Pub Date : 2026-04-17DOI: 10.1136/jech-2026-225923
Gum-Ryeong Park, Siu Ming Chan, Haitao Du
Background: Housing affordability stress is a significant determinant of psychological health among young adults in urban settings. However, prior studies often rely on a single indicator, limiting understanding of how objective financial burdens and subjective experiences of affordability stress relate to depressive symptoms and suicidal ideation. This study addresses these gaps by jointly examining objective and subjective housing affordability stress.
Methods: We used longitudinal data from the Seoul Young Adult Panel Study (2021-2024), comprising 5155 individuals and 13 735 person-wave observations. Objective housing affordability stress was defined as allocating 30% or more of total household expenditures to housing, while subjective affordability stress captured self-reported difficulty paying housing-related expenses. Individual fixed-effects regression models were estimated to examine within-person associations between housing affordability stress and depressive symptoms and suicidal ideation.
Results: Both objective and subjective housing affordability stress were significantly associated with higher depressive symptoms and increased likelihood of suicidal ideation. Subjective affordability stress showed a stronger association with depressive symptoms than objective measures. When the two measures were considered jointly, individuals experiencing both objective and subjective affordability stress had the highest levels of depressive symptoms and suicidal ideation, indicating an additive effect of dual affordability stress.
Conclusions: Objective and subjective measures of housing affordability stress capture distinct yet complementary dimensions of housing-related hardship and identify different at-risk groups. A joint measurement approach provides a more comprehensive assessment of housing-related psychological health risks among urban young adults than reliance on a single indicator.
{"title":"Two sides of housing affordability stress: objective and subjective burdens and depression and suicidal ideation among urban young adults.","authors":"Gum-Ryeong Park, Siu Ming Chan, Haitao Du","doi":"10.1136/jech-2026-225923","DOIUrl":"https://doi.org/10.1136/jech-2026-225923","url":null,"abstract":"<p><strong>Background: </strong>Housing affordability stress is a significant determinant of psychological health among young adults in urban settings. However, prior studies often rely on a single indicator, limiting understanding of how objective financial burdens and subjective experiences of affordability stress relate to depressive symptoms and suicidal ideation. This study addresses these gaps by jointly examining objective and subjective housing affordability stress.</p><p><strong>Methods: </strong>We used longitudinal data from the Seoul Young Adult Panel Study (2021-2024), comprising 5155 individuals and 13 735 person-wave observations. Objective housing affordability stress was defined as allocating 30% or more of total household expenditures to housing, while subjective affordability stress captured self-reported difficulty paying housing-related expenses. Individual fixed-effects regression models were estimated to examine within-person associations between housing affordability stress and depressive symptoms and suicidal ideation.</p><p><strong>Results: </strong>Both objective and subjective housing affordability stress were significantly associated with higher depressive symptoms and increased likelihood of suicidal ideation. Subjective affordability stress showed a stronger association with depressive symptoms than objective measures. When the two measures were considered jointly, individuals experiencing both objective and subjective affordability stress had the highest levels of depressive symptoms and suicidal ideation, indicating an additive effect of dual affordability stress.</p><p><strong>Conclusions: </strong>Objective and subjective measures of housing affordability stress capture distinct yet complementary dimensions of housing-related hardship and identify different at-risk groups. A joint measurement approach provides a more comprehensive assessment of housing-related psychological health risks among urban young adults than reliance on a single indicator.</p>","PeriodicalId":54839,"journal":{"name":"Journal of Epidemiology and Community Health","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-17DOI: 10.1136/jech-2025-225477
Huihui Song, Roberta Piroddi, Philip McHale, Benjamin Barr
Background: Health-related economic inactivity in England has risen, with more working-age adults claiming disability and incapacity benefits. The 2016 Welfare Reform and Work Act reduced weekly payments for Employment and Support Allowance recipients deemed capable of some work from April 2017, potentially affecting poverty, mental health and employment among people with long-term conditions (LTCs). Evidence on its causal impact is limited.
Data and methods: Using UK Household Longitudinal Survey data (2010-2019), we evaluated the reform's impact on working-age individuals with LTCs. Triple-difference and difference-in-differences models assessed transitions in employment, poverty risk (income <40% median) and incident poor mental health (defined as SF-12 Mental Component Score ≤45.6 among those without prior poor mental health), controlling for age, gender, children and education.
Results: The 2017 reform was associated with a 5.5 percentage point increase in poverty risk among individuals with LTCs leaving employment (95% CI 1.4% to 9.6%, p=0.008) and an 8.9 percentage point increase in the incidence of poor mental health in this group (95% CI 1.1% to 16.7%, p=0.025). No significant effects on transitions into or out of employment were observed at the 95% confidence level.Applying these estimates to national employment figures suggests that the reform may have resulted in approximately 37254 additional people entering severe poverty and 60117 additional cases of poor mental health annually.
Conclusions: These findings suggest that reductions in disability-related benefits may exacerbate financial and mental health vulnerability among affected individuals but not affect employment. This highlights the need for policy measures that balance fiscal objectives with social protection.
背景:英格兰与健康相关的经济不活动有所增加,越来越多的工作年龄成年人申请残疾和丧失工作能力福利。2016年福利改革和工作法案从2017年4月起减少了就业和支持津贴领取者的每周支付,这可能会影响长期疾病患者(LTCs)的贫困,心理健康和就业。关于其因果影响的证据有限。数据和方法:使用英国家庭纵向调查数据(2010-2019年),我们评估了改革对劳动年龄LTCs个体的影响。结果:2017年的改革与LTCs离职个体的贫困风险增加5.5个百分点(95% CI 1.4%至9.6%,p=0.008)以及该群体中心理健康不良发生率增加8.9个百分点(95% CI 1.1%至16.7%,p=0.025)相关。在95%的置信水平下,未观察到对进入或退出就业的过渡有显著影响。将这些估计数应用于全国就业数字表明,改革可能导致每年约有37254人额外陷入严重贫困,另有60117人精神健康状况不佳。结论:这些发现表明,残疾相关福利的减少可能会加剧受影响个人的经济和心理健康脆弱性,但不会影响就业。这凸显了采取政策措施平衡财政目标与社会保护的必要性。
{"title":"Health, poverty and employment effects of cutting income replacement benefits for the disabled: a difference-in-differences analysis of the 2017 welfare reforms.","authors":"Huihui Song, Roberta Piroddi, Philip McHale, Benjamin Barr","doi":"10.1136/jech-2025-225477","DOIUrl":"https://doi.org/10.1136/jech-2025-225477","url":null,"abstract":"<p><strong>Background: </strong>Health-related economic inactivity in England has risen, with more working-age adults claiming disability and incapacity benefits. The 2016 Welfare Reform and Work Act reduced weekly payments for Employment and Support Allowance recipients deemed capable of some work from April 2017, potentially affecting poverty, mental health and employment among people with long-term conditions (LTCs). Evidence on its causal impact is limited.</p><p><strong>Data and methods: </strong>Using UK Household Longitudinal Survey data (2010-2019), we evaluated the reform's impact on working-age individuals with LTCs. Triple-difference and difference-in-differences models assessed transitions in employment, poverty risk (income <40% median) and incident poor mental health (defined as SF-12 Mental Component Score ≤45.6 among those without prior poor mental health), controlling for age, gender, children and education.</p><p><strong>Results: </strong>The 2017 reform was associated with a 5.5 percentage point increase in poverty risk among individuals with LTCs leaving employment (95% CI 1.4% to 9.6%, p=0.008) and an 8.9 percentage point increase in the incidence of poor mental health in this group (95% CI 1.1% to 16.7%, p=0.025). No significant effects on transitions into or out of employment were observed at the 95% confidence level.Applying these estimates to national employment figures suggests that the reform may have resulted in approximately 37254 additional people entering severe poverty and 60117 additional cases of poor mental health annually.</p><p><strong>Conclusions: </strong>These findings suggest that reductions in disability-related benefits may exacerbate financial and mental health vulnerability among affected individuals but not affect employment. This highlights the need for policy measures that balance fiscal objectives with social protection.</p>","PeriodicalId":54839,"journal":{"name":"Journal of Epidemiology and Community Health","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-17DOI: 10.1136/jech-2025-225160
Siri Høivik Storeng, Erik Reidar Sund, Knut Eirik Dalene, Simon Lergenmuller, Inger Ariansen, Steinar Krokstad
Background: Allostatic load (AL) is the physiological burden of stress, and it is suggested to be a mediator between socioeconomic position and health. The aim of this article was to study life-course trajectories in levels of AL by employing data collected over three decades (1994-2019) to compare sex and socioeconomic groups in the adult Norwegian population.
Methods: Harmonised data from the following Norwegian health studies were used: the Trøndelag Health Study, the Tromsø Study, the Age 40 Program and CONOR. In total, 264 824 participants aged 30-79 years contributed with 346 312 health examinations. A combined AL score was calculated as the number of biomarkers in the worst quartile among the following eight variables: systolic blood pressure, diastolic blood pressure, resting heart rate, triglycerides, total cholesterol, high-density lipoprotein cholesterol, body mass index and waist-hip ratio. High-sensitivity C reactive protein and glycated haemoglobin were included in sensitivity analyses for a subset of participants. Life-course trajectories were analysed by using a linear mixed model. A shared-parameter model was employed to evaluate attrition caused by death.
Results: Participants with primary education had higher AL compared with secondary and tertiary educated people in all age groups. Men had higher AL than women throughout the life-course. Overall, AL increased with age but levelled off at higher ages among women and decreased at higher ages among men.
Conclusions: We found significant socioeconomic inequalities and sex differences in AL throughout the life-course. This highlights a potential for improvement in public health by effective treatment and public health measures to reduce AL inequities.
{"title":"Socioeconomic inequalities in allostatic load in a large Norwegian cohort study: the NCDNOR project.","authors":"Siri Høivik Storeng, Erik Reidar Sund, Knut Eirik Dalene, Simon Lergenmuller, Inger Ariansen, Steinar Krokstad","doi":"10.1136/jech-2025-225160","DOIUrl":"https://doi.org/10.1136/jech-2025-225160","url":null,"abstract":"<p><strong>Background: </strong>Allostatic load (AL) is the physiological burden of stress, and it is suggested to be a mediator between socioeconomic position and health. The aim of this article was to study life-course trajectories in levels of AL by employing data collected over three decades (1994-2019) to compare sex and socioeconomic groups in the adult Norwegian population.</p><p><strong>Methods: </strong>Harmonised data from the following Norwegian health studies were used: the Trøndelag Health Study, the Tromsø Study, the Age 40 Program and CONOR. In total, 264 824 participants aged 30-79 years contributed with 346 312 health examinations. A combined AL score was calculated as the number of biomarkers in the worst quartile among the following eight variables: systolic blood pressure, diastolic blood pressure, resting heart rate, triglycerides, total cholesterol, high-density lipoprotein cholesterol, body mass index and waist-hip ratio. High-sensitivity C reactive protein and glycated haemoglobin were included in sensitivity analyses for a subset of participants. Life-course trajectories were analysed by using a linear mixed model. A shared-parameter model was employed to evaluate attrition caused by death.</p><p><strong>Results: </strong>Participants with primary education had higher AL compared with secondary and tertiary educated people in all age groups. Men had higher AL than women throughout the life-course. Overall, AL increased with age but levelled off at higher ages among women and decreased at higher ages among men.</p><p><strong>Conclusions: </strong>We found significant socioeconomic inequalities and sex differences in AL throughout the life-course. This highlights a potential for improvement in public health by effective treatment and public health measures to reduce AL inequities.</p>","PeriodicalId":54839,"journal":{"name":"Journal of Epidemiology and Community Health","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-11DOI: 10.1136/jech-2025-225672
Tim A Bruckner, Brenda Bustos, Emtiaz Hritan, Samantha Gailey
Background: Bridging capital (ie, friendships across socioeconomic strata) increases upward economic mobility, yet its role in shaping health outcomes remains poorly understood. Evidence appears especially limited for low-income communities and populations experiencing disproportionate health risks. We examine the association between economic connectivity, a type of bridging capital, and perinatal health disparities. We used a recently released zip code level measure of bridging capital derived from Facebook data on more than 70 million US adults to examine the associations between social connectedness and fetal and infant death in California (8 million births; 2005 to 2021).
Methods: We used generalised estimating equations to test the association between the z-scored economic connectivity and the odds of fetal death and infant death. We used information on median household income in each zip code to focus on mothers residing in the lowest quartile neighbourhoods of income. We also examined non-Hispanic (NH) black mothers in low-income neighbourhoods given that they experience persistently elevated risks of perinatal mortality.
Results: We found strong protective associations (p<0.001) between bridging capital and fetal and infant death among residents of low-income areas (OR: 0.75, 95% CI 0.70 to 0.80 ; OR: 0.82, 95% CI 0.82 to 0.94). We also found strong protective associations when restricting to NH black persons only for fetal death (OR: 0.81, 95% CI 0.71 to 0.93) and infant death (OR: 0.79, 95% CI 0.70 to 0.90).
Conclusion: Cross-class social connections may play an important but underexamined role in promoting maternal and infant health, particularly within disadvantaged communities.
{"title":"Economic connectedness and fetal and infant death: a population-based cross-sectional study of California.","authors":"Tim A Bruckner, Brenda Bustos, Emtiaz Hritan, Samantha Gailey","doi":"10.1136/jech-2025-225672","DOIUrl":"https://doi.org/10.1136/jech-2025-225672","url":null,"abstract":"<p><strong>Background: </strong>Bridging capital (ie, friendships across socioeconomic strata) increases upward economic mobility, yet its role in shaping health outcomes remains poorly understood. Evidence appears especially limited for low-income communities and populations experiencing disproportionate health risks. We examine the association between economic connectivity, a type of bridging capital, and perinatal health disparities. We used a recently released zip code level measure of bridging capital derived from Facebook data on more than 70 million US adults to examine the associations between social connectedness and fetal and infant death in California (8 million births; 2005 to 2021).</p><p><strong>Methods: </strong>We used generalised estimating equations to test the association between the z-scored economic connectivity and the odds of fetal death and infant death. We used information on median household income in each zip code to focus on mothers residing in the lowest quartile neighbourhoods of income. We also examined non-Hispanic (NH) black mothers in low-income neighbourhoods given that they experience persistently elevated risks of perinatal mortality.</p><p><strong>Results: </strong>We found strong protective associations (p<0.001) between bridging capital and fetal and infant death among residents of low-income areas (OR: 0.75, 95% CI 0.70 to 0.80 ; OR: 0.82, 95% CI 0.82 to 0.94). We also found strong protective associations when restricting to NH black persons only for fetal death (OR: 0.81, 95% CI 0.71 to 0.93) and infant death (OR: 0.79, 95% CI 0.70 to 0.90).</p><p><strong>Conclusion: </strong>Cross-class social connections may play an important but underexamined role in promoting maternal and infant health, particularly within disadvantaged communities.</p>","PeriodicalId":54839,"journal":{"name":"Journal of Epidemiology and Community Health","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Socioeconomic inequalities in mortality persist across welfare systems. Income, a key determinant of material resources and long-term security, is rarely measured at the individual level in epidemiological studies due to data limitations. This study addresses this gap by combining individual-level income and mortality data in Italy, focusing on the elderly, for whom income may be a more sensitive socioeconomic indicator than education.
Methods: A nationwide retrospective cohort study was conducted on residents aged ≥65 years (n=12.8 million), as of 31 December 2018. Individual income for 2018 was obtained from administrative tax and social security data and integrated with 2019 mortality using national population registers. Mortality Rate Ratios (MRRs) with 95% CIs were estimated using negative binomial regression models, both age-adjusted and fully adjusted for marital status, education and geographic area. Analyses were stratified by sex.
Results: A clear income gradient in mortality was observed. Excess mortality gradually decreased across ascending income groups. In fully adjusted models, individuals in the lowest income class had significantly higher mortality than those in the highest (MRR=1.65, 95% CI 1.61 to 1.70 in men; MRR=1.47, 95% CI 1.43 to 1.50 in women). Education and marital status also influenced mortality, while geographic differences were minimal.
Conclusions: In Italy, substantial income-related inequalities in mortality persist among the older population, showing that socioeconomic disparities remain marked even with broad access to healthcare. Individual-level income is a key predictor of mortality and should be prioritised in addressing health inequalities in ageing societies, as it better reflects material conditions relevant to health than educational attainment.
背景:死亡率的社会经济不平等在福利制度中持续存在。收入是物质资源和长期安全的关键决定因素,但由于数据限制,在流行病学研究中很少在个人层面进行测量。本研究通过结合意大利的个人收入和死亡率数据来解决这一差距,重点关注老年人,对他们来说,收入可能是一个比教育更敏感的社会经济指标。方法:截至2018年12月31日,在全国范围内对年龄≥65岁的居民(n= 1280万)进行回顾性队列研究。2018年的个人收入来自行政税收和社会保障数据,并通过国家人口登记与2019年的死亡率相结合。使用负二项回归模型估计95% ci的死亡率比(MRRs),包括年龄调整和完全调整婚姻状况、教育程度和地理区域。分析按性别分层。结果:在死亡率上观察到明显的收入梯度。高收入群体的超额死亡率逐渐下降。在完全调整后的模型中,最低收入阶层的个体死亡率明显高于最高收入阶层(男性MRR=1.65, 95% CI 1.61至1.70;女性MRR=1.47, 95% CI 1.43至1.50)。教育和婚姻状况也影响死亡率,但地域差异很小。结论:在意大利,与收入有关的死亡率不平等现象在老年人口中持续存在,这表明即使享有广泛的医疗保健,社会经济差距仍然很明显。个人收入是死亡率的一个关键预测指标,在解决老龄化社会中的健康不平等问题时应优先考虑,因为它比受教育程度更能反映与健康有关的物质条件。
{"title":"Mortality by income in the elderly population in Italy: new evidence from an innovative microdata integration.","authors":"Nicolás Zengarini, Lucia Coppola, Enrico Grande, Isabella Siciliani, Marilena Pappagallo, Luisa Frova","doi":"10.1136/jech-2025-224857","DOIUrl":"10.1136/jech-2025-224857","url":null,"abstract":"<p><strong>Background: </strong>Socioeconomic inequalities in mortality persist across welfare systems. Income, a key determinant of material resources and long-term security, is rarely measured at the individual level in epidemiological studies due to data limitations. This study addresses this gap by combining individual-level income and mortality data in Italy, focusing on the elderly, for whom income may be a more sensitive socioeconomic indicator than education.</p><p><strong>Methods: </strong>A nationwide retrospective cohort study was conducted on residents aged ≥65 years (n=12.8 million), as of 31 December 2018. Individual income for 2018 was obtained from administrative tax and social security data and integrated with 2019 mortality using national population registers. Mortality Rate Ratios (MRRs) with 95% CIs were estimated using negative binomial regression models, both age-adjusted and fully adjusted for marital status, education and geographic area. Analyses were stratified by sex.</p><p><strong>Results: </strong>A clear income gradient in mortality was observed. Excess mortality gradually decreased across ascending income groups. In fully adjusted models, individuals in the lowest income class had significantly higher mortality than those in the highest (MRR=1.65, 95% CI 1.61 to 1.70 in men; MRR=1.47, 95% CI 1.43 to 1.50 in women). Education and marital status also influenced mortality, while geographic differences were minimal.</p><p><strong>Conclusions: </strong>In Italy, substantial income-related inequalities in mortality persist among the older population, showing that socioeconomic disparities remain marked even with broad access to healthcare. Individual-level income is a key predictor of mortality and should be prioritised in addressing health inequalities in ageing societies, as it better reflects material conditions relevant to health than educational attainment.</p>","PeriodicalId":54839,"journal":{"name":"Journal of Epidemiology and Community Health","volume":" ","pages":"281-286"},"PeriodicalIF":3.7,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-09DOI: 10.1136/jech-2025-224750
Paul N Zivich, Bonnie E Shook-Sa, Stephen R Cole, Eric T Lofgren, Jessie K Edwards
Introduction: Accounting for missing data by imputing or weighting conditional on covariates relies on the variable with missingness being observed at least some of the time for all unique covariate values. This requirement is referred to as positivity, and positivity violations can result in bias. Here, we review a novel approach to addressing positivity violations in the context of systolic blood pressure.
Methods: To illustrate the proposed approach, we estimate the mean systolic blood pressure among children and adolescents aged 2-17 years old in the USA using data from the 2017-2018 National Health and Nutrition Examination Survey (NHANES). As blood pressure was not measured for those aged 2-7, there exists a positivity violation by design. Using a recently proposed synthesis of statistical and mathematical models, we integrate external information with NHANES to address our motivating question.
Results: With the synthesis model, the estimated mean systolic blood pressure was 100.5 (95% CI 99.9 to 101.0), which is notably lower than either a complete-case analysis or extrapolation from a statistical model. The synthesis results were supported by a diagnostic comparing the performance of the mathematical model in the positive region.
Discussion: Positivity violations pose a threat to quantitative medical research, and standard approaches to addressing non-positivity rely on restrictive untestable assumptions. Using a synthesis model, like the one detailed here, offers a viable alternative.
通过对协变量的输入或加权条件来计算缺失数据依赖于对所有唯一协变量值至少在某些时间内观察到缺失的变量。这个要求被称为正性,违反正性会导致偏差。在这里,我们回顾了一种解决收缩压阳性侵犯的新方法。方法:为了说明所提出的方法,我们使用2017-2018年国家健康与营养检查调查(NHANES)的数据估计了美国2-17岁儿童和青少年的平均收缩压。由于没有测量2-7岁儿童的血压,因此存在故意的阳性违规。使用最近提出的综合统计和数学模型,我们将外部信息与NHANES相结合,以解决我们的激励问题。结果:综合模型估计的平均收缩压为100.5 (95% CI 99.9 ~ 101.0),明显低于全病例分析或统计模型外推的结果。综合结果得到了诊断的支持,比较了数学模型在正区域的性能。讨论:阳性违反对定量医学研究构成威胁,解决非阳性的标准方法依赖于限制性的不可检验的假设。使用综合模型,就像这里详细介绍的那样,提供了一个可行的替代方案。
{"title":"Accounting for missing data in public health research using a synthesis of statistical and mathematical models.","authors":"Paul N Zivich, Bonnie E Shook-Sa, Stephen R Cole, Eric T Lofgren, Jessie K Edwards","doi":"10.1136/jech-2025-224750","DOIUrl":"10.1136/jech-2025-224750","url":null,"abstract":"<p><strong>Introduction: </strong>Accounting for missing data by imputing or weighting conditional on covariates relies on the variable with missingness being observed at least some of the time for all unique covariate values. This requirement is referred to as positivity, and positivity violations can result in bias. Here, we review a novel approach to addressing positivity violations in the context of systolic blood pressure.</p><p><strong>Methods: </strong>To illustrate the proposed approach, we estimate the mean systolic blood pressure among children and adolescents aged 2-17 years old in the USA using data from the 2017-2018 National Health and Nutrition Examination Survey (NHANES). As blood pressure was not measured for those aged 2-7, there exists a positivity violation by design. Using a recently proposed synthesis of statistical and mathematical models, we integrate external information with NHANES to address our motivating question.</p><p><strong>Results: </strong>With the synthesis model, the estimated mean systolic blood pressure was 100.5 (95% CI 99.9 to 101.0), which is notably lower than either a complete-case analysis or extrapolation from a statistical model. The synthesis results were supported by a diagnostic comparing the performance of the mathematical model in the positive region.</p><p><strong>Discussion: </strong>Positivity violations pose a threat to quantitative medical research, and standard approaches to addressing non-positivity rely on restrictive untestable assumptions. Using a synthesis model, like the one detailed here, offers a viable alternative.</p>","PeriodicalId":54839,"journal":{"name":"Journal of Epidemiology and Community Health","volume":" ","pages":"352-356"},"PeriodicalIF":3.7,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7618619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-09DOI: 10.1136/jech-2024-222234
Juan Carlos Rivillas-Garcia, Eleanor Margaret Winpenny, Emilie Courtin, Rin Wada, Rachel Neil, Paolo Vineis
Background: Adverse childhood experiences (ACEs) are traumatic events that occur before a child reaches the age of 15 with long-term health consequences, economic costs and intergenerational challenges for society. This study investigated the association between ACEs and cardiometabolic risk (cardiovascular disease (CVD), diabetes, hypertension and obesity) in adulthood.
Methods: We used data from the Survey on Health, Well-Being and Ageing (SABE)-Colombia (n=18 044 adults aged >65). Exposures were defined as single and cumulative ACEs score. Logistic regression, adjusted for demographics and socioeconomic position, was used to investigate associations.
Results: 41.3% reported at least one ACE and 4.2% reported four or more. Associations between individual ACEs and outcomes differed by gender. In women, exposure to all ACEs, except childhood migration, was associated with increased odds of CVD, for example, emotional abuse (OR=1.69 (95% CI 1.32 to 2.13)) and poor childhood health status (OR=1.64 (95% CI 1.39 to 1.91)). Among men, these associations were much weaker and often non-statistically significant, except childhood migration that showed increased odds of CVD (OR=1.55 (95% CI 1.09 to 2.15), diabetes (OR=1.55 (95% CI 1.11 to 2.14)) and hypertension (OR=1.40 (95% CI 1.07 to 1.83) in adulthood). A significant association was observed between cumulative ACEs score and odds of CVD, diabetes and hypertension in both men and women. This pattern was not observed for obesity.
Conclusion: The long-term health consequences of ACEs differ by gender. Longitudinal studies are needed to establish causality and identify mediators. Public health interventions should adopt gender-sensitive, holistic approaches integrating biological, environmental, social and behavioural dimensions, and prioritise early-life interventions to address long-term health inequalities.
背景:童年不良经历(ace)是发生在儿童15岁之前的创伤性事件,具有长期健康后果、经济成本和对社会的代际挑战。本研究调查了ace与成年期心脏代谢风险(心血管疾病、糖尿病、高血压和肥胖)之间的关系。方法:我们使用来自哥伦比亚健康、福祉和老龄化调查(SABE)的数据(n= 18044名年龄在18至65岁之间的成年人)。暴露被定义为单次和累积的ace得分。采用Logistic回归,根据人口统计学和社会经济地位进行调整,以调查相关关系。结果:41.3%报告至少一次ACE, 4.2%报告四次或更多。个体ace与结果之间的关系因性别而异。在女性中,除了儿童期移民外,暴露于所有ace与CVD的几率增加有关,例如,情绪虐待(OR=1.69 (95% CI 1.32至2.13))和儿童健康状况不佳(OR=1.64 (95% CI 1.39至1.91))。在男性中,这些关联要弱得多,而且通常没有统计学意义,除了儿童期移民显示心血管疾病(OR=1.55 (95% CI 1.09至2.15),糖尿病(OR=1.55 (95% CI 1.11至2.14))和高血压(OR=1.40 (95% CI 1.07至1.83)在成年期增加的几率。在男性和女性中,累积ace评分与心血管疾病、糖尿病和高血压的发生率之间存在显著关联。这种模式在肥胖中没有观察到。结论:ace的长期健康后果因性别而异。需要进行纵向研究来确定因果关系并确定中介因素。公共卫生干预措施应采取对性别问题有敏感认识的整体办法,将生物、环境、社会和行为等方面结合起来,并优先考虑早期生活干预措施,以解决长期健康不平等问题。
{"title":"Associations between adverse childhood experiences and cardiometabolic health in later adulthood in Colombia.","authors":"Juan Carlos Rivillas-Garcia, Eleanor Margaret Winpenny, Emilie Courtin, Rin Wada, Rachel Neil, Paolo Vineis","doi":"10.1136/jech-2024-222234","DOIUrl":"10.1136/jech-2024-222234","url":null,"abstract":"<p><strong>Background: </strong>Adverse childhood experiences (ACEs) are traumatic events that occur before a child reaches the age of 15 with long-term health consequences, economic costs and intergenerational challenges for society. This study investigated the association between ACEs and cardiometabolic risk (cardiovascular disease (CVD), diabetes, hypertension and obesity) in adulthood.</p><p><strong>Methods: </strong>We used data from the Survey on Health, Well-Being and Ageing (SABE)-Colombia (n=18 044 adults aged >65). Exposures were defined as single and cumulative ACEs score. Logistic regression, adjusted for demographics and socioeconomic position, was used to investigate associations.</p><p><strong>Results: </strong>41.3% reported at least one ACE and 4.2% reported four or more. Associations between individual ACEs and outcomes differed by gender. In women, exposure to all ACEs, except childhood migration, was associated with increased odds of CVD, for example, emotional abuse (OR=1.69 (95% CI 1.32 to 2.13)) and poor childhood health status (OR=1.64 (95% CI 1.39 to 1.91)). Among men, these associations were much weaker and often non-statistically significant, except childhood migration that showed increased odds of CVD (OR=1.55 (95% CI 1.09 to 2.15), diabetes (OR=1.55 (95% CI 1.11 to 2.14)) and hypertension (OR=1.40 (95% CI 1.07 to 1.83) in adulthood). A significant association was observed between cumulative ACEs score and odds of CVD, diabetes and hypertension in both men and women. This pattern was not observed for obesity.</p><p><strong>Conclusion: </strong>The long-term health consequences of ACEs differ by gender. Longitudinal studies are needed to establish causality and identify mediators. Public health interventions should adopt gender-sensitive, holistic approaches integrating biological, environmental, social and behavioural dimensions, and prioritise early-life interventions to address long-term health inequalities.</p>","PeriodicalId":54839,"journal":{"name":"Journal of Epidemiology and Community Health","volume":" ","pages":"301-308"},"PeriodicalIF":3.7,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145716875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-09DOI: 10.1136/jech-2025-224112
Timo T Hugg, Janne Lehto, Jouni J K Jaakkola, Simo-Pekka Kiihamäki, Matti Koivuranta, Sanna Pätsi, Annika Saarto, Marko Korhonen
Background: Little is known about the association between direct pollen exposure and cognitive performance. The aim of our study is to investigate the effect of pollen exposure on performance in the Finnish matriculation examination.
Methods: The study was conducted among students who participated in the national high school matriculation examinations in the metropolitan area of Helsinki and Turku in southern Finland between 2006 and 2020. Daily regional pollen counts of alder and hazel were monitored throughout the study period as part of the Finnish pollen monitoring network. Extensive data on matriculation examination results were retrieved from Statistics Finland, and air pollution and weather data from the Finnish Meteorological Institute. A fixed effect regression analysis was used to identify the effect of pollen exposure (as independent variables) on matriculation examination results (as dependent variable) controlling for student-semester fixed effects, pollutants and precipitation.
Results: The regression coefficients indicated that on average an increase of 10 pollen grains in alder and hazel reduced the matriculation examination score by 0.0034 (p<0.01) and 0.0144 (p<0.05) standard deviations (SDs), respectively. Increasing pollen exposure per additional unit (an increase of 10 pollen grains) especially dropped examination scores in mathematical subjects among males (alder -0.0118 (p<0.001) and hazel -0.0328 (p<0.05) SDs). The association between alder pollen exposure (low, moderate and abundant) and examination scores was inversely U-shaped.
Conclusion: Exposure to pollen can hinder a student's performance in the matriculation exam, which strongly determines the future opportunities and emphasises early initiation of medication.
{"title":"Pollen exposure and matriculation exam performance among students in Finland.","authors":"Timo T Hugg, Janne Lehto, Jouni J K Jaakkola, Simo-Pekka Kiihamäki, Matti Koivuranta, Sanna Pätsi, Annika Saarto, Marko Korhonen","doi":"10.1136/jech-2025-224112","DOIUrl":"10.1136/jech-2025-224112","url":null,"abstract":"<p><strong>Background: </strong>Little is known about the association between direct pollen exposure and cognitive performance. The aim of our study is to investigate the effect of pollen exposure on performance in the Finnish matriculation examination.</p><p><strong>Methods: </strong>The study was conducted among students who participated in the national high school matriculation examinations in the metropolitan area of Helsinki and Turku in southern Finland between 2006 and 2020. Daily regional pollen counts of alder and hazel were monitored throughout the study period as part of the Finnish pollen monitoring network. Extensive data on matriculation examination results were retrieved from Statistics Finland, and air pollution and weather data from the Finnish Meteorological Institute. A fixed effect regression analysis was used to identify the effect of pollen exposure (as independent variables) on matriculation examination results (as dependent variable) controlling for student-semester fixed effects, pollutants and precipitation.</p><p><strong>Results: </strong>The regression coefficients indicated that on average an increase of 10 pollen grains in alder and hazel reduced the matriculation examination score by 0.0034 (p<0.01) and 0.0144 (p<0.05) standard deviations (SDs), respectively. Increasing pollen exposure per additional unit (an increase of 10 pollen grains) especially dropped examination scores in mathematical subjects among males (alder -0.0118 (p<0.001) and hazel -0.0328 (p<0.05) SDs). The association between alder pollen exposure (low, moderate and abundant) and examination scores was inversely U-shaped.</p><p><strong>Conclusion: </strong>Exposure to pollen can hinder a student's performance in the matriculation exam, which strongly determines the future opportunities and emphasises early initiation of medication.</p>","PeriodicalId":54839,"journal":{"name":"Journal of Epidemiology and Community Health","volume":" ","pages":"287-293"},"PeriodicalIF":3.7,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Early cardiovascular disease risk detection opportunities are limited in men, whereas gestational diabetes, gestational hypertension and preeclampsia are risk indicators in women. We hypothesised adverse pregnancy outcomes also signal risk in fathers, due to shared environments and behaviours.
Methods: Our retrospective cohort study included fathers whose female partners had at least two singleton deliveries between April 1990 and December 2012. We examined population-based data up to April 2019 from Quebec province, Canada (health administrative databases, birth, stillbirth and death registries). The primary exposure was cumulative gestational diabetes, gestational hypertension and preeclampsia occurrences across two pregnancies. Outcomes were new diagnoses of diabetes, hypertension and cardiovascular disease in fathers, analysed using Cox proportional hazards models.
Results: Among 415 730 fathers, 17 065 developed diabetes, 44 315 developed hypertension and 9695 experienced a cardiovascular disease event over more than a decade. Compared with no gestational diabetes or gestational hypertension/preeclampsia occurrences in partners, the hazards of diabetes in fathers increased by 21% with a single occurrence (HR 1.21, 95% CI 1.16 to 1.26), 40% with two (HR 1.40, 95% CI 1.30 to 1.50) and 84% with three or more (HR 1.84, 95% CI 1.54 to 2.21). Corresponding increases in hypertension hazards were 11% (HR 1.11, 95% CI 1.08 to 1.14), 17% (HR 1.17, 95% CI 1.12 to 1.23) and 39% (HR 1.39, 95% CI 1.22 to 1.58), respectively. Cardiovascular disease hazards increased by 15% with two or more occurrences (HR 1.15, 95% CI 1.04 to 1.27).
Conclusion: More maternal adverse pregnancy outcomes lead to greater paternal cardiometabolic disease hazards. Partner pregnancy history may help identify at-risk men to support early prevention.
背景:男性早期心血管疾病风险检测机会有限,而妊娠糖尿病、妊娠高血压和先兆子痫是女性的风险指标。我们假设,由于共同的环境和行为,不良妊娠结果也表明父亲有风险。方法:我们的回顾性队列研究纳入了1990年4月至2012年12月期间女性伴侣至少有两次单胎分娩的父亲。我们检查了截至2019年4月来自加拿大魁北克省的基于人群的数据(卫生行政数据库、出生、死产和死亡登记处)。主要暴露是两次妊娠期间累积妊娠糖尿病、妊娠高血压和先兆子痫的发生。结果是父亲中新诊断的糖尿病、高血压和心血管疾病,使用Cox比例风险模型进行分析。结果:在415730名父亲中,17065名患有糖尿病,44315名患有高血压,9695名在10年以上发生过心血管疾病。与无妊娠期糖尿病或妊娠期高血压/先兆子痫的伴侣相比,父亲患糖尿病的风险在单次发生时增加21% (HR 1.21, 95% CI 1.16至1.26),两次发生时增加40% (HR 1.40, 95% CI 1.30至1.50),三次或以上发生时增加84% (HR 1.84, 95% CI 1.54至2.21)。相应的高血压风险增加分别为11% (HR 1.11, 95% CI 1.08 ~ 1.14)、17% (HR 1.17, 95% CI 1.12 ~ 1.23)和39% (HR 1.39, 95% CI 1.22 ~ 1.58)。发生两次或两次以上心血管疾病的风险增加15% (HR 1.15, 95% CI 1.04 - 1.27)。结论:母亲不良妊娠结局越多,父亲患心脏代谢疾病的风险越大。伴侣的怀孕史可能有助于识别有风险的男性,从而支持早期预防。
{"title":"Associations of pregnancy complications with paternal cardiovascular risk: a retrospective cohort study.","authors":"Joseph Mussa, Lingsheng Wen, Mona Sharafi, Jean-Philippe Gouin, Elham Rahme, Kaberi Dasgupta","doi":"10.1136/jech-2025-224673","DOIUrl":"10.1136/jech-2025-224673","url":null,"abstract":"<p><strong>Background: </strong>Early cardiovascular disease risk detection opportunities are limited in men, whereas gestational diabetes, gestational hypertension and preeclampsia are risk indicators in women. We hypothesised adverse pregnancy outcomes also signal risk in fathers, due to shared environments and behaviours.</p><p><strong>Methods: </strong>Our retrospective cohort study included fathers whose female partners had at least two singleton deliveries between April 1990 and December 2012. We examined population-based data up to April 2019 from Quebec province, Canada (health administrative databases, birth, stillbirth and death registries). The primary exposure was cumulative gestational diabetes, gestational hypertension and preeclampsia occurrences across two pregnancies. Outcomes were new diagnoses of diabetes, hypertension and cardiovascular disease in fathers, analysed using Cox proportional hazards models.</p><p><strong>Results: </strong>Among 415 730 fathers, 17 065 developed diabetes, 44 315 developed hypertension and 9695 experienced a cardiovascular disease event over more than a decade. Compared with no gestational diabetes or gestational hypertension/preeclampsia occurrences in partners, the hazards of diabetes in fathers increased by 21% with a single occurrence (HR 1.21, 95% CI 1.16 to 1.26), 40% with two (HR 1.40, 95% CI 1.30 to 1.50) and 84% with three or more (HR 1.84, 95% CI 1.54 to 2.21). Corresponding increases in hypertension hazards were 11% (HR 1.11, 95% CI 1.08 to 1.14), 17% (HR 1.17, 95% CI 1.12 to 1.23) and 39% (HR 1.39, 95% CI 1.22 to 1.58), respectively. Cardiovascular disease hazards increased by 15% with two or more occurrences (HR 1.15, 95% CI 1.04 to 1.27).</p><p><strong>Conclusion: </strong>More maternal adverse pregnancy outcomes lead to greater paternal cardiometabolic disease hazards. Partner pregnancy history may help identify at-risk men to support early prevention.</p>","PeriodicalId":54839,"journal":{"name":"Journal of Epidemiology and Community Health","volume":" ","pages":"334-342"},"PeriodicalIF":3.7,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-09DOI: 10.1136/jech-2025-223917
Sungchul Park, Jiani Yu, Hye-Young Jung
Background: Telehealth has become a critical tool for improving access to care among populations facing physical barriers to in-person care. However, its potential role in delivering care to adults with social barriers remains underexplored. We examined whether adults with loneliness or social isolation are more likely to use telehealth care versus in-person care compared to adults without loneliness or social isolation.
Methods: This cross-sectional study analysed data for US adults in the 2021 Medical Expenditure Panel Survey. Loneliness and social isolation were measured using the UCLA Loneliness Scale and the Berkman-Syme Social Network Index. Three indicators of healthcare utilisation were used as outcomes: in-person care only, telehealth care only and a combination of both.
Results: Among adults experiencing loneliness and social isolation, the likelihood of using only in-person care was lower by 4.1 (95% CI -6.1 to -2.1) and 2.8 (95% CI -5 to -0.6) percentage points. In contrast, the likelihood of using only telehealth care was higher by 2.6 (1.1-4.2) and 5.4 (3.9-6.9). The likelihood of using both in-person and telehealth care was also higher by 2.3 (0.7-3.9) and 5.2 (3.7-6.7), but telehealth was used more frequently than in-person care. Furthermore, telehealth utilisation for mental health services was higher among adults experiencing loneliness or social isolation.
Conclusion: Compared with adults who are not lonely or socially isolated, adults experiencing loneliness and social isolation are more likely to use telehealth and less likely to use in-person care. Telehealth may serve as a viable alternative for individuals facing social challenges in accessing in-person services.
背景:远程医疗已成为改善面临面对面护理物理障碍的人群获得护理的关键工具。然而,它在为有社会障碍的成年人提供护理方面的潜在作用仍未得到充分探索。我们研究了与没有孤独或社会隔离的成年人相比,孤独或社会隔离的成年人是否更有可能使用远程医疗服务而不是面对面护理。方法:本横断面研究分析了2021年医疗支出小组调查中美国成年人的数据。孤独感和社会隔离使用加州大学洛杉矶分校孤独感量表和伯克曼-赛姆社会网络指数进行测量。医疗保健利用的三个指标被用作结果:仅现场护理、仅远程保健以及两者的结合。结果:在经历孤独和社会隔离的成年人中,仅使用面对面护理的可能性降低了4.1 (95% CI -6.1至-2.1)和2.8 (95% CI -5至-0.6)个百分点。相比之下,仅使用远程保健的可能性高出2.6(1.1-4.2)和5.4(3.9-6.9)。同时使用现场医疗和远程医疗的可能性分别为2.3(0.7-3.9)和5.2(3.7-6.7),但使用远程医疗的频率高于现场医疗。此外,在感到孤独或社会孤立的成年人中,远程保健对心理健康服务的利用程度较高。结论:与没有孤独或社会孤立的成年人相比,经历孤独和社会孤立的成年人更倾向于使用远程医疗,而不太可能使用面对面护理。对于在获得面对面服务方面面临社会挑战的个人来说,远程保健可以作为一种可行的替代方案。
{"title":"Utilisation of in-person and telehealth care among US adults with loneliness and social isolation.","authors":"Sungchul Park, Jiani Yu, Hye-Young Jung","doi":"10.1136/jech-2025-223917","DOIUrl":"10.1136/jech-2025-223917","url":null,"abstract":"<p><strong>Background: </strong>Telehealth has become a critical tool for improving access to care among populations facing physical barriers to in-person care. However, its potential role in delivering care to adults with social barriers remains underexplored. We examined whether adults with loneliness or social isolation are more likely to use telehealth care versus in-person care compared to adults without loneliness or social isolation.</p><p><strong>Methods: </strong>This cross-sectional study analysed data for US adults in the 2021 Medical Expenditure Panel Survey. Loneliness and social isolation were measured using the UCLA Loneliness Scale and the Berkman-Syme Social Network Index. Three indicators of healthcare utilisation were used as outcomes: in-person care only, telehealth care only and a combination of both.</p><p><strong>Results: </strong>Among adults experiencing loneliness and social isolation, the likelihood of using only in-person care was lower by 4.1 (95% CI -6.1 to -2.1) and 2.8 (95% CI -5 to -0.6) percentage points. In contrast, the likelihood of using only telehealth care was higher by 2.6 (1.1-4.2) and 5.4 (3.9-6.9). The likelihood of using both in-person and telehealth care was also higher by 2.3 (0.7-3.9) and 5.2 (3.7-6.7), but telehealth was used more frequently than in-person care. Furthermore, telehealth utilisation for mental health services was higher among adults experiencing loneliness or social isolation.</p><p><strong>Conclusion: </strong>Compared with adults who are not lonely or socially isolated, adults experiencing loneliness and social isolation are more likely to use telehealth and less likely to use in-person care. Telehealth may serve as a viable alternative for individuals facing social challenges in accessing in-person services.</p>","PeriodicalId":54839,"journal":{"name":"Journal of Epidemiology and Community Health","volume":" ","pages":"316-319"},"PeriodicalIF":3.7,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}