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Glenohumeral arthritis impairs shoulder mobility and promotes dynamic compensatory strategies during overhead reach. 肩关节关节炎损害肩关节的活动能力并促进头顶活动时的动态代偿策略。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-03-04 DOI: 10.1016/j.jse.2026.02.019
Nicholas Morriss, Patrick Castle, Dylan N Greif, Joshua Pezzullo, Matthew Ambalavanar, Jordan Manning, Ye Shu, Jacob Earnhart, Gabriel Ramirez, Gregg Nicandri, Sandeep Mannava, Ram Haddas, Ilya Voloshin

Background: Glenohumeral arthritis (GHA) decreases shoulder range of motion, yet the extent of glenohumeral motion loss and accompanying whole-body compensations are not well quantified.

Methods: Eighty-six patients with GHA completed an overhead reach task using both symptomatic and asymptomatic shoulders in a motion-tracking laboratory. Range of motion and peak angles of symptomatic to asymptomatic contralateral shoulders were compared.

Results: The symptomatic shoulder demonstrated 38° less flexion (84° symptomatic vs. 122° asymptomatic, P < .001), 4° less abduction (25° vs. 29°, P < .001), and 22° less internal rotation (21° vs. 43°, P < .001) compared to the asymptomatic shoulder. Patients compensated for these deficits via greater lumbar extension (6° vs. 5°, P < .01), greater lumbar rotation (9° vs. 3°, P < .001), contralateral pelvic rotation (6° vs. 2°, P < .001), reduced cervical flexion (9° vs. 18°, P < .001) with altered lateral bending (7° vs. 11°, P < .001), and greater elbow flexion (26° vs. 4°, P .001).

Conclusions: GHA is associated with substantial loss of shoulder motion during an overhead reach task that mimics daily activities, which leads to compensatory increases in cervical, lumbar, pelvic, and elbow kinematics.

背景:肩关节关节炎(GHA)会降低肩关节的活动度,但肩关节活动丧失的程度和伴随的全身代偿还没有很好的量化。方法:86例GHA患者在运动跟踪实验室中使用有症状和无症状的肩膀完成了头顶到达任务。比较有症状和无症状对侧肩关节的活动范围和峰值角。结果:有症状的肩部屈曲度减少38°(有症状的84°对无症状的122°)。结论:GHA与模拟日常活动的头顶伸展任务中肩部运动的大量丧失有关,这导致颈椎、腰椎、骨盆和肘关节运动的代偿性增加。临床相关性:GHA与肩部运动减少有关,导致日常工作中代偿性脊柱运动增加。这种增加的代偿性脊柱运动可能增加脊柱长期病理的风险。
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引用次数: 0
Eccentric mechanical stimulation promotes rotator cuff healing by regulating macrophage polarization in a murine model 在小鼠模型中,偏心机械刺激通过调节巨噬细胞极化促进肩袖愈合。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-03-01 Epub Date: 2025-08-22 DOI: 10.1016/j.jse.2025.07.008
Yundong Peng PhD , Luyu Diao PhD , Fengxing Li PhD , Jieping Wang PhD , Yonghong Yu MSc , Shaohui Jia PhD , Cheng Zheng PhD, MD

Background

Eccentric mechanical stimulation (EMS) has been proposed as a potential therapy for tendon-bone injuries. Macrophages, as key immune cells, may play a significant role in promoting tendon-bone injury healing through mechanical stimulation, because of their polarization. This study aims to investigate the role of macrophages in rotator cuff injury repair promoted by EMS.

Methods

A total of 96 male C57BL/6 mice were used to establish a rotator cuff injury repair model and were randomly divided into 4 groups: Control, EMS, control + clodronate liposomes, and EMS + clodronate liposomes. Specimens were collected at 2 and 4 weeks postoperatively for histologic, radiologic, immunohistochemical, and biomechanical analyses.

Results

At 2 weeks postoperatively, the EMS group exhibited a thicker fibrocartilage layer and increased expression of M2 macrophages compared with other groups. At 4 weeks, histologic analysis revealed higher fibrocartilage and proteoglycan content in the EMS group, with increased local expression of M2 macrophages and reduced expression of M1 macrophages. Micro–computed tomography results showed superior bone volume–total volume fraction, trabecular bone number, and trabecular bone thickness in the EMS group. Biomechanical testing indicated higher failure load and ultimate strength in the EMS group. The positive effects of mechanical stimulation were significantly diminished after macrophage depletion using clodronate liposomes.

Conclusion

Macrophages may play a crucial role in the repair of rotator cuff injuries promoted by EMS. The therapeutic benefits are partly attributed to the regulation of macrophage function, with EMS reducing M1 macrophage expression and enhancing M2 macrophage polarization. This promotes the healing of rotator cuff tendon–bone injuries and suggests that targeting macrophage polarization may have positive effects on tendon-bone interface injury recovery.
背景:偏心机械刺激(EMS)已被提出作为一种潜在的治疗肌腱-骨损伤的方法。巨噬细胞作为关键的免疫细胞,由于其极化特性,可能在通过机械刺激促进肌腱-骨损伤愈合中发挥重要作用。本研究旨在探讨巨噬细胞在EMS促进肩袖损伤修复中的作用。方法:选取96只雄性C57BL/6小鼠建立肩袖损伤修复模型,随机分为对照组、EMS组、对照组+氯膦酸盐脂质体(Con-CL)组和EMS- cl组。术后2周和4周采集标本进行组织学、放射学、免疫组织化学和生物力学分析。结果:术后2周,EMS组纤维软骨层较其他组增厚,M2巨噬细胞表达增加。4周时,组织学分析显示,EMS组纤维软骨和蛋白多糖含量较高,局部M2巨噬细胞表达增加,M1巨噬细胞表达减少。显微ct结果显示骨体积分数(BV/TV)、骨小梁数(Tb。N), EMS组小梁厚度(Tb.Th)。生物力学测试表明,EMS组的破坏负荷(FL)和极限强度(US)更高。使用CL清除巨噬细胞后,机械刺激的积极作用明显减弱。结论:巨噬细胞可能在偏心机械刺激引起的肩袖损伤修复中起重要作用。治疗效果部分归因于巨噬细胞功能的调节,偏心机械刺激降低M1巨噬细胞表达,增强M2巨噬细胞极化。这促进了肩袖肌腱-骨损伤的愈合,提示靶向巨噬细胞极化可能对肩袖修复中肌腱-骨界面损伤的恢复愈合具有积极作用。证据水平:基础科学研究;体内动物模型。
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引用次数: 0
Effect of time from injury to surgery on surgical technique and complication rate in distal biceps tendon repair 损伤至手术时间对肱二头远端肌腱修复术技术及并发症发生率的影响。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-03-01 Epub Date: 2025-09-01 DOI: 10.1016/j.jse.2025.07.027
Laura J. Morrison MD, MSc , Chloe Elliott BS , Bayan Ghalimah MD , Eric C. Sayre PhD , Neil J. White MD

Background

Surgical treatment options for distal biceps tendon ruptures vary based on time from injury to surgery. While direct repair (DR) is preferred for acute injuries, high flexion angle (HFA) repair and allograft reconstruction (AR) are alternatives for chronic cases. This study examines the relationship between time to surgery, surgical technique selection, and complication rates.

Methods

A retrospective chart review was conducted on patients treated surgically for distal biceps tendon ruptures at a single center from January 2012 to June 2023. Cases were identified through electronic medical records and included patients aged ≥ 18 years with unilateral ruptures. Demographics, time to surgery, surgical techniques (DR, HFA repair, and AR), and complications were recorded. Descriptive statistics and multinomial logistic regression were used to assess the association between time to surgery and surgical technique.

Results

A total of 373 patients were included, with 90% undergoing DR (n = 334), 6% HFA repair (n = 22), and 5% AR (n = 17). The mean (standard deviation) time from injury to surgery was 16 (± 30) days for DR, 82 (± 162) days for HFA repair, and 274 (± 455) days for AR. Surgical technique selection was significantly associated with time to surgery (Kruskal Wallis P < .001), with DR favored in acute cases and HFA repair/AR in chronic presentations. The inflection point for equal probabilities of DR, HFA repair, and AR occurred at 25-27 weeks postinjury. The overall complication rate was 12% (n = 45), with nerve injuries being the most common (7%, n = 25).

Conclusion

Timing significantly impacts surgical technique selection in distal biceps tendon ruptures. DR remains the standard for acute injuries, while HFA repair and AR are viable options for chronic cases. The multinomial probability graphic can be used to educate and counsel patients on surgical decision-making for chronic distal biceps ruptures.
背景:肱二头肌远端肌腱断裂的手术治疗选择取决于从受伤到手术的时间。而直接修复(DR)是首选急性损伤,高屈曲角修复(HFA)和同种异体移植物重建(AR)是替代慢性病例。本研究探讨手术时间、手术技术选择和并发症发生率之间的关系。方法:回顾性分析2012年1月至2023年6月单中心手术治疗肱二头肌远端肌腱断裂的病例。病例通过电子病历确定,包括≥18岁的单侧破裂患者。记录人口统计学、手术时间、手术技术(DR、HFA、AR)和并发症。使用描述性统计和多项逻辑回归来评估手术时间与手术技术之间的关系。结果:共纳入373例患者,其中90%接受DR (n=334), 6%接受HFA (n=22), 5%接受AR (n=17)。从损伤到手术的平均(标准差)时间DR为16(±30)天,HFA为82(±162)天,AR为274(±455)天。手术技术选择与手术时间显著相关(Kruskal Wallis p)结论:时间选择显著影响远端二头肌肌腱断裂的手术技术选择。DR仍然是急性损伤的标准,而HFA和AR是慢性病例的可行选择。多项概率图(图2)可用于教育和指导慢性二头肌远端骨折患者的手术决策。
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引用次数: 0
Corrigendum to ‘Return to sport after arthroscopic xenograft bone block associated with Bankart repair and subscapularis augmentation in competitive contact athletes with recurrent anterior shoulder instability’ [Journal of Shoulder and Elbow Surgery (2025) e954] “关节镜下异种移植骨块联合Bankart修复和肩胛下肌增强治疗复发性前肩不稳的竞技接触运动员后恢复运动”的勘误表[肩肘外科杂志(2025)e954]。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-03-01 Epub Date: 2025-11-10 DOI: 10.1016/j.jse.2025.10.001
Raffaele Russo MD , Alberto Fontanarosa MD , Marco Montemagno MD , Alfonso Fedele MD , Angelo De Crescenzo MD , Francesco Di Pietto MD , Roberto Calbi MD , Raffaele Garofalo MD
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引用次数: 0
Augmented 4-screw vs. nonaugmented 6-screw PHILOS plating in low-bone quality proximal humerus fractures: a biomechanical human cadaveric study 4枚骨水泥增强螺钉与6枚非增强螺钉治疗肱骨低骨密度骨折的生物力学性能比较。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-03-01 Epub Date: 2025-08-20 DOI: 10.1016/j.jse.2025.07.006
Fabian Pretz MD , Frank J.P. Beeres MD, PhD (Prof) , Björn-Christian Link MD, PD , Yannic Lecoultre MD , Reto Babst MD (Prof) , Boyko Gueorguiev PhD (Prof) , Peter Varga PhD, PD , Bryan J.M. van de Wall MD, PhD, PD , Ivan Zderic PhD , Torsten Pastor MD, PhD, PD

Background

Proximal humerus fractures are frequent in patients with low bone quality. PHILOS plates are widely used with either minimally invasive plate osteosynthesis (MIPO) or open reduction and internal fixation (ORIF) techniques. However, it remains unclear whether plating with 4 cement-augmented proximal screws provides biomechanical stability comparable to using 4 nonaugmented proximal screws plus 2 additional calcar screws in unstable low bone quality proximal humerus fractures.

Methods

Fourteen paired human cadaveric humeri with low bone quality and simulated unstable 3-part proximal humerus fractures (AO 11-B1) were assigned to 2 groups – 4S+ and 6S – and stabilized using PHILOS plates with 4 proximal head screws in both groups. In the 6S group, 2 additional calcar (inferomedial support) screws were used, whereas in the 4S+ group, the 4 screw tips were augmented with bone cement. Cyclic axial loading tests were conducted until failure. Interfragmentary movements were monitored via motion tracking.

Results

Initial axial construct stiffness and cycles to failure showed no significant differences between groups (P = .171, P = .397). Although interfragmentary movements were slightly higher in the 4S+ group, this difference was not significant (P ≥ .071). Under cyclic loading, the 6S group exhibited a significant progressive increase over cycles for varus deformation (P = .029), humeral head displacement (P = .038), and screw bending in row A (P = .003), whereas no significant increase over cycles was observed in the 4S+ group and between the groups.

Conclusion

From a biomechanical perspective, PHILOS plating with 4 cement-augmented screws demonstrated comparable stability versus plating with 4 nonaugmented head screws plus 2 additional calcar screws, suggesting that the former fixation technique represents a valid alternative to the latter, particularly in case of low bone quality.
背景:肱骨近端骨折常见于骨密度低的患者。PHILOS钢板广泛用于微创钢板接骨术(MIPO)或切开复位内固定(ORIF)技术。然而,在骨质疏松的不稳定骨折中,四个水泥增强螺钉是否比四个非增强螺钉加两个额外的跟骨螺钉提供生物力学稳定性尚不清楚。方法:采用PHILOS钢板固定两组14对模拟不稳定肱骨近端三节段骨折(AO 11-B1)的人尸体肱骨(排A和B;图1C)。6S组增加2枚内侧支撑螺钉,4S+组增加4枚骨水泥螺钉。循环轴向加载试验直至失效。比较各组之间的片段间运动。结果:初始轴向结构刚度和失效循环次数组间差异无统计学意义(p=0.171, p=0.397)。虽然4S+组的碎片间运动略高,但差异无统计学意义(p=0.071)。在循环载荷下,6S组内翻变形(p=0.029)、头部位移(p=0.038)、a排螺钉弯曲(p=0.003)显著递增,而4S+组无显著递增。结论:从生物力学的角度来看,在可能的ORIF螺钉配置中,与PHILOS钢板4枚非增强头螺钉加2枚额外的跟螺钉相比,4枚水泥增强螺钉的PHILOS钢板在初始结构稳定性和失效周期方面具有可同性。虽然4S+组的绝对碎片间运动略高,但只有6S组在重复负荷下表现出进行性不稳定。这些研究结果表明,水泥增强的4S+是一种生物力学上有效的6S替代品,特别是在骨质疏松性骨中。
{"title":"Augmented 4-screw vs. nonaugmented 6-screw PHILOS plating in low-bone quality proximal humerus fractures: a biomechanical human cadaveric study","authors":"Fabian Pretz MD ,&nbsp;Frank J.P. Beeres MD, PhD (Prof) ,&nbsp;Björn-Christian Link MD, PD ,&nbsp;Yannic Lecoultre MD ,&nbsp;Reto Babst MD (Prof) ,&nbsp;Boyko Gueorguiev PhD (Prof) ,&nbsp;Peter Varga PhD, PD ,&nbsp;Bryan J.M. van de Wall MD, PhD, PD ,&nbsp;Ivan Zderic PhD ,&nbsp;Torsten Pastor MD, PhD, PD","doi":"10.1016/j.jse.2025.07.006","DOIUrl":"10.1016/j.jse.2025.07.006","url":null,"abstract":"<div><h3>Background</h3><div>Proximal humerus fractures are frequent in patients with low bone quality. PHILOS plates are widely used with either minimally invasive plate osteosynthesis (MIPO) or open reduction and internal fixation (ORIF) techniques. However, it remains unclear whether plating with 4 cement-augmented proximal screws provides biomechanical stability comparable to using 4 nonaugmented proximal screws plus 2 additional calcar screws in unstable low bone quality proximal humerus fractures.</div></div><div><h3>Methods</h3><div>Fourteen paired human cadaveric humeri with low bone quality and simulated unstable 3-part proximal humerus fractures (AO 11-B1) were assigned to 2 groups – 4S+ and 6S – and stabilized using PHILOS plates with 4 proximal head screws in both groups. In the 6S group, 2 additional calcar (inferomedial support) screws were used, whereas in the 4S+ group, the 4 screw tips were augmented with bone cement. Cyclic axial loading tests were conducted until failure. Interfragmentary movements were monitored via motion tracking.</div></div><div><h3>Results</h3><div>Initial axial construct stiffness and cycles to failure showed no significant differences between groups (<em>P</em> = .171, <em>P</em> = .397). Although interfragmentary movements were slightly higher in the 4S+ group, this difference was not significant (<em>P</em> ≥ .071). Under cyclic loading, the 6S group exhibited a significant progressive increase over cycles for varus deformation (<em>P</em> = .029), humeral head displacement (<em>P</em> = .038), and screw bending in row A (<em>P</em> = .003), whereas no significant increase over cycles was observed in the 4S+ group and between the groups.</div></div><div><h3>Conclusion</h3><div>From a biomechanical perspective, PHILOS plating with 4 cement-augmented screws demonstrated comparable stability versus plating with 4 nonaugmented head screws plus 2 additional calcar screws, suggesting that the former fixation technique represents a valid alternative to the latter, particularly in case of low bone quality.</div></div>","PeriodicalId":50051,"journal":{"name":"Journal of Shoulder and Elbow Surgery","volume":"35 3","pages":"Pages 765-774"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of tranexamic acid reduces opioid consumption after arthroscopic rotator cuff repair 使用氨甲环酸可减少关节镜下肩袖修复术后阿片类药物的消耗。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-03-01 Epub Date: 2025-09-02 DOI: 10.1016/j.jse.2025.07.023
Katherine A. Burns MD , Lynn M. Robbins PA-C , Laura A. Humphrey PA-C , Angela R. LeMarr RN, BSN, ONC , Diane J. Morton MS, MWC , Melissa L. Wilson MPH, PhD

Background

Tranexamic acid (TXA) is an antifibrinolytic agent that has effectively reduced transfusion risk and minimized blood loss after total joint arthroplasty. TXA use has had mixed results on postoperative pain after arthroscopic rotator cuff repair (ARCR). The purpose of this prospective, double-blind, randomized, controlled trial was to examine the impact of TXA on prescription opioid consumption for 3 postoperative days in an outpatient population after ARCR. Intraoperative visualization and postoperative pain scores also were collected.

Methods

Patients scheduled to have ARCR with one surgeon at one institution were eligible for inclusion in a prospective, double-blind, randomized, and placebo-controlled trial comparing a cohort receiving intravenous administration of TXA 1,000 mg with a cohort receiving an equivalent volume of intravenous saline. The primary outcome was opioid consumption as measured by morphine milligram equivalents for the first 3 days after surgery. The secondary outcome was subjective measurement of pain as measured by the visual analog scale for the first 3 days after surgery.

Results

A total of 165 patients were enrolled, with 82 patients in the TXA group and 81 in placebo after 2 exclusions. No significant differences between groups were found for age, race, sex, size of rotator cuff tear, number of anchors used, or modifiable risk factors including preoperative opioid use and smoking tobacco status. TXA use independently reduced opioid consumption significantly for the first 3 days after ARCR by 18 morphine milligram equivalents (β = −18.0 [−35.4, −0.5], P = .044). Age also affected opioid use, with older patients consuming slightly less opioid than younger patients per year of age (β = −1.5 [−2.5, −0.5], P = .003). Factors that significantly increased opioid use included prior opioid use (β = 64.2 [32.0, 96.3], P < .001) and increasing number of anchors used (per anchor, β = 7.9 [4.0, 11.7], P < .001).

Conclusion

TXA use significantly reduced opioid consumption after ARCR. Advancing age modulated postoperative opioid consumption, whereas preoperative opioid use and number of anchors used increased opioid consumption in the first 3 days after ARCR. No differences were found in subjective pain score as measured by visual analog scale for the first 3 days after ARCR.
背景:氨甲环酸(TXA)是一种抗纤溶药物,可有效降低全关节置换术后输血风险和减少失血量。TXA用于关节镜下肩袖修复(ARCR)术后疼痛的效果好坏参半。这项前瞻性、双盲、随机对照试验的目的是检查TXA对门诊人群术后三天处方阿片类药物消费的影响。同时收集术中视觉和术后疼痛评分。方法:计划在一个机构的一名外科医生处进行ARCR的患者有资格纳入一项前瞻性、双盲、随机、安慰剂对照试验,比较接受静脉注射(IV) TXA 1,000 mg的队列和接受等量静脉注射生理盐水的队列。主要结局是术后前3天阿片类药物的消耗,以吗啡毫克当量(MME)衡量。次要结局是术后前3天用视觉模拟量表(VAS)主观测量疼痛。结果:共纳入165例患者,在两次排除后,82例患者为TXA组,81例患者为安慰剂组。各组之间在年龄、种族、性别、肩袖撕裂大小、使用锚钉数量或可改变的危险因素(包括术前阿片类药物使用和吸烟状况)方面均无显著差异。在ARCR后的前3天,单独使用TXA可显著减少阿片类药物消耗18 MME [β=-18.0 (-35.4, -0.5), p=0.044]。年龄也影响阿片类药物的使用,老年患者每年阿片类药物的使用量略低于年轻患者[β=-1.5 (-2.5, -0.5), p=0.003]。阿片类药物使用增加的因素包括既往阿片类药物使用[β=64.2(32.0, 96.3)],结论:使用TXA可显著减少ARCR后阿片类药物的使用。年龄的增长调节了术后阿片类药物的使用,而术前阿片类药物的使用和锚的使用数量在ARCR后的前3天增加了阿片类药物的使用。在ARCR后的前3天,VAS测量的主观疼痛评分无差异。
{"title":"Use of tranexamic acid reduces opioid consumption after arthroscopic rotator cuff repair","authors":"Katherine A. Burns MD ,&nbsp;Lynn M. Robbins PA-C ,&nbsp;Laura A. Humphrey PA-C ,&nbsp;Angela R. LeMarr RN, BSN, ONC ,&nbsp;Diane J. Morton MS, MWC ,&nbsp;Melissa L. Wilson MPH, PhD","doi":"10.1016/j.jse.2025.07.023","DOIUrl":"10.1016/j.jse.2025.07.023","url":null,"abstract":"<div><h3>Background</h3><div>Tranexamic acid (TXA) is an antifibrinolytic agent that has effectively reduced transfusion risk and minimized blood loss after total joint arthroplasty. TXA use has had mixed results on postoperative pain after arthroscopic rotator cuff repair (ARCR). The purpose of this prospective, double-blind, randomized, controlled trial was to examine the impact of TXA on prescription opioid consumption for 3 postoperative days in an outpatient population after ARCR. Intraoperative visualization and postoperative pain scores also were collected.</div></div><div><h3>Methods</h3><div>Patients scheduled to have ARCR with one surgeon at one institution were eligible for inclusion in a prospective, double-blind, randomized, and placebo-controlled trial comparing a cohort receiving intravenous administration of TXA 1,000 mg with a cohort receiving an equivalent volume of intravenous saline. The primary outcome was opioid consumption as measured by morphine milligram equivalents for the first 3 days after surgery. The secondary outcome was subjective measurement of pain as measured by the visual analog scale for the first 3 days after surgery.</div></div><div><h3>Results</h3><div>A total of 165 patients were enrolled, with 82 patients in the TXA group and 81 in placebo after 2 exclusions. No significant differences between groups were found for age, race, sex, size of rotator cuff tear, number of anchors used, or modifiable risk factors including preoperative opioid use and smoking tobacco status. TXA use independently reduced opioid consumption significantly for the first 3 days after ARCR by 18 morphine milligram equivalents (<span><math><mrow><mi>β</mi></mrow></math></span> = −18.0 [−35.4, −0.5], <em>P</em> = .044). Age also affected opioid use, with older patients consuming slightly less opioid than younger patients per year of age (<span><math><mrow><mi>β</mi></mrow></math></span> = −1.5 [−2.5, −0.5], <em>P</em> = .003). Factors that significantly increased opioid use included prior opioid use (<span><math><mrow><mi>β</mi></mrow></math></span> = 64.2 [32.0, 96.3], <em>P</em> &lt; .001) and increasing number of anchors used (per anchor, <span><math><mrow><mi>β</mi></mrow></math></span> = 7.9 [4.0, 11.7], <em>P</em> &lt; .001).</div></div><div><h3>Conclusion</h3><div>TXA use significantly reduced opioid consumption after ARCR. Advancing age modulated postoperative opioid consumption, whereas preoperative opioid use and number of anchors used increased opioid consumption in the first 3 days after ARCR. No differences were found in subjective pain score as measured by visual analog scale for the first 3 days after ARCR.</div></div>","PeriodicalId":50051,"journal":{"name":"Journal of Shoulder and Elbow Surgery","volume":"35 3","pages":"Pages 757-764"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does prophylactic antibiotic choice for total shoulder arthroplasty matter? A matched cohort analysis 全肩关节置换术预防性抗生素选择重要吗?匹配队列分析。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-03-01 Epub Date: 2025-08-25 DOI: 10.1016/j.jse.2025.07.017
Tej Joshi MD , Akhil Katakam MD , Daniel Calem MD , Daniella Ogilvie MD , Eitan M. Kohan MD , Francis G. Alberta MD

Background

Periprosthetic joint infection (PJI) of the shoulder is a devastating complication following total shoulder arthroplasty (TSA). The majority of literature regarding antibiotic choice for TSA is from accompanying literature in other orthopedic subspecialties. The purpose of this study was to delineate the relationship between various perioperative antibiotics, including local, topical vancomycin, and their potential protective effect on PJI following shoulder arthroplasty.

Methods

A retrospective cohort study was conducted using the TriNetX database to identify 28,098 patients who underwent TSA. Patients were stratified into cohorts based on the type of prophylactic antibiotic received in the perioperative period–only cefazolin, noncefazolin prophylaxis, vancomycin only, cefazolin with any form of vancomycin, cefazolin with topical vancomycin, only clindamycin, and cefazolin with clindamycin. The later 6 cohorts were one-to-one propensity score matched with the cefazolin-only cohort for risk analysis. The 90-day and 2-year risk of PJI and revision was analyzed, in addition to other surgical, hospital readmission, or emergency department visit complications.

Results

At 2 years, cefazolin monotherapy was associated with a significantly lower incidence of prosthetic joint infection and overall infection than noncefazolin regimens. No significant differences were found when cefazolin was compared with vancomycin alone or clindamycin alone. Adding local vancomycin did not significantly reduce the risk of PJI at any time point. Secondary antibiotic prophylaxis in addition to cefazolin was not associated with a decreased risk of infection at any time point.

Conclusion

Antibiotic prophylaxis choice for TSA may vary based on the surgeon's preference. Noncefazolin prophylaxis may not provide the same protection against PJI and overall infection as cefazolin prophylaxis. Cefazolin monotherapy is associated with lower infection rates compared to other noncefazolin regimens, suggesting that cefazolin should be used preferentially. However, prospective trials are required to further elucidate this finding.
背景:肩关节假体周围感染(PJI)是全肩关节置换术(TSA)后的严重并发症。大多数关于TSA抗生素选择的文献来自其他骨科亚专科的相关文献。本研究的目的是描述各种围手术期抗生素之间的关系,包括局部和外用万古霉素,以及它们对肩关节置换术后PJI的潜在保护作用。方法:使用TriNetX数据库进行回顾性队列研究,确定28,098例接受TSA的患者。根据围手术期预防性抗生素的类型,将患者分层为队列——仅头孢唑林、非头孢唑林预防、仅万古霉素、头孢唑林与任何形式的万古霉素、头孢唑林与外用万古霉素、仅克林霉素、头孢唑林与克林霉素。后6个队列进行一对一倾向评分,与仅头孢唑林队列进行风险分析。分析90天和2年PJI和翻修的风险,以及其他手术、医院再入院或急诊室就诊并发症。结果:在2年时,头孢唑林单药治疗与非头孢唑林方案相比,假体关节感染(PJI)和总体感染的发生率显著降低。头孢唑林与单用万古霉素或单用克林霉素比较无显著差异。在任何时间点,局部添加万古霉素都没有显著降低PJI的风险。在任何时间点,除头孢唑林外的二级抗生素预防与感染风险的降低无关。结论:TSA的抗生素预防选择可能根据外科医生的偏好而有所不同。非头孢唑林预防可能不能提供与头孢唑林预防相同的预防PJI和整体感染的保护。与其他非头孢唑林方案相比,头孢唑林单药治疗的感染率较低,这表明应优先使用头孢唑林。然而,需要前瞻性试验来进一步阐明这一发现。证据等级:三级;基于大型数据库的回顾性队列比较治疗研究。
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引用次数: 0
Preoperative testosterone replacement therapy is associated with increased rates of periprosthetic joint infection, acute kidney injury, and emergency department utilization after total shoulder arthroplasty: a propensity-score matched analysis 术前睾酮替代治疗与全肩关节置换术后PJI和医学并发症发生率增加相关:一项倾向评分匹配分析
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-03-01 Epub Date: 2025-09-01 DOI: 10.1016/j.jse.2025.07.022
Alexander E. White MD , Argen Omurzakov BA , Arsen M. Omurzakov BA , Christian E. Athanasian BA , Christopher M. Brusalis MD , Michelle E. Kew MD , Michael C. Fu MD , Lawrence V. Gulotta MD , Samuel A. Taylor MD

Background

The use of testosterone replacement therapy (TRT) has increased in recent years; however, its effect on surgical outcomes and long-term implant survival in total shoulder arthroplasty (TSA) remains unclear. This study aimed to assess the association between preoperative TRT and postoperative complications following TSA.

Methods

The TriNetX database was queried to identify patients undergoing TSA before 2020. Patients were then stratified based on preoperative TRT within 1 year before surgery. Propensity score matching was performed in a 1:1 ratio to balance demographic variables and comorbidities. Outcomes assessed included 90-day and 1-year medical and implant complications and 5-year implant complications. Statistical analyses were performed using TriNetX's built-in analytics platform.

Results

Following propensity score matching, 1,369 patients were included in each cohort and no baseline differences were detected. At 90 days postoperatively, TRT patients had significantly higher rates of emergency department (ED) visits (13.7% vs. 8.1%, risk ratio [RR]: 1.69, P < .001). At 1 year, TRT patients demonstrated increased rates of ED utilization (26.6% vs. 16.9%, RR: 1.58, P < .001), acute kidney injury (17.5% vs. 12.1%, RR: 1.45, P < .001), and periprosthetic joint infection (PJI) (4.8% vs. 2.4%, RR: 2.00, P < .001). At 5 years, TRT was associated with increased rates of PJI (7.9% vs. 4.5%, RR: 1.74, P < .001).

Conclusions

Preoperative TRT is associated with an increased risk of PJI, acute kidney injury, and postoperative ED visits following TSA. These findings highlight the need for careful preoperative risk assessment and patient counseling when considering TSA in patients on TRT.
背景:睾酮替代疗法(TRT)的使用近年来有所增加,然而,其对全肩关节置换术(TSA)手术结果和长期植入物存活的影响尚不清楚。本研究旨在评估术前TRT与TSA术后并发症的关系。方法:查询TriNetX数据库,确定2020年前接受TSA的患者。然后根据术前TRT在术前一年内对患者进行分层。倾向评分匹配(PSM)以1:1的比例进行,以平衡人口统计学变量和合并症。评估的结果包括90天和1年的医疗和种植体并发症,以及5年的种植体并发症。统计分析使用TriNetX的内置分析平台进行。结果:PSM后,每个队列纳入1369例患者,未发现基线差异。在术后90天,TRT患者急诊科(ED)就诊率显著升高(13.7% vs. 8.1%, RR: 1.69)。结论:术前TRT与TSA后假体周围关节感染、急性肾损伤和术后ED就诊风险增加相关。这些发现强调了在考虑TRT患者的TSA时,需要仔细的术前风险评估和患者咨询。
{"title":"Preoperative testosterone replacement therapy is associated with increased rates of periprosthetic joint infection, acute kidney injury, and emergency department utilization after total shoulder arthroplasty: a propensity-score matched analysis","authors":"Alexander E. White MD ,&nbsp;Argen Omurzakov BA ,&nbsp;Arsen M. Omurzakov BA ,&nbsp;Christian E. Athanasian BA ,&nbsp;Christopher M. Brusalis MD ,&nbsp;Michelle E. Kew MD ,&nbsp;Michael C. Fu MD ,&nbsp;Lawrence V. Gulotta MD ,&nbsp;Samuel A. Taylor MD","doi":"10.1016/j.jse.2025.07.022","DOIUrl":"10.1016/j.jse.2025.07.022","url":null,"abstract":"<div><h3>Background</h3><div>The use of testosterone replacement therapy (TRT) has increased in recent years; however, its effect on surgical outcomes and long-term implant survival in total shoulder arthroplasty (TSA) remains unclear. This study aimed to assess the association between preoperative TRT and postoperative complications following TSA.</div></div><div><h3>Methods</h3><div>The TriNetX database was queried to identify patients undergoing TSA before 2020. Patients were then stratified based on preoperative TRT within 1 year before surgery. Propensity score matching was performed in a 1:1 ratio to balance demographic variables and comorbidities. Outcomes assessed included 90-day and 1-year medical and implant complications and 5-year implant complications. Statistical analyses were performed using TriNetX's built-in analytics platform.</div></div><div><h3>Results</h3><div>Following propensity score matching, 1,369 patients were included in each cohort and no baseline differences were detected. At 90 days postoperatively, TRT patients had significantly higher rates of emergency department (ED) visits (13.7% vs. 8.1%, risk ratio [RR]: 1.69, <em>P</em> &lt; .001). At 1 year, TRT patients demonstrated increased rates of ED utilization (26.6% vs. 16.9%, RR: 1.58, <em>P</em> &lt; .001), acute kidney injury (17.5% vs. 12.1%, RR: 1.45, <em>P</em> &lt; .001), and periprosthetic joint infection (PJI) (4.8% vs. 2.4%, RR: 2.00, <em>P</em> &lt; .001). At 5 years, TRT was associated with increased rates of PJI (7.9% vs. 4.5%, RR: 1.74, <em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>Preoperative TRT is associated with an increased risk of PJI, acute kidney injury, and postoperative ED visits following TSA. These findings highlight the need for careful preoperative risk assessment and patient counseling when considering TSA in patients on TRT.</div></div>","PeriodicalId":50051,"journal":{"name":"Journal of Shoulder and Elbow Surgery","volume":"35 3","pages":"Pages 689-696"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Baek et al. regarding: “Machine learning models can define clinically relevant bone density subgroups based on patient-specific calibrated computed tomography scans in patients undergoing reverse shoulder arthroplasty” 回复致编辑的关于“机器学习模型可以根据接受反向肩关节置换术的患者的特定校准计算机断层扫描来定义临床相关的骨密度亚组”的信。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-03-01 Epub Date: 2025-09-10 DOI: 10.1016/j.jse.2025.07.034
Daniel Ritter MSc, Patrick J. Denard MD, Patric Raiss MD, Brian C. Werner MD, Asheesh Bedi MD, Samuel Bachmaier MSc
{"title":"Response to Baek et al. regarding: “Machine learning models can define clinically relevant bone density subgroups based on patient-specific calibrated computed tomography scans in patients undergoing reverse shoulder arthroplasty”","authors":"Daniel Ritter MSc,&nbsp;Patrick J. Denard MD,&nbsp;Patric Raiss MD,&nbsp;Brian C. Werner MD,&nbsp;Asheesh Bedi MD,&nbsp;Samuel Bachmaier MSc","doi":"10.1016/j.jse.2025.07.034","DOIUrl":"10.1016/j.jse.2025.07.034","url":null,"abstract":"","PeriodicalId":50051,"journal":{"name":"Journal of Shoulder and Elbow Surgery","volume":"35 3","pages":"Pages e518-e520"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiological and electrodiagnostic insights into suprascapular nerve dysfunction: a key predictor of poor functional outcomes in shoulder hemiarthroplasty 肩胛上神经功能障碍的放射学和电诊断:肩关节置换术中功能不良预后的关键预测因子。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-03-01 Epub Date: 2025-08-14 DOI: 10.1016/j.jse.2025.07.001
Ahmet Keskin MD , Niyazi Iğde MD , Bülent Karslıoğlu MD , Fethi Mıhlayanlar MD , Onur Akan MD , Ahmet Akçay MD , Yunus İmren MD , Süleyman Semih Dedeoğlu MD
<div><h3>Background</h3><div>Suprascapular nerve (SSN) dysfunction has emerged as an underexplored factor influencing functional outcomes after shoulder hemiarthroplasty (SHA) for proximal humerus fractures. Despite achieving optimal tuberosity healing and prosthesis alignment, some patients continue to experience poor functional recovery. This study investigates the role of SSN dysfunction as a key determinant of unfavorable outcomes following SHA.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed 38 patients who underwent SHA for Neer type III or IV proximal humerus fractures. Inclusion criteria included radiographic confirmation of tuberosity healing, absence of pre-existing rotator cuff tears, and sufficient follow-up. Patients were divided into 2 groups based on the Constant Shoulder Score (CSS) at 12 months postoperatively: group G (good outcomes, CSS difference between prosthetic and healthy shoulders <30) and group P (poor outcomes, CSS difference ≥30). Electrophysiologicalassessments were performed bilaterally to evaluate SSN function. Compound muscle action potentials and needle electromyography were used to measure nerve conduction and detect chronic neurogenic changes. Bilateral ultrasound imaging quantified supraspinatus muscle thickness at medial, central, and lateral points. These measurements provided a detailed comparison of prosthetic and healthy shoulders, identifying patterns of nerve dysfunction and muscle atrophy.</div></div><div><h3>Results</h3><div>Group P exhibited significantly lower American Shoulder and Elbow Surgeons scores, higher visual analog scale scores, and reduced shoulder motion (<em>P</em> < .01 for all). Findings revealed significantly lower compound muscle action potential amplitudes in the prosthetic shoulder of group P (2.55 ± 0.42 mV) compared with the prosthetic shoulders of healthy side (4.82 ± 0.67 mV, <em>P</em> < .001) and group G (4.27 ± 0.55 mV, <em>P</em> < .001). Reductions in amplitude exceeded 50% on the prosthetic side for group P. Needle electromyography of prosthetic shoulders in group P demonstrated chronic neurogenic changes, including fibrillation potentials and polyphasic motor unit potentials, in the supraspinatus and infraspinatus muscles. Ultrasound measurements revealed significant supraspinatus muscle atrophy on the prosthetic side in group P, with medial thickness reduction identified as the strongest predictor of poor outcomes (odds ratio = 1.312, 95% confidence interval: 1.042-1.654, <em>P</em> = .021). Healthy shoulders in group P exhibited no significant neurogenic abnormalities, highlighting localized dysfunction in the prosthetic side.</div></div><div><h3>Conclusion</h3><div>SSN dysfunction, evidenced by reduced nerve amplitudes and supraspinatus muscle atrophy, significantly predicts poor functional outcomes following SHA, even when tuberosities are well healed. These findings highlight the importance of perioperative nerve preservation stra
背景:肩胛上神经(SSN)功能障碍是影响肱骨近端骨折肩关节置换术(SHA)后功能预后的一个未被充分研究的因素。尽管获得了最佳的结节愈合和假体对齐,但一些患者继续经历较差的功能恢复。本研究探讨肩胛上神经功能障碍作为SHA后不良预后的关键决定因素的作用。方法:本回顾性研究分析了38例肱骨近端III型或IV型骨折接受SHA治疗的患者。纳入标准包括影像学证实结节愈合,没有先前存在的肩袖撕裂和充分的随访。根据术后12个月的肩部恒定评分(CSS)将患者分为两组:G组(预后良好,假体与健康肩部的CSS差异)结果:P组患者的as评分较低,VAS评分较高,肩部活动减少(P)。肩胛上神经功能障碍,表现为神经振幅降低和冈上肌萎缩,显著预示着SHA后功能不良的预后,即使结节愈合良好。这些发现强调了围手术期神经保存策略和术后神经学评估的重要性。将神经学评估纳入常规临床实践可以改善SHA后患者的恢复和预后。证据等级:三级;回顾性队列比较;预后研究。
{"title":"Radiological and electrodiagnostic insights into suprascapular nerve dysfunction: a key predictor of poor functional outcomes in shoulder hemiarthroplasty","authors":"Ahmet Keskin MD ,&nbsp;Niyazi Iğde MD ,&nbsp;Bülent Karslıoğlu MD ,&nbsp;Fethi Mıhlayanlar MD ,&nbsp;Onur Akan MD ,&nbsp;Ahmet Akçay MD ,&nbsp;Yunus İmren MD ,&nbsp;Süleyman Semih Dedeoğlu MD","doi":"10.1016/j.jse.2025.07.001","DOIUrl":"10.1016/j.jse.2025.07.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Suprascapular nerve (SSN) dysfunction has emerged as an underexplored factor influencing functional outcomes after shoulder hemiarthroplasty (SHA) for proximal humerus fractures. Despite achieving optimal tuberosity healing and prosthesis alignment, some patients continue to experience poor functional recovery. This study investigates the role of SSN dysfunction as a key determinant of unfavorable outcomes following SHA.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This retrospective study analyzed 38 patients who underwent SHA for Neer type III or IV proximal humerus fractures. Inclusion criteria included radiographic confirmation of tuberosity healing, absence of pre-existing rotator cuff tears, and sufficient follow-up. Patients were divided into 2 groups based on the Constant Shoulder Score (CSS) at 12 months postoperatively: group G (good outcomes, CSS difference between prosthetic and healthy shoulders &lt;30) and group P (poor outcomes, CSS difference ≥30). Electrophysiologicalassessments were performed bilaterally to evaluate SSN function. Compound muscle action potentials and needle electromyography were used to measure nerve conduction and detect chronic neurogenic changes. Bilateral ultrasound imaging quantified supraspinatus muscle thickness at medial, central, and lateral points. These measurements provided a detailed comparison of prosthetic and healthy shoulders, identifying patterns of nerve dysfunction and muscle atrophy.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Group P exhibited significantly lower American Shoulder and Elbow Surgeons scores, higher visual analog scale scores, and reduced shoulder motion (&lt;em&gt;P&lt;/em&gt; &lt; .01 for all). Findings revealed significantly lower compound muscle action potential amplitudes in the prosthetic shoulder of group P (2.55 ± 0.42 mV) compared with the prosthetic shoulders of healthy side (4.82 ± 0.67 mV, &lt;em&gt;P&lt;/em&gt; &lt; .001) and group G (4.27 ± 0.55 mV, &lt;em&gt;P&lt;/em&gt; &lt; .001). Reductions in amplitude exceeded 50% on the prosthetic side for group P. Needle electromyography of prosthetic shoulders in group P demonstrated chronic neurogenic changes, including fibrillation potentials and polyphasic motor unit potentials, in the supraspinatus and infraspinatus muscles. Ultrasound measurements revealed significant supraspinatus muscle atrophy on the prosthetic side in group P, with medial thickness reduction identified as the strongest predictor of poor outcomes (odds ratio = 1.312, 95% confidence interval: 1.042-1.654, &lt;em&gt;P&lt;/em&gt; = .021). Healthy shoulders in group P exhibited no significant neurogenic abnormalities, highlighting localized dysfunction in the prosthetic side.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;SSN dysfunction, evidenced by reduced nerve amplitudes and supraspinatus muscle atrophy, significantly predicts poor functional outcomes following SHA, even when tuberosities are well healed. These findings highlight the importance of perioperative nerve preservation stra","PeriodicalId":50051,"journal":{"name":"Journal of Shoulder and Elbow Surgery","volume":"35 3","pages":"Pages 719-730"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Shoulder and Elbow Surgery
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