Hellenic Journal of Cardiology最新文献

英文中文

Comparative outcomes of aortic root preservation versus root replacement for acute type A aortic dissection: balancing survival, durability, and reoperation 急性A型主动脉夹层主动脉根保留与根置换的比较结果：平衡生存、耐久性和再手术。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Hellenic Journal of Cardiology

Pub Date : 2025-11-01 Epub Date: 2025-06-06 DOI: 10.1016/j.hjc.2025.05.008

Dimitrios E. Magouliotis , Serge Sicouri , Massimo Baudo , Francesco Cabrucci , Yoshiyuki Yamashita , Basel Ramlawi

Objective

We reviewed the available literature on patients undergoing aortic repair for acute type A aortic dissection (ATAAD) with either aortic root preservation (RP) or root replacement (RR).

Methods

Original research studies that evaluated the long-term outcomes of the RP versus RR group were identified from 2000 to 2025. Median overall survival (OS) was the primary endpoint. Reoperation-free OS was the secondary endpoint. Sensitivity analyses were performed including risk-adjusted populations, subgroups, and using the leave-one-out method.

Results

Seventeen studies were included in the qualitative and quantitative synthesis, incorporating data from 7569 patients with a follow-up period of up to 25 years. According to our analysis, RP (4266 patients) demonstrated higher OS compared to RR (2589 patients) groups (HR: 0.83; 95% CI:0.76, 0.91; p < 0.01). The median OS was 13.57 years for the RP group and 13.48 years for the RR group. Nonetheless, the reoperation-free OS was higher in the RR group (HR: 1.39; 95% CI: 1.16, 1.67; p < 0.01). Valve-sparing RR (VSRR) demonstrated the highest long-term OS (p < 0.05).

Conclusion

RP is associated with superior OS but a higher risk of reoperation, while RR offers greater durability with fewer reoperations, and VSRR may provide the optimal balance of longevity and native valve preservation, warranting further prospective studies.

目的：我们回顾了急性A型主动脉夹层（ATAAD）患者行主动脉修复术(主动脉根保留（RP）或主动脉根置换（RR）的现有文献。方法：从2000年到2025年，对RP组与RR组的长期结果进行了评估的原始研究。中位总生存期（OS）是主要终点。无再手术OS是次要终点。进行敏感性分析，包括风险调整人群、亚组，并使用留一法。结果：定性和定量综合纳入了17项研究，纳入了7,569例患者的数据，随访时间长达25年。根据我们的分析，RP组（4266例）比RR组（2589例）表现出更高的OS (HR: 0.83；95% ci:0.76, 0.91；结论：根保存术总体生存率更高，但再手术风险更高，而根置换术可减少再手术次数，提供更大的耐久性，VSRR可能提供寿命和天然瓣膜保存的最佳平衡，值得进一步的前瞻性研究。

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引用次数: 0

Impact of the COVID-19 pandemic on CTO PCI: analysis from the PROGRESS-CTO registry COVID-19 大流行对 CTO PCI 的影响：PROGRESS-CTO 登记的分析。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Hellenic Journal of Cardiology

Pub Date : 2025-11-01 Epub Date: 2024-11-23 DOI: 10.1016/j.hjc.2024.11.005

Dimitrios Strepkos , Michaella Alexandrou , Deniz Mutlu , Pedro E.P. Carvalho , Ali Bahbah , James W. Choi , Sevket Gorgulu , Farouc A. Jaffer , Raj Chandwaney , Khaldoon Alaswad , Mir B. Basir , Lorenzo Azzalini , Bavana V. Rangan , Olga C. Mastrodemos , Konstantinos Voudris , Ahmed Al-Ogaili , M. Nicholas Burke , Yader Sandoval , Emmanouil S. Brilakis , Luiz F. Ybarra , Ahmed Elguindy

引用次数: 0

The burden of cardiovascular disease and related risk factors in Greece: the ATTICA epidemiological study (2002–2022) 希腊心血管疾病负担及相关风险因素；ATTICA 流行病学研究（2002-2022 年）。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Hellenic Journal of Cardiology

Pub Date : 2025-11-01 Epub Date: 2024-05-10 DOI: 10.1016/j.hjc.2024.05.009

Demosthenes Panagiotakos , Evangelia G. Sigala , Evangelia Damigou , Asimina Loukina , Dimitriοs Dalmyras , Georgios Mentzantonakis , Fotios Barkas , Petros S. Adamidis , Evrydiki Kravvariti , Evangelos Liberopoulos , Petros P. Sfikakis , Costas Tsioufis , Christos Pitsavos , Christina Chrysohoou

Objective

The aim of this study was to present the burden of cardiovascular disease (CVD) and its related risk factors based on a 20-year observation period (2002–2022).

Methods

In 2002, 3042 Greek adults (aged: 45 (12) years) free of CVD, cancer, or any other chronic infections were enrolled. In 2022, the 20-year follow-up was performed on 2169 participants (1988 had complete data for CVD). Lifetime risk for CVDs and disability-adjusted-life-years (DALYs) lost were also calculated.

Results

The 20-year CVD incidence was 3600 cases/10,000 individuals (man-to-woman ratio 5:4). At the index age of 40 years, the lifetime risk for developing CVD was 68% for men and 63% for women; as the participants were getting older, the lifetime risk declined by approximately 19% and 13% for men and women, respectively, but remained at high levels, reaching 55% for both sexes. Participants between 45 and 55 years exhibited the highest CVD burden concerning aggregated DALYs. The burden was greater in men than in women, at ages below 35 years; beyond this age threshold, this trend shifted, and women exhibited a higher CVD burden.

Conclusion

The burden of CVD in Greece has shown increasing trends over the past 20 years as a result of the accumulative growth of the prevalence of modifiable CVD risk factors. The disability-adjusted life-years lost are the most observed ever before, urging for efficient public health strategies and measures.

目的：本研究旨在根据 20 年的观察期（2002-2022 年）介绍心血管疾病（CVD）的负担及其相关风险因素：方法：2002 年，3,042 名希腊成年人（年龄为方法：2002 年，3,042 名无心血管疾病、癌症或任何其他慢性感染的希腊成年人（年龄：45 (12)岁）接受了调查。2022 年，对 2,169 名参与者（1,988 人有完整的心血管疾病数据）进行了为期 20 年的随访。同时还计算了心血管疾病的终生风险和残疾调整寿命损失年数（DALYs）：结果：20 年的心血管疾病发病率为 3,600 例/10,000 人（男女比例为 5:4）。随着年龄的增长，男性和女性终生罹患心血管疾病的风险分别下降了约 19% 和 13%，但仍保持在较高水平，男性和女性均达到 55%。45-55 岁的参与者的心血管疾病负担（DALYs）总和最高。在35岁以下的年龄段，男性的心血管疾病负担大于女性；超过这个年龄段后，这一趋势发生了变化，女性的心血管疾病负担更高：结论：在过去的20年中，由于可改变的心血管疾病风险因素发病率的累积增长，希腊的心血管疾病负担呈上升趋势。根据残疾调整寿命年数计算，希腊的心血管疾病造成的损失是有史以来最大的，因此需要采取有效的公共卫生战略和措施。

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引用次数: 0

Prognostic impact of shock in patients with type A acute aortic syndrome. Results of a nationwide multicenter study A 型急性主动脉综合征患者休克的预后影响。全国多中心研究结果。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Hellenic Journal of Cardiology

Pub Date : 2025-11-01 Epub Date: 2024-05-09 DOI: 10.1016/j.hjc.2024.05.005

Carlos Ferrera , Isidre Vilacosta , José F. Rodríguez Palomares , Francisco Calvo Iglesias , Antonio J. Barros-Membrilla , Manel Azqueta Molluna , Víctor Mosquera , Rubén Tarrío , Ana Revilla Orodea , David Toral Sepúlveda , Inés Ramos González-Cristóbal , Luis Maroto Castellanos , Augusto Sao , Artur Evangelista

Objective

To evaluate the clinical characteristics, imaging findings, treatment, and prognosis of patients with type A acute aortic syndrome (AAS-A) presenting with shock. To assess the impact of surgery on this patient population.

Methods

The study included 521 patients with A-AAS enrolled in the Spanish Registry of Acute Aortic Syndrome (RESA-III) from January 2018 to December 2019. The RESA-III is a prospective, multicenter registry that contains AAS data from 30 tertiary-care hospitals. Patients were classified into two groups according to their clinical presentation, with or without shock. Shock was defined as persistent systolic blood pressure <80 mmHg despite adequate volume resuscitation.

Results

97 (18.6%) patients with A-AAS presented with shock. Clinical presentation with syncope was much more common in the Shock group (45.4% vs 10.1%, p = 0.001). Patients in the Shock group had more complications at diagnosis and before surgery: cardiac tamponade (36.2% vs 9%, p < 0.001), acute renal failure (28.9% vs 18.2%, p = 0.018), and need for orotracheal intubation (40% vs 9.1%, p < 0.001). There were no significant differences in aortic regurgitation (51.6% vs 46.7%, p = 0.396) between groups. In-hospital mortality was higher among patients with shock (48.5% vs 27.4%, p < 0.001). Surgery was associated with a significant mortality reduction both in patients with and without shock. Surgery had an independent protective effect on mortality (OR 0.03, 95% CI (0.00–0.32)).

Conclusion

Patients with AAS-A admitted with shock have a heavily increased risk of mortality. Syncope and pericardial effusion at diagnosis are strongly associated with shock. Surgery was independently associated with a mortality reduction in patients with AAS-A and shock.

目的评估出现休克的A型急性主动脉综合征（AAS-A）患者的临床特征、影像学检查结果、治疗和预后。评估手术对这类患者的影响：研究纳入了 2018 年 1 月至 2019 年 12 月期间在西班牙急性主动脉综合征登记处（RESA-III）登记的 521 名 A-AAS 患者。RESA-III是一个前瞻性多中心登记系统，包含来自30家三级医院的AAS数据。患者根据临床表现分为有休克和无休克两组。休克的定义是收缩压持续升高：97名（18.6%）A-AAS患者出现休克。休克组中出现晕厥的临床表现更为常见（45.4% 对 10.1%，P=0.001）。休克组患者在诊断时和手术前出现更多并发症：心脏填塞（36.2% 对 9%，P=0.001）：因休克入院的 AAS-A 患者的死亡风险大大增加。诊断时的晕厥和心包积液与休克密切相关。手术治疗与降低 AAS-A 和休克患者的死亡率密切相关。

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引用次数: 0

Baseline right ventricular-to-pulmonary artery coupling and outcomes after transcatheter aortic valve replacement: a systematic review and meta-analysis 经导管主动脉瓣置换术后基线右心室-肺动脉耦合和结果：一项系统回顾和荟萃分析。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Hellenic Journal of Cardiology

Pub Date : 2025-11-01 Epub Date: 2025-04-17 DOI: 10.1016/j.hjc.2025.04.003

Panagiotis Theofilis , Athanasios Sakalidis , Panayotis K. Vlachakis , Emmanouil Mantzouranis , Paschalis Karakasis , Konstantinos Pamporis , Sotirios Dardas , Evangelos Oikonomou , Maria Drakopoulou , Kyriakos Dimitriadis , Konstantina Aggeli , Konstantinos Tsioufis , Dimitris Tousoulis

引用次数: 0

Dietary habits among 177,091 Greek schoolchildren by age, sex, weight status, region, and living area. A cross-sectional study 按年龄、性别、体重状况、地区和居住区分列的 177 091 名希腊学童的饮食习惯。横断面研究

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Hellenic Journal of Cardiology

Pub Date : 2025-09-01 Epub Date: 2024-04-16 DOI: 10.1016/j.hjc.2024.04.004

Konstantinos D. Tambalis , Demosthenes B. Panagiotakos , Labros S. Sidossis

Background

This study aimed to investigate the dietary habits from early childhood to adolescence among participants from all regions of the country and living areas (rural/urban) and assess potential associations between dietary habits and obesity in both sexes.

Methods

Population data were derived from a cross-sectional health survey on a representative sample of 177,091 children aged 6–18 years. Dietary habits were considered via a self-completed questionnaire (Mediterranean diet quality index for children and adolescents [KIDMED]). Trained investigators assessed the anthropometric data.

Results

KIDMED scores were 6.7 ± 2.4 and 6.8 ± 2.3 for boys and girls, respectively, whereas a percentage of almost 10% of the total study population had insufficient dietary habits. Dietary habits peaked around age 11 years and then gradually worsened until the end of adolescence in both sexes, with an annual trend equal to −0.28 ± 0.02 (p < 0.001) for boys and −0.31 ± 0.03 (p < 0.001) for girls. Schoolchildren who are overweight/obese presented higher percentages in all unhealthy dietary habits (e.g., skipping breakfast, going often to a fast food restaurant, and consuming a lot of sweets) than children with a normal weight (all p-values < 0.001). Dietary habits did not noteworthy differ by area of living, that is, urban versus rural, of participants in both sexes. In addition, no noticeable differences in the values of the KIDMED index were found among all regions of Greece, with the highest values in Attica and Crete in both sexes.

Conclusions

Because Greek schoolchildren do not fully adopt the traditional cardio-protective Mediterranean diet, it could be helpful to provide certain recommendations, especially for adolescents, to decrease the risk for future adverse health consequences.

本研究旨在调查来自全国各地区和生活区（农村/城市）的参与者从幼儿期到青春期的饮食习惯，并评估饮食习惯与男女肥胖之间的潜在关联。人口数据来自于对 177,091 名 6-18 岁儿童的代表性样本进行的横断面健康调查。饮食习惯通过自填问卷（儿童和青少年地中海饮食质量指数 [KIDMED]）进行考量。训练有素的调查人员对人体测量数据进行了评估。男童和女童的 KIDMED 分数分别为 6.7 ± 2.4 和 6.8 ± 2.3，而饮食习惯不良者占研究总人数的近 10%。男女学生的饮食习惯在 11 岁左右达到高峰，然后逐渐恶化，直至青春期结束，男生的年趋势为-0.28 ± 0.02（p < 0.001），女生为-0.31 ± 0.03（p < 0.001）。与体重正常的儿童相比，超重/肥胖的学龄儿童在所有不健康饮食习惯（如不吃早餐、经常去快餐店和吃大量甜食）方面的比例都更高（所有 p 值均小于 0.001）。男女参与者的饮食习惯并没有因居住地区（即城市和农村）的不同而产生显著差异。此外，希腊各地区的 KIDMED 指数值也没有明显差异，其中阿提卡和克里特岛的男女生指数值最高。由于希腊学童并不完全采用传统的保护心血管的地中海饮食，因此提供一些建议（尤其是针对青少年）可能会有所帮助，从而降低未来对健康造成不良影响的风险。

{"title":"Dietary habits among 177,091 Greek schoolchildren by age, sex, weight status, region, and living area. A cross-sectional study","authors":"Konstantinos D. Tambalis , Demosthenes B. Panagiotakos , Labros S. Sidossis","doi":"10.1016/j.hjc.2024.04.004","DOIUrl":"10.1016/j.hjc.2024.04.004","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the dietary habits from early childhood to adolescence among participants from all regions of the country and living areas (rural/urban) and assess potential associations between dietary habits and obesity in both sexes.</div></div><div><h3>Methods</h3><div>Population data were derived from a cross-sectional health survey on a representative sample of 177,091 children aged 6–18 years. Dietary habits were considered via a self-completed questionnaire (Mediterranean diet quality index for children and adolescents [KIDMED]). Trained investigators assessed the anthropometric data.</div></div><div><h3>Results</h3><div>KIDMED scores were 6.7 ± 2.4 and 6.8 ± 2.3 for boys and girls, respectively, whereas a percentage of almost 10% of the total study population had insufficient dietary habits. Dietary habits peaked around age 11 years and then gradually worsened until the end of adolescence in both sexes, with an annual trend equal to −0.28 ± 0.02 (p < 0.001) for boys and −0.31 ± 0.03 (p < 0.001) for girls. Schoolchildren who are overweight/obese presented higher percentages in all unhealthy dietary habits (e.g., skipping breakfast, going often to a fast food restaurant, and consuming a lot of sweets) than children with a normal weight (all p-values < 0.001). Dietary habits did not noteworthy differ by area of living, that is, urban versus rural, of participants in both sexes. In addition, no noticeable differences in the values of the KIDMED index were found among all regions of Greece, with the highest values in Attica and Crete in both sexes.</div></div><div><h3>Conclusions</h3><div>Because Greek schoolchildren do not fully adopt the traditional cardio-protective Mediterranean diet, it could be helpful to provide certain recommendations, especially for adolescents, to decrease the risk for future adverse health consequences.</div></div>","PeriodicalId":55062,"journal":{"name":"Hellenic Journal of Cardiology","volume":"85 ","pages":"Pages 3-11"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140830483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the effectiveness of the latest 4th-generation cryoballoon catheters in pulmonary vein isolation using high-resolution mapping 利用高分辨率绘图分析最新第四代冷冻气球导管在肺静脉隔离中的有效性

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Hellenic Journal of Cardiology

Pub Date : 2025-09-01 Epub Date: 2024-04-23 DOI: 10.1016/j.hjc.2024.04.006

Charis Gkalapis , Konstantinos Vlachos , Marios Papadakis , Nikonas Pavleros , Hans-Jörg Hippe , Karim Benali , George Bazoukis , Konstantinos P. Letsas , Antonio Frontera , Pierre Jais , Michael Gotzmann

Background

Long-term data showed that up to 27% of pulmonary veins are reconnected using cryoballoon ablation. This study aimed to evaluate the efficacy of the latest 4th-generation cryoballoon catheters using ultra high-resolution mapping.

Methods

In patients with atrial fibrillation, a standard pulmonary vein isolation (PVI) with the latest 4th-generation cryoballoon catheter (Arctic Front Advance PRO, Medtronic Minneapolis, USA) and the spiral mapping catheter (Achieve Advance, Medtronic, Minneapolis, MN, USA) was performed. Subsequently, high-resolution mapping was achieved using the novel multipolar grid mapping catheter (Advisor HD Grid SE, Abbott Laboratories, USA). Follow-up was obtained after 6 months by means of a 7-day Holter electrocardiogram.

Results

In our study, acute PVI was successfully achieved in all 31 patients. The latest 4th-generation cryoballoon catheter is safe in the acute phase of PVI. Additional high-resolution mapping (mean points per map 21,001 ± 4911) using the multipolar grid mapping catheter enabled us to identify residual gaps only in the carina pulmonary vein region; therefore, no additional ablation was performed. Three of 31 patients (10%) presented with atrial arrhythmia recurrence always related with pulmonary vein reconnection; using high-resolution mapping had no additional benefit in identifying pulmonary veins in which reconnection will occur.

Conclusion

The utility of additional high-density mapping, facilitated by the HD Grid catheter after PVI with the 4th-generation cryoballoon catheter do not substantiate a discernible advantage over conventional mapping methodologies, particularly, the spiral mapping catheter. Residual carinal conduction was observed in a substantial cohort of patients (48%), highlighting a persistent challenge in achieving complete electrical isolation.

长期数据显示，使用冷冻气球消融术重新连接肺静脉的比例高达 27%。这项研究旨在利用超高分辨率绘图评估最新第四代冷冻气球导管的疗效。在心房颤动患者中，使用最新的第四代冷冻气球导管（Arctic Front Advance PRO，美敦力公司，美国明尼阿波利斯）和螺旋绘图导管（Achieve Advance，美敦力公司，美国明尼阿波利斯）进行了标准的肺静脉隔离（PVI）。随后，使用新型多极网格映射导管（Advisor HD Grid SE，美国雅培实验室）实现了高分辨率映射。6 个月后通过 7 天 Holter 心电图进行随访。在我们的研究中，所有 31 名患者都成功实施了急性 PVI。最新的第四代冷冻气球导管在急性 PVI 阶段是安全的。使用多极网格映射导管进行的额外高分辨率映射（每幅映射图的平均点数为 21,001 ± 4911）使我们仅在心肺静脉区域发现了残余间隙，因此没有进行额外的消融。31 例患者中有 3 例（10%）房性心律失常复发总是与肺静脉再连接有关；使用高分辨率绘图在确定将发生再连接的肺静脉方面没有额外的益处。在使用第四代冷冻球囊导管进行 PVI 后，使用 HD Grid 导管进行额外的高密度测绘，与传统的测绘方法（尤其是螺旋测绘导管）相比，并没有明显的优势。在相当一部分患者（48%）中观察到了残余心端传导，这凸显了实现完全电隔离的长期挑战。

{"title":"Analysis of the effectiveness of the latest 4th-generation cryoballoon catheters in pulmonary vein isolation using high-resolution mapping","authors":"Charis Gkalapis , Konstantinos Vlachos , Marios Papadakis , Nikonas Pavleros , Hans-Jörg Hippe , Karim Benali , George Bazoukis , Konstantinos P. Letsas , Antonio Frontera , Pierre Jais , Michael Gotzmann","doi":"10.1016/j.hjc.2024.04.006","DOIUrl":"10.1016/j.hjc.2024.04.006","url":null,"abstract":"<div><h3>Background</h3><div>Long-term data showed that up to 27% of pulmonary veins are reconnected using cryoballoon ablation. This study aimed to evaluate the efficacy of the latest 4th-generation cryoballoon catheters using ultra high-resolution mapping.</div></div><div><h3>Methods</h3><div>In patients with atrial fibrillation, a standard pulmonary vein isolation (PVI) with the latest 4th-generation cryoballoon catheter (Arctic Front Advance PRO, Medtronic Minneapolis, USA) and the spiral mapping catheter (Achieve Advance, Medtronic, Minneapolis, MN, USA) was performed. Subsequently, high-resolution mapping was achieved using the novel multipolar grid mapping catheter (Advisor HD Grid SE, Abbott Laboratories, USA). Follow-up was obtained after 6 months by means of a 7-day Holter electrocardiogram.</div></div><div><h3>Results</h3><div>In our study, acute PVI was successfully achieved in all 31 patients. The latest 4th-generation cryoballoon catheter is safe in the acute phase of PVI. Additional high-resolution mapping (mean points per map 21,001 ± 4911) using the multipolar grid mapping catheter enabled us to identify residual gaps only in the carina pulmonary vein region; therefore, no additional ablation was performed. Three of 31 patients (10%) presented with atrial arrhythmia recurrence always related with pulmonary vein reconnection; using high-resolution mapping had no additional benefit in identifying pulmonary veins in which reconnection will occur.</div></div><div><h3>Conclusion</h3><div>The utility of additional high-density mapping, facilitated by the HD Grid catheter after PVI with the 4th-generation cryoballoon catheter do not substantiate a discernible advantage over conventional mapping methodologies, particularly, the spiral mapping catheter. Residual carinal conduction was observed in a substantial cohort of patients (48%), highlighting a persistent challenge in achieving complete electrical isolation.</div></div>","PeriodicalId":55062,"journal":{"name":"Hellenic Journal of Cardiology","volume":"85 ","pages":"Pages 12-23"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140830403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated eicosapentaenoic acid to arachidonic acid ratio and rapid coronary blood flow restoration in ST-elevation myocardial infarction st段抬高型心肌梗死患者二十碳五烯酸/花生四烯酸比值升高与冠状动脉血流快速恢复。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Hellenic Journal of Cardiology

Pub Date : 2025-09-01 Epub Date: 2025-01-22 DOI: 10.1016/j.hjc.2025.01.003

Ryota Yamada, Manabu Uematsu, Takamitsu Nakamura, Tsuyoshi Kobayashi, Takeo Horikoshi, Toru Yoshizaki, Miu Eguchi, Toshiki Takei, Yosuke Watanabe, Kazuto Nakamura, Akira Sato

引用次数: 0

Discordance between remnant cholesterol and low-density lipoprotein cholesterol predicts cardiovascular disease: the Kailuan prospective cohort study 残余胆固醇与低密度脂蛋白胆固醇之间的不一致性可预测心血管疾病：开滦前瞻性队列研究。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Hellenic Journal of Cardiology

Pub Date : 2025-09-01 Epub Date: 2024-06-03 DOI: 10.1016/j.hjc.2024.05.002

Yijun Zhang , Shouling Wu , Xue Tian , Qin Xu , Xue Xia , Xiaoli Zhang , Jing Li , Shuohua Chen , Fen Liu , Anxin Wang

Objective

Previous studies have shown that remnant cholesterol (RC) is associated with cardiovascular disease (CVD). The study aimed to identify the association of RC and the discordance between RC and lipoprotein cholesterol (LDL-C) with CVD.

Methods

Data were obtained from the Kailuan study. RC was calculated as the non–high-density lipoprotein cholesterol minus LDL-C. Discordant RC and LDL-C were defined by percentile difference and clinical cut-off points. Cox proportional hazard models were used to explore the association of RC and the discordance between RC and LDL-C with CVD.

Results

A total of 96,769 participants were included, with a median age of 51.61 years and 79.56% were male. There was a significant association between RC levels and the risk of CVD, with an HR of 1.10 (95% CI, 1.08–1.13) in the continuous analysis. The group with a discordantly high RC had a significant increase in CVD, MI, and stroke risk, with HRs of 1.18 (95% CI, 1.10–1.26), 1.23 (1.06–1.43), and 1.15 (1.07–1.24), respectively. Compared with the group with low LDL-C and low RC, the group with low LDL-C and high RC had significantly higher incidences of CVD (HR, 1.33 [95% CI, 1.26–1.40]), MI (HR, 1.59 [95% CI, 1.41–1.80]), and stroke (HR, 1.28 [95% CI, 1.20–1.35]).

Conclusions

Elevated levels of RC and discordantly high RC with LDL-C were associated with the risk of CVD, MI, and stroke. These findings demonstrate the clinical significance of identifying residual risk related to RC.

背景：以往的研究表明，残余胆固醇（RC）与心血管疾病（CVD）有关。本研究旨在确定残余胆固醇以及残余胆固醇与脂蛋白胆固醇（LDL-C）之间的不一致性与心血管疾病的关系：方法：数据来自开滦研究。RC的计算方法是非高密度脂蛋白胆固醇减去低密度脂蛋白胆固醇。不一致的 RC 和 LDL-C 由百分位数差异和临床临界点定义。采用 Cox 比例危险模型探讨 RC 和 RC 与 LDL-C 不一致与心血管疾病的关系：共纳入 96 769 名参与者，中位年龄为 51.61 岁，男性占 79.56%。RC水平与心血管疾病风险之间存在明显关联，连续分析的HR值为1.10（95% CI，1.08-1.13）。不一致的高 RC 组心血管疾病、心肌梗死和中风风险显著增加，HR 分别为 1.18（95%CI，1.10-1.26）、1.23（1.06-1.43）和 1.15（1.07-1.24）。与低 LDL-C 和低 RC 组相比，低 LDL-C 和高 RC 组的心血管疾病（HR，1.33 [95% CI，1.26-1.40]）、心肌梗死（HR，1.59 [95% CI，1.41-1.80]）和中风（HR，1.28 [95% CI，1.20-1.35]）发病率明显更高：RC水平升高以及RC与低密度脂蛋白胆固醇（LDL-C）不一致的高水平均与心血管疾病、心肌梗死和脑卒中的风险有关。这些发现表明，识别与 RC 相关的残余风险具有重要的临床意义。

{"title":"Discordance between remnant cholesterol and low-density lipoprotein cholesterol predicts cardiovascular disease: the Kailuan prospective cohort study","authors":"Yijun Zhang , Shouling Wu , Xue Tian , Qin Xu , Xue Xia , Xiaoli Zhang , Jing Li , Shuohua Chen , Fen Liu , Anxin Wang","doi":"10.1016/j.hjc.2024.05.002","DOIUrl":"10.1016/j.hjc.2024.05.002","url":null,"abstract":"<div><h3>Objective</h3><div>Previous studies have shown that remnant cholesterol (RC) is associated with cardiovascular disease (CVD). The study aimed to identify the association of RC and the discordance between RC and lipoprotein cholesterol (LDL-C) with CVD.</div></div><div><h3>Methods</h3><div>Data were obtained from the Kailuan study. RC was calculated as the non–high-density lipoprotein cholesterol minus LDL-C. Discordant RC and LDL-C were defined by percentile difference and clinical cut-off points. Cox proportional hazard models were used to explore the association of RC and the discordance between RC and LDL-C with CVD.</div></div><div><h3>Results</h3><div>A total of 96,769 participants were included, with a median age of 51.61 years and 79.56% were male. There was a significant association between RC levels and the risk of CVD, with an HR of 1.10 (95% CI, 1.08–1.13) in the continuous analysis. The group with a discordantly high RC had a significant increase in CVD, MI, and stroke risk, with HRs of 1.18 (95% CI, 1.10–1.26), 1.23 (1.06–1.43), and 1.15 (1.07–1.24), respectively. Compared with the group with low LDL-C and low RC, the group with low LDL-C and high RC had significantly higher incidences of CVD (HR, 1.33 [95% CI, 1.26–1.40]), MI (HR, 1.59 [95% CI, 1.41–1.80]), and stroke (HR, 1.28 [95% CI, 1.20–1.35]).</div></div><div><h3>Conclusions</h3><div>Elevated levels of RC and discordantly high RC with LDL-C were associated with the risk of CVD, MI, and stroke. These findings demonstrate the clinical significance of identifying residual risk related to RC.</div></div>","PeriodicalId":55062,"journal":{"name":"Hellenic Journal of Cardiology","volume":"85 ","pages":"Pages 48-57"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic steatosis and its association with left ventricular concentric remodeling: insights from the Corinthia study 肝脏脂肪变性及其与左心室同心重塑的关系：科林斯研究的启示

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Hellenic Journal of Cardiology

Pub Date : 2025-09-01 Epub Date: 2024-11-02 DOI: 10.1016/j.hjc.2024.10.007

Panagiotis Theofilis , Vasiliki-Chara Mystakidi , Athina Goliopoulou , George-Angelos Papamikroulis , George Lazaros , Maria Anastasiou , Sotiris Tsalamandris , Georgia Vavouranaki , Emmanouil Korakas , Vaia Lambadiari , Gerasimos Siasos , Evangelos Oikonomou , Dimitris Tousoulis

引用次数: 0

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