Burns最新文献

英文中文

Factors affecting skin keratinocyte and fibroblast extraction yields for the production of living skin substitutes to treat severely burned patients 影响皮肤角质细胞和成纤维细胞提取产量的因素，用于生产治疗严重烧伤患者的活皮肤替代品

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-03-01 Epub Date: 2025-11-20 DOI: 10.1016/j.burns.2025.107805

Ludivine Dubourget , Danielle Larouche , Sergio Cortez Ghio , Véronique J. Moulin , Chanel Beaudoin-Cloutier , Lucie Germain

Backgrounds

As autografting is limited for severely burned patients due to a lack of healthy donor sites, tissue-engineered autologous skin substitutes have emerged as a promising alternative. Yet, challenges persist, particularly regarding production time. Since cell culture is influenced by multiple factors, identifying these factors is crucial for improving culture yields. This retrospective study aimed to identify factors affecting skin cell extraction yields.

Methods

Culture data (method used, etc.) and clinical data (medical history, etc.) from all available patient records over a 35-year-period were collected. 18 variables were assessed using XGBoost as a variable selection tool, before fitting mixed-effects multivariate linear modeling.

Results

As expected, age inversely correlated with keratinocyte and fibroblast extraction yields, decreasing by 0.048 × 10⁶ cells/cm² per year (CI_95 % = [-0.065;-0.031]) and 0.035 × 10⁶ cells/cm² per year (CI_95 % = [-0.050;-0.019]), respectively. Keratinocyte yield also rose by 0.936 × 10⁶ cells/cm² (CI_95 % = [0.175;1.697]) when hairs could be grasped during the epidermis-dermis separation. Conversely, fibroblast yield increased by 0.042 × 10⁶ cells/cm² per day post-burn (CI_95 % = [0.007;0.076]) and by 0.019 × 10⁶ cells/cm² per percentage of TBSA burned (CI_95 % = [0.002;0.036]).

Conclusions

This findings provide valuable insights into factors influencing skin cell extraction yields, which may help optimize skin biopsy parameters, ultimately improving production efficiency.

由于缺乏健康的供体部位，严重烧伤患者的自体移植受到限制，组织工程自体皮肤替代品已成为一种有前途的替代方法。然而，挑战依然存在，特别是在生产时间方面。由于细胞培养受多种因素影响，因此确定这些因素对于提高培养产量至关重要。本回顾性研究旨在确定影响皮肤细胞提取率的因素。方法收集35年来所有可查病例的培养资料（所用方法等）和临床资料（病史等）。在拟合混合效应多元线性模型之前，使用XGBoost作为变量选择工具评估了18个变量。结果如预期的那样，年龄与角质形成细胞和成纤维细胞提取率呈负相关，分别减少0.048 × 106个细胞/cm²/年（CI95 % =[-0.065;-0.031]）和0.035 × 106个细胞/cm²/年（CI95 % =[-0.050;-0.019]）。表皮真皮分离过程中抓毛时，角质细胞产量增加0.936 × 106个细胞/cm²（CI95 % =[0.175;1.697]）。相反，烧伤后每天成纤维细胞产量增加0.042 × 106个细胞/cm²（CI95 % = [0.007;0.076]），TBSA烧伤后每天成纤维细胞产量增加0.019 × 106个细胞/cm²（CI95 % =[0.002;0.036]）。结论本研究结果为皮肤细胞提取收率的影响因素提供了有价值的见解，有助于优化皮肤活检参数，最终提高生产效率。

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引用次数: 0

Fire safety measures in commercial complex residents: Application of protection motivation theory 商业综合体居民的消防安全措施：保护动机理论的应用。

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-03-01 Epub Date: 2025-12-10 DOI: 10.1016/j.burns.2025.107830

Mohammadreza Shokouhi , Fahimeh Ramezani , Ali Fardi , Maryam Afshari , Salman Khazaei , Forouzan Rezapur-Shahkolai

Background

Fires in commercial buildings are of particular concern given their essential role in economic and social development. While fire safety research has often emphasized structural aspects of buildings, comparatively less attention has been paid to residents’ behavioral responses during fire incidents. Moreover, a considerable portion of the existing literature on fire safety lacks a robust theoretical foundation. To address this gap, the present study applies the Protection Motivation Theory (PMT) to examine factors influencing fire prevention behaviors among residents of commercial complexes.

Materials and methods

This cross-sectional study was conducted between September and December 2024 among 910 residents of commercial complexes in Hamadan. Participants were selected using a stratified sampling method based on complex size, followed by simple random sampling for individual inclusion. Data were collected through structured interviews with a questionnaire consisting of two sections: demographic and background information, and constructs derived from the PMT.

Results

The mean age of participants was 41.6 years, with an average of 7.6 working hours per day. Most participants were male (81.2 %) and had a middle school level of education (52.2 %). Nearly 12.2 % reported previous experience with a fire incident. In addition, higher scores of perceived susceptibility, perceived severity, fear, self-efficacy, response efficacy, perceived rewards, and protection motivation were associated with increased engagement in preventive measures. Daily working hours were also found to have a statistically significant correlation with the adoption of protective behaviors against fire in commercial buildings.

Conclusion

The findings of this study highlight the critical importance of fire prevention among individuals working in commercial complexes, given their unique occupational conditions. To ensure effective planning and implementation of preventive and intervention programs, it is essential to comprehensively identify the determinants of protective behaviors.

背景：商业建筑火灾在经济和社会发展中发挥着重要作用，因此受到特别关注。虽然消防安全研究经常强调建筑物的结构方面，但相对较少关注居民在火灾事件中的行为反应。此外，相当一部分现有的关于消防安全的文献缺乏坚实的理论基础。为了弥补这一空白，本研究运用保护动机理论（PMT）研究商业综合体居民防火行为的影响因素。材料与方法：本横断面研究于2024年9月至12月在哈马丹商业综合体的910名居民中进行。采用基于复杂尺寸的分层抽样方法选择参与者，然后进行简单随机抽样以进行个体纳入。数据通过结构化访谈收集，问卷包括两个部分：人口统计和背景信息，以及来自PMT的结构。结果：参与者的平均年龄为41.6岁，平均每天工作7.6小时。大多数参与者为男性（81.2 %），受教育程度为中学（52.2% %）。近12.2 %的人报告有过火灾事故的经历。此外，感知易感性、感知严重性、恐惧、自我效能、反应效能、感知奖励和保护动机得分较高，与参与预防措施的增加有关。每日工作时间也被发现与商业建筑防火保护行为的采用有统计学上的显著相关。结论：本研究的结果强调了在商业综合体中工作的个人，鉴于其独特的职业条件，防火的重要性。为了确保有效规划和实施预防和干预方案，必须全面确定保护性行为的决定因素。

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引用次数: 0

Editorial: The rise of the robot authors 编辑：机器人作家的崛起

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-03-01 Epub Date: 2026-01-18 DOI: 10.1016/j.burns.2026.107862

Leopoldo C. Cancio

引用次数: 0

Glucagon-like peptide-1 receptor agonists after recent burn injury are associated with lower rates of infection, mortality, and opioid prescriptions 近期烧伤后胰高血糖素样肽-1受体激动剂与较低的感染率、死亡率和阿片类药物处方相关

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-03-01 Epub Date: 2025-12-29 DOI: 10.1016/j.burns.2025.107848

Matthew Q. Dao , Anika Y. Kim , Sarah Wang , Paul Won , Matteo Laspro , T. Justin Gillenwater , Haig A. Yenikomshian , Maxwell B. Johnson

Introduction

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely prescribed for glycemic control and weight loss. In addition, these medications have been associated with anti-inflammatory activity, modulation of wound healing, and reduction of substance use disorders. Therefore, GLP-1 RAs may have therapeutic benefits in burn care. This study investigates whether early administration of GLP-1 RAs after burn injury is associated with clinical outcomes.

Methods

The Global Collaborative Network was queried in TriNetX, a database of electronic health records. The treatment group included burn patients who received GLP-1 RAs within 30 days of injury. This group was propensity matched with patients who did not receive GLP-1 RAs. Patients were matched by demographics, comorbidities, and burn characteristics. Outcomes at 90 days and 1 year following burn injury were compared, with statistical significance defined as p < 0.05.

Results

Following matching, each group was composed of 3231 patients. At 90 days post-burn, the GLP-1 RA group had significantly lower rates of soft tissue infection, opioid prescriptions, readmission, and mortality (all p < 0.05). At 1 year post-burn, lower rates of opioid prescriptions, readmission, and mortality persisted (all p < 0.05), while soft tissue infection rates remained numerically lower but did not reach statistical significance. No significant differences were observed for wound disruption, hypertrophic scar formation, or contracture formation at either time point.

Conclusions

GLP-1 RAs after recent burn injury were associated with lower risk of infection, opioid prescriptions, readmission, and mortality. Their utility in burn care is promising, and additional research is needed.

lucagon-like peptide-1 receptor agonists （GLP-1 RAs）被广泛用于血糖控制和减肥。此外，这些药物与抗炎活性、伤口愈合调节和减少物质使用障碍有关。因此，GLP-1 RAs可能在烧伤护理中具有治疗益处。本研究探讨烧伤后早期给予GLP-1 RAs是否与临床结果相关。方法在电子健康档案数据库TriNetX中查询全球协同网络。治疗组包括在伤后30天内接受GLP-1 RAs治疗的烧伤患者。该组与未接受GLP-1 RAs治疗的患者倾向匹配。根据人口统计学、合并症和烧伤特征对患者进行匹配。烧伤后90天和1年的结果比较，p <； 0.05定义为有统计学意义。结果经配对后，每组共3231例患者。烧伤后90天，GLP-1 RA组软组织感染、阿片类药物处方、再入院率和死亡率显著降低（p均为 <； 0.05）。烧伤后1年，较低的阿片类药物处方率、再入院率和死亡率持续存在（p均 <； 0.05），而软组织感染率在数字上仍然较低，但没有达到统计学意义。在两个时间点上，伤口破裂、增生性瘢痕形成或挛缩形成均无显著差异。结论近期烧伤后glp -1 RAs与较低的感染、阿片类药物处方、再入院和死亡率相关。它们在烧伤护理中的应用是有希望的，需要进一步的研究。

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引用次数: 0

Galangin enhances skin flap survival by inhibiting ferroptosis via SIRT1-mediated FOXO1 deacetylation 高良姜通过sirt1介导的fox01去乙酰化抑制铁下垂，从而提高皮瓣存活率

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-03-01 Epub Date: 2026-01-19 DOI: 10.1016/j.burns.2026.107872

Jialong Yang , An Wang , Zhengyang Qi , Panshen Xu , Hebin Pan , Weilong Song , Kaitao Wang , Dingsheng Lin

Background

Skin flap necrosis due to ischemia-reperfusion (I/R) injury remains a major obstacle in plastic and reconstructive surgery. Galangin (Gal) is a natural flavonoid with potent antioxidant and anti-inflammatory properties; its effect on ischemic flap necrosis remains unclear.

Methods

Network pharmacology and molecular docking were used to predict the interaction between Gal and SIRT1. In vitro, human umbilical vein endothelial cells were subjected to oxygen-glucose deprivation/reperfusion to simulate I/R injury, and subsequent assessments of cell viability and ferroptosis were performed. The SIRT1 inhibitor EX527 and the ferroptosis inhibitor Ferrostatin-1 were used to verify the ferroptosis-related mechanisms. In vivo, a modified McFarlane skin flap model was created in rats. Gal-treated groups were compared to a control group to evaluate flap survival, blood perfusion, histological changes, and the expression of key proteins in the SIRT1/FOXO1 pathway.

Results

In vitro, Gal protected HUVECs by suppressing ferroptosis. Mechanistically, Gal upregulated SIRT1, promoted FOXO1 deacetylation, increased expression of downstream proteins and inhibited lipid peroxidation. These protective effects were diminished by SIRT1 inhibition. In vivo, Gal treatment significantly increased flap survival area and blood perfusion in a dose-dependent manner. It also suppressed neutrophil infiltration, reduced MDA levels, increased SOD activity, and inhibited pro-inflammatory cytokines and activate anti-ferroptosis proteins.

Conclusions

Gal enhances skin flap survival by suppressing ferroptosis, oxidative stress, and inflammation via activation of the SIRT1/FOXO1 pathway.

背景：缺血再灌注（I/R）损伤引起的皮瓣坏死仍然是整形和重建手术的主要障碍。高良姜素（Gal）是一种天然类黄酮，具有有效的抗氧化和抗炎特性；其对缺血性皮瓣坏死的影响尚不清楚。方法采用网络药理学和分子对接方法预测Gal与SIRT1的相互作用。体外，对人脐静脉内皮细胞进行氧-葡萄糖剥夺/再灌注模拟I/R损伤，并对细胞活力和铁凋亡进行评估。使用SIRT1抑制剂EX527和铁下垂抑制剂Ferrostatin-1来验证铁下垂相关机制。在体内，建立了改良的麦克法兰皮瓣模型。将gal处理组与对照组进行比较，评估皮瓣存活、血液灌注、组织学变化以及SIRT1/FOXO1通路关键蛋白的表达。结果在体外，Gal通过抑制铁下垂对HUVECs有保护作用。在机制上，Gal上调SIRT1，促进FOXO1去乙酰化，增加下游蛋白的表达，抑制脂质过氧化。这些保护作用因SIRT1抑制而减弱。在体内，Gal处理显著增加皮瓣存活面积和血流灌注，并呈剂量依赖性。抑制中性粒细胞浸润，降低MDA水平，提高SOD活性，抑制促炎细胞因子，激活抗铁下垂蛋白。结论gal通过激活SIRT1/FOXO1通路，抑制铁下垂、氧化应激和炎症，提高皮瓣存活。

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引用次数: 0

Beyond the patient: A dyadic intervention paradigm for improved post-burn recovery outcomes 超越病人：改善烧伤后恢复结果的双重干预范式

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-03-01 Epub Date: 2026-01-18 DOI: 10.1016/j.burns.2026.107868

Jonathan Bayuo

引用次数: 0

Comment on: Characterization and analysis of the skin mycobiome in keloid: A case-control study 点评：瘢痕疙瘩中皮肤真菌群的特征和分析：一项病例对照研究

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-03-01 Epub Date: 2026-01-12 DOI: 10.1016/j.burns.2026.107866

Yan-Yan Chen , Yi-Fei Yang , Yu-Yun Xiong, Hui Sun , Yu-Mei Li

引用次数: 0

Corrigendum to “Impact of hospital procedure volume on inpatient outcomes of burns covering 20–50 % of the total body surface receiving skin allograft: An analysis of the US Nationwide Inpatient Sample 2005–2020” [Burns 51(8) (2025) 107647] “医院手术量对烧伤住院患者结果的影响，烧伤覆盖20 - 50% %的体表接受同种异体皮肤移植：2005-2020年美国全国住院患者样本分析”[烧伤51(8)(2025)107647]

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-03-01 Epub Date: 2026-01-24 DOI: 10.1016/j.burns.2025.107831

Chao-Ming Wu

引用次数: 0

“A window of looking at the good, bad, and the stress:” A mixed-methods art therapy study with hospitalized adult burn patients “看到好的，坏的和压力的窗口：”住院成人烧伤患者的混合方法艺术治疗研究

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-03-01 Epub Date: 2025-12-07 DOI: 10.1016/j.burns.2025.107821

Bani Malhotra , Linwood R. Haith Jr. , Patricia A. Shewokis , Johanna Czamanski-Cohen , Minjung Shim , Megan Stair-Buchmann , Girija Kaimal

Background

Improving psychosocial functioning in hospitalized burn survivors involves minimizing distress and pain and fostering emotion regulation. Art therapy could uniquely address the non-verbal aspects of distressing experiences, facilitating healthy emotional expression.

Method

This small N mixed-methods study examined the effect of 4-session art therapy intervention among 12 adult hospitalized burn patients on psychosocial outcomes of distress (Distress thermometer), affect (Positive and Negative Affect Schedule), change-perception (Patient Global Impression of Change), pain (Graphic Numeric Rating Scale), and self-expression and regulation (Self-Expression and Emotion Regulation in Art Therapy Scale, SERATS).

Results

Quantitative results using repeated ANOVA showed significant improvements in distress (F[1,9]=6.84, p = .028), positive affect (F[1,8]=5.5, p = 0.047), negative affect (F[1,8]=8.12, p = .022), and pain (F[1,9]=13.22, p = .005) across the four sessions. The global percentage change indicated positive trends in the outcomes. Changes did not reach statistical significance within-sessions. One-sample t-test showed a significant improvement in patients’ impression of change (t[10]=−4.183, two-sided p = .002) with mean responses approaching ‘much improved.’ Patients perceived art therapy as fostering emotional expression and regulation ‘often’ indicated by mean response scores approaching “4” for each item on SERATS. Thematic analysis elaborated on symptom management, expanded expression and perspective with art serving as tangible reminders, and creative engagement across sessions and with varied art media. Mixed-methods integration demonstrated congruent findings across art therapy sessions.

Conclusion

Art therapy can be a viable intervention to boost psychosocial health in hospitalized burn patients.

背景：改善住院烧伤幸存者的社会心理功能包括尽量减少痛苦和痛苦，培养情绪调节能力。艺术疗法可以独特地解决痛苦经历的非语言方面，促进健康的情感表达。方法采用小N混合方法，对12例住院烧伤患者进行4期艺术治疗干预，观察其在痛苦（痛苦温度计）、情绪（积极和消极情绪量表）、改变感知（患者对变化的整体印象）、疼痛（图形数字评定量表）和自我表达和调节（艺术治疗自我表达和情绪调节量表，SERATS）等心理社会结局方面的影响。结果重复方差分析的定量结果显示，焦虑症状有显著改善（F[1,9]=6.84, p = ）。028),积极的影响(F (1,8) = 5.5, p = 0.047),消极影响(F (1,8) = 8.12, p = 。022)，疼痛（F[1,9]=13.22, p = ）。（2005）。全球百分比变化表明结果呈积极趋势。在会议期间，变化没有达到统计学意义。单样本t检验显示患者对改变的印象有显著改善（t[10]=−4.183，双侧p = ）。002)，平均回答接近“大大改善”。患者认为艺术治疗是促进情绪表达和调节的“通常”，在SERATS上每个项目的平均反应得分接近“4”。专题分析详细阐述了症状管理、以艺术作为有形提醒的扩展表达和视角，以及跨会议和不同艺术媒体的创造性参与。混合方法整合在艺术治疗过程中显示出一致的结果。结论艺术治疗是促进烧伤住院患者心理健康的有效干预手段。

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引用次数: 0

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IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-03-01 Epub Date: 2025-12-08 DOI: 10.1016/j.burns.2025.107824

Ruihan Zhang, Keqiang Ma, Shuyang Chen, Chenyu Zhao

引用次数: 0

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