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[A rare case of complex pyelocutaneous fistula following microwave ablation for recurrent renal cell carcinoma successfully managed with radical nephrectomy] 【微波消融治疗复发性肾癌合并根治性肾切除术成功治疗一例复杂肾盂皮瘘】
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-03-01 Epub Date: 2026-01-10 DOI: 10.1016/j.eucr.2026.103344
Lianpeng Gao , Bo Zhu , Xiaoxia Li , Yuyun Wu , Wenbo Zhou , Jiongming Li
A complex pyelocutaneous fistula developed after microwave ablation for recurrent clear cell renal carcinoma following partial nephrectomy. The fistula persisted despite prolonged drainage, antibiotics, ureteral stenting, and other conservative measures. Definitive management required laparoscopic radical nephrectomy with complete excision of the fistulous tract and involved psoas tissue. Histopathology showed chronic inflammation without residual malignancy. This case supports early consideration of radical nephrectomy for refractory, anatomically complex pyelocutaneous fistulas.
摘要透明细胞肾癌部分切除后复发,微波消融后并发复杂肾盂皮瘘。尽管长期引流、抗生素、输尿管支架置入和其他保守措施,瘘管仍然存在。最终的治疗需要腹腔镜根治性肾切除术,完全切除瘘道和累及的腰肌组织。组织病理学表现为慢性炎症,无恶性肿瘤残留。本病例支持早期考虑根治性肾切除术治疗难治性、解剖结构复杂的肾盂皮瘘。
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引用次数: 0
Recurrent bladder paraganglioma with peritoneal dissemination: An unusual pattern of metastatic progression. Case report and literature review 复发性膀胱副神经节瘤伴腹膜播散:一种不寻常的转移进展模式。病例报告及文献复习
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-03-01 Epub Date: 2026-01-10 DOI: 10.1016/j.eucr.2026.103342
Paolo Guedes Oliva , Pablo Jiménez Marrero , Rubén Espino Espino , Reinaldo Marrero Domínguez , Irene Expósito Remedios , Rafael Camacho Galán
We report the case of a 26-year-old man diagnosed with multifocal bladder paraganglioma, an exceptionally rare neuroendocrine tumor. The patient presented with hypertension and adrenergic symptoms triggered by micturition, associated with elevated metanephrines and multiple pelvic lesions. He underwent complete laparoscopic resection, including partial cystectomy, achieving initial biochemical remission. Early local recurrence and subsequent peritoneal carcinomatosis, an uncommon metastatic pattern, were observed, requiring systemic therapy. This case highlights the diagnostic challenges, potential for aggressive behavior, and limited therapeutic options in metastatic bladder paraganglioma, underscoring the need for high clinical suspicion, adequate preoperative management, and long-term follow-up.
我们报告一个26岁的男子诊断为多灶性膀胱副神经节瘤,一个异常罕见的神经内分泌肿瘤。患者表现出由排尿引起的高血压和肾上腺素能症状,伴有肾上腺素升高和多发性盆腔病变。他接受了完整的腹腔镜切除术,包括部分膀胱切除术,初步生化缓解。观察到早期局部复发和随后的腹膜癌,一种罕见的转移模式,需要全身治疗。本病例强调了转移性膀胱副神经节瘤的诊断挑战、潜在的侵袭性行为和有限的治疗选择,强调了高度临床怀疑、充分的术前管理和长期随访的必要性。
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引用次数: 0
Solitary adrenal gland metastasis detected at 24-month follow-up for muscle-invasive bladder cancer 肌肉浸润性膀胱癌患者24个月随访发现单发肾上腺转移
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-03-01 Epub Date: 2025-12-30 DOI: 10.1016/j.eucr.2025.103334
Nicola Schiavone , Marco Finati , Anna Ricapito , Antonio Fanelli , Gaetano Valerio Palella , Ugo Giovanni Falagario , Luigi Cormio , Carlo Bettocchi , Gian Maria Busetto , Giuseppe Carrieri
Solitary adrenal metastasis from bladder urothelial carcinoma is extremely uncommon. We report a 52-year-old man with high-grade pT3bN0R0 urothelial carcinoma of the bladder, who developed a solitary right adrenal metastasis (59 × 31 mm) 20 months after neoadjuvant chemotherapy and cystectomy (visible at the November 2024 CT, absent in March 2024). Surgical adrenalectomy was aborted due to adhesions and muscular invasion. After systemic therapy, the disease progressed with bilateral adrenal involvement. Adrenal metastases occur in 14 % of bladder cancer cases, isolated adrenal involvement is rare and aggressive; guidelines emphasise individualized multimodal management and suggest that earlier PET/CT may improve outcomes.
膀胱尿路上皮癌单发肾上腺转移极为罕见。我们报告一名52岁男性高级别pT3bN0R0膀胱尿路上皮癌患者,在新辅助化疗和膀胱切除术后20个月发生单发右侧肾上腺转移(59 × 31 mm)(2024年11月CT可见,2024年3月未见)。肾上腺切除术因粘连及肌肉侵入而流产。经过全身治疗后,病情进展到双侧肾上腺受累。14%的膀胱癌病例发生肾上腺转移,孤立的肾上腺受累是罕见的和侵袭性的;指南强调个性化的多模式管理,并建议早期PET/CT可能改善预后。
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引用次数: 0
A rare entity in the retroperitoneum: Case report of a primary seminoma 腹膜后罕见肿瘤:原发性精原细胞瘤1例
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-03-01 Epub Date: 2026-01-02 DOI: 10.1016/j.eucr.2025.103335
Luowu Wang, Ke Yang, Chaojin Liang, Jun xing, Yao Bai
Primary retroperitoneal seminoma is an extremely rare extragonadal germ cell tumor. A 61-year-old male was referred following the discovery of a retroperitoneal mass on routine physical examination. Computed tomography and PET-CT revealed a soft-tissue nodule near the left renal hilum, suggestive of a neoplasm. The patient underwent surgical resection, and histopathology confirmed seminoma. Scrotal ultrasound showed no testicular abnormalities, thereby excluding a metastatic origin and confirming the diagnosis of primary retroperitoneal seminoma. This case underscores the importance of considering this rare entity in the differential diagnosis of retroperitoneal masses.
原发性腹膜后精原细胞瘤是一种极为罕见的生殖道外生殖细胞肿瘤。一位61岁男性病人在常规体格检查中发现腹膜后肿块。计算机断层扫描和PET-CT显示左肾门附近软组织结节,提示肿瘤。患者接受手术切除,组织病理学证实为精原细胞瘤。阴囊超声未见睾丸异常,因此排除转移来源,确认原发性腹膜后精原细胞瘤的诊断。这个病例强调了在鉴别诊断腹膜后肿块时考虑这种罕见实体的重要性。
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引用次数: 0
A case report: Synchronous occurrence of clear cell renal cell carcinoma and low-malignant-potential multicystic renal tumor within the same kidney 透明细胞肾细胞癌与低恶性潜能多囊肾肿瘤同时发生1例。
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-03-01 Epub Date: 2026-01-28 DOI: 10.1016/j.eucr.2026.103360
Chaojin Liang, Ke Yang, Jun Xing, Luowu Wang, Yao Bai, Yuanman Luo
The simultaneous occurrence of different tumor types in the same kidney is relatively rare. This report describes a 76-year-old male patient presenting with concurrent clear cell renal cell carcinoma (ccRCC) and multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) in a single kidney. CT imaging revealed a solid mass in the upper pole and a Bosniak III cyst in the lower pole. The patient underwent radical nephrectomy, and pathological examination confirmed the coexistence of both lesions. This highlights the limitations of imaging diagnosis and underscores the critical importance of histopathological diagnosis for treatment decision-making.
在同一肾脏同时发生不同类型肿瘤是比较罕见的。本文报告一例76岁男性患者,单肾同时出现透明细胞肾细胞癌(ccRCC)和低恶性潜能多室囊性肾肿瘤(MCRNLMP)。CT显示上极有一个实性肿块,下极有一个Bosniak III型囊肿。患者行根治性肾切除术,病理检查证实两种病变并存。这突出了影像学诊断的局限性,并强调了组织病理学诊断对治疗决策的关键重要性。
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引用次数: 0
Management of a crochet hook penetrating perineal injury: A case report 钩针刺穿会阴伤1例
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-03-01 Epub Date: 2025-12-30 DOI: 10.1016/j.eucr.2025.103336
Asmelash Gebresilase Tewelde , Yirgalem Teklebirhan Gebreziher , Hadush Tesfay Negash , Birhane Mekonen Negash
Removing an embedded barbed hook in the body without causing further tissue damage is a challenge in the emergency department (ED). A crochet hook is one of these barbed hooks.
A 6-year-old male child presented to our hospital after 1 hour of crochet hook needle injury to the perineum. On perineal examination there was a sharp material imbedded in the anterior perineal area on the right side from the medial raphe. His follow-up course was uneventful.
The advance-and-cut method is the most practiced and successful. The choice of management techniques depends on the anatomic location and depth of the hook.
如何在不造成进一步组织损伤的情况下取出体内嵌入的倒钩是急诊科(ED)面临的一个挑战。钩针就是其中一种带刺的钩。一6岁男童会阴钩针损伤1小时后就诊。会阴检查发现在会阴前区右侧有一个尖锐的物质从内侧缝处嵌入。他接下来的旅程平淡无奇。先进后切的方法是最常用和最成功的方法。处理技术的选择取决于钩的解剖位置和深度。
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引用次数: 0
Primary renal angiosarcoma with renal vein thrombus: Case report and Review of literature 原发性肾血管肉瘤合并肾静脉血栓1例并文献复习
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-03-01 Epub Date: 2026-01-19 DOI: 10.1016/j.eucr.2026.103351
Mauricio S. Rodríguez-Mar , Jose Manuel Torres-Zazueta , Ricardo Fernández-Ferreira , Josué Farid Elías-Delgado , Luis A. Jiménez-López , Abel A. Ricardez-Espinosa , Mariana Hernández-Ramírez
Primary angiosarcoma of the kidney is extremely rare and aggressive cancer when it presents renal vein thrombus. This presentation confers poor prognosis, with limited therapeutic options. We present a case that began with anemia and macroscopic hematuria. At diagnosis, computed tomography (CT) showed thrombosis of the left renal vein, and a radical nephrectomy was performed. Histological examination revealed a carcinoma of the collecting ducts of Bellini, with immunohistochemistry positive for epithelioid angiosarcoma.
原发性肾脏血管肉瘤是一种非常罕见的恶性肿瘤,当它表现为肾静脉血栓时。这种表现预后不良,治疗选择有限。我们报告一个以贫血和肉眼可见的血尿开始的病例。诊断时,计算机断层扫描(CT)显示左肾静脉血栓形成,并进行根治性肾切除术。组织学检查显示Bellini集合管癌,上皮样血管肉瘤免疫组化阳性。
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引用次数: 0
Targeting mutant VHL-gene results in therapy response in metastatic clear cell carcinoma of rete testis 靶向突变vhl基因在睾丸网转移性透明细胞癌中的治疗效果。
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-03-01 Epub Date: 2026-02-16 DOI: 10.1016/j.eucr.2026.103376
Michael Karl Melzer , Angelika Mattigk , Verena I. Gaidzik , Nadine Therese Gaisa , Julia Schwenke , Friedemann Zengerling
Epididymal and rete testis tumors are exceedingly rare. We report a 69-year-old male who presented with progressive swelling of the right testis/epididymis; histopathology confirmed clear cell carcinoma of the rete testis. Staging with FDG-PET-CT revealed bilateral pulmonary metastases. Subsequent gene panel sequencing identified a pathogenic variant of VHL and a likely pathogenic variant of TP53. Off-label treatment with belzutifan was initiated. Regression of the pulmonary lesion with ongoing complete remission at 12 months of follow-up was observed. This case highlights the importance of molecular profiling for personalized therapy in rare tumor entities.
附睾和睾丸网肿瘤极为罕见。我们报告一个69岁的男性谁表现为进行性肿胀的右睾丸/附睾;组织病理学证实为睾丸网透明细胞癌。FDG-PET-CT分期显示双侧肺转移。随后的基因面板测序确定了VHL的致病性变异和TP53的可能致病性变异。开始使用贝祖替芬进行说明书外治疗。随访12个月,观察到肺部病变消退并持续完全缓解。这个病例强调了分子谱分析在罕见肿瘤实体个体化治疗中的重要性。
{"title":"Targeting mutant VHL-gene results in therapy response in metastatic clear cell carcinoma of rete testis","authors":"Michael Karl Melzer ,&nbsp;Angelika Mattigk ,&nbsp;Verena I. Gaidzik ,&nbsp;Nadine Therese Gaisa ,&nbsp;Julia Schwenke ,&nbsp;Friedemann Zengerling","doi":"10.1016/j.eucr.2026.103376","DOIUrl":"10.1016/j.eucr.2026.103376","url":null,"abstract":"<div><div>Epididymal and rete testis tumors are exceedingly rare. We report a 69-year-old male who presented with progressive swelling of the right testis/epididymis; histopathology confirmed clear cell carcinoma of the rete testis. Staging with FDG-PET-CT revealed bilateral pulmonary metastases. Subsequent gene panel sequencing identified a pathogenic variant of <em>VHL</em> and a likely pathogenic variant of <em>TP53</em>. Off-label treatment with belzutifan was initiated. Regression of the pulmonary lesion with ongoing complete remission at 12 months of follow-up was observed. This case highlights the importance of molecular profiling for personalized therapy in rare tumor entities.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103376"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bladder paraganglioma with lymph node metastasis treated by surgery with long-term recurrence-free survival: A case report 膀胱副神经节瘤伴淋巴结转移行手术治疗,长期无复发生存1例
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-03-01 Epub Date: 2026-02-06 DOI: 10.1016/j.eucr.2026.103363
Takanori Hayase , Hiroshi Takashima , Yohei Sawada , Riku Mitsui , Toshiki Tsuboi , Hirohiko Morimoto , Junichi Fukushima , Satoru Hayashi
We report a rare case of bladder paraganglioma with lymph node metastasis. A 51-year-old man presented with gross hematuria caused by a bladder tumor. During transurethral resection, a sudden hypertensive crisis occurred, raising suspicion of a catecholamine-producing tumor. Pathological analysis confirmed bladder paraganglioma. Partial cystectomy combined with left pelvic lymph node dissection was performed because preoperative computed tomography showed mild swelling of the left obturator lymph node. At the time of writing, the patient has remained disease-free for 5 years. This case suggests that complete surgical resection may achieve long-term recurrence-free survival even in patients with localized lymph node metastasis.
我们报告一例罕见的膀胱副神经节瘤伴淋巴结转移。一个51岁的男性提出肉眼血尿引起的膀胱肿瘤。经尿道切除时,突然出现高血压危象,引起对产生儿茶酚胺肿瘤的怀疑。病理证实为膀胱副神经节瘤。由于术前计算机断层扫描显示左侧闭孔淋巴结轻度肿胀,因此进行了部分膀胱切除术并左盆腔淋巴结清扫。在撰写本文时,患者已无病5年。本病例提示,即使局部淋巴结转移的患者,完全手术切除也可以实现长期无复发生存。
{"title":"Bladder paraganglioma with lymph node metastasis treated by surgery with long-term recurrence-free survival: A case report","authors":"Takanori Hayase ,&nbsp;Hiroshi Takashima ,&nbsp;Yohei Sawada ,&nbsp;Riku Mitsui ,&nbsp;Toshiki Tsuboi ,&nbsp;Hirohiko Morimoto ,&nbsp;Junichi Fukushima ,&nbsp;Satoru Hayashi","doi":"10.1016/j.eucr.2026.103363","DOIUrl":"10.1016/j.eucr.2026.103363","url":null,"abstract":"<div><div>We report a rare case of bladder paraganglioma with lymph node metastasis. A 51-year-old man presented with gross hematuria caused by a bladder tumor. During transurethral resection, a sudden hypertensive crisis occurred, raising suspicion of a catecholamine-producing tumor. Pathological analysis confirmed bladder paraganglioma. Partial cystectomy combined with left pelvic lymph node dissection was performed because preoperative computed tomography showed mild swelling of the left obturator lymph node. At the time of writing, the patient has remained disease-free for 5 years. This case suggests that complete surgical resection may achieve long-term recurrence-free survival even in patients with localized lymph node metastasis.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103363"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of blue-light cystoscopy and tumor-informed ctDNA for management of recurrent high-risk NMIBC with prostatic urethral involvement: A case report 蓝光膀胱镜检查和肿瘤知情ctDNA治疗复发性高风险NMIBC伴前列腺尿道累及1例报告
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-03-01 Epub Date: 2026-01-27 DOI: 10.1016/j.eucr.2026.103362
Mahdi Hemmati Ghavshough, Melinda Z. Fu, Jennifer Sykes, Disha Patel, Saum Ghodoussipour, Vignesh T. Packiam
Non–muscle-invasive bladder cancer (NMIBC) with prostatic urethral involvement (PUI) is rare and difficult to manage, especially after intravesical therapy or pelvic radiation. We report a 78-year-old man with recurrent high-risk NMIBC and PUI after bacillus Calmette–Guérin and mitomycin C. Blue-light cystoscopy (BLC) during restaging identified additional carcinoma in situ and high-grade T1 disease not seen with white light. Histopathology showed no stromal invasion, and tumor-informed circulating tumor DNA (ctDNA) testing was negative, indicating no molecular residual disease. Despite favorable findings, the patient elected radical cystectomy, which revealed no residual tumor. This case highlights the complementary roles of BLC and ctDNA.
非肌肉浸润性膀胱癌(NMIBC)合并前列腺尿道累及(PUI)是罕见且难以治疗的,特别是在膀胱内治疗或盆腔放射治疗后。我们报告一名78岁男性,在卡介苗-谷氨酰胺芽孢杆菌和丝裂霉素c后复发高风险NMIBC和PUI。在重新分期期间,蓝光膀胱镜(BLC)发现了白光未见的其他原位癌和高级别T1疾病。组织病理学未见间质浸润,肿瘤通知循环肿瘤DNA (ctDNA)检测呈阴性,表明无分子残留疾病。尽管结果良好,但患者选择根治性膀胱切除术,未发现残留肿瘤。本病例强调了BLC和ctDNA的互补作用。
{"title":"Utility of blue-light cystoscopy and tumor-informed ctDNA for management of recurrent high-risk NMIBC with prostatic urethral involvement: A case report","authors":"Mahdi Hemmati Ghavshough,&nbsp;Melinda Z. Fu,&nbsp;Jennifer Sykes,&nbsp;Disha Patel,&nbsp;Saum Ghodoussipour,&nbsp;Vignesh T. Packiam","doi":"10.1016/j.eucr.2026.103362","DOIUrl":"10.1016/j.eucr.2026.103362","url":null,"abstract":"<div><div>Non–muscle-invasive bladder cancer (NMIBC) with prostatic urethral involvement (PUI) is rare and difficult to manage, especially after intravesical therapy or pelvic radiation. We report a 78-year-old man with recurrent high-risk NMIBC and PUI after bacillus Calmette–Guérin and mitomycin C. Blue-light cystoscopy (BLC) during restaging identified additional carcinoma in situ and high-grade T1 disease not seen with white light. Histopathology showed no stromal invasion, and tumor-informed circulating tumor DNA (ctDNA) testing was negative, indicating no molecular residual disease. Despite favorable findings, the patient elected radical cystectomy, which revealed no residual tumor. This case highlights the complementary roles of BLC and ctDNA.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103362"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Urology Case Reports
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