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Climate change shifts almond bloom dates in Afghanistan 气候变化改变了阿富汗的杏花日期。
IF 3 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2026-07-28 DOI: 10.1007/s00484-026-03288-0
Atifullah Shinwari, Lars Caspersen, Katja Schiffers, Eike Luedeling

Climate change is reshaping the spring phenology of temperate fruit and nut trees worldwide, causing uneven bud break and yield losses across major production regions. Almond trees, including those cultivated in Afghanistan, are susceptible to these shifts. Afghanistan produces over 50 almond varieties, with official exports worth around USD 40 million in 2024. Yet, this value remains below potential due to multiple challenges along the value chain, one of which is the ongoing temperature increase affecting phenology and yields.

We projected the flowering dynamics of 51 Afghan almond cultivars using long-term temperature data (1980–2023) and phenological observations (2011–2023). Two historical reference periods (1980 and 2020) and future projections for 2050 and 2085 were simulated under three Shared Socioeconomic Pathway (SSP) scenarios (SSP1-2.6, SSP2-4.5, SSP5-8.5) based on 15 General Circulation Models. Bloom predictions were obtained using the PhenoFlex modeling framework with a recently developed combined-fitting approach. The model accurately reproduced observed bloom patterns, achieving a Root Mean Square Error of Prediction below four days for all cultivars. Compared to 1980, bloom dates advanced by roughly two weeks by 2020. Future projections suggest additional advances of up to 16 days for most cultivars, whereas a few exhibited delays of up to 12 days. Pronounced shifts exceeding seven days were found in about 25% of all predictions driven by specific cultivars, especially by 2085 under intermediate and high-emission scenarios. These results emphasize the significant and ongoing changes in almond phenology, highlighting the importance of adaptive management to sustain production and export potential under future climates.

气候变化正在重塑全球温带果树和坚果树木的春季物候特征,导致主要产区发芽不均和产量损失。杏树,包括在阿富汗种植的杏树,很容易受到这些变化的影响。阿富汗生产50多种杏仁,2024年官方出口额约为4000万美元。然而,由于价值链上的多重挑战,这个价值仍然低于潜在价值,其中之一是持续的温度升高影响物候和产量。利用1980-2023年的长期温度数据和2011-2023年的物候观测数据,预测了51个阿富汗杏仁品种的开花动态。基于15种大气环流模式,在共享社会经济路径(SSP)情景(SSP1-2.6、SSP2-4.5、SSP5-8.5)下模拟了两个历史参考期(1980年和2020年)以及2050年和2085年的未来预测。Bloom预测是使用PhenoFlex建模框架和最近开发的组合拟合方法获得的。该模型准确地再现了观察到的开花模式,所有品种的预测均方根误差均低于4天。与1980年相比,到2020年,开花日期提前了大约两周。未来的预测表明,大多数品种的额外提前达16天,而少数品种则表现出长达12天的延迟。在特定品种驱动的所有预测中,约有25%的预测出现了超过7天的显著变化,特别是在中排放和高排放情景下,到2085年。这些结果强调了杏仁物候的重大和持续变化,强调了适应性管理在未来气候条件下维持生产和出口潜力的重要性。
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引用次数: 0
The dual challenge of climate change in otolaryngology: Environmental impacts on airway diseases and emission reduction strategies in surgical care 气候变化对耳鼻喉科的双重挑战:环境对气道疾病的影响和外科护理中的减排策略。
IF 3 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2026-07-24 DOI: 10.1007/s00484-026-03289-z
Nuray Bayar Muluk

This review examines the dual relationship between climate change and otolaryngology by assessing the environmental impacts on upper airway diseases, particularly allergic rhinitis (AR), and identifying concrete, evidence-based strategies to reduce greenhouse gas (GHG) emissions within surgical practice. A narrative literature review was conducted to provide an interpretative synthesis of current knowledge across two distinct but interconnected domains: climate-driven airway health impacts and the environmental sustainability of surgical care. Literature was purposively selected from major databases to support this discussion. Available evidence suggests that elevated CO₂ and particulate matter (PM2.5) act synergistically to increase the allergenicity and mucosal penetration of pollen, significantly exacerbating AR, chronic rhinosinusitis, and sleep-disordered breathing. Marginalized populations face disproportionate exposure to these health impacts due to socioeconomic disparities. In the surgical domain, healthcare contributes approximately 5.2% of global emissions, with operating rooms generating up to 30% of hospital waste. Transitioning from single-use devices to reusable alternatives—such as replacing disposable instruments that account for 68% of the carbon footprint in tonsillectomies—and optimizing anesthetic gas management significantly reduce Scope 3 emissions without compromising patient safety. Otolaryngologists face a critical dual challenge: managing the escalating, climate-driven burden of upper aerodigestive tract disorders while actively mitigating the specialty’s own carbon footprint. Recognizing socioeconomic vulnerabilities and adopting rigorous, LCA-backed sustainable surgical practices are vital. However, widespread clinical implementation remains restricted by infrastructural and financial constraints, particularly in low- and middle-income countries (LMICs).

本综述通过评估环境对上呼吸道疾病,特别是过敏性鼻炎(AR)的影响,以及确定在外科实践中减少温室气体(GHG)排放的具体循证策略,探讨了气候变化与耳鼻喉科之间的双重关系。我们进行了一项叙述性文献综述,以提供两个不同但相互关联的领域的现有知识的解释性综合:气候驱动的气道健康影响和手术护理的环境可持续性。有目的地从主要数据库中选择文献来支持本讨论。现有证据表明,升高的CO₂和颗粒物(PM2.5)协同作用,增加花粉的致敏性和粘膜渗透,显著加剧AR、慢性鼻窦炎和睡眠呼吸障碍。由于社会经济差距,边缘化人群面临着这些健康影响的不成比例暴露。在外科领域,医疗保健约占全球排放量的5.2%,手术室产生的废物占医院废物的30%。从一次性使用设备过渡到可重复使用的替代品,例如替换占扁桃体切除术碳足迹68%的一次性器械,并优化麻醉气体管理,可显着减少范围3的排放,同时不影响患者的安全。耳鼻喉科医生面临着一个关键的双重挑战:管理不断升级的,由气候驱动的上呼吸道疾病负担,同时积极减少专业自身的碳足迹。认识到社会经济脆弱性并采用严格的、lca支持的可持续外科实践是至关重要的。然而,广泛的临床实施仍然受到基础设施和财政限制的限制,特别是在低收入和中等收入国家。
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引用次数: 0
Climatotherapy in marine and dead sea environments for musculoskeletal and rheumatologic conditions: a systematic review of effectiveness and safety 海洋和死海环境中的气候疗法治疗肌肉骨骼和风湿病:有效性和安全性的系统综述。
IF 3 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2026-07-23 DOI: 10.1007/s00484-026-03279-1
Tatiana Leite Müller, Fernando Hellmann, Daniel Maurício de Oliveira Rodrigues, María Lorena Vela, Francisco Maraver

Climatotherapy (including thalassotherapy, sun exposure, and marine mud therapy) has long been used as a complementary intervention for musculoskeletal and rheumatologic disorders (MSRDs), yet its evidence base remains fragmented and methodologically heterogeneous. To synthesize the effectiveness and safety of climatotherapy in marine or Dead Sea environments for MSRDs, focusing on pain, physical function, and health-related quality of life. Following Joanna Briggs Institute methodology and PRISMA 2020, PubMed, PEDro, and the Cochrane Library were searched (May 2024; updated September 2025) for randomized and non-randomized trials of climatotherapy in marine or Dead Sea settings. Methodological quality was assessed with the PEDro scale. A structured narrative synthesis was complemented by a limited meta-analysis of pain; given the few trials and substantial heterogeneity, pooled estimates are exploratory. Ten articles representing nine studies (n = 465) were included. Interventions consistently produced short-term improvements in pain, physical function, and quality of life. Pooling was feasible only for pain (k = 2) and was statistically inconclusive, but condition-specific analysis showed a large, significant effect in osteoarthritis and a smaller, non-significant effect in fibromyalgia. Single-study estimates indicated benefits for tender point count and physical quality of life. No serious adverse events were reported, though safety was inconsistently assessed. Climatotherapy shows consistent short-term benefits, particularly for pain and physical function in osteoarthritis. Methodological limitations preclude firm pooled conclusions; rigorous multicenter trials with standardized outcomes and safety reporting are needed.

Trial RegistrationPROSPERO CRD42024534694 (registered May 2024).

气候疗法(包括地中海疗法、阳光照射和海洋泥浆疗法)长期以来一直被用作肌肉骨骼和风湿病(msrd)的辅助干预措施,但其证据基础仍然是碎片化的,方法上也存在差异。综合海洋或死海环境中气候疗法对msrd的有效性和安全性,重点关注疼痛、身体功能和与健康相关的生活质量。根据乔安娜布里格斯研究所的方法和PRISMA 2020, PubMed、PEDro和Cochrane图书馆(2024年5月;2025年9月更新)检索了海洋或死海环境中气候疗法的随机和非随机试验。采用PEDro量表评估方法学质量。有组织的叙事综合辅以有限的疼痛元分析;由于试验少,异质性大,综合估计是探索性的。纳入了代表9项研究的10篇文章(n = 465)。干预措施持续在短期内改善疼痛、身体功能和生活质量。仅对疼痛可行(k = 2),且在统计学上尚无定论,但针对特定疾病的分析显示,对骨关节炎有较大且显著的效果,对纤维肌痛则有较小且不显著的效果。单项研究估计表明对压痛点计数和身体生活质量有好处。虽然安全性评估不一致,但没有严重不良事件的报道。气候疗法显示出一致的短期效益,特别是对骨关节炎的疼痛和身体功能。方法上的局限性使我们无法得出确定的综合结论;严格的多中心试验需要标准化的结果和安全报告。试验注册号prospero CRD42024534694(注册于2024年5月)。
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引用次数: 0
Assessment of outdoor thermal comfort in Northwestern India using effective temperature (ET) and the temperature-humidity index (THI) 利用有效温度(ET)和温湿指数(THI)评价印度西北部地区室外热舒适。
IF 3 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2026-07-23 DOI: 10.1007/s00484-026-03271-9
Tanmay Sanjay Jadhav, Amit Gulabrao Dhorde

Understanding long-term and intra-annual variations in human thermal discomfort is essential for climate-health assessments in climate-sensitive regions. In this paper, thermal comfort dynamics have been analyzed at seven locations in Northwestern India by utilizing Effective Temperature (ET) and Temperature-Humidity Index (THI) data for a period of 54 years (1969–2022). Climatic data for dry-bulb temperature (DBT), wet-bulb temperature (WBT), relative humidity (RH), and wind speed (WS) on a daily basis were acquired from the India Meteorological Department (IMD), while missing data were supplemented from NASA’s MERRA-2. Analyses were conducted at annual, seasonal, monthly, and weekly scales. Annual averages of ET and THI indicate generally comfortable conditions; however, higher-resolution analyses reveal substantial thermal stress periods that annual means obscure. At Delhi and Amritsar, ET shows either weak or non-significant trends, while THI exhibits significant warming due to increased WBT, reduced RH, and wind stilling. Trends analyzed on a monthly and weekly basis reveal pronounced seasonal intensification of heat stress. During the pre-summer period, ET shows notable warming, with weekly trends reaching + 0.081 to + 0.086 °C/year in Ambala and Patiala. Pre-monsoon warming is more evident in THI, increasing by + 0.058 to + 0.077 °C/year during mid-May in Delhi, Patiala, and Amritsar. Persistent peak heat from June to mid-July coincides with WBT increases of approximately + 0.05 °C/year at several stations. In contrast, winter and post-monsoon periods exhibit cooling in THI associated with reductions in WBT and DBT, while ET shows weaker declines due to concurrent decreases in wind speed. These contrasting ET and THI responses highlight the importance of multi-index and ventilation-sensitive assessments for thermal risk evaluation, public health preparedness, and climate adaptation planning in Northwestern India.

了解人类热不适的长期和年内变化对于气候敏感地区的气候健康评估至关重要。本文利用1969-2022年的有效温度(ET)和温湿度指数(THI)数据,对印度西北部7个地点的热舒适动态进行了分析。每天的干球温度(DBT)、湿球温度(WBT)、相对湿度(RH)和风速(WS)的气候数据来自印度气象部门(IMD),而缺失的数据则来自美国宇航局的MERRA-2。按年、季节、月和周进行分析。ET和THI的年平均值表明环境总体舒适;然而,更高分辨率的分析揭示了大量的热应力周期,而这些周期的年平均值是模糊的。在德里和阿姆利则,ET表现出微弱或不显著的趋势,而THI则表现出明显的变暖,这是由于WBT增加、相对湿度减少和风静止。按月和按周分析的趋势显示,热压力的季节性明显加剧。夏前期ET明显变暖,Ambala和Patiala的周趋势达到+ 0.081 ~ + 0.086°C/年。季风前变暖在THI中更为明显,5月中旬在德里、帕蒂亚拉和阿姆利则增加了+ 0.058至+ 0.077°C/年。6月至7月中旬持续的峰值温度与若干站点的年平均湿热升高约+ 0.05°C一致。相比之下,冬季和季风后时期THI的降温与WBT和DBT的减少有关,而ET的下降则由于风速的同时减少而减弱。这些对比的ET和THI响应突出了多指数和通风敏感评估对印度西北部热风险评估、公共卫生准备和气候适应规划的重要性。
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引用次数: 0
Can time-series of Landsat data be used to map the onset of growth at 78°N (central Svalbard)? 陆地卫星数据的时间序列能否用于绘制北纬78°(斯瓦尔巴群岛中部)的生长开始?
IF 3 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2026-07-22 DOI: 10.1007/s00484-026-03276-4
Laura Stendardi, Giovanni Argenti, Luigi Ranghetti, Stein Rune Karlsen

Mapping vegetation phenology in the high Arctic is critical for understanding ecosystem responses to rapid warming, but persistent cloud cover and low solar angles pose substantial challenges for optical satellite monitoring. We evaluated whether Landsat 8 can successfully map the start of growing season (SOS) at 78°N in Svalbard by developing spectral-based cloud detection algorithms tailored to Arctic conditions. From 17 images during the 2014 growing season, we generated cloud-free NDVI time series and extracted SOS dates at 30-m resolution across Adventdalen (Advent Valley). Validation against six field plots equipped with phenocameras demonstrated strong agreement (R² = 0.884, RMSE = 4.1 days, NSE = 0.869). The resulting SOS map revealed systematic spatial patterns ranging from late May to early August, with elevation explaining 6.6% of variance as the strongest single predictor. Combined topographic models (elevation, slope, distance from sea) explained 14.6% of variance, indicating that unmeasured factors particularly aspect, snow distribution, and vegetation composition exert dominant controls on phenological timing. These results confirm the viability of Landsat-based phenology mapping in the high Arctic. Critically, by establishing a validated processing framework this study provides the methodological foundation for application to the historical Landsat archive (Landsat 4/5 TM and Landsat 7 ETM+), subject to cross-sensor radiometric calibration. This opens unprecedented opportunities for reconstructing 30-m resolution phenological time series extending back to 1984, enabling quantification of four decades of vegetation responses to Arctic warming in regions experiencing some of Earth’s most rapid climate change.

绘制高北极地区植被物候图对于了解生态系统对快速变暖的响应至关重要,但持续的云层覆盖和低太阳角度对光学卫星监测构成了重大挑战。我们通过开发适合北极条件的基于光谱的云检测算法,评估了Landsat 8是否能够成功地绘制出斯瓦尔巴群岛北纬78°的生长期开始(SOS)。从2014年生长季的17幅图像中,我们生成了无云NDVI时间序列,并提取了Adventdalen (Advent Valley)地区30米分辨率的SOS数据。对6个配备了现象相机的野外地块进行验证,结果非常吻合(R²= 0.884,RMSE = 4.1天,NSE = 0.869)。由此得到的SOS地图揭示了从5月下旬到8月上旬的系统空间格局,海拔是最强大的单一预测因子,解释了6.6%的方差。组合地形模型(高程、坡度、离海距离)解释了14.6%的方差,表明未测量的因素,特别是坡向、积雪分布和植被组成对物候时间起主导作用。这些结果证实了陆地卫星物候制图在高北极地区的可行性。重要的是,通过建立一个经过验证的处理框架,本研究为应用于历史Landsat档案(Landsat 4/5 TM和Landsat 7 ETM+)提供了方法论基础,并进行了跨传感器辐射校准。这为重建可追溯到1984年的30米分辨率物候时间序列提供了前所未有的机会,从而可以量化经历地球上一些气候变化最迅速地区40年来植被对北极变暖的响应。
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引用次数: 0
Validity and field applicability of the environmental stress index (ESI) for heat stress assessment in outdoor workers of arid/semi-arid climates 环境应力指数(ESI)在干旱/半干旱气候下户外工作者热应激评价中的有效性和现场适用性
IF 3 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2026-07-22 DOI: 10.1007/s00484-026-03282-6
Roghayeh Akbari, Mehdi Asghari, Mohamad Amrolahi, Abolfazl Hossein Nataj, Seyed Ehsan Samaei

The Wet-Bulb Globe Temperature (WBGT) is the benchmark for occupational heat-stress assessment, yet its accuracy can be constrained by variability in humidity, air movement, and solar load. The Environmental Stress Index (ESI), derived from routinely available meteorological variables, has been proposed as a low-cost field surrogate. This study evaluated the agreement and physiological relevance of ESI versus WBGT among outdoor workers across arid and semi-arid climates in Iran. A cross-sectional study was conducted on 150 sand-and-gravel mine workers in arid and semi-arid regions of Iran. Environmental and physiological data were collected at different times. The WBGT (based on ISO 7243) and ESI (based on ambient parameters) were calculated. Between-climate differences were analyzed using t-test or Mann–Whitney U; agreement was assessed by ICC; and associations with meteorological and physiological variables were evaluated using GEE (α = 0.05). In the semi-arid site, the values of both WBGT and ESI were higher during the warmer hours (p < 0.001). Regression analyses revealed statistically significant relationships between the thermal indices and most environmental parameters in both climates (p < 0.05). The agreement between WBGT and ESI was high (ICCarid:0.98, ICCsemi−arid:0.97) with statistically significant correlations in both climates (p < 0.001). In the arid site, both WBGT and ESI showed significant positive correlations with physiological responses, whereas in the semi-arid site, only the ESI index exhibited significant correlations with physiological responses (p < 0.05). Overall, ESI demonstrated performance equivalent to WBGT in the arid site and was suitable for field screening applications. ESI shows strong agreement with WBGT and meaningful physiological validity in arid sites, making it a viable low-cost screening tool when WBGT devices are unavailable. It is recommended that industries in arid regions adopt ESI for daily heat-stress monitoring.

湿球温度(WBGT)是职业热应力评估的基准,但其准确性可能受到湿度、空气运动和太阳能负荷变化的限制。环境压力指数(ESI)是从常规可获得的气象变量中得出的,被认为是一种低成本的野外替代方法。本研究评估了伊朗干旱和半干旱气候下户外工作者的ESI与WBGT的一致性和生理相关性。对伊朗干旱和半干旱地区的150名砂砾矿工人进行了横断面研究。在不同时间采集环境和生理数据。计算了WBGT(基于ISO 7243)和ESI(基于环境参数)。气候间差异分析采用t检验或Mann-Whitney U;国际商会评估了协议;用GEE评价其与气象和生理变量的相关性(α = 0.05)。在半干旱区,WBGT和ESI值在温暖时段均较高(p arid:0.98, icc半干旱区:0.97),且在两种气候条件下具有显著的统计学相关性(p
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引用次数: 0
Sustained control of PM2.5 concentrations in low concentration areas can improve life expectancy for patients with specific cardiovascular diseases 持续控制低浓度地区的PM2.5浓度可以提高特定心血管疾病患者的预期寿命。
IF 3 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2026-07-22 DOI: 10.1007/s00484-026-03233-1
Anqi You, Weiyao Cai, Yuanhong Zeng, Yanlin Huang, Ye Xiao, Lili Yu, Jinxi Shu, Qingping Xue, Yajie Zhang, Zhaoqiong Chen

A growing number of studies suggest that exposure to particulate matters with aerodynamic diameters < 2.5 μm (PM2.5) below air quality standards still increases the risk of death from cardiovascular disease (CVD), and the risk of death from ischemic heart disease (IHD) and stroke, the largest cause of CVD death. The aim of this study was to investigate the effect of PM2.5 exposure at lower levels on years of life lost (YLL) and potential life expectancy benefits for IHD and stroke. We investigated the relationship between daily PM2.5 and YLL for IHD and stroke using a generalized additive model (GAM) based on Poisson distribution. Furthermore, we extended our analysis to estimate the Potential Gain in Life Expectancy (PGLE) and the Attributable Fraction (AF) under the current Chinese air quality standards and more stringent World Health Organization (WHO) air quality guidelines. Findings reveal that for each 10 µg/m3 increase in PM2.5, YLL rose by 1.69 years for IHD and 1.34 years for stroke, with the most significant effects observed on the day of exposure for IHD and three days post-exposure for stroke. The impact was more pronounced among women and those aged ≥ 65 years. If PM2.5 levels met the 2021 WHO air quality guidelines, PGLE of 0.22 years for IHD and 0.16 years for stroke could be achieved. The study highlights the need for stricter PM2.5 control measures to enhance cardiovascular health and reduce mortality, even in regions with relatively low pollution levels.

越来越多的研究表明,暴露于空气动力学直径低于空气质量标准2.5)的颗粒物仍然会增加死于心血管疾病(CVD)的风险,以及死于缺血性心脏病(IHD)和中风(CVD死亡的最大原因)的风险。本研究的目的是调查PM2.5暴露在较低水平下对IHD和中风的寿命损失年数(YLL)和潜在预期寿命益处的影响。我们使用基于泊松分布的广义加性模型(GAM)研究了每日PM2.5与IHD和中风的YLL之间的关系。此外,我们扩展了我们的分析,以估计在当前中国空气质量标准和更严格的世界卫生组织(WHO)空气质量指南下预期寿命的潜在增益(PGLE)和归因分数(AF)。研究结果显示,PM2.5每增加10微克/立方米,IHD患者的寿命就会增加1.69年,卒中患者的寿命会增加1.34年,其中IHD暴露当天和卒中暴露后3天的影响最为显著。这种影响在女性和年龄≥65岁的人群中更为明显。如果PM2.5水平符合2021年世卫组织空气质量指南,IHD患者的平均寿命为0.22年,卒中患者的平均寿命为0.16年。该研究强调,即使在污染水平相对较低的地区,也需要采取更严格的PM2.5控制措施,以增强心血管健康,降低死亡率。
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引用次数: 0
Heat stress associated depression and allied affliction: Therapeutic roles of nutrition, micronutrients, and phytochemicals-a review 热应激相关的抑郁和相关疾病:营养、微量营养素和植物化学物质的治疗作用综述。
IF 3 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2026-07-21 DOI: 10.1007/s00484-026-03286-2
Taha Majid Mahmood Sheikh, Abdul Malik Tareen, Muhammad Asif Arain

Heat stress is a critical environmental factor disrupting systemic homeostasis and impairing mental health, with increasing evidence linking prolonged thermal exposure to depression and related neuropsychological disorders. Chronic heat stress induces neuroendocrine dysregulation via hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis, alongside oxidative stress, neuroinflammation, mitochondrial dysfunction, and altered neurotransmitter signaling, collectively elevating risks of mood disturbances, anxiety, cognitive decline, and sleep disorders. Emerging evidence highlights nutrition as a key modulator of heat stress–induced neuropathology. Adequate macronutrient intake supports energy balance and thermoregulation, while micronutrients such as B vitamins, vitamin D, magnesium, zinc, selenium, and iron are essential for neurotransmission, antioxidant defense, and immune function. Additionally, phytochemicals including polyphenols, flavonoids, and carotenoids exert neuroprotective, anti-inflammatory, and HPA-regulatory effects, partly through modulation of the gut-brain axis. This integrative approach offers promising non-pharmacological strategies to enhance resilience against heat-induced depression.

热应激是破坏系统内稳态和损害心理健康的关键环境因素,越来越多的证据表明长时间的热暴露与抑郁症和相关的神经心理障碍有关。慢性热应激通过下丘脑-垂体-肾上腺(HPA)轴的过度激活,以及氧化应激、神经炎症、线粒体功能障碍和神经递质信号改变,诱导神经内分泌失调,共同增加情绪障碍、焦虑、认知能力下降和睡眠障碍的风险。新出现的证据强调营养是热应激诱导的神经病理的关键调节剂。充足的宏量营养素摄入有助于能量平衡和体温调节,而微量营养素如B族维生素、维生素D、镁、锌、硒和铁对神经传递、抗氧化防御和免疫功能至关重要。此外,包括多酚、类黄酮和类胡萝卜素在内的植物化学物质发挥神经保护、抗炎和hpa调节作用,部分通过调节肠脑轴。这种综合方法提供了有希望的非药物策略,以增强抵御热引起的抑郁症。
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引用次数: 0
Modeling the potential distribution of Nothotsuga longibracteata in China under current and future climate scenarios using the biomod2 model 基于biomod2模型的中国长苞Nothotsuga longbracteata在当前和未来气候情景下的潜在分布
IF 3 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2026-07-20 DOI: 10.1007/s00484-026-03277-3
Zhuangpeng Zheng, Haojun Deng, Weilan Xu, Yahui Mao, Gangbo Guo, Zhipeng Zhou, Weijie Yang, Shuwei Huang

Nothotsuga longibracteata is an endangered tree species endemic to China whose conservation is constrained by limited information on habitat suitability. Using the biomod2 platform, we developed an ensemble model integrating climatic, topographic, edaphic, and human-related variables to predict its current and future potential distribution under climate change. The ensemble model consistently outperformed individual algorithms across evaluation metrics. The most important predictors were precipitation of the coldest quarter (Bio19), mean diurnal temperature range (Bio2), human footprint, elevation, precipitation of the warmest quarter (Bio18), and mean temperature of the driest quarter (Bio9). Under current conditions, the suitable habitat for N. longibracteata covers approximately 872.5 × 10³km², concentrated in Hunan, Jiangxi, and Guangxi, with high-suitability areas primarily in southern Hunan, northeastern Guangxi, and northwestern Guangdong. Future projections revealed a decoupling between habitat extent and habitat quality, with low-suitability areas expanding while moderate- and high-suitability habitats declined, accompanied by shifts in the distribution centroid toward higher latitudes and elevations. This pattern suggests that changes in total suitable area alone may underestimate decline risk. Given the limited overlap between suitable habitat and existing protected areas, we recommend prioritizing in situ conservation in core regions, especially Hunan and Guangxi, while considering Hubei, Anhui, and Chongqing as potential areas for assisted migration and climate-adaptive cultivation.

Clinical Trial Registration: Not applicable.

长苞木杉(Nothotsuga longibrteata)是中国特有的濒危树种,其保护受到生境适宜性信息有限的制约。利用biomod2平台,我们建立了一个综合气候、地形、地理和人类相关变量的集合模型,以预测其在气候变化下的当前和未来的潜在分布。集成模型始终优于跨评估度量的单个算法。最冷季降水(Bio19)、平均日温差(Bio2)、人类足迹、海拔、最暖季降水(Bio18)和最干季平均气温(Bio9)是最重要的预测因子。在现有条件下,长苞草适宜生境面积约为872.5 × 10³km²,主要分布在湖南、江西和广西,高适宜区主要分布在湘南、广西东北部和广东西北部。未来的预测结果显示,低适宜性区域扩大,中、高适宜性区域减少,生境分布重心向高纬度和高程方向移动。这种模式表明,仅改变总适宜面积可能低估了下降风险。考虑到适宜栖息地与现有保护区之间的重叠有限,我们建议优先考虑在核心地区(特别是湖南和广西)进行就地保护,同时考虑湖北、安徽和重庆作为辅助迁徙和气候适应栽培的潜在地区。临床试验注册:不适用。
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引用次数: 0
Effects of medical mud-pack therapy on inflammatory gene expression and clinical outcomes in patients with knee osteoarthritis 医用泥包疗法对膝关节骨性关节炎患者炎症基因表达及临床预后的影响
IF 3 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2026-07-20 DOI: 10.1007/s00484-026-03258-6
Mustafa Kahraman, Serap Seringeç Karabulut, Kevser Gumussu, Sıla Hidayet Bozdoğan Polat, Ayla Şahin, Fevziye Naile Mısırlıoğlu, Abdülkadir Polat, Sükrü Öztürk

This study aimed to evaluate the association of medical mud-pack therapy with changes in gene expression of key inflammatory markers, miRNA and clinical outcomes in patients with knee osteoarthritis. Thirty-two patients with knee osteoarthritis were assigned to a medical mud-pack therapy (MMT) group (n = 16) or control group (n = 16). Molecular assessments used quantitative PCR for key cytokines and miRNA expressions. Clinical outcomes were evaluated with the VAS for pain and WOMAC for function. Pre- and post-treatment measurements were obtained, with the MMT group receiving mud-pack therapy plus standard care, while controls performed exercise only. The MMT group showed significant reductions in gene expression of TNF-α (1.90 ± 0.41 to 1.43 ± 0.33, p < 0.05), IL-6 (1.34 ± 0.31 to 0.93 ± 0.27, p < 0.05), and IL-1β (2.20 ± 0.40 to 1.81 ± 0.34, p < 0.05), whereas the control group showed no significant molecular changes. Between-group comparisons showed greater reductions in the MMT group for all cytokines (Δ difference: −0.38 to − 0.51, 95% CI not crossing zero, p < 0.05) with large effect sizes (d = 0.88–1.12). miR-140 expression remained unchanged in both groups (p > 0.05). Clinically, the MMT group showed significant VAS pain reduction after adjustment for baseline values (ANCOVA: post-treatment and first-month VAS both p < 0.001), while the control group showed minimal change. Groups were similar in age and sex distribution. Medical mud-pack therapy combined with exercise was associated with reduced expression of key inflammatory cytokines and pain relief in knee osteoarthritis. Further studies are required to explore underlying molecular mechanisms of mud-pack interventions.

本研究旨在评估药物泥包治疗与膝关节骨关节炎患者关键炎症标志物、miRNA基因表达变化和临床结局的关系。32例膝关节骨性关节炎患者被分为药物泥包治疗组(n = 16)和对照组(n = 16)。分子鉴定采用定量PCR检测关键细胞因子和miRNA表达。临床结果以VAS评估疼痛,WOMAC评估功能。获得治疗前和治疗后的测量,MMT组接受泥包治疗和标准护理,而对照组只进行运动。MMT组TNF-α基因表达显著降低(1.90±0.41 ~ 1.43±0.33,p 0.05)。在临床上,MMT组在调整基线值后VAS疼痛明显减轻(ANCOVA:治疗后和第一个月VAS均p
{"title":"Effects of medical mud-pack therapy on inflammatory gene expression and clinical outcomes in patients with knee osteoarthritis","authors":"Mustafa Kahraman,&nbsp;Serap Seringeç Karabulut,&nbsp;Kevser Gumussu,&nbsp;Sıla Hidayet Bozdoğan Polat,&nbsp;Ayla Şahin,&nbsp;Fevziye Naile Mısırlıoğlu,&nbsp;Abdülkadir Polat,&nbsp;Sükrü Öztürk","doi":"10.1007/s00484-026-03258-6","DOIUrl":"10.1007/s00484-026-03258-6","url":null,"abstract":"<div><p>This study aimed to evaluate the association of medical mud-pack therapy with changes in gene expression of key inflammatory markers, miRNA and clinical outcomes in patients with knee osteoarthritis. Thirty-two patients with knee osteoarthritis were assigned to a medical mud-pack therapy (MMT) group (n = 16) or control group (n = 16). Molecular assessments used quantitative PCR for key cytokines and miRNA expressions. Clinical outcomes were evaluated with the VAS for pain and WOMAC for function. Pre- and post-treatment measurements were obtained, with the MMT group receiving mud-pack therapy plus standard care, while controls performed exercise only. The MMT group showed significant reductions in gene expression of TNF-α (1.90 ± 0.41 to 1.43 ± 0.33, p &lt; 0.05), IL-6 (1.34 ± 0.31 to 0.93 ± 0.27, p &lt; 0.05), and IL-1β (2.20 ± 0.40 to 1.81 ± 0.34, p &lt; 0.05), whereas the control group showed no significant molecular changes. Between-group comparisons showed greater reductions in the MMT group for all cytokines (Δ difference: −0.38 to − 0.51, 95% CI not crossing zero, p &lt; 0.05) with large effect sizes (d = 0.88–1.12). miR-140 expression remained unchanged in both groups (p &gt; 0.05). Clinically, the MMT group showed significant VAS pain reduction after adjustment for baseline values (ANCOVA: post-treatment and first-month VAS both p &lt; 0.001), while the control group showed minimal change. Groups were similar in age and sex distribution. Medical mud-pack therapy combined with exercise was associated with reduced expression of key inflammatory cytokines and pain relief in knee osteoarthritis. Further studies are required to explore underlying molecular mechanisms of mud-pack interventions.</p></div>","PeriodicalId":588,"journal":{"name":"International Journal of Biometeorology","volume":"70 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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International Journal of Biometeorology
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