. Ahmed","doi":"10.1016/j.rcreu.2025.03.004","DOIUrl":"10.1016/j.rcreu.2025.03.004","url":null,"abstract":"<div><h3>Introduction</h3><div>In recent decades, vitamin D has been extensively researched in relation to several autoimmune diseases, including Rheumatoid Arthritis (RA).</div></div><div><h3>Objective</h3><div>The primary objective of this study is to investigate the relationship between RA and polymorphism in vitamin D receptor gene Cdx2 in a sample of women.</div></div><div><h3>Methods</h3><div>Eighty females (60 with RA and 20 controls) participated in this case–control investigation. The Cdx2 single nucleotide polymorphism (SNP) of the VDR gene was genotyped using the tetra-primer amplification refractory mutation system-polymerase chain reaction technique (ARMS-PCR).</div></div><div><h3>Results</h3><div>The current study found that 51 RA patients have the heterozygous GA genotype of the Cdx2 polymorphism despite non-significant values. Although the present findings showed no significant association between Cdx2 gene polymorphism and the risk of RA, this genotype still represents the majority among the study's RA patients. Moreover, vitamin D3 serum was significantly lower in RA with the GA genotype compared to healthy controls (HC) with a similar genotype (<em>p</em> <!-->=<!--> <!-->.0002). Also, RA patients with heterozygote GA genotype for Cdx2 had a relatively lower mean VD3 serum level than those with homozygote GG genotype.</div></div><div><h3>Conclusion</h3><div>The novelty of this study is to discover the probable association of Vitamin D receptor, caudal-related homeobox<span> 2 (VDR-Cdx2) polymorphism with RA in the given study group for the first time in our society using a tetra primer ARMS-PCR. Additionally, the tetra-primer ARMS-PCR technique is simple, reliable, and cost-effective, making it a potentially valuable alternative to Restriction Fragment Length Polymorphism-Polymerase Chain Reaction (RFLP-PCR) for (SNP) genotyping.</span></div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 3","pages":"Article 102179"},"PeriodicalIF":0.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The cultural adaptation, reliability and validity of the Turkish version of the Maastricht Social Participation Profile questionnaire in patients with rheumatoid arthritis 土耳其版马斯特里赫特社会参与问卷在类风湿关节炎患者中的文化适应性、信度和效度
IF 0.5 Q3 Health Professions Pub Date : 2026-07-01 Epub Date: 2026-04-05 DOI: 10.1016/j.rcreu.2026.504888
Aylin Cicekli, Saniye Yardim, Sebahat Yaprak Cetin, Atif Cicekli, Ayse Ayan

Introduction

Social participation of individuals with chronic physical disabilities is crucial because it examines their processes of integration, which contributes to the identification of their quality of life, inclusion in life situations, and processes of discrimination.

Objective

This study aimed to investigate the validity and reliability of the Turkish version of the Maastricht Social Participation Profile (MSPP) in patients with rheumatoid arthritis (RA).

Materials and methods

The study involved experts in consulting who evaluated the scale's content validity after retrospective translation into Turkish. The sample consisted of 130 volunteer patients diagnosed with RA by a rheumatologist. The reliability and validity of the scale used in the research was examined with confirmatory factor analysis (CFA), the Cronbach's alpha coefficient. The Cronbach alpha reliability coefficients were calculated to test the internal consistency and reliability of scales. Also, intraclass correlation coefficient (ICC) was used to evaluate the consistency or reproducibility of the scale.

Results

The MSPP research data showed an acceptable fit in terms of goodness-of-fit index values. Structural differences emerged in all sub-dimensions, with the modified MSPP Cronbach's alpha calculated at 0.86 for the total scale.

Conclusion

In conclusion, the Turkish version of the MSPP is valid, reliable, and appropriate tool for evaluating the social participation of RA patients. This study aims to fill the gap in the evaluation of social participation among chronic illness patients with RA in Turkey. By developing a scale for this purpose, it is expected to provide valuable guidance for future research.
慢性身体残疾患者的社会参与至关重要,因为它检查了他们的融入过程,这有助于确定他们的生活质量,融入生活状况和歧视过程。目的本研究旨在探讨土耳其版马斯特里赫特社会参与量表(MSPP)在类风湿关节炎(RA)患者中的效度和信度。材料和方法本研究涉及咨询专家,他们在回顾性翻译成土耳其语后评估量表的内容效度。样本包括由风湿病学家诊断为类风湿性关节炎的130名志愿者患者。采用验证性因子分析(CFA)、Cronbach’s alpha系数对研究中使用的量表进行信度和效度检验。计算Cronbach α信度系数,检验量表的内部一致性和信度。用类内相关系数(ICC)评价量表的一致性或再现性。结果MSPP研究数据在拟合优度指数方面具有可接受的拟合性。所有子维度都存在结构性差异,总量表的修正MSPP Cronbach's alpha计算值为0.86。结论土耳其版的MSPP量表是评估RA患者社会参与的有效、可靠和合适的工具。本研究旨在填补土耳其慢性疾病类风湿性关节炎患者社会参与评估的空白。通过为此目的编制量表,有望为今后的研究提供有价值的指导。
{"title":"The cultural adaptation, reliability and validity of the Turkish version of the Maastricht Social Participation Profile questionnaire in patients with rheumatoid arthritis","authors":"Aylin Cicekli,&nbsp;Saniye Yardim,&nbsp;Sebahat Yaprak Cetin,&nbsp;Atif Cicekli,&nbsp;Ayse Ayan","doi":"10.1016/j.rcreu.2026.504888","DOIUrl":"10.1016/j.rcreu.2026.504888","url":null,"abstract":"<div><h3>Introduction</h3><div>Social participation of individuals with chronic physical disabilities is crucial because it examines their processes of integration, which contributes to the identification of their quality of life, inclusion in life situations, and processes of discrimination.</div></div><div><h3>Objective</h3><div>This study aimed to investigate the validity and reliability of the Turkish version of the Maastricht Social Participation Profile (MSPP) in patients with rheumatoid arthritis (RA).</div></div><div><h3>Materials and methods</h3><div>The study involved experts in consulting who evaluated the scale's content validity after retrospective translation into Turkish. The sample consisted of 130 volunteer patients diagnosed with RA by a rheumatologist. The reliability and validity of the scale used in the research was examined with confirmatory factor analysis (CFA), the Cronbach's alpha coefficient. The Cronbach alpha reliability coefficients were calculated to test the internal consistency and reliability of scales. Also, intraclass correlation coefficient (ICC) was used to evaluate the consistency or reproducibility of the scale.</div></div><div><h3>Results</h3><div>The MSPP research data showed an acceptable fit in terms of goodness-of-fit index values. Structural differences emerged in all sub-dimensions, with the modified MSPP Cronbach's alpha calculated at 0.86 for the total scale.</div></div><div><h3>Conclusion</h3><div>In conclusion, the Turkish version of the MSPP is valid, reliable, and appropriate tool for evaluating the social participation of RA patients. This study aims to fill the gap in the evaluation of social participation among chronic illness patients with RA in Turkey. By developing a scale for this purpose, it is expected to provide valuable guidance for future research.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 3","pages":"Article 504888"},"PeriodicalIF":0.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of lung ultrasound in connective tissue disease associated interstitial lung disease 肺超声在结缔组织病相关间质性肺疾病中的应用
IF 0.5 Q3 Health Professions Pub Date : 2026-07-01 Epub Date: 2026-04-01 DOI: 10.1016/j.rcreu.2026.504876
Esther Vicente-Rabaneda, Maria Carolina Torres, Pedro Santos-Moreno, Julia Recalde-Reyes, Wilder Carvajal-Gutierrez
Pulmonary involvement is a common manifestation of various rheumatologic diseases, significantly impacting prognosis. Early diagnosis is crucial, and the recent use of bedside ultrasound by clinicians has opened new diagnostic avenues. This review explores the current state of the art regarding rheumatologic diseases and their ultrasound representation.
肺部受累是各种风湿病的常见表现,严重影响预后。早期诊断是至关重要的,最近临床医生使用床边超声开辟了新的诊断途径。这篇综述探讨了风湿病及其超声表征的最新进展。
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引用次数: 0
Update on ultrasound in crystal arthropathies 超声在晶体关节病中的最新进展
IF 0.5 Q3 Health Professions Pub Date : 2026-07-01 Epub Date: 2026-02-23 DOI: 10.1016/j.rcreu.2026.504875
Alessandro Lucia, Jairo Cajamarca, Rodolfo Fabbri, Georgios Filippou, Mario Díaz
Crystal-induced arthropathies (CIAs), which include gout, calcium pyrophosphate deposition (CPPD) disease, and basic calcium phosphate deposition (BCPD) disease, are prevalent yet intricate conditions characterized by the deposition of specific crystal types in joints and periarticular tissues. While synovial fluid analysis using polarized light microscopy remains a cornerstone for diagnosis, musculoskeletal ultrasound (US) has emerged as a highly sensitive, non-invasive diagnostic modality for the evaluation of CIAs. The capability of ultrasound to produce real-time, high-resolution, and dynamic imaging positions it as an invaluable tool in the assessment and management of these disorders. In recent years, US has been rigorously studied and validated for its diagnostic accuracy and reliability, particularly in gout and CPPD. Its sensitivity in detecting features such as the double contour sign in gout and CPP aggregates in fibrocartilage and hyaline cartilage in case of CPPD has been well-documented. Conversely, while US is frequently utilized in BCPD for diagnostic purposes, monitoring disease progression, and guiding imaging-assisted procedures, a robust and comprehensive validation of its utility in this condition remains lacking. This review underscores the role of ultrasound in the diagnosis and management of CIAs, with a focus on its applications in gout, CPPD, and BCPD. It discusses its clinical benefits and the current evidence supporting its use. Additionally, the review highlights gaps in research, particularly for BCPD, and outlines future directions to enhance the integration of ultrasound in the diagnostic and therapeutic landscape of CIAs.
晶体性关节病(CIAs)包括痛风、焦磷酸钙沉积(CPPD)病和碱性磷酸钙沉积(BCPD)病,是一种普遍而复杂的疾病,其特征是关节和关节周围组织中特定晶体类型的沉积。虽然使用偏振光显微镜进行滑液分析仍然是诊断的基础,但肌肉骨骼超声(US)已成为评估cia的一种高度敏感、非侵入性的诊断方式。超声产生实时、高分辨率和动态成像的能力使其成为评估和管理这些疾病的宝贵工具。近年来,美国已被严格研究和验证其诊断的准确性和可靠性,特别是在痛风和CPPD。它在检测痛风的双轮廓征和CPPD时纤维软骨和透明软骨的CPP聚集等特征方面的敏感性已经得到了充分的证明。相反,虽然超声在BCPD中经常用于诊断目的、监测疾病进展和指导成像辅助手术,但仍缺乏对其在这种情况下的实用性的可靠和全面的验证。本文综述了超声在cia诊断和治疗中的作用,重点介绍了超声在痛风、CPPD和BCPD中的应用。它讨论了它的临床益处和目前支持其使用的证据。此外,该综述还强调了研究中的空白,特别是对于BCPD,并概述了加强超声在cia诊断和治疗领域整合的未来方向。
{"title":"Update on ultrasound in crystal arthropathies","authors":"Alessandro Lucia,&nbsp;Jairo Cajamarca,&nbsp;Rodolfo Fabbri,&nbsp;Georgios Filippou,&nbsp;Mario Díaz","doi":"10.1016/j.rcreu.2026.504875","DOIUrl":"10.1016/j.rcreu.2026.504875","url":null,"abstract":"<div><div>Crystal-induced arthropathies (CIAs), which include gout, calcium pyrophosphate deposition (CPPD) disease, and basic calcium phosphate deposition (BCPD) disease, are prevalent yet intricate conditions characterized by the deposition of specific crystal types in joints and periarticular tissues. While synovial fluid analysis using polarized light microscopy remains a cornerstone for diagnosis, musculoskeletal ultrasound (US) has emerged as a highly sensitive, non-invasive diagnostic modality for the evaluation of CIAs. The capability of ultrasound to produce real-time, high-resolution, and dynamic imaging positions it as an invaluable tool in the assessment and management of these disorders. In recent years, US has been rigorously studied and validated for its diagnostic accuracy and reliability, particularly in gout and CPPD. Its sensitivity in detecting features such as the double contour sign in gout and CPP aggregates in fibrocartilage and hyaline cartilage in case of CPPD has been well-documented. Conversely, while US is frequently utilized in BCPD for diagnostic purposes, monitoring disease progression, and guiding imaging-assisted procedures, a robust and comprehensive validation of its utility in this condition remains lacking. This review underscores the role of ultrasound in the diagnosis and management of CIAs, with a focus on its applications in gout, CPPD, and BCPD. It discusses its clinical benefits and the current evidence supporting its use. Additionally, the review highlights gaps in research, particularly for BCPD, and outlines future directions to enhance the integration of ultrasound in the diagnostic and therapeutic landscape of CIAs.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 3","pages":"Article 504875"},"PeriodicalIF":0.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Eye of Horus” sign on ultrasound in a case of polymyalgia rheumatica 多肌痛风湿病超声示“荷露之眼”征1例
IF 0.5 Q3 Health Professions Pub Date : 2026-07-01 Epub Date: 2026-04-01 DOI: 10.1016/j.rcreu.2026.504879
José S. Cortés, Diego Niño, Carlos Darío Ochoa Rojas

Introduction

Ultrasound is useful in the assessment of polymyalgia rheumatica, a condition characterized by involvement of the shoulder and pelvic girdles. The “Eye of Horus” sign on ultrasound, corresponding to subacromial-subdeltoid bursitis and biceps brachii tenosynovitis, has been described in this patient.

Case report

A 70-year-old woman presented with pain and limitation in the shoulder and pelvic girdles, along with elevated acute-phase reactants. Ultrasound revealed the “Eye of Horus” sign. A diagnosis of polymyalgia rheumatica was made. She was treated with corticosteroids and methotrexate, showing improvement.

Conclusion

The “Eye of Horus” sign supports the diagnosis of polymyalgia rheumatica.
超声在评估风湿性多肌痛是有用的,这种疾病的特征是累及肩和骨盆带。超声显示“荷露之眼”征,对应肩峰下-三角下滑囊炎和肱二头肌腱鞘炎。病例报告:一名70岁女性表现为肩部和骨盆带疼痛和受限,并伴有急性期反应物升高。超声显示了“荷鲁斯之眼”的标志。诊断为风湿性多肌痛。经皮质类固醇和甲氨蝶呤治疗,病情有所好转。结论“荷鲁斯眼”征支持风湿病多肌痛的诊断。
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引用次数: 0
期刊
Revista Colombiana de Reumatologia
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