Trends in Analytical Chemistry最新文献_第5页

Towards portable enzyme-free electrochemical sensing of biomolecules using a metal-organic framework as an electro-catalyst 利用金属-有机骨架作为电催化剂实现生物分子的便携式无酶电化学传感

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2026-03-01 Epub Date: 2025-12-17 DOI: 10.1016/j.trac.2025.118608

Md Zainul Abedeen , Fardeen Islam , Lalita Yadav , Ragini Gupta

Biomolecules are considered the building blocks of life and are essential in correct proportions for maintaining the physiological function of human body. An electrochemical sensor is a suitable choice due to its benefits, including rapid analysis with a fast response time, portability, on-site sensing, high selectivity and sensitivity, scalability, and seamless integration with the Internet of Things. This review article encompasses a recently developed metal-organic frameworks (MOFs) based electrochemical sensors (2019–2024) that target the detection of biologically important small molecules. The article begins with a brief introduction, followed by a synthesis strategy for constructing MOFs, characterisation techniques, and methods to enhance electrocatalytic behaviour. A detailed discussion of electrochemical detection techniques, methodology, and the sensing mechanisms involved in detecting biomolecules is given. The article concludes with a discussion on the challenges and future perspectives, aiming to catalyze and motivate researchers to accelerate the research and development of portable electrochemical sensors.

生物分子被认为是生命的基石，是维持人体生理功能所必需的正确比例。电化学传感器是一个合适的选择，因为它的优点，包括快速分析，快速响应时间，便携性，现场传感，高选择性和灵敏度，可扩展性，以及与物联网的无缝集成。这篇综述文章涵盖了最近开发的基于金属有机框架（mof）的电化学传感器（2019-2024），其目标是检测生物学上重要的小分子。文章首先简要介绍了mof的合成策略、表征技术和提高电催化性能的方法。详细讨论了电化学检测技术、方法和检测生物分子的传感机制。文章最后讨论了便携式电化学传感器面临的挑战和未来的展望，旨在催化和激励研究人员加快便携式电化学传感器的研究和开发。

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引用次数: 0

From waste to worth: A comprehensive review on waste-derived nanomaterials for optical sensing applications 从废物到价值：废物衍生的光学传感纳米材料的综合综述

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2026-03-01 Epub Date: 2026-01-21 DOI: 10.1016/j.trac.2026.118694

Elham Madani-Nejad , Ahmad Reza Bagheri , Ardeshir Shokrollahi , Faezeh Shahdost-Fard

This review article provides a comprehensive overview of the latest advances in the preparation, properties, and sensing performance of waste-derived nanomaterials (NMs). This article is novel and informative in its scope, since: (a) different approaches for the synthesis of NMs are investigated, considering the advantages and disadvantages of each one; (b) the efficiency of waste-derived NMs in optical sensors is evaluated; (c) it is discussed how waste precursor chemistry can dictate NM surface functionalities and resulting optical selectivity and sensitivity; (d) it is reviewed how heteroatom doping can tune the electronic structure, bandgap, defect states, and optical absorption of waste-derived NMs; (e) different optical sensing mechanisms of waste-derived NMs, including fluorescence enhancing/quenching, inner-filter effect, Förster resonance energy transfer, and surface-state modulation, are assessed; and (f) current trends and future bottlenecks in relation to the synthesis and use of waste-derived NMs in optical sensing platforms are illustrated.

本文综述了废物源纳米材料（NMs）的制备、性能和传感性能的最新进展。本文在其范围内是新颖和翔实的，因为：(a)研究了合成NMs的不同方法，并考虑了每种方法的优缺点；(b)评估光学传感器中废物衍生NMs的效率；(c)讨论了废弃前体化学如何决定纳米表面功能和由此产生的光学选择性和灵敏度；(d)综述了杂原子掺杂如何调节废纳米管的电子结构、带隙、缺陷态和光吸收；(e)评估了废物衍生纳米粒子的不同光学传感机制，包括荧光增强/猝灭、内部过滤效应、Förster共振能量转移和表面态调制；(f)说明了在光学传感平台中合成和使用废物衍生纳米材料的当前趋势和未来瓶颈。

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引用次数: 0

Revealing the potential of magnetic micro-nano architectures in analytical chemistry: From design to application 揭示磁性微纳结构在分析化学中的潜力：从设计到应用

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2026-03-01 Epub Date: 2026-01-15 DOI: 10.1016/j.trac.2026.118677

Yinwei Gu , Tongtong Tian , Jing Jin , Yan Li , Wei Guo , Ning Gu

Magnetic micro-and nano-architectures (MMNAs) have emerged as powerful tools in analytical chemistry due to their unique physicochemical properties, mainly responsible for the separation, enrichment, and signal detection of target analytes. This review provides a comprehensive overview of the properites, synthesis, design, and multifunctional applications of these materials. Firstly, we summarized the core magnetic properties and the synthesis strategies developed for their functionality. Then, we delved into their various cutting-edge applications, emphasizing their roles as separation and enrichment tools, signal sources in magnetic sensing, signal enhancers in biosensors, and actuators for droplet manipulation. Finally, we discuss the current challenges and future perspectives. MMNAs will undoubtedly be an important driving force for the development of next-generation analytical platforms.

磁性微纳米结构（mmna）由于其独特的物理化学性质而成为分析化学中强有力的工具，主要负责目标分析物的分离、富集和信号检测。本文对该类材料的性能、合成、设计及其多功能应用进行了综述。首先，我们概述了磁芯的磁性和为其功能性而开发的合成策略。然后，我们深入研究了它们的各种前沿应用，强调了它们作为分离和富集工具、磁传感中的信号源、生物传感器中的信号增强器和液滴操纵的致动器的作用。最后，我们讨论了当前的挑战和未来的展望。mmna无疑将成为下一代分析平台发展的重要推动力。

引用次数: 0

Challenges in translating machine learning integrated microfluidic paper-based biosensors from lab to field: A critical analysis of scalability and socio-economic barriers 将机器学习集成微流体纸基生物传感器从实验室转化为现场的挑战：可扩展性和社会经济障碍的关键分析

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2026-03-01 Epub Date: 2026-01-17 DOI: 10.1016/j.trac.2025.118637

Tianren Liu , Javaria Ashiq , Mudassar Jamil , Sara Riaz , Yingming Ma , Mian Hasnain Nawaz , Li Niu

Food safety and contamination are serious global challenges because of their magnified impact on health and social well-being. Conventional detection techniques, despite their accuracy, rely on laboratory equipment, skilled operators, and time-consuming steps, which limit their use for on-site analysis. Microfluidic paper-based biosensors (μPAD-BS) have appeared as a simple, low-cost, and reliable solution for rapid food testing. Additionally, the machine learning assisted microfluidic paper-based devices have more advantages in their analytical performances and reliability. These platforms can handle complicated data, improve detection accuracy, and facilitate real-time decision-making via portable devices like smartphones when paired with machine learning. This review critically examines the integration of machine learning algorithms with μPAD-BS. It also discusses fabrication methods, algorithm selection criteria, and the trade-offs between computational cost and interpretability. It also provides insights from related fields such as biomedical diagnostics and environmental monitoring to offer scalable, ethical, and user-friendly designs. In spite of machine learning-enhanced μPAD-BS showing promising outputs, the need for further research to develop more user-oriented and intelligent sensing tools for robust food safety analysis has also been discussed in the future perspectives section.

食品安全和污染是严重的全球挑战，因为它们对健康和社会福祉的影响很大。传统的检测技术，尽管他们的准确性，依赖于实验室设备，熟练的操作人员，和耗时的步骤，这限制了他们的使用现场分析。微流控纸基生物传感器（μPAD-BS）是一种简单、低成本、可靠的食品快速检测解决方案。此外，机器学习辅助的微流控纸基设备在分析性能和可靠性方面更具优势。这些平台可以处理复杂的数据，提高检测精度，并通过智能手机等便携式设备与机器学习相结合，促进实时决策。这篇综述批判性地研究了机器学习算法与μPAD-BS的集成。它还讨论了制造方法，算法选择标准，以及计算成本和可解释性之间的权衡。它还提供来自相关领域的见解，如生物医学诊断和环境监测，以提供可扩展的、合乎道德的和用户友好的设计。尽管机器学习增强的μPAD-BS显示出有希望的结果，但在未来展望部分也讨论了进一步研究开发更多面向用户和智能的食品安全分析传感工具的必要性。

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引用次数: 0

TMB-mediated catalytic SERS systems: Applications, innovations, and future prospects tmb介导的催化SERS系统：应用、创新和未来展望

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2026-03-01 Epub Date: 2025-12-26 DOI: 10.1016/j.trac.2025.118632

Yutong Wang , Sihang Zhang , Qingchun Yin , Jing Wei , Jiawei Liu , Long Wu

Surface-enhanced Raman scattering (SERS) is a powerful analytical technique offering simplicity, ultra-high sensitivity, molecular fingerprint specificity, and rapid detection. The development of Raman probes is crucial for advancing SERS performance. Notably, 3,3′,5,5′-Tetramethylbenzidine (TMB), a widely used chromogenic substrate, possesses distinct redox, electrochemical properties and spectroscopic properties. The oxidized forms of TMB (ox-TMB) act as SERS probes, enabling sensitive and reliable SERS detection. Integration of TMB-SERS with other analytical techniques allows multimodal sensing, improving detection accuracy in applications such as disease diagnosis, environmental monitoring, and food safety. Although TMB has been mentioned in reviews on SERS substrates, probes, nanozyme-assisted SERS, and catalytic sensing, a comprehensive, substrate-focused review of TMB-mediated catalytic SERS is still lacking. This review systematically summarizes the chemical and redox properties of TMB, clarifies the mechanism of Raman activation, and highlights key applications. Design principles, current challenges, and future directions for TMB-mediated SERS systems.

表面增强拉曼散射（SERS）是一种功能强大的分析技术，具有简单、超高灵敏度、分子指纹特异性和快速检测等特点。拉曼探针的发展对提高SERS性能至关重要。值得注意的是，3,3 ',5,5 ' -四甲基联苯胺（TMB）是一种广泛使用的显色底物，具有独特的氧化还原、电化学和光谱性质。氧化形式的TMB （ox-TMB）作为SERS探针，实现灵敏可靠的SERS检测。TMB-SERS与其他分析技术的集成允许多模态传感，提高疾病诊断，环境监测和食品安全等应用的检测准确性。尽管TMB在SERS底物、探针、纳米酶辅助SERS和催化传感等方面的综述中都有提到，但对TMB介导的催化SERS的全面、以底物为中心的综述仍然缺乏。本文系统综述了TMB的化学性质和氧化还原性质，阐明了其拉曼活化的机理，并重点介绍了其应用前景。tmb介导的SERS系统的设计原则、当前挑战和未来方向。

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引用次数: 0

Near-infrared spectroscopy for energetic materials: Instruments, chemometrics, and process analytics (2001–2025) 含能材料的近红外光谱：仪器、化学计量学和过程分析（2001-2025）

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2026-03-01 Epub Date: 2025-12-26 DOI: 10.1016/j.trac.2025.118631

Dexiang Wang , Tianlong Zhang , Kewei Ding , Hongsheng Tang , Hua Li

Energetic materials (EMs) require analytical methods that are rapid, non-destructive, and capable of real-time monitoring—capabilities frequently lacking in classical techniques. Through a structured literature survey (2001–2025), this review demonstrates that Near-infrared spectroscopy (NIRS) coupled with advanced chemometrics has emerged as a powerful tool to overcome these limitations. This review highlights pivotal applications in qualitative analysis for rapid identification of EMs and their precursors; in quantitative analysis, where high-precision determination of component concentrations and critical physicochemical properties is enabled; and in process analysis, where real-time monitoring of manufacturing steps is realized. These applications contribute to enhanced safety, quality control, and production efficiency. The realization of such diverse applications relies on a synergistic workflow combining advanced instrumentation with robust chemometric strategies. Finally, persistent challenges (such as complex matrices and model robustness) are addressed, and emerging trends are highlighted, including AI-driven data processing, multimodal sensor fusion, and digital-twin-enabled process optimization.

含能材料（em）需要快速、非破坏性和能够实时监测的分析方法，这是传统技术经常缺乏的能力。通过结构化的文献调查（2001-2025），本综述表明，近红外光谱（NIRS）与先进的化学计量学相结合已成为克服这些局限性的有力工具。本文综述了在定性分析中的关键应用，以快速鉴定EMs及其前体；在定量分析中，可以对成分浓度和关键理化性质进行高精度测定；在过程分析中，实现了对制造环节的实时监控。这些应用有助于提高安全性、质量控制和生产效率。实现这种多样化的应用依赖于将先进仪器与稳健的化学计量策略相结合的协同工作流程。最后，解决了持续存在的挑战（如复杂矩阵和模型鲁棒性），并强调了新兴趋势，包括人工智能驱动的数据处理、多模态传感器融合和数字孪生支持的流程优化。

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引用次数: 0

Microplastics and persistent organic pollutants' impacts on soil ecosystem services supply 微塑料和持久性有机污染物对土壤生态系统服务供给的影响

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2026-03-01 Epub Date: 2026-01-09 DOI: 10.1016/j.trac.2026.118667

Paulo Pereira , Emoke Dalma Kovacs , Melinda Haydee Kovacs , Miguel Inácio , Eric C. Brevik , Damia Barcelo

Microplastics and persistent organic pollutants (POPs) harm the environment. Although this topic is widely studied, few works have linked it to soil ecosystem services (ES). Here, we aim to discuss the impacts of microplastics and POPS on soil-regulating, provisioning, and cultural ES. These pollutants increase toxicity, alter biogeochemical processes, and microbial activity, affecting plants' health. This cascade of negative impacts hurts all the soil-regulating ES, including erosion, flood and climate regulation, pollination, air quality regulation, nutrient cycling, carbon sequestration, soil formation, and water purification. Soil degradation and reduced soil productivity also reduce the supply of food, water, biomass, timber, and medicinal resources. Soil pollution and its effects on vegetation degradation negatively affect Cultural ES, such as heritage and landscape aesthetics. It is important to highlight that microplastics and POPs adversely affect all soil-related ES, and it is urgent to develop cost-effective measures to remove them from the environment on a large scale.

微塑料和持久性有机污染物（POPs）危害环境。虽然这一主题被广泛研究，但很少有研究将其与土壤生态系统服务（ES）联系起来。在这里，我们旨在讨论微塑料和持久性有机污染物对土壤调节、供给和文化ES的影响。这些污染物增加毒性，改变生物地球化学过程和微生物活动，影响植物健康。这一连串的负面影响损害了所有调节土壤的生态系统，包括侵蚀、洪水和气候调节、授粉、空气质量调节、养分循环、碳固存、土壤形成和水净化。土壤退化和土壤生产力下降也减少了粮食、水、生物质、木材和医药资源的供应。土壤污染及其对植被退化的影响对文化ES产生负面影响，如遗产和景观美学。必须强调的是，微塑料和持久性有机污染物会对所有与土壤有关的环境污染产生不利影响，迫切需要制定具有成本效益的措施，大规模地将它们从环境中清除。

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引用次数: 0

Structure-engineered colorimetric sensors for volatile amine detection: Advances in freshness monitoring of meat and aquatic products 用于挥发性胺检测的结构工程比色传感器：肉类和水产品新鲜度监测的进展

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2026-03-01 Epub Date: 2026-01-07 DOI: 10.1016/j.trac.2026.118661

Bo Peng , Yujie Li , Jichao Qin , Zhuoqun Qiao , Yue Li , Jie Yang , Peiyuan Zhou , Xiaojun Zhao , Ying Kuang , Kao Wu , Fatang Jiang

Timely and accurate monitoring of meat and aquatic product freshness is crucial for public health and food industry. Volatile amine (VA) colorimetric sensors show great potential, but require structural innovation to improve accuracy in complex environments. In this review, we focused on novel structures (porous film, multi-layer film, hydrogel, and aerogel structure) in VA colorimetric sensors. The formation processes and the mechanism for the enhancement in VA sensing performance by these structures were summarized. The macromolecular interactions were the crucial factors that influence sensor structure. By enhancing VA capturing efficiency, optimizing mass transport pathways, and extending diffusion paths of dyes, the sensing performances were improved. Then, recent advances in VA colorimetric sensors for meat and aquatic products’ freshness monitoring were summarized. We also suggested future prospects in this field, including establishing structure-performance relationship, engineering selectivity of the sensor, and using artificial intelligence for sensor design and freshness monitoring in practice.

及时准确地监测肉类和水产品的新鲜度对公共卫生和食品工业至关重要。挥发性胺（VA）比色传感器显示出巨大的潜力，但需要结构创新来提高复杂环境下的精度。在这篇综述中，我们重点介绍了新型结构（多孔膜、多层膜、水凝胶和气凝胶结构）在VA比色传感器中的应用。综述了这些结构的形成过程和增强VA传感性能的机理。高分子相互作用是影响传感器结构的关键因素。通过提高VA捕获效率，优化质量传递途径，延长染料的扩散路径，提高了染料的传感性能。综述了VA比色传感器在肉类和水产品新鲜度监测中的研究进展。展望了该领域的发展前景，包括建立结构-性能关系，传感器的工程选择性，以及在实践中应用人工智能进行传感器设计和新鲜度监测。

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引用次数: 0

From mechanism to sensitivity: Engineering CRISPR/Cas systems for clinical-grade diagnostics 从机制到敏感性：用于临床级诊断的工程CRISPR/Cas系统

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.trac.2026.118656

Minzhi Liao , Lu Chen , Yuxuan Yang , Xinyao Yi , Mengyi Xiong , Lin Yuan

Accurate and sensitive molecular detection underpins modern clinical diagnostics and precision medicine. The advent of CRISPR/Cas systems has revolutionized nucleic acid detection, offering programmable specificity and versatile adaptability for clinical biomarker analysis. However, the intrinsically low abundance of disease-associated nucleic acids in clinical samples remains a major barrier, as the native sensitivity of CRISPR-based assays is often insufficient for direct quantification. To bridge this gap and enable clinical translation, extensive efforts have been devoted to enhancing CRISPR detection sensitivity through multifaceted engineering and optimization. Owing to the modular architecture of CRISPR systems, sensitivity can be improved at multiple levels including Cas protein engineering, crRNA design, signal transduction, and reaction condition optimization, many of which can act synergistically. This review provides a systematic overview of recent advances in sensitivity enhancement strategies for CRISPR-based diagnostics and discusses their implications for the development of robust, amplification-free, point-of-care testing platforms. We anticipate that this work will serve as a conceptual framework and technical reference for researchers advancing CRISPR technologies toward clinical applications.

准确灵敏的分子检测是现代临床诊断和精准医学的基础。CRISPR/Cas系统的出现彻底改变了核酸检测，为临床生物标志物分析提供了可编程的特异性和通用适应性。然而，临床样本中疾病相关核酸固有的低丰度仍然是一个主要障碍，因为基于crispr的检测方法的固有灵敏度往往不足以直接定量。为了弥补这一差距并使临床翻译成为可能，人们已经通过多方面的工程和优化来提高CRISPR检测的灵敏度。由于CRISPR系统的模块化结构，可以在Cas蛋白工程、crRNA设计、信号转导和反应条件优化等多个层面提高灵敏度，其中许多层面可以协同作用。这篇综述系统地概述了基于crispr的诊断灵敏度增强策略的最新进展，并讨论了它们对开发健壮的、无扩增的、即时检测平台的影响。我们期望这项工作将为研究人员将CRISPR技术推向临床应用提供一个概念框架和技术参考。

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引用次数: 0

Recent advances in analytical methods for plastic thermochemical conversion: from feedstocks to products 塑料热化学转化分析方法的最新进展：从原料到产品

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2026-03-01 Epub Date: 2026-01-17 DOI: 10.1016/j.trac.2026.118681

Zhiliang Wu , Yanshan Yin , Nai Shi , Shihao Lv , Ruiqi Wang , Md Maksudur Rahman , Hongqi Wang , Zehua Wang , Wenran Gao , Carol Sze Ki Lin , Zhenyao Wang , Ao Xia , Bing Song

The rising accumulation of plastic waste poses a global challenge, highlighting the need for efficient recycling and valorization. Thermochemical conversion offers a promising route for transforming plastics into value-added products, but its optimization relies on robust analytical methods capable of accurately identifying feedstocks and characterizing reaction products. This review summarizes recent advances in analytical methods across the entire thermochemical conversion chain. For feedstock identification, conventional sorting manual and density-based sorting have evolved toward advanced spectroscopic techniques like Fourier-transform infrared and Raman, enabling rapid and non-destructive polymer detection. For product characterization, chromatographic, thermal, spectroscopic, and microscopic tools are essential for analyzing gaseous, liquid, and solid products and for uncovering reaction pathways. Emerging integration of artificial intelligence and machine learning is also highlighted for enhancing real-time analysis and process decision-making. This review offers guidance for selecting and applying analytical tools to improve the environmental and economic feasibility of thermochemical plastic recycling.

塑料垃圾的不断积累对全球构成了挑战，凸显了有效回收和增值的必要性。热化学转化为将塑料转化为增值产品提供了一条有前途的途径，但其优化依赖于能够准确识别原料和表征反应产物的强大分析方法。本文综述了整个热化学转化链中分析方法的最新进展。在原料鉴定方面，传统的手工分选和基于密度的分选已经向傅里叶变换红外和拉曼等先进的光谱技术发展，从而实现了快速、无损的聚合物检测。对于产品表征，色谱，热，光谱和显微工具是分析气体，液体和固体产品和揭示反应途径所必需的。还强调了人工智能和机器学习的新兴集成，以增强实时分析和流程决策。本文综述为选择和应用分析工具以提高热化学塑料回收的环境和经济可行性提供了指导。

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引用次数: 0